Epidemiology is the study of disease patterns in populations and the factors influencing these patterns. Some key points:
- Epidemiology aims to determine disease origins, investigate control, and understand ecology and impacts on populations.
- Descriptive epidemiology characterizes disease distribution, who is affected, when and where. Analytic epidemiology examines why through comparing groups and potential risk factors.
- Studies include experimental, cross-sectional, case-control, and cohort designs to analyze associations between exposures and outcomes.
- Methods include surveys, monitoring, surveillance and studying sentinel populations to track disease occurrence and changes over time.
Control and Eradication of Animal diseases.pptxBhoj Raj Singh
The presentation details different methods and terminologies used in disease management. It briefs about different types of disease control programs run at global, regional, and national levels. It also tells about the success and failure of different disease control programs. The presentation also briefed about methods of disease control.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Control and Eradication of Animal diseases.pptxBhoj Raj Singh
The presentation details different methods and terminologies used in disease management. It briefs about different types of disease control programs run at global, regional, and national levels. It also tells about the success and failure of different disease control programs. The presentation also briefed about methods of disease control.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Epidemiology is the study and analysis of the patterns, causes, and effects of health, disease & production conditions in defined populations, in terms of space and temporality.
Transboundary diseases and animal welfare concerns Alex Sabuni
Interest in TAD has been direct towards: Socio economic and, Public Health impacts of these diseases with disregard to the welfare of the animals. Decision to initiate control efforts has always ben dictated by the impacts of these diseases to health and livelihoods. Disease causes pain to animals, which is a welfare issue that requires urgent addressing.
This PPT discusses
Basics measurements in epidemiology
Basics requirements of measurements
Tools of measurements
Measures of morbidity
Measures of disability
Measures of mortality
Important Zoonotic disease and its prevention and control By: Dr.Manoj karkimanojj123
Zoonosis are those disease and infection which are naturally transmitted between animals and human. (WHO & FAO, 1959).
Zoonosis word derived from Greek word “ZOO” means Animals and “NOSES” means Disease.
One Health is not a new concept, but it has become more important in recent years because many factors have changed the interaction among human, animals and the environment. These changes have caused the emergence and re-emergence of many disease.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
Presentation by Delia Grace at the first United Nations Environment Programme (UNEP) Science-Policy Forum ahead of the Second Session of the United Nations Environment Assembly (UNEA-2), Nairobi, Kenya, 20 May 2016.
Brucellosis: Epidemiology and Control in indiaBhoj Raj Singh
Brucellosis is an important endemic infectious disease in animals in India. In India brucellosis was first recognized in 1942 by Polding. It causes economic loss to the tune of nearly Rs. 350 million/year. Bovine brucellosis is caused by the bacterium Brucella abortus. In countries where cattles are kept in close association with sheep and goat it can also be caused by B. melitensis. Occasionally B. suis may also cause disease in mammary gland of cattle but it has not been reported to cause abortion and usually does not spread to other animals. Principal manifestations of animal brucellosis are reproductive failure, i.e., abortion, still births and birth of unthrifty offspring in females, and orchitis and epididymitis in males. Genus Brucella has six recognized species on the basis of host specificity viz. B. abortus, B. melitensis, B. ovis, B. suis, B. canis and B. neotome, infecting cattle, goats and sheep, sheep, pig, dog and rats, respectively. All Brucella species may also infect wildlife species. Classical Brucella species have been isolated from a great variety of wildlife species such as bison, elk, feral swine, wild boar, fox, hare, African buffalo, reindeer, and caribou. Infection in wildlife can hinder eradication efforts in cattle.
The classical species viz., B. abortus, B. melitensis, and B. suis have been identified as category B bioterrorism agents (Rotz et al. 2002, CDC 2005) because they are zoonotic and capable of causing considerable morbidity with low mortality if used in a mass event.
The STUDY of the DISTRIBUTION and DETERMINANTS of HEALTH-RELATED STATES in specified POPULATIONS, and the application of this study to CONTROL of health problems."
Epidemiology is the study and analysis of the patterns, causes, and effects of health, disease & production conditions in defined populations, in terms of space and temporality.
