The document discusses Ebola virus disease (EVD), also known as Ebola hemorrhagic fever (EHF). It was first discovered in 1976 near the Ebola River in the Democratic Republic of Congo. Fruit bats are believed to be the natural reservoir of the Ebola virus and can spread it to humans through contact with their blood/body fluids. Ebola causes severe hemorrhagic fever in humans and non-human primates with symptoms like fever, muscle pain and bleeding, often leading to death within 6-16 days. The 2014-2016 outbreak in West Africa was the largest on record, spreading from Guinea to Liberia and Sierra Leone. There is currently no approved vaccine or
In the absence of effective treatment and a human vaccine, raising awareness of the risk factors for Ebola infection and the protective measures individuals can take is the only way to reduce human infection and death.
Its a small presentation about corona virus. Hope you will get an idea about it. Its not detail its just to give an overview of the virus and its mode of transmission. Preventive measures are also discussed.
Description about recent outbreak of Ebola virus in West African countries with history, pathogenesis, clinical signs and prevention measures of Filoviruses are presented in comprehensive manner.
Compiled while the recent outbreak of this year 2014 is still on. Although labeled as Ebola, includes one or two slide about viral hemorrhagic fevers and some more about Marburg virus as well. Being a budding microbiologist, I have focused on disease, agent and prevention. Statistics up to the date 31.10.2014 included with references. Indian scenario is also considered. Let us all hope that this will be the last update for this presentation.Suggestions are welcome.
MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS (MERS CoV)Dhruvendra Pandey
Middle East Respiratory Syndrome, countries affected by MERS virus, preventive and control strategies for MERS infection, recommendation for healthcare professionals and hospitals in case of MERS corona virus infection, time trend of different events in corona virus infection, MERS Cov is associated with camels, Saudi Arabia guideline for travellers to haj and umrah, MERS CoV Vaccine
Hello friends i am BSc Nursing intern.This presentation of mine covers almost each and every aspect related to swine flu.Hope it will help you to increase your knowledge regarding the topic.Looking forward to your feedback.Thank you
Ebola virus disease (EVD; also Ebola hemorrhagic fever, or EHF), or simply Ebola, is a disease of humans and other primates caused by ebolaviruses. Ebola virus disease is a serious illness that originated in Africa, where there is currently an outbreak
SARS-CoV-2 variants of concern and variants under investigation in EnglandSociété Tripalio
Rapport officiel du Public Health England concernant l'épidémie de coronavirus en Angleterre. Ce document montre que les vaccinés sont plus souvent malades du COVID (variant indien) que les non-vaccinés.
In the absence of effective treatment and a human vaccine, raising awareness of the risk factors for Ebola infection and the protective measures individuals can take is the only way to reduce human infection and death.
Its a small presentation about corona virus. Hope you will get an idea about it. Its not detail its just to give an overview of the virus and its mode of transmission. Preventive measures are also discussed.
Description about recent outbreak of Ebola virus in West African countries with history, pathogenesis, clinical signs and prevention measures of Filoviruses are presented in comprehensive manner.
Compiled while the recent outbreak of this year 2014 is still on. Although labeled as Ebola, includes one or two slide about viral hemorrhagic fevers and some more about Marburg virus as well. Being a budding microbiologist, I have focused on disease, agent and prevention. Statistics up to the date 31.10.2014 included with references. Indian scenario is also considered. Let us all hope that this will be the last update for this presentation.Suggestions are welcome.
MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS (MERS CoV)Dhruvendra Pandey
Middle East Respiratory Syndrome, countries affected by MERS virus, preventive and control strategies for MERS infection, recommendation for healthcare professionals and hospitals in case of MERS corona virus infection, time trend of different events in corona virus infection, MERS Cov is associated with camels, Saudi Arabia guideline for travellers to haj and umrah, MERS CoV Vaccine
Hello friends i am BSc Nursing intern.This presentation of mine covers almost each and every aspect related to swine flu.Hope it will help you to increase your knowledge regarding the topic.Looking forward to your feedback.Thank you
Ebola virus disease (EVD; also Ebola hemorrhagic fever, or EHF), or simply Ebola, is a disease of humans and other primates caused by ebolaviruses. Ebola virus disease is a serious illness that originated in Africa, where there is currently an outbreak
SARS-CoV-2 variants of concern and variants under investigation in EnglandSociété Tripalio
Rapport officiel du Public Health England concernant l'épidémie de coronavirus en Angleterre. Ce document montre que les vaccinés sont plus souvent malades du COVID (variant indien) que les non-vaccinés.
