DNA is made up of nucleotides that form a double helix structure. In the 1940s, Avery discovered that DNA, not proteins, is responsible for heredity. Chargaff determined that DNA bases pair up with equal ratios. Franklin's X-ray images helped Watson and Crick deduce the double helix structure in 1953. The structure consists of a sugar-phosphate backbone with nitrogen bases projecting into the helix. DNA replicates semi-conservatively, with each original strand serving as a template to create a new complementary strand. Genes are segments of DNA that code for polypeptides.