Transboundary diseases and animal welfare concerns Alex Sabuni
Interest in TAD has been direct towards: Socio economic and, Public Health impacts of these diseases with disregard to the welfare of the animals. Decision to initiate control efforts has always ben dictated by the impacts of these diseases to health and livelihoods. Disease causes pain to animals, which is a welfare issue that requires urgent addressing.
This PPT discusses
Basics measurements in epidemiology
Basics requirements of measurements
Tools of measurements
Measures of morbidity
Measures of disability
Measures of mortality
Important Zoonotic disease and its prevention and control By: Dr.Manoj karkimanojj123
Zoonosis are those disease and infection which are naturally transmitted between animals and human. (WHO & FAO, 1959).
Zoonosis word derived from Greek word “ZOO” means Animals and “NOSES” means Disease.
One Health is not a new concept, but it has become more important in recent years because many factors have changed the interaction among human, animals and the environment. These changes have caused the emergence and re-emergence of many disease.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
Presentation by Delia Grace at the first United Nations Environment Programme (UNEP) Science-Policy Forum ahead of the Second Session of the United Nations Environment Assembly (UNEA-2), Nairobi, Kenya, 20 May 2016.
Brucellosis: Epidemiology and Control in indiaBhoj Raj Singh
Brucellosis is an important endemic infectious disease in animals in India. In India brucellosis was first recognized in 1942 by Polding. It causes economic loss to the tune of nearly Rs. 350 million/year. Bovine brucellosis is caused by the bacterium Brucella abortus. In countries where cattles are kept in close association with sheep and goat it can also be caused by B. melitensis. Occasionally B. suis may also cause disease in mammary gland of cattle but it has not been reported to cause abortion and usually does not spread to other animals. Principal manifestations of animal brucellosis are reproductive failure, i.e., abortion, still births and birth of unthrifty offspring in females, and orchitis and epididymitis in males. Genus Brucella has six recognized species on the basis of host specificity viz. B. abortus, B. melitensis, B. ovis, B. suis, B. canis and B. neotome, infecting cattle, goats and sheep, sheep, pig, dog and rats, respectively. All Brucella species may also infect wildlife species. Classical Brucella species have been isolated from a great variety of wildlife species such as bison, elk, feral swine, wild boar, fox, hare, African buffalo, reindeer, and caribou. Infection in wildlife can hinder eradication efforts in cattle.
The classical species viz., B. abortus, B. melitensis, and B. suis have been identified as category B bioterrorism agents (Rotz et al. 2002, CDC 2005) because they are zoonotic and capable of causing considerable morbidity with low mortality if used in a mass event.
The STUDY of the DISTRIBUTION and DETERMINANTS of HEALTH-RELATED STATES in specified POPULATIONS, and the application of this study to CONTROL of health problems."
Community foundations, health care staff and residents link arms to improve l...C.S. Mott Foundation
At its core, a community foundation is designed to help pool local resources to meet local needs while striving to actively involve residents in determining and prioritizing their community’s needs. Through its Cultivating Community Engagement Project, CFLeads, a national support organization for community foundations, is helping local philanthropies like the Foundation for the Mid South partner effectively with local nonprofits to meet local challenges.
Introduction to Epidemiology
History of Epidemiology.
Definition of Epidemiology and its components.
Epidemiological Basic concepts.
Aims of Epidemiology.
Ten Uses of Epidemiology.
Scope or The Areas of Application .
Types of Epidemiological Studies.
CHAPTER 1 ITRODUCTION TO EPIDEMIOLOGICAL METHODS.pptxjohnsniky
Technique:
The needle is held with the needle holder and it should enter the tissues at right angles and be no less than 2-3mm from the incision.
The needle is then carried through the tissue where it follows the needle’s curvature.
Sutures of any type that are placed in the interdental papilae should enter and exit the tissue at a point located below the imaginary line that forms the base of the triangle of the interdental papilla.
Epidemiology is: a) a quantitative basic science based on a working knowledge of statistics, probability, and sound research methods; b) a causal reasoning method based on the development and testing of morbidity and mortality hypotheses; and c) a tool for promoting and protecting public health action based on science, causal reasoning, and practical common sense.