About EBOLA, Origin, types, Causes,Mode of Transmission, Symptoms, Treatment, Means to Help to Ease Symptoms, Teats & Diagnosis, Treatment & Drugs, Prevention, Vaccine Development,
Ebola virus (Ebola Hemorrhagic Fever) by S Shivani Shastrulagari shivani shastrulagari
WHAT IS EBOLA?
Ebola is the most lethal virus known to man.
Ebola hemorrhagic fever is a very contagious illness that is often fatal in humans and nonhuman primates (monkeys, gorillas, and chimpanzees).
An introduction to the 2014 West Africa Ebola outbreak for educational use, with additional sources for health professionals in need of up-to-date information.
Updated on 7th December, 2014, with additional infographics and WHO data.
Infographics may be requested for professional use on a creative commons/source attribution basis (micrognome.priobe.net). An interactive version will be available for educational use via the Nearpod share site.
The Ebola virus causes an acute, serious illness which is often fatal if untreated. Ebola virus disease (EVD) first appeared in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo. The latter occurred in a village near the Ebola River, from which the disease takes its name.
The current outbreak in west Africa, (first cases notified in March 2014), is the largest and most complex Ebola outbreak since the Ebola virus was first discovered in 1976. There have been more cases and deaths in this outbreak than all others combined. It has also spread between countries starting in Guinea then spreading across land borders to Sierra Leone and Liberia, by air (1 traveller only) to Nigeria, and by land (1 traveller) to Senegal.
The most severely affected countries, Guinea, Sierra Leone and Liberia have very weak health systems, lacking human and infrastructural resources, having only recently emerged from long periods of conflict and instability. On August 8, the WHO Director-General declared this outbreak a Public Health Emergency of International Concern.
A separate, unrelated Ebola outbreak began in Boende, Equateur, an isolated part of the Democratic Republic of Congo.
The virus family Filoviridae includes 3 genera: Cuevavirus, Marburgvirus, and Ebolavirus. There are 5 species that have been identified: Zaire, Bundibugyo, Sudan, Reston and Taï Forest. The first 3, Bundibugyo ebolavirus, Zaire ebolavirus, and Sudan ebolavirus have been associated with large outbreaks in Africa. The virus causing the 2014 west African outbreak belongs to the Zaire species.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. Discovery of EBOLA
Ebola viruses are found
in several African
countries. Ebola was
first discovered in 1976
near the Ebola River in
what is now the
Democratic Republic of
the Congo. Since then,
outbreaks have
appeared sporadically
in Africa.
Dr.T.V.Rao MD 2
3. Origin of Ebola virus remains
unknown
The natural reservoir host of
Ebola virus remains
unknown. However, on the
basis of evidence and the
nature of similar viruses,
researchers believe that the
virus is animal-borne and
that bats are the most likely
reservoir. Four of the five
virus strains occur in an
animal host native to Africa.
Dr.T.V.Rao MD 3
4. Ebola and Marburg Virus
Ebola and Marburg viruses are
highly virulent in humans and
non human primates, ends in
death.
Both the viruses are identified to
cause African hemorrhagic fevers
Dr.T.V.Rao MD 4
5. Filo virus
Filo is Latin for Thread
Marburg and Ebola are
members of the Filoviridae
Appear as long threads,
Can be U shaped,
Genome 19 kb long
Enveloped viruses.
A single stranded,
unregimented, -Helical, –ve
sense RNA genome 80 nm
Diameter
Dr.T.V.Rao MD 5
6. Fruit Bats Harbour Virus
and Spread the Virus
Fruit bats are believed to be
the normal carrier in nature,
able to spread the virus
without being affected.
Humans become infected
by contact with the bats or a
living or dead animal that
has been infected by bats.
Dr.T.V.Rao MD 6
8. Ebola haemorrhagic fever
Ebola virus disease (EVD), Ebola haemorrhagic fever
(EHF) Ebola is a disease of humans and other
mammals caused by Ebola virus. Signs and
symptoms typically start between two days and three
weeks after contracting the virus, with a fever, sore
throat, muscle pain and headaches. Then, vomiting,
diarrhoea and rash usually follows, along with
decreased function of the liver and kidneys. Around
this time, infected people may begin to bleed both
within the body and externally. Death, if it occurs, is
typically six to sixteen days after symptoms appear
and is often due to low blood pressure from fluid los
9. Ebola haemorrhagic fever
Around this time, infected
people may begin to
bleed both within the
body and externally.
