Diuretics are substances that promote urine formation and loss of salt from the body. They are prescribed to treat high blood pressure, fluid retention due to conditions like heart failure or kidney disease, and edema. There are three types of diuretic medications that work by lowering salt and water levels in the body. Diuretics can interact with other medications a person is taking, so patients should inform their doctor about all medicines and supplements. Common side effects include weakness, cramps, rashes, and gastrointestinal issues.