Epidemiology is the study of the distribution of health related events. It is concerned with epidemic of communicable disease, non communicable infectious disease, chronic disease,maternal-child health, occupational health, environment health etc.
Basics of Epidemiology and Descriptive epidemiology by Dr. Sonam AggarwalDr. Sonam Aggarwal
Epidemiology is the basic science of Preventive and Social Medicine.
Epidemiology is scientific discipline of public health to study diseases in the community to acquire knowledge for health care of the society. (prevention, control and treatment).
Issues in Veterinary Disease Diagnosis.pptxBhoj Raj Singh
Diagnosis of a disease or a problem is the first step towards solution/ treatment/ control/ prevention.
Diagnosis is successfully. important to determine Prevalence (True prevalence, apparent prevalence) and Incidence of the disease to estimate the disease burden so that prevention and control measures can be planned and implemented.
However, in few years with the invasion of pharmaco-politics in disease control the term got vitiated.
Epidemiological Approaches for Evaluation of diagnostic tests.pptxBhoj Raj Singh
Diagnosis of a disease or a problem is the first step towards solution/ treatment. Clinical Diagnosis or Provisional Diagnosis is the first step in diagnosis and is done after a physical examination of the patient by a clinician. Clinical diagnosis may or may not be true and to reach Final diagnosis Laboratory Investigations using gross and microscopic pathological observations and determining the disease indicators are required. The diagnostic tests may be Non-dichotomous Diagnostic Tests (when continuous values are given by the test in a range starting from sub-normal to above-normal range) and Dichotomous Diagnostic Tests (when results are given either plus or minus, disease or no-disease). To make non- Dichotomous diagnostic test a Dichotomous one you need to establish the cut-off values based on reference values or Gold Standard test readings or with the use of Receiver operator characteristic (ROC) curves, Precision-Recall Curves, Likelihood Ratios, etc., and finally establishing statistical agreement (using Kappa values, Level of Agreement, χ2 Statistics) between the true diagnosis and laboratory diagnosis. Thereafter, the Accuracy, Precision, Bias, Sensitivity, Specificity, Positive Predictive value, and Negative Predictive value, of a diagnostic test are established for use in clinical practice. Diagnostic tests are also used to determine Prevalence (True prevalence, apparent prevalence) and Incidence of the disease to estimate the disease burden so that control measures can be implemented. There are several Phases in the development and use of a diagnostic assay starting from conceptualization of the diagnostic test, development and evaluation to determine flaws in diagnostic test use and Interpretation influencers. This presentation mainly deals with the epidemiological evaluation procedures for diagnostic tests.
Types of Trials in Medicine, vaccine efficacy or effectiveness trials and rel...Bhoj Raj Singh
The importance of learning about medicines’ and vaccines’ efficacy or effectiveness trials is not only necessary to those who are developing, producing or marketing these pharmaceutical products but to the users also because: The Emergency approval of Covid-19 vaccines and many other medicines in last few years has created so much fuss to understand the reality. The lesson learnt from Covid-19 vaccine(s) by vaccine production, marketing, vaccination and finally the revenue earned by vaccine developers and producers, and political gain by politicians, is proving deleterious to the society as several vaccine(s), useless or scarcely proven safe and useful, are going to infest and some have already infested the market (the health industry). So reading this presentation may be useful to you so that you may question the authorities if any is engaged in bluffing you. The presentation talks briefly about Prevention trials, Screening trials, Treatment trials, Feasibility studies, Pilot studies, Phases in clinical trial, Multi-arm multi-stage (MAMS) trials, Global Clinical Trials, Vaccine efficacy, Vaccine safety, Emergency Use Authorization (EUA), Serious Adverse Events (SAE), SEA rules, The Vaccine Adverse Event Reporting System (VAERS), Vaccine Safety Datalink (VSD), The Advisory Committee on Immunization Practices (ACIP), Clinical Immunization Safety Assessment (CISA), CDSCO Rules Governing Clinical Trials, Schedule Y, The Ethics Committee, Empowered Committee on Animal Health, Tracking Vaccine Quality, Pre-clinical and Clinical data, Proof of Concept, Biological License Application (BLA) and Clinical hold.
