Preface
If not coincidence, at least it was in the same decade when endoscopic sinus surgery and computed tomography were introduced to Otolaryngologists, which have changed the approach to sinonasal problems dramatically. Probably, there are no such coincidences in the history of medicine where two new modalities of approaches appeared at the same time, to deal with the same problem and complement each other while doing so. The asset of improved visualization and magnification, available through endoscopes, has revolutionized the understanding of the pathophysiology of sinusitis, and resulted in better appreciation of the anatomy of the paranasal sinuses. However, non-invasive diagnostic endoscopy has its limits, and the deeper structures cannot be evaluated by endoscopy alone . Computed tomography, which has an ability to optimally display bone, soft tissue and air simultaneously, can not only complement endoscopic examination, it can provide a surgical road map delineating the anatomy, defining the obstructing lesions, and noting anatomic variations that may predispose to operative complications.
Computed tomography has scored over plain radiographs and polytomographs as an imaging modality in this area. Even though surpassing CT's capacity to image soft tissue, MRI is less suitable as an imaging modality for evaluation of this area because of the similar signal intensities for bone and air.
CT scanning has become imaging modality of choice and the cooperation required between the Radiologist and the Surgeon is mandatory for both evaluation and treatment of paranasal disorders. It is of paramount importance on the part of the Otolaryngologists to understand interpretation of CT films, Radiological anatomy of the paranasal sinuses, Anatomical variations and the pathology to complement the endoscopy findings for initial screening, surgical planning, reduce postoperative complications and to provide better results. This Presentations is prepared to help Otolaryngology colleagues to learn the Imaging/radiological aspects required for endoscopic sinus surgery.
Sinus tymapni shape and depth can influence surgical approach in cholesteatoma surgery. In the case of a shallower ST, an exclusive endoscopic exploration is chosen; while in the case of a deeper ST, a retrofacial approach is usually preferred.
Preface
If not coincidence, at least it was in the same decade when endoscopic sinus surgery and computed tomography were introduced to Otolaryngologists, which have changed the approach to sinonasal problems dramatically. Probably, there are no such coincidences in the history of medicine where two new modalities of approaches appeared at the same time, to deal with the same problem and complement each other while doing so. The asset of improved visualization and magnification, available through endoscopes, has revolutionized the understanding of the pathophysiology of sinusitis, and resulted in better appreciation of the anatomy of the paranasal sinuses. However, non-invasive diagnostic endoscopy has its limits, and the deeper structures cannot be evaluated by endoscopy alone . Computed tomography, which has an ability to optimally display bone, soft tissue and air simultaneously, can not only complement endoscopic examination, it can provide a surgical road map delineating the anatomy, defining the obstructing lesions, and noting anatomic variations that may predispose to operative complications.
Computed tomography has scored over plain radiographs and polytomographs as an imaging modality in this area. Even though surpassing CT's capacity to image soft tissue, MRI is less suitable as an imaging modality for evaluation of this area because of the similar signal intensities for bone and air.
CT scanning has become imaging modality of choice and the cooperation required between the Radiologist and the Surgeon is mandatory for both evaluation and treatment of paranasal disorders. It is of paramount importance on the part of the Otolaryngologists to understand interpretation of CT films, Radiological anatomy of the paranasal sinuses, Anatomical variations and the pathology to complement the endoscopy findings for initial screening, surgical planning, reduce postoperative complications and to provide better results. This Presentations is prepared to help Otolaryngology colleagues to learn the Imaging/radiological aspects required for endoscopic sinus surgery.
Sinus tymapni shape and depth can influence surgical approach in cholesteatoma surgery. In the case of a shallower ST, an exclusive endoscopic exploration is chosen; while in the case of a deeper ST, a retrofacial approach is usually preferred.
