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Presented by:
Jon Brown
Leonard Bagwala
WHAT IS EBOLA

- Ebola hemorrhagic fever:
Named after a river in the Congo
where it was first found

- Often-fataldisease in humans and
nonhuman primates (monkeys,
gorillas, and chimpanzees)

- Has appeared sporadically since
its initial recognition in 1976

- Mortality rate can reach 90%
-Family: Filoviridae

                   -Order: Mononegavirales
Family and Order      -5 distinct sub-species
                          -Cote d’Ivorie(Ivory Coast)
                          ebolavirus
                          -Reston ebolavirus
                          -Sudan ebolavirus
                          -Zaire ebloavirus
                          -Bundibugyo ebolavirus

                   - Characteristics of Filoviruses:

                     - Filamentous form with a uniform
                   diameter of approximately 80 nm but
                   display great variation in length.

                    - Nonsegmented negative-stranded
                   RNA genome containing 7 structural
                   and regulatory genes.
Where is the Ebola virus found in
               nature
• Natural reservoir of the Ebola virus remains unknown.

• Zoonotic (animal-borne)

• Four of the 5 subtypes occur in an animal host native to
  Africa 1 occurs in Philippine monkeys .

• Origination: Africa...The virus is not known to be native to
  other continents, such as North America.
Modes of Infection
Early Symptoms
           During the incubation period, (2 to 21
              days),     symptoms include:

•   Arthritic pain
•   Backache (low-back pain)
•   Chills
•   Diarrhea
•   Fatigue
•   Fever
•   Headache
•   Malaise (general feeling of being unwell)
•   Nausea
•   Sore throat
•   Vomiting
Late Symptoms
Late symptoms include:

• Bleeding from eyes, ears, and nose
• Bleeding from the mouth and rectum (gastrointestinal
  bleeding)
• Depression
• Eye inflammation (conjunctivitis)
• Genital swelling (labia and scrotum)
• Increased feeling of pain in skin
• Rash over the entire body that often contains blood
  (hemorrhagic)
• Roof of mouth looks red
• Seizures, coma, delirium

As many as 90% of patients die from the disease. Patients usually
die from shock rather than from blood loss.
How it works
Tetherin: A human cellular protein
which inhibits retrovirus infection
by preventing the diffusion of virus
particles after budding from
infected cells




                                 Threadlike Ebola virions bud from
                                 a cell.
                                 The Ebola virus disables a cell's
                                 tetherin protein.
Hope on the Horizon?




 Ebola virus glycoprotein, or
 "spike protein,"

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Ebola presentation

  • 2. WHAT IS EBOLA - Ebola hemorrhagic fever: Named after a river in the Congo where it was first found - Often-fataldisease in humans and nonhuman primates (monkeys, gorillas, and chimpanzees) - Has appeared sporadically since its initial recognition in 1976 - Mortality rate can reach 90%
  • 3. -Family: Filoviridae -Order: Mononegavirales Family and Order -5 distinct sub-species -Cote d’Ivorie(Ivory Coast) ebolavirus -Reston ebolavirus -Sudan ebolavirus -Zaire ebloavirus -Bundibugyo ebolavirus - Characteristics of Filoviruses: - Filamentous form with a uniform diameter of approximately 80 nm but display great variation in length. - Nonsegmented negative-stranded RNA genome containing 7 structural and regulatory genes.
  • 4. Where is the Ebola virus found in nature • Natural reservoir of the Ebola virus remains unknown. • Zoonotic (animal-borne) • Four of the 5 subtypes occur in an animal host native to Africa 1 occurs in Philippine monkeys . • Origination: Africa...The virus is not known to be native to other continents, such as North America.
  • 5.
  • 7. Early Symptoms During the incubation period, (2 to 21 days), symptoms include: • Arthritic pain • Backache (low-back pain) • Chills • Diarrhea • Fatigue • Fever • Headache • Malaise (general feeling of being unwell) • Nausea • Sore throat • Vomiting
  • 8. Late Symptoms Late symptoms include: • Bleeding from eyes, ears, and nose • Bleeding from the mouth and rectum (gastrointestinal bleeding) • Depression • Eye inflammation (conjunctivitis) • Genital swelling (labia and scrotum) • Increased feeling of pain in skin • Rash over the entire body that often contains blood (hemorrhagic) • Roof of mouth looks red • Seizures, coma, delirium As many as 90% of patients die from the disease. Patients usually die from shock rather than from blood loss.
  • 9. How it works Tetherin: A human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells Threadlike Ebola virions bud from a cell. The Ebola virus disables a cell's tetherin protein.
  • 10. Hope on the Horizon? Ebola virus glycoprotein, or "spike protein,"

Editor's Notes

  1. Slide #1: Our presentation will be on the deadly Ebola Virus, which can cause Ebola type hemorrhagic fever.
  2. What is Ebola?:According CDC, Ebola hemorrhagic fever is a deadly disease in both humans and nonhuman primates (monkeys and chimpanzees) caused by the Ebola virus; characterized by high fever and severe internal bleeding; can be spread from person to person; is largely limited to Africa.First found in the area of the Democratic Republic of the Congo, near the River Congo in 1976 mortality rate: 90%, that’s why is called deadly disease.
  3. Highest fatality Rate is found in the Zaire sub-species. The only reported cases in the U.S., Italy and England were all part of the Reston sub-species.
  4. Natural reservoir of Ebola Virus still unknown until now. Its Zoonoticall 4 of 5 subtypes an animal Host in Africa
  5. The virus itself stores its nucleic acid in the form of a +mRNA genome and serves as a means of delivery of that genome into cells it targets as an obligate parasite (Cannot live independently of the Host cell), and constitutes the infection. Once in the host's cell, the RNA strands undergo reverse transcription in the cytoplasm and are integrated into the host's genome, at which point the retroviral DNA is referred to as a provirus (A provirus is a virus genome that is integrated into the DNA of a host cell). It is difficult to detect the virus until it has infected the host.