Detection and Characterization of Pathotypes, Serotypes, Biotypes, Phenotypes...Bhoj Raj Singh
This presentation of my lecture, to Epidemiology students, briefs about different methods for differentiating or finding similarities among isolates of pathogens required establishing causal associations in epidemiological disease diagnosis.
Epidemiology of antigenic, genetic and biological diversity amongst pathogens...Bhoj Raj Singh
This presentation briefly describes the Antigenic, genetic and biological diversity amongst pathogens, and their origin and emergence. It also discusses with their association with different forms associated with a disease/ outbreak. The presentation also enlists diversity in strains causing some common diseases of livestock in India.
Differentiation of field isolates (wild) from vaccine strains (Marker, DIVA &...Bhoj Raj Singh
Nowadays vaccination is often reported as the cause of disease outbreaks. To ward off this misconception (vaccines are made to save the masses not to risk their lives)or to understand vaccination failures, it is necessary to understand the difference between a field strain causing the disease and a vaccine strain having attenuated virulence. This presentation talks about DIVA and DISA vaccines too.
Lumpy skin disease (LSD) Globally and in India.pptxBhoj Raj Singh
LSD has emerged as a dairy industry devastating disease in India in the last four years. First noticed in Orrisa and is now present all over India. Recurring outbreaks are now noticed in Rajasthan, Uttarakhand and other states indicating that the disease is becoming endemic in India.
Molecular determinants of pathogenicity and virulence among pathogens.pptxBhoj Raj Singh
The presentation discusses the pathogenicity and virulence of pathogens, their determinants and their interaction with the host. It talks briefly about pathogenicity, virulence, adhesions, invasions, toxins, disease, pathogenesis, pathogenicity islands (PAIs), intracellular, extracellular, bacteria, virus, fungi, prion, metazoan worms, protozoa, tuberculosis, E. coli, Salmonella, Yersinia, Mycobacterium, cytotoxins, enterotoxins, exotoxins, neurotoxins, endotoxins, in-silico, in-Vitro, in-vivo, immunohistology, haemagglutinins, spike proteins, integrins, and phagolysosomes.
Molecular epidemiology and Disease causation.pptxBhoj Raj Singh
This short presentation describes molecular epidemiology, differentiate it from genetic epidemiology, and also deals with ascertaining the cause of disease.
My research proposals, to porotect holy cow, rejected by the ICAR-IVRI in the...Bhoj Raj Singh
The presentation relates to my three research proposals, aimed at Protection of Holy cow, rejected at ICAR-ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India, in last five years
Clinical evaluation of newly advocated therapies for brucellosis in cattle and buffaloes. Duration: September 2019 to August 2021
A cross-sectional survey of Holy Cow Infectious Problems in Gaushalas (Gaushalas are protective shelters for stray cows in India). Duration: September 2022-August 2024
Explorative study on Epidemiological determinants associated with a drastic reduction in Milk Production of Dairy Animals with reference to communicable diseases. Duration: September 2022-August 2024
Animal Disease Control and Antimicrobial Resistance-A Message to Veterinary S...Bhoj Raj Singh
This presentation is for
• Introspection by all authorities before criticizing Veterinarians for an increase in AMR & to Doyens of Veterinary Science sitting mum when Vets are criticized!
• To realize that DAHD and State Animal/ Livestock Departments are:
– Fake data masters!
A realization to Doyens of Veterinary Science that they are:
– Spineless when their voice is the most needed!
– Don’t understand epidemiology to the least and make minimal attempts to improve Epidemiological understanding in veterinarians!
– The real negative thinkers!
– Suffering from an inferiority complex!
– Real killers of the holy cow!
– Interested to develop the best vet doctors but creating butchers!
– Real anti-nationals!
They talk of one health without understanding it!
– Much more!!!
