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Protein for Athletes
 American College of Sports Medicine (ACSM) /
American Dietetic Association (ADA)
–Endurance athletes, 1.2 to 1.4 g/kg per day
• Accounts for greater use of protein as fuel for energy
–Strength athletes, 1.2 to 1.7 g/kg per day
• To support muscle growth, particularly during early training phase when gains
are greatest and protein utilization is less efficient
 Clinical studies suggest there is no apparent
benefit at intakes above 2.0 g/kg per day
How much protein for athletes?
• Many athletes may already meet or exceed protein
recommendations
– Definition of “high protein” can be the absolute amount of
protein, % of total energy (calories), or protein ingested
per kg of body weight
• Strength athletes in particular may believe that much
higher protein intakes are needed for muscle building
– Intakes at 4- to 6-g/kg range are not uncommon
– Unlikely to provide benefit beyond 2.0 g/kg
– It is possible that this much protein intake could adversely
affect the nutrient quality of the overall diet
Risks of High Protein
 Hydration status
– Nitrogen that is obtained from consuming protein must be excreted in the
urine as urea
– Increased urinary output due to high protein load may increase chances of
dehydration
 Diets very high in protein may lack appropriate amounts
of carbohydrate, fiber, and some vitamins/minerals
– Could impair exercise performance
– Could increase long-term risk of diseases such as colon cancer
• Possibly due to lack of fiber or increased intake of red meat
 Excessively fatty protein sources could increase risk
of cardiovascular disease
– Choose mostly lean protein sources
• For example, salmon is more desirable than a ribeye steak
Branched Chain Amino Acids
• Make up 40% of the daily requirements of essential amino
acids
Branched Chain Amino Acids
 BCAAs are
 Unlike other amino acids, most BCAA
metabolism occurs in skeletal muscle
– Liver lacks first 2 enzymes in the pathway that break
down BCAAs
 Supplemental free form, bypass the liver and gut
and go directly into the blood stream.
 BCAAs inhibit brains ability to uptake tryptophan
Leucine
– The bodies need for leucine is 25 times greater than
the available free amino acid pool.
– Stimulates protein synthesis by activating insulin
– Insulin increases a.a. uptake
– Incorporation of BCAAs in muscle is IGF-1 dependent
– IGF-1 stimulates muscle synthesis
– Chronic low levels of BCAAs will show up in urine
– β-hydroxy-β-methylbutyrate (HMB) is derived from the
breakdown of leucin
– Some evidence in humans that doses of 3 g/day may
be effective at preventing muscle breakdown
• Additive benefits with creatine
– Some studies suggest that HMB may provide greater
benefit to untrained people who start weight training
compared with previously conditioned athletes
Should athletes Supplement?
 If protein requirements are met, the individual AA
requirements should be met as well
 Estimated that 3-18% of workout energy is provided by
BCAAs
 Leucine increases release of fats for energy
 Claims mainly center on decreasing muscle soreness and
improving either performance or recovery from exercise
 Doses can range from 2 to 7 g/day to more than 20 g/day
taken before during and after
 There are potential risks associated with AA supplements
– Large doses of single AAs can prevent the absorption of other AAs, which may
lead to diarrhea
– Can indirectly cause deficiency of other AAs as a result
Phosphocreatine
• aka creatine phosphate (PCr)
• Rapidly mobilizable reserve
of high energy phosphate for
skeletal muscle (and brain)
• Formed from parts of Arg,
Gly & Met
• Can donate phosphate to
ADP anaerobically in the first
2-7 seconds following an
intense muscular effort
• Forward and reverse reaction
catalyzed by CK, which is a
marker of muscle damage
Alcohol
• Ethanol
• Not a nutrient
• 7 kcal/g
• 50% alcohol = 100 proof
Alcohol Absorption
• Small amounts absorbed
in mouth and esophagus