Definition and Terminology
PD is characterized by idiopathic progressive expansion of one or more paranasal sinuses beyond the normal margins, without evidence of mucous membrane changes. The expansion may involve the complete sinus or a part of it.3
The medical literature offers various labels to describe enlargement of the sinus by air, including frontal sinus hypertrophy, PD, pneumosinus frontalis, aerocele, pneumocele, sinus ectasia, hyperpneumatization, pneumatocele, air cyst, and others.1,4,5
The varying terminology used to describe abnormal expansion of the frontal sinus has caused some confusion about the etiology and diagnosis of the condition.1 Urken et al4 classified the deformity into three groups—hypersinus, pneumocele, and PD—as follows:
Hypersinus or hyperpneumatization was defined as an enlarged frontal sinus that has developed beyond the upper limits of normal. The walls are normal, and the hyperaerated sinus does not extend over the normal limits of the frontal bone. The patient is asymptomatic, and the condition requires no intervention.1
Pneumocele refers to an aerated sinus with variable thinning of the sinus walls. The thinning, focal or generalized, differentiates pneumocele from PD. It is a pathological abnormality.1
PD is a condition where the sinus abnormally expands beyond the normal limits of the frontal bone. The bony walls of the sinus are of normal thickness, but are displaced, causing frontal bossing. There is no evidence of erosion, and the mucosa is of normal appearance. The frontal sinus is most commonly affected, and the ethmoidal, sphenoidal, or unilateral maxillary sinus may be involved.6,7
Etiology
The etiology of primary PD has been the source of great debate for many years. It is still unknown, but eight possible mechanisms have been proposed as follows: a spontaneously draining mucocele, the presence of a gas-forming microorganism, the presence of a one-way valve, congenital abnormality, hormonal change, local growth disturbances, osteoclastic and osteoblastic activity, and trauma.1,7-9
Generally, frontonasal duct obstruction of any cause and the subsequent increase in sinus pressure seem to be the most important factors in the pathogenesis of PD.1,3,4 In this case, the ostium was inspected and found to be macroscopically normal, and we did not find a clear etiology.
Review of the literature reveals that age at presentation varies from puberty to the elderly, but PD has not been reported in children. This may be due to the age at which the normal paranasal sinus develops, as well as the gradual onset of PD.5,6
Diagnosis
Diagnosis is made by clinical examination, and confirmation by radiography (plain film or CT), when the characteristic enlargement of the sinus is seen.7,8
Clinical symptoms are typically related to the displaced structures. In the case of outward expansion, the typical signs are frontal bossing and prominence of the supraorbital ridge.
moya moya disease or angiopathy is name of vascular pathology causing vascular sequelae in the cerebral circulation. this powerpoint is a brief description of its presentation, diagnosis and management.
Cerebrovascular Vasospasm - Etiopathogenesis and ManagementDr. Rahul Jain
Cerebrovascular vasospasm is a consequence of subarachnoid hemorrhage following aneurysmal rupture. its types, causes, etiology, incidence, diagnois and treatment protocols should be understood for better identification and management of this condition.
chiari or arnold chiari malformations, various types and pathophysiology, radiological and clinical presentation of the types, signs symptoms, investigations and treatment of these malformations both conservative and surgical. considerations and controversiies in management of chiari malformation associated with various conditions.
Journal Club - Extra axial Endoscopic Third Ventriculostomy.pptxDr. Rahul Jain
journal club including 2 journals from same authors on topic of extra axial subfrontal endoscopic thord ventricuostomy, its techniques, advantages, limitations, principles
diffuse midline gliomas are high grade gliomas and typically involve pediatric population, carry poor prognosis and limited treatment options. this powerpoint carries detailed description of clinical features, diagnosis, management of diffuse pontine gliomas.
Microscopes and Endoscopes in Neurosurgery.pptxDr. Rahul Jain
history, working, optics and salient features of operating microscopes in neurosurgery and endoscope. role of endoscopes in various surgeries and newer prospects of both microscopes and endoscopes
techniques, methods, indications and complications of various fusion techniques for subaxial cervical spine. comparison of anterior versus posterior techniques, their indications and complication.
carotid stenosis is a progressive gradual narrowing of carotid artery resulting in TIA and stroke. managemnet of this is challenging owing to various factors and different management options available to choose from.
Arteriovenous Malformations are one of the toughest cerebral pathologies to manage with high post op mortality and morbidity. this powerpoint contains classification, grading and managment of various severity of AVMs
intracranial vascular bypass is done to maintain blood flow to region of interest. this slideshow entails the indications, various categories, types as per flow, their advantages and disadvantages
anterior choroidal artery course, clinical implications, angiography and surgical importance
clinical features of aneurysm, AVM involving the anterior choridal artery
introduction, indications, types of decompressive craniectomy. brain trauma foundation 4th edition guidelines of decompressive craniectomy with revised update of 2020.
complications of decompressive craniectomy and how to avoid them. decompressive craniectomy in MCA infarct and Trauma
description of various audiological assessment tests at bedside and via instruments for measurement of degree of hearing loss and help in identifying cause for hearing loss and type of hearing loss.
hydrocephalus, clinical features in various age groups, investigations, treatment options to create a basic understanding of the underlying pathology and management
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. Background
• Hermann Schloffer (1907) performed the first
transsphenoidal pituitary surgery via a lateral
rhinotomy approach
• Oscar Hirsch and Harvey Cushing attempted to
refine the technique in 1910.
• In 1965, Hardy was the first to use a microscope to
approach the sella, pioneering the transsphenoidal
approach.