Causes of Disease and Preserving Health in Different systems of Medicine.pptxBhoj Raj Singh
This presentation deals with concepts of disease causation and methods used for the alleviation of those causes to ensure health. It has briefed the causes of diseases according to Ayurvedic medicine, Unani medicine, Siddham medicine, Naturopathy, Homeopathy, Chinese medicine, Touch therapy- Reiki, Mantra therapy, and Allopathy. It also summarizes the treatments and practices in different systems of medicine. DOI: 10.13140/RG.2.2.30883.22569
AMR challenges in human from animal foods- Facts and Myths.pptxBhoj Raj Singh
This presentation talks about ÄMR: A public health threat, a “silent pandemic”.
Infections caused by Antimicrobial-drug-resistant (AMR) pathogens caused >1.27 million deaths worldwide in 2019 (low level or no surveillance) and increasing year after year which may be > million in coming decades. Covid-19 caused ~6.8 million deaths in >3 years but now the pandemic is ending but the AMR pandemic has no timeline for its ending. Many deaths are also attributed to AMR pathogens.
More antibiotic use (irrespective of the sector) = More AMR.
This presentation also talks about ways and means to mitigate the AMR pandemic. 1. Stopping the blame game. All are equally responsible for the emergence of AMR, the share of developed and educated communities is much more than poor and un-educated communities.
2. Working together: On-Line Real-Time AST Data Sharing Platform for different diagnostic and research laboratories doing AST routinely.
3. Implementing not only antibiotic veterinary and medical stewardship but antimicrobial production and distribution stewardship too.
4. Educating for Environmental health not only human, plant, and animal health.
5. AMR's solution is not in searching for alternatives to antibiotics but in establishing environmental harmony.
6. More emphasis on AMR epidemiology than on AMR microbiology and pharmacology.
7. Development of understanding that bacteria and other microbes are more essential for life on earth than the human race. Microbes can live without humans, but humans can’t without microbes.
Global-Health is of prime importance than economic growth/ greediness.
Herbal antimicrobials are considered as an important alternative to antibiotic and probable tools to mitigate emerging antimicrobial-drug-resistance (AMR). However, it is difficult to accept that microbes may not adapt to herbal antimicrobials as rapidly as to antibiotics. This is now well documented that herbal antimicrobial resistance is also common among common pathogenic microbes and genes are now known to encode herbal drug-resistance too. This lecture gives description how resistance to conventional antimicrobials impacts susceptibility of microbes for herbal antimicrobials. Lecture Scheduled on 21st February 2023, In: Antimicrobial Resistance (AMR) in Foodborne pathogens” sponsored under the ICAR-NAHEP-CAAST project by the MAFSU, Mumbai Veterinary College, at the Division of Veterinary Public Health, ICAR-IVRI from 20th February to 25th February, 2023.
Epidemiological characterisation of Burkholderia cepacia complex (Bcc) from c...Bhoj Raj Singh
The presentation is extracted from the thesis talking about
1. The presence of Bcc organisms in the clinical infections of animals.
2. Ultrasound gels as a potential source of pathogens, especially Bcc.
3. Multidrug resistance in BCCs.
4. Lack of regulatory guidelines in Indian Pharmacopeia as existing in USP.
There are hundreds of diseases of livestock and pet animals that can be printed through properly used quality vaccines. This presentation summarises different types of vaccines used by veterinarians to control/ prevent diseases. The presentation enlists the vaccine-preventable diseases of pets and livestock, and also the different vaccines used.
Major flaws in Animal Disease Control Leading to Partial Success or Failure.pptxBhoj Raj Singh
This presentation summarises major problems of Animal Disease Control Programs ongoing in India. India is a hyperendemic country for many animal diseases and zoonotic diseases. Every year billions of rupees are spent on disease control, surveillance, monitoring, and vaccination against vaccine-preventable diseases. However, due to the failure of most animal disease control programs for one or other reasons India directly losses about 20 and 25 thousand crores annually due to endemicity of FMD & brucellosis, respectively. The presentation identifies problems at different levels of different ongoing disease control programs in India. The non-availability of authentic disease data and flaws in vaccine quality control are the biggest problems.
Animal Disease Control Programs in India.pptBhoj Raj Singh
India is a hyperendemic country for many animal diseases and zoonotic diseases. Every year billions of rupees are spent on disease control, surveillance, monitoring, and vaccination against vaccine-preventable diseases. However, due to the failure of most animal disease control programs for one or other reasons India directly losses about 20 and 25 thousand crores annually due to endemicity of FMD & brucellosis, respectively. The presentation describes the pros and cons of different ongoing disease control programs going on in India.