• 20% absorbed directly
across stomach wall
• Food delays diffusion
• Most absorbed by simple
diffusion in the upper
small intestine
• Distributed wherever
water is found
Alcohol metabolism
1) Alcohol Dehydrogenase System
- women have less
- varies among ethnic groups
- NADH production turns of TCA cycle
- Excess acetyl CoA converted to FATTY ACIDS
- Fatty liver develops
2) Microsomal Ethanol-oxidizing
System (MEOS)
• When ADH cannot keep up with demand
• Occurs in liver, in cytosol of cells
• Also used to metabolize drugs and foreign substances
• Reduces bodies ability to detoxify drugs  overdose
• Increases alcohol metabolism, thus tolerance  leads to weight
loss
3) Catalase Metabolism of Alcohol
• Found in liver
• Minor pathway for alcohol metabolism
Ethanol Acetaldehyde
H2O2 H2O
Catalase
Alcohol Metabolism
• Depends on:
- Sex
- race
- size
- food
- physical condition
- alcohol content
• Amount of alcohol
dehydrogenase
• Alcohol cannot be
stored and has priority
in metabolism
Negative effects on vitamins and
minerals
• Thiamin
• Niacin
• B6
• B12
• Folate
• Vitamin C
• Vitamin A
• Vitamin D
• Vitamin K
• Vitamin E
• Magnesium
• Zinc
• Iron
Alcoholics and malnutrition
• Poor diet
• Alcohol has energy but no nutrients
• Lack of interest in food: GI problems
• Alcohol interferes with absorption of amino
acids
• Alcohol races blood level of fats
Liver Damage
• Build up of
acetaldehyde
• Production of free
radicals
• Alcohol inhibits
body’s natural
antioxidant systems
• Advanced stages of
liver damage are
not reversible
Fetal Alcohol Syndrome
• Alcohol reaches fetus
• Deprives brain of
oxygen and nutrients
• About 4 drinks a day or
binge drinking while
pregnant
• Prenatal and postnatal
growth retardation
• Brain and CNS
impairment
• Abnormalities of face
and skull
• increased rate of birth
defects
Health Benefits of Alcohol
• Moderate drinking
associated with reduced
mortality
• ≤ 2 drinks for men, ≤ 1
drink for femal
• Reduced cardiovascular
disease
-reduces blood clotting
-increase HDL
-reduced inflammation
• Polyphenols
• Relaxation and
socialization
Fiber
• Plant cell wall contains > 95% of dietary fibers
- cellulose, hemicellulose, lignin, pectins
-Lignin  structural support
-Pectin  intercellular cement
-Cereal bran  hemicellulose and lignin
-Fruit & Vegetables  cellulose and pectin
• Starch  energy storage is found within the
cells walls
Fiber = ability to resist digestion
in the small intestine
Fiber
Dietary + Functional = Total Fiber
• Dietary – Found natuRally in foods
• Functional – forms added to foods
• Insoluble – Not fermented by bacteria
in the colon
• Soluble – Fermentable
Fiber
Soluble Insoluble
• Pectin
• Gums
• Mucilages
• Some
hemicellulose
• Lignin
• Cellulose
• Some
hemicellulose
Polysaccharides
1. Cellulose
• Polysaccharide of glucose
• Most abundant substance
in plant kingdom
• Β- 1,4 glycosidic linkages
• Water insoluble
• Does not provide energy
• Bran, legumes, nuts peas,
root vegetables, cabbage
• Cotton is pure cellulose
Insoluble fibers – Exterior/hulls &
Structural
2. Hemi-cellulose
• Mixture of
pentoses &
hexoses
• Linked to lignin
in cell wall
• Amorphous
• Partially soluble
in mild alkali
3. Lignin
• Highly branched
• Not digested by
colonic bacteria
• Non-CHO
• Structural support
• Roots vegetables,
carrots, wheat,
fruits with seeds
Soluble Fibers – inside & around plant
4. Pectin
• gel forming
• Amorphous
• Intracellular cement –
spaces b/w cell wall
• Almost completely
metabolized by colonic
bacteria
• Apples, strawberries &
citrus
• Added jellies & jams
5. Gums/Mucilages
• Secreted at the site of
plant injury: tree
exudates
• Highly branched
• Highly fermented by
colon bacteria
• Gum arabic is a food
additive for gelling
• Caramels, gumdrops,
toffee, bakery goods,
salad dressings, oatmeal
Physiological & Metabolic Effects
Effects of Fiber
1. Solubility in water
• delay gastric emptying
• Increase transit time
• Decrease nutrient absorption
2. Water-holding capacity