Death, if it occurs, is
typically six to sixteen
days after symptoms
appear and is often due
to low blood pressure
from fluid loss
Dr.T.V.Rao MD 9
10. Events on Ebola
Ebola virus were discovered in 1976 with
occurrence of two severe epidemics of
hemorrhagic fever in Sudan and Zaire.
The Epidemic involved > 500 persons and killed
> 400 infected individual.
The importance of epidemic lies with in each
outbreak hospital staff become infected through
close contact with patients, their blood and
excreta.
The mean time of death from onset to symptoms
is 7 – 8 days.
Dr.T.V.Rao MD 10
11. 2014 Ebola virus epidemic in West
Africa
In March 2014, the World Health Organization (WHO)
reported a major Ebola outbreak in Guinea, a western
African nation Researchers traced the outbreak to a
two-year old child who died on 28 December 2013.
The disease then rapidly spread to the neighbouring
countries of Liberia and Sierra Leone. It is the largest
Ebola outbreak ever documented, and the first
recorded in the region
Dr.T.V.Rao MD 11
13. Reservoir Hosts
Reservoirs can be a Rodent or
Bat
Humans infected accidentally
Monkeys are not proved as
reservoirs as die with
infection early
Infected humans are rich
source of infections to others.
By direct contact with blood
and body fluids of infected
persons can spread the
disease
Dr.T.V.Rao MD 13
14. Spread of Infections
Transmission appears to be associated with
contamination of Blood, Blood stained body
fluids or tissues.
Nosocomial spread is common mode of
spread, Doctors and Nurses at risk when
attending the patients.
Transmission by sexual intercourse has been on
record from a case of man infecting his wife 83
days after initial infection.
Dr.T.V.Rao MD 14
15. Viral Replication
The viruses are grown in
variety of cell lines
including
Vero
M A 104
S W 13 cells
Filoviruses replicates in the
cytoplasam
Dr.T.V.Rao MD 15
16. Pathology and Pathogenesis
The viruses belong to
group of Filo viruses
The viruses have
tropism for Cells of
macrophage system
Dendritic cells
Interstitial fibroblasts
Endothelial cells
Dr.T.V.Rao MD 16
21. Virus infect Several Organs
High titer of viruses are
found in
Liver
Spleen,
Lungs
Kidneys
Blood
Other Body fluids
Dr.T.V.Rao MD 21
22. Symptoms
Symptoms usually begin with a sudden influenza-like
stage characterized by feeling tired, fever, pain in the
muscles and joints, headache, and sore throat. The
fever is usually greater than 38.3 °C (100.9 °F).This is
often followed by: vomiting, diarrheal and abdominal
pain. Shortness of breath and chest pain may occur
next along with swelling, headaches and confusion. In
about half of cases the skin may develop a
maculopapular rash.
23. How the Illness is Presented in
Marburg and Ebola
Fever
Head ache
Sore throat
Muscle pain
Abdominal pain,
Vomitting
Diarrhea
Incubation period 3 -9 days in Marburg
In Ebola 2 – 21 days.
Dr.T.V.Rao MD 23
24. Serious manifestation of
Ebola and Marburg
Internal and
External
bleeding,
Shock,
Death
Dr.T.V.Rao MD 24
25. When you suspect
EBOLA
When the diagnosis of EVD is suspected, the travel and
work history along with exposure to wildlife are important
factors to consider. The diagnosis is confirmed by isolating
the virus, detecting its RNA or proteins, or detecting
antibodies against the virus in a person's blood. Isolating
the virus by cell culture, detecting the viral RNA by
polymerase chain reaction (PCR) and detecting proteins by
enzyme-linked immunosorbent assay (ELISA) works best
early and in those who have died from the disease.