• use of the endoscope was first described by Jho
and Carrau in 1997.
3. Advantages of an Endoscope
• The endoscope can physically enter into the
sphenoid sinus and provide a wide-angled
panoramic view with zooming capability.
• endoscope shows a diverging flask-shaped wide-
angled view.
• Angled views may be advantageous when large
suprasellar macroadenomas are to be removed or
direct visualization of the medial wall of a
cavernous sinus is required.
4. Microscope vs Endoscope
Parameter Microscope Endoscope
Fogging No Yes
Vision 3D 2D
Hemostasis Good Difficult
Dissection Good (Bimanual) Difficult
Exposure Tubular Panoramic
Extent of visualisation Narrow Wide
Extent of removal ++ ++++
C-Arm Yes Yes/No
Nasal Packing Yes Yes/No
5.
6. Sinonasal Anatomy
Nasal Cavity is bordered
• medially – nasal septum (composed of the septal
cartilage, the perpendicular plate of the ethmoid bone,
and the vomer);
• superiorly by the cribriform plate of the ethmoid bone
and bridge of the nose (consisting of the nasal portion
of the frontal bone, nasal bone, and frontal process of
the maxilla);
• inferiorly by the floor of the nasal cavity (involving the
palatine process of the maxilla and the horizontal plate
of the palatine bone); and
• conchae or turbinates laterally (inferior, middle,
superior, and sometimes supreme turbinates).
7.
8. • The superior and middle conchae (along with the
occasional supreme concha) are components of the
ethmoid bone, whereas the inferior concha is a
separate bone.
• The EE-TS procedure traverses the,region medial to
the middle turbinate, between the middle
turbinate and the nasal septum, on the way to the
sphenoid sinus then the pituitary fossa at the sella
turcica.
9. Osteomeatal Complex
• normal sinonasal anatomy located laterally to the
middle turbinate is referred to as the osteomeatal
complex (OMC) and comprises a key set of
structures for sinonasal function.
• consists of the middle turbinate, uncinate process,
hiatus semilunaris, ethmoid infundibulum, and
ethmoid bulla.
10. Hiatus semilunaris is
essentially a two-
dimensional (2D) crescent-
shaped opening leading
from the middle meatus
into the three-dimensional
(3D) funnel-shaped
ethmoid infundibulum to
which the frontal sinus,
anterior ethmoid sinus,
and maxillary sinus usually
drain.
11.
12. • important point is that there are individual structural
variations, which can affect paranasal sinus physiology
and surgical anatomy.
• When the path of physiologic mucus flow is interrupted
mechanically or functionally, the paranasal sinuses can
retain stagnant mucus, which can subsequently
become infected and result in sinusitis.
• Anatomic variations may also include a pneumatized or
aerated turbinate, most frequently the middle
turbinate, which is referred to as concha bullosa and
can be enlarged.
13. • Despite these variations or the presence of any
nasal polyps, the main point is that structures of
the OMC should not be significantly disturbed en
route to the sphenoid sinus during EE-TS.
14. Ethmoidal Air Cells Variations
1. Agger Nasi cells
• Most anterior ethmoidal cells located just anterior
and lateral to the nasofrontal recess.
• For EE-TS, the surgeon should be aware that a
hyperpneumatized agger nasi cell can occasionally
present as a bulge that mimics the anterior view of
a turbinate.
15. 2. Haller cells
• infraorbital ethmoid air cells or
maxilloethmoidal cells.
• closely related to the ethmoid
infundibulum along the medial
roof of the maxillary sinus.
• Because Haller cells are quite
lateral, these usually do not
present a problem during EE-TS,
although their proximity to the
ethmoid infundibulum can
result in inadvertent orbital
entry if not recognized.
16. 3. Onodi Cells
• sphenoethmoidal cells
• posterior ethmoidal air cells that can project superiorly
into the sphenoid sinus toward the lateral side and can
potentially be confused with a septated region of the
sphenoid sinus.
• optic nerve and/or internal carotid artery (ICA) can
bulge into Onodi cells instead of the sphenoid sinus
proper or occasionally may have either partial or
complete bony dehiscence at the sphenoid sinus,
presenting risk for injury during surgery.
17.
18. Nasal Turbinates
• inferior turbinate (IT) extends along the length of
the nasal cavity. Mucosal inferior turbinate
hypertrophy is its most common variation and may
narrow the nasal corridor space, but it usually
shrivels with the use of topical decongestants.
• middle turbinate (MT) has three attachments in the
sagittal, coronal and horizontal planes from an
anterior to posterior direction. MT presents with
many variations, its pneumatisation being the
commonest.