• Delay gastric emptying
• Reduced mixing of GI contents w/ digestive
enzymes
• Delayed nutrient absorption
• Shortened transit time
3. Ability to bind (adsorption) molecules
• Decreased absorption of lipids
• Increased bile excretion
• Lower serum cholesterol
• Altered mineral balance
4. Fermentability by intestinal bacteria
• Microflora produces SCFAs
- energy
- cell proliferation
-increases water absorption in the colon
Physiological & Metabolic Effects
Effects of Fiber
Soluble Fiber Fermented SCFA
• Acetic acid
• Butyric acid
• Proprionic acid
Fuel for cells
≈1.5-2.5 kcal/g
Blood stream
CO2, H2, CH4
Pre & Pro – biotic Diets
Medical Nutritional Therapy
• Pro-biotic
- ingestion of certain foods with live cultures containing
certain strains of bacteria to increase the counts of
specific microflora of the GI tract
-Yogurt
-survive digestion and then colonize lower GI tract
• Prebiotic
-food ingredients that are not digested or absorbed but
can stimulate the growth/activity of selected types of
bacteria in the colon
- Oligofructose or inulin (non-digestible oligosaccharides)
Health benefits of Dietary Fiber
• Promotes softer, larger stool and regularity
• Slows glucose absorption
• Increases satiety
• Reduces blood cholesterol
• Reduces heath disease
• Reduces hemorrhoids and diverticula
Nutrition and GI disorders
• Constipation
- reduced by fiber, fluid intake, exercise
• Diarrhea
• Diverticulosis
- Pouches along colon
- high fiber diet reduces formation
Recommended Dietary Fiber Intake
• Adequate intake (14g/1000 kcal):
- 25 g/day for women
- 38 g/day for men
- US intake: 13-17 g/day
• Too much fiber (>60 g/day)
- require extra intake of fluid
- binds to some minerals (Fe & Zn)
- fill the stomach of young child quickly

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Exercise, fiber, alcohol

  • 1. Protein for Athletes  American College of Sports Medicine (ACSM) / American Dietetic Association (ADA) –Endurance athletes, 1.2 to 1.4 g/kg per day • Accounts for greater use of protein as fuel for energy –Strength athletes, 1.2 to 1.7 g/kg per day • To support muscle growth, particularly during early training phase when gains are greatest and protein utilization is less efficient  Clinical studies suggest there is no apparent benefit at intakes above 2.0 g/kg per day
  • 2. How much protein for athletes? • Many athletes may already meet or exceed protein recommendations – Definition of “high protein” can be the absolute amount of protein, % of total energy (calories), or protein ingested per kg of body weight • Strength athletes in particular may believe that much higher protein intakes are needed for muscle building – Intakes at 4- to 6-g/kg range are not uncommon – Unlikely to provide benefit beyond 2.0 g/kg – It is possible that this much protein intake could adversely affect the nutrient quality of the overall diet
  • 3. Risks of High Protein  Hydration status – Nitrogen that is obtained from consuming protein must be excreted in the urine as urea – Increased urinary output due to high protein load may increase chances of dehydration  Diets very high in protein may lack appropriate amounts of carbohydrate, fiber, and some vitamins/minerals – Could impair exercise performance – Could increase long-term risk of diseases such as colon cancer • Possibly due to lack of fiber or increased intake of red meat  Excessively fatty protein sources could increase risk of cardiovascular disease – Choose mostly lean protein sources • For example, salmon is more desirable than a ribeye steak
  • 4. Branched Chain Amino Acids • Make up 40% of the daily requirements of essential amino acids
  • 5. Branched Chain Amino Acids  BCAAs are  Unlike other amino acids, most BCAA metabolism occurs in skeletal muscle – Liver lacks first 2 enzymes in the pathway that break down BCAAs  Supplemental free form, bypass the liver and gut and go directly into the blood stream.  BCAAs inhibit brains ability to uptake tryptophan