The presentation summarises important methods and protocols of Clinical Microbiology. It may be useful to learners of Clinical microbiology at the undergraduate label. The presentation describes the procedures for collecting clinical samples, transport, and testing. It also describes the different methods of antimicrobial susceptibility testing and standards.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Epidemiology an overview
1. Epidemiology: An Overview
Dr. Bhoj R Singh, Principal Scientist (VM)
I/C Epidemiology; Centre for Animal Disease Research and Diagnosis
Indian Veterinary Research Institute, Izatnagar-243122, Bareilly, UP,
India.
TeleFax +91-581-2302188
2. Epidemiology
Father of Epidemiology: Hippocrates, 400 BC
The first person known to have examined the
relationships between the occurrence of disease and
environmental influences.
He coined the term ‘epidemic’ in his essay entitled “On
Airs, Waters, and Places,”
Clinicians are concerned with the health of an individual;
epidemiologists are concerned with the collective health of
the population in one or other area.
3. History
• Hippcrates (400 BC) an essay entitled “On Airs, Waters, and Places,”.
• Another early contributor to epidemiology was John Graunt, a
London haberdasher who published his landmark analysis of
mortality data in 1662. He was the first to quantify patterns of birth,
death, and disease occurrence, noting male-female disparities, high
infant mortality, urbanrural differences, and seasonal variations.
• In 1854, William Farr wrote a book ‘Cholera’. He began to
systematically collect and analyze Britain’s mortality statistics. Farr,
considered the father of modern vital statistics and surveillance,
developed many of the basic practices used today in vital statistics
and disease classification. He extended the epidemiologic analysis
of morbidity and mortality data, looking at the effects of marital
status, occupation, and altitude. He also developed many
epidemiologic concepts and techniques still in use today.
4. • Epidemiology= (Epi=upon/ among+demos=people/
district+logos=discourse/ study)
• Epizootiology= epi=upon+zoo=animal+logos=discourse)
• Epidemic= outbreak of disease in human population
• Epizootic= outbreak of disease in animal population
• Epornitics= outbreak of disease in bird population
• Epidemein= to visit a community, I.e., a diseases which comes periodically,
not present continuously
• Endemein= resides within (the diseases continuously present in a
population)
• Epidemiology is the study of health-event, health-characteristic, or health-
determinant patterns in a population.
• “Epidemiology is the study of the distribution and determinants of health-
related states or events in specified populations, and the application of
this study to the control of health problems.” (Last JM, 1988)
5. More Definitions
• Mayer inferentially acknowledges the epidemiologic character of
population phenomena, for as its etymology indicates, (epi, upon;
demos, people; logos, study), epidemiology is the study of what
“comes upon” groups of people. More specifically epidemiology is
concerned with the distribution of disease and death, and with
their determinants and consequences in population groups.
• Epidemiology is: a) a quantitative basic science built on a working
knowledge of probability, statistics, and sound research methods; b)
a method of causal reasoning based on developing and testing
hypotheses pertaining to occurrence and prevention of morbidity
and mortality; and c) a tool for public health action to promote and
protect the public’s health based on science, causal reasoning, and a
dose of practical common sense. (Cates WJ. 1982)
• the study of the distribution and determinates of health related
states in specified populations and the application of this study to
control health problems (Peterson DR 1970)
7. Objectives of Epidemiology
1. To determine origin of disease in a population
when etiology is known
2. To investigate and control a disease where
etiology is obscure or little understood
3. To determine ecology and natural history of a
disease
4. Planning and monitoring of disease control
programme
5. Assessment of economic effects of a disease and
cost/benefit of a control programme
8. Uses of Epidemiology
Epidemiology assists
• to identify the etiology or cause of a disease and the risk factors."
• "to study the natural history and prognosis of disease".
• "to evaluate new models of health care delivery."
• "to provide a scientific foundation for regulatory decisions relating
to health or environmental problems.
• "to provide a clue to changes taking place over time…"
• "to identify subgroups in the population who are at high risk for
disease."