Detecting antibodies against the virus works best late in the
disease and in those who recover
26. Laboratory testing
Changes on laboratory tests as a result of Ebola virus
disease include a low platelet count in the blood, an
initially decreased white blood cell count followed by
an increase in the white blood cell count, elevated
levels of the liver enzymes alanine aminotransferase
(ALT) and aspartate aminotransferase (AST), and
abnormalities in clotting often consistent with
disseminated intravascular coagulation (DIC) such as
a prolonged prothrombin time, partial thromboplastin
time, and bleeding time
27. Diagnosis
can be difficult to distinguish EVD from other infectious diseases such
as malaria, typhoid fever and meningitis. Confirmation that symptoms
are caused by Ebola virus infection are made using the following
investigations:
antibody-capture enzyme-linked immunosorbent assay (ELISA)
antigen-capture detection tests
serum neutralization test
reverse transcriptase polymerase chain reaction (RT-PCR) assay
electron microscopy
virus isolation by cell culture.
28. Diagnosis
Viruses are isolated from
Blood by cell culture on
Vero cells ( Vero –E 6 )
ELISA for antigen
detection
ELISA for IgM
RT - PCR
Dr.T.V.Rao MD 28
29. Infection control
The risk of transmission is increased
amongst Ebola caregivers. Recommended
measures when caring for people infected
with Ebola include barrier-isolation,
sterilizing equipment and surfaces, and
wearing protective clothing including masks,
gloves, gowns, and goggles If a person with
Ebola dies, direct contact with the body of
the deceased patient should be avoided
30. Control of Infection
Isolation facilities
within the Hospital
remain the most
important effective
measure.
Barrier nursing
remain the basic need
in control of infection
spread
Dr.T.V.Rao MD 30
31. WHO RECOMENDS
One step recommended by the World Health
Organization is the education of the general public of
the risk factors for Ebola infection and of the protective
measures individuals can take. These include
avoiding direct contact with infected people and
regular hand washing using soap and water. Bush
meat, an important source of protein in the diet of
some Africans, should be handled with appropriate
protective clothing and thoroughly cooked before
consumption.
32.
33. Trends on QUARANTINE
Quarantine, also known as enforced isolation, is usually
effective in decreasing spread. Governments often
quarantine areas where the disease is occurring or
individuals who may transmit the disease outside of an
initial area. In the United States, the law allows quarantine
of those infected with Ebola viruses. During the 2014
outbreak, Liberia closed schools. On October 16, 2014,
some schools were closed in Ohio and Texas as a
precaution after one of two nurses who contracted Ebola
after caring for Dallas Ebola victim Thomas Eric Duncan,
had returned to the Cleveland area and may have been on
the same plane as some students, teachers and parents of
students from those schools.
34. The health care workers
should
Avoid
Infected Blood,
secretions,
Tissues,
Wastes
Dr.T.V.Rao MD 34
35. Treatment of Ebola
and Marburg
Antiviral drugs are not available
Interferon's are not effective
To date no Vaccine
Electrolyte corrections
Dealing with hemorrhagic complications.
Dr.T.V.Rao MD 35
36. WHO Declares as International
Public Health emergency
On 8 August 2014, the WHO declared the epidemic to
be an international public health emergency. Urging
the world to offer aid to the affected regions, the
Director-General said, "Countries affected to date
simply do not have the capacity to manage an
outbreak of this size and complexity on their own. I
urge the international community to provide this
support on the most urgent basis possible. By mid-
August 2014, Doctors Without Borders reported the
situation in Liberia's capital Monrovia as "catastrophic"
and "deteriorating daily".
Dr.T.V.Rao MD 36
37. Ebola and Bioterrorism
Ebola virus is classified as a biosafety level 4
agent, as well as a Category A bioterrorism
agent by the Centres for Disease Control and
Prevention. It has the potential to be weaponized
for use in biological warfare, and was
investigated by the Biopreparat for such use, but
might be difficult to prepare as a weapon of
mass destruction because the virus becomes
ineffective quickly in open air.
Dr.T.V.Rao MD 37
48. OUR VISION TO FUTURE
In spite many advances in Science, Medicine and Technology we
deal with Infection and Biohazard in casual ways, not following many
simple procedures like Hand Washing. The AIDS, SARS,
INFLUENZA AND EBOLA Teaches many Lessons everyone's life is
at threat from patients and casual approaches will make the Doctors,
nurses, or families and the Society at Risk I wish all the
Microbiologists, and Public Health Professionals to take more active
interest to Improve the Awareness on Infection Control, Let us not
forget every fear and danger has some solutions, try practising the
BIOSAFTEY
Dr.T.V.Rao MD Professor of Microbiology
Dr.T.V.Rao MD 48
49. Created for Health
awareness on EBOLA
Dr.T.V.Rao MD
Email
doctortvrao@gmail.com
Dr.T.V.Rao MD 49