  • 6. Leucine – The bodies need for leucine is 25 times greater than the available free amino acid pool. – Stimulates protein synthesis by activating insulin – Insulin increases a.a. uptake – Incorporation of BCAAs in muscle is IGF-1 dependent – IGF-1 stimulates muscle synthesis – Chronic low levels of BCAAs will show up in urine – β-hydroxy-β-methylbutyrate (HMB) is derived from the breakdown of leucin – Some evidence in humans that doses of 3 g/day may be effective at preventing muscle breakdown • Additive benefits with creatine – Some studies suggest that HMB may provide greater benefit to untrained people who start weight training compared with previously conditioned athletes
  • 7. Should athletes Supplement?  If protein requirements are met, the individual AA requirements should be met as well  Estimated that 3-18% of workout energy is provided by BCAAs  Leucine increases release of fats for energy  Claims mainly center on decreasing muscle soreness and improving either performance or recovery from exercise  Doses can range from 2 to 7 g/day to more than 20 g/day taken before during and after  There are potential risks associated with AA supplements – Large doses of single AAs can prevent the absorption of other AAs, which may lead to diarrhea – Can indirectly cause deficiency of other AAs as a result
  • 8. Phosphocreatine • aka creatine phosphate (PCr) • Rapidly mobilizable reserve of high energy phosphate for skeletal muscle (and brain) • Formed from parts of Arg, Gly & Met • Can donate phosphate to ADP anaerobically in the first 2-7 seconds following an intense muscular effort • Forward and reverse reaction catalyzed by CK, which is a marker of muscle damage
  • 9. Alcohol • Ethanol • Not a nutrient • 7 kcal/g • 50% alcohol = 100 proof
  • 10. Alcohol Absorption • Small amounts absorbed in mouth and esophagus • 20% absorbed directly across stomach wall • Food delays diffusion • Most absorbed by simple diffusion in the upper small intestine • Distributed wherever water is found
  • 11. Alcohol metabolism 1) Alcohol Dehydrogenase System - women have less - varies among ethnic groups - NADH production turns of TCA cycle - Excess acetyl CoA converted to FATTY ACIDS - Fatty liver develops
  • 12. 2) Microsomal Ethanol-oxidizing System (MEOS) • When ADH cannot keep up with demand • Occurs in liver, in cytosol of cells • Also used to metabolize drugs and foreign substances • Reduces bodies ability to detoxify drugs  overdose • Increases alcohol metabolism, thus tolerance  leads to weight loss
  • 13. 3) Catalase Metabolism of Alcohol • Found in liver • Minor pathway for alcohol metabolism Ethanol Acetaldehyde H2O2 H2O Catalase
  • 14. Alcohol Metabolism • Depends on: - Sex - race - size - food - physical condition - alcohol content • Amount of alcohol dehydrogenase • Alcohol cannot be stored and has priority in metabolism
  • 15.
  • 16. Negative effects on vitamins and minerals • Thiamin • Niacin • B6 • B12 • Folate • Vitamin C • Vitamin A • Vitamin D • Vitamin K • Vitamin E • Magnesium • Zinc • Iron
  • 17. Alcoholics and malnutrition • Poor diet • Alcohol has energy but no nutrients • Lack of interest in food: GI problems • Alcohol interferes with absorption of amino acids • Alcohol races blood level of fats
  • 18. Liver Damage • Build up of acetaldehyde • Production of free radicals • Alcohol inhibits body’s natural antioxidant systems • Advanced stages of liver damage are not reversible
  • 19. Fetal Alcohol Syndrome • Alcohol reaches fetus • Deprives brain of oxygen and nutrients • About 4 drinks a day or binge drinking while pregnant • Prenatal and postnatal growth retardation • Brain and CNS impairment • Abnormalities of face and skull • increased rate of birth defects
  • 20. Health Benefits of Alcohol • Moderate drinking associated with reduced mortality • ≤ 2 drinks for men, ≤ 1 drink for femal • Reduced cardiovascular disease -reduces blood clotting -increase HDL -reduced inflammation • Polyphenols • Relaxation and socialization