• to determine the best or most appropriate types of primary and
secondary prevention.'
– primary prevention prevents disease in healthy individual
(vaccination).
– Secondary prevention limits disease by early detention usually
through screening programs.
10. Disciplines of Epidemiology
• Computational epidemiology
• Genetic epidemiology
• Molecular epidemiology
• Environmental epidemiology
• Nutritional epidemiology
• Applied Epidemiology
– Clinical epidemiology
– Micro-epidemiology (Study of disease in small group of
individuals as study of feline AIDS in kittens and then application
to understand human AIDS)= Comparative epidemiology
– Macro epidemiology (Study of disease in population in national
and international perspective)
11. Descriptive Epidemiology
• The science of characterization of the distribution
of health-related states or events is one broad
aspect of epidemiology called descriptive
epidemiology. Descriptive epidemiology provides
the What, Who, When, and Where of health-
related events.
• We temporarily classify a case as suspect or
probable until laboratory results are available.
• When we receive the laboratory report, we then
reclassify the case as either confirmed or “not a
case,” depending on the lab results.
12. Analytic epidemiology
• Analytic epidemiology attempts to provide the
Why and How of such events by comparing
groups with different rates of disease occurrence
and with differences in demographic
characteristics, genetic or immunologic make-up,
behaviours, environmental exposures, and other
so-called potential risk factors. Under ideal
circumstances, epidemiologic findings provide
sufficient evidence to direct swift and effective
public health control and prevention measures.
13. Applied epidemiology
• The term applied epidemiology is sometimes used to
describe the application or practice of epidemiology to
address public health issues. Examples of applied
epidemiology include the following:
• the monitoring of reports of communicable diseases in
the community
• the study of whether a particular dietary component
influences risk of developing a disease
• evaluation of the effectiveness and impact of a health
awareness or production improvement program
• analysis of historical trends and current data to project
future health and production resource needs
14. Concepts of Disease causation
• Demons: (Placation- sacrifice, exorcism, evasion-millet seeds,
transference- scapegoats, Gadarene swine, amulets, talismans,
fetishes and icons.
• Divine wrath: From Old testament, Persian and Aztec writings.
• Metaphysical: Stars, planets (treated with foul medicine, swallowing
of toads, fishes, moles roasted alive).
• Miasmata:
– Derangement of four humours of body (Geeks; Heat, moisture,
dryness and cold; air, earth, water and fire) creating mismata
(Malaria).
– Vedic theory, three humors and tridosha (Vat, pitta, cough)
• Contagion (Contagium animatum- Edward Jenner, 17th Century;
contagium vivum fluidum- virus, Beijerinck, 1998-99)
15. Studies in Epidemiology
1. Experimental (Full control of investigator on formation
of groups, clinical trials, nutritional trials)
2. Cross-sectional: Investigator tries to find a relation
between occurrence of disease with a hypothesized
cause)
3. Case-Control: Investigator compares groups of diseased
with healthy population with respect to exposure to a
hypothesized causal agent.
4. Co-hort: Investigator compares two groups one
exposed to hypothesized cause and other not exposed
for occurrence of disease (Prospective)
16. Methods in epidemiology
• Survey: Examination of aggregates of units of disease in population i.e., record of
events
• Types of Surveys
– Sample Survey (On a sample of population)
– Census (On total population)
– Cross sectional (record of events a defined point of time)
– Longitudinal (record of events over a period of time): Prospective (present to future),
Retrospective (records of past events)
– Screening: A kind of survey for identification of undiagnosed cases of a disease often with
some rapid test/ examination.
• Monitoring: Routine observation on health/ production of a population and
environmental factors, without much emphasis on identification of a diseased
animals. (Regular meat/ milk recording, abattoir examination, meat inspection
etc.)
• Surveillance: More intensive form of monitoring often associated with a control
programme, identification of an individual with disease in view to detect changes
in population and its environmental health.
• Sentinel units: Units selected for monitoring and surveillance as abattoirs, some
clinics, farms etc), horses may be sentinel for VEE, stray dogs for Canine distemper)
• Study in epidemiology means comparison of groups for occurance of disease/
production, thus survey is not a study.