19. • A pneumatised MT, known as the concha bullosa,
needs to be opened (by means of conchoplasty), before
lateralising the MT. Sometimes, the MT may be
bulbous, owing to its bony structure, in which case,
conchoplasty cannot be performed, Neither can it be
lateralised easily to achieve wide nasal corridor.
• In such cases it is advisable to sacrifice the MT. We also
perform middle turbinectomy in cases which require
extended trans-sphenoidal route, transpterygoid route
or in paediatric patients, in whom adequate space is of
prime importance during the surgery.
20. • superior turbinate (ST) carries majority of the
olfactory fibres. Hence superior turbinectomy is
generally avoided to maintain post-op olfaction.
• In cases which require extended endoscopic trans-
sphenoid surgery, or in cases (where the sphenoid
is filled with pathology and the landmarks are
difficult to visualise, or in cases where space is
premium (for parking the endoscope, partial
superior turbinectomy is done and the posterior
ethmoids are opened.
21. Right partial superior turbincetomy done to expose posterior ethmoid cells
(white arrow)
22. Vasculature of Nasal Septum
• The blood supply originates from the ophthalmic
branch of the internal carotid artery (ICA) and
maxillary and facial branches of the external carotid
artery (ECA).
• The blood supply to the upper nasal septum is from
the anastomosis of anterior and posterior
ethmoidal arteries which are branches of
ophthalmic artery.
23. • Majority of nasal septum is supplied by
Sphenopalatine artery (SPA), branch of ECA.
• SPA perfuses the posterior and inferior division of
septa.
• SPA enters the nasal cavity through sphenopalatine
foramen where it divides into 2 major branches
namely septal and posterior lateral nasal artery.
24. • Septal artery exits SP foramen, courses through
rostrum of sphenoid and distributes the nasal
septum with 2-3 branches. Hence nasoseptal flap
should be wide enough including atleast 2-3
branches to maintain its viability.
25.
26. Anatomic Landmarks in Stages of
EE-TS Pituitary Surgery
4 stages
1. Nasal stage
2. Sphenoid stage
3. Sellar stage
4. Reconstruction stage
Recognition of important landmarks during each of
these stages is the key to a safe exposure.
27. Nasal Stage
• endoscope is inserted in line with the floor of the
nasal cavity, parallel to the MT at an angle of 25°
inferiorly to initially visualize the choana.
• choana is the anatomic reference point.
• inferior margin of the MT leads to clival
indentation, which is about 1 cm, below the level of
sellar floor. This is quite a consistent surgical
landmark.
28.
29. • Hadad Bassagasteguy (HB) flap is most commonly
used nasoseptal flap to seal off meninges from
nasal cavity and harvested prior to tumor
dissection. It is local, robust, easily harvestable flap.
• Based on sphenopalatine artery it is considered
gold standard for endoscopic skull base
reconstruction.
• Landmarks for harvesting HB flap – sphenoid
ostium, ST, MT, Eustachian tube, Choanal arch,
Mucocutaneous junction of septum.
30.
31. • Factors determining side on which HB flap is taken:-
• Sharp spur which might lead to tear
• Lateral extension of sella tumor
• Lateral sphenoid CSF leak which requires sacrifice of septal
branch.
32. Sphenoid Stage
• sphenoid ostium (SO) is identified posterior and
inferior to the root of the ST in the lateral rostral
corner of sphenoid rostrum.
• Submucosal dissection along the contralateral side
of the sphenoidal rostrum to visualize the
sphenoidal ostium (SO) contralateral to the side of
approach gives the classical “owl eye appearance”.
33. • vomer is drilled and the rostrum of the sphenoid sinus
is removed
• The limits of the sphenoidotomy include: Cranially, the
superior limit of SO providing adequate visualization of
the planum sphenoidale, the optico-carotid recesses
and the optic protuberances; caudally, the
pterygo-sphenoid synchondrosis/vidian canal at 5 and 7
O’ clock position.
• The lateral limit is the crest marking the the junction of
the sphenoid and ethmoid sinuses with visualization of
the carotid artery (CA) protuberance.
34. Sellar Stage
• sphenoidal mucosa located only on the anterior
wall of the sella and the floor is coagulated with a
bipolar and excised.
• Anatomical landmarks are identified in the aerial
panoramic view and mimic a “fetal face”.
• Gentle drilling with a diamond burr under low
speed is done to thin the sellar floor to an egg shell
thickness.
35.
36. • The anterior wall of the sella and its floor is
removed millimeter by millimeter circumferentially
till four blue lines (both the superiorly and inferiorly
located inter-cavernous sinuses and the laterally
located cavernous sinuses) are seen.
37.
38. References
1. Schmidek and Sweet’s operative neurosurgical
techniques 7th Ed. Vol 1
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