  • 21. Fiber • Plant cell wall contains > 95% of dietary fibers - cellulose, hemicellulose, lignin, pectins -Lignin  structural support -Pectin  intercellular cement -Cereal bran  hemicellulose and lignin -Fruit & Vegetables  cellulose and pectin • Starch  energy storage is found within the cells walls
  • 22. Fiber = ability to resist digestion in the small intestine
  • 23. Fiber Dietary + Functional = Total Fiber • Dietary – Found natuRally in foods • Functional – forms added to foods • Insoluble – Not fermented by bacteria in the colon • Soluble – Fermentable
  • 24. Fiber Soluble Insoluble • Pectin • Gums • Mucilages • Some hemicellulose • Lignin • Cellulose • Some hemicellulose
  • 25. Polysaccharides 1. Cellulose • Polysaccharide of glucose • Most abundant substance in plant kingdom • Β- 1,4 glycosidic linkages • Water insoluble • Does not provide energy • Bran, legumes, nuts peas, root vegetables, cabbage • Cotton is pure cellulose
  • 26. Insoluble fibers – Exterior/hulls & Structural 2. Hemi-cellulose • Mixture of pentoses & hexoses • Linked to lignin in cell wall • Amorphous • Partially soluble in mild alkali 3. Lignin • Highly branched • Not digested by colonic bacteria • Non-CHO • Structural support • Roots vegetables, carrots, wheat, fruits with seeds
  • 27. Soluble Fibers – inside & around plant 4. Pectin • gel forming • Amorphous • Intracellular cement – spaces b/w cell wall • Almost completely metabolized by colonic bacteria • Apples, strawberries & citrus • Added jellies & jams 5. Gums/Mucilages • Secreted at the site of plant injury: tree exudates • Highly branched • Highly fermented by colon bacteria • Gum arabic is a food additive for gelling • Caramels, gumdrops, toffee, bakery goods, salad dressings, oatmeal
  • 28. Physiological & Metabolic Effects Effects of Fiber 1. Solubility in water • delay gastric emptying • Increase transit time • Decrease nutrient absorption 2. Water-holding capacity • Delay gastric emptying • Reduced mixing of GI contents w/ digestive enzymes • Delayed nutrient absorption • Shortened transit time
  • 29. 3. Ability to bind (adsorption) molecules • Decreased absorption of lipids • Increased bile excretion • Lower serum cholesterol • Altered mineral balance 4. Fermentability by intestinal bacteria • Microflora produces SCFAs - energy - cell proliferation -increases water absorption in the colon Physiological & Metabolic Effects Effects of Fiber
  • 30. Soluble Fiber Fermented SCFA • Acetic acid • Butyric acid • Proprionic acid Fuel for cells ≈1.5-2.5 kcal/g Blood stream CO2, H2, CH4
  • 31. Pre & Pro – biotic Diets Medical Nutritional Therapy • Pro-biotic - ingestion of certain foods with live cultures containing certain strains of bacteria to increase the counts of specific microflora of the GI tract -Yogurt -survive digestion and then colonize lower GI tract • Prebiotic -food ingredients that are not digested or absorbed but can stimulate the growth/activity of selected types of bacteria in the colon - Oligofructose or inulin (non-digestible oligosaccharides)
  • 32. Health benefits of Dietary Fiber • Promotes softer, larger stool and regularity • Slows glucose absorption • Increases satiety • Reduces blood cholesterol • Reduces heath disease • Reduces hemorrhoids and diverticula
  • 33. Nutrition and GI disorders • Constipation - reduced by fiber, fluid intake, exercise • Diarrhea • Diverticulosis - Pouches along colon - high fiber diet reduces formation
  • 34. Recommended Dietary Fiber Intake • Adequate intake (14g/1000 kcal): - 25 g/day for women - 38 g/day for men - US intake: 13-17 g/day • Too much fiber (>60 g/day) - require extra intake of fluid - binds to some minerals (Fe & Zn) - fill the stomach of young child quickly

Editor's Notes

  1. Acetaldehyde dehyrogenase
  2. Short chain fatty acids Energy mostly used by bacteria
  3. Trapped mass of indigestible plant components