This document describes left displaced abomasum (LDA) in cattle. LDA typically occurs in dairy cows within a month of calving, often due to nutritional management issues. The abomasum is displaced to the left side of the abdominal cavity due to atony from volatile fatty acids in the diet. Clinical signs include reduced appetite and milk production. Treatment involves surgical correction, usually using right flank omentopexy to fix the abomasum, along with supportive care like fluids and anti-inflammatories. Proper nutritional management can help prevent LDA.
A common disease of cattle and may also in dog, cat, sheep, goat, mare, Buffalo. The slides contain an introduction, causes of torsion, clinical signs and symptoms, torsion causes, treatment.
A common disease of cattle and may also in dog, cat, sheep, goat, mare, Buffalo. The slides contain an introduction, causes of torsion, clinical signs and symptoms, torsion causes, treatment.
Achalasia cardia is a primary oesophageal motility disorder. Barium swallow demonstrates a classic bird beak appearance. This presentation briefly explains the barium swallow procedure and findings in achalasia cardia.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Ocular injury ppt Upendra pal optometrist upums saifai etawah
Displacement of the abomasum in cattle
1. NAME :AMEER HAMZA
CLASS# 01
DVM FINAL YEAR
(SEMESTER:09)
SEC:A
SESSION:2016-2020
MEDICINE CLINIC 3
ASSIGNMENT SUBMITTED TO :
DR HAQ AMAN ULLAH
Assignment No.3
Describe in detail the etiology, pathogenesis, and treatment
of following diseases:
Displacement of abomasum in cattle
LEFT DISPLACED ABOMASUM
Left displaced abomasum (LDA) typically occurs more commonly during the winter
housing period in dairy cows in the month following calving. Some association with
high-concentrate/low-fibre rations, previous episodes of hypocalcaemia, twinning
and endometritis have been reported. Increasingly, LDA is seen in recently calved
heifers, which may reflect poor nutritional management before entering the milking
herd. LDA is rarely seen in
beef cows or intensively fattened cattle.
ETIOLOGY
2. Displacement of the abomasum occurs to either the left or the right of the abdominal
cavity. Atony, secondary to highly volatile fatty acid concentrations from continued
fermentation of high carbohydrate rations within the abomasum, results in
accumulation of gas and displacement.
CLINICAL SIGNS:
The clinical signs are most severe when LDA occurs in conjunction with puerperal
metritis and associated toxaemia in the first week after calving.
The cow is often febrile (39.5–41°C), depressed and anorexic, with a reduced milk
yield. There is profuse, often fetid, diarrhoea.
However, most LDA cases occur more than 10 days after calving when there are
concurrent clinical signs of chronic endometritis and secondary ketosis. A typical case
presents 15–30 days post calving with a history of poor milk yield , reduced appetite
with chronic weight loss
The cow is slow to move and dull and has a dry staring coat. The rectal temperature is
normal and the cow is often constipated. A sprung rib cage may be obvious on the left
side with a severely distended abomasum present.
A hypochloraemic, hypokalaemic metabolic alkalosis can develop in chronic cases.
The distended abomasum occupies the craniodorsal area of the left side of the
abdominal cavity (under the rib cage) and auscultation and percussion reveal
high-pitched metallic ‘pinging’ sounds. Rumen movements can be heard caudally in
the sublumbar fossa. It is uncommon to be able to palpate the caudal edge of the
displaced abomasum on rectal examination.
DIFFERENTIAL DIAGNOSIS
Rumen void syndrome (i.e. a gap [vacuum]) formed between the left flank and the
shrunken dorsal sac of the rumen, which yields a ‘ping’ upon percussion; gas cap in
rumen associated with grain overload; pneumoperitoneum.
DIAGNOSIS
3. 1. clinical examination, remembering that more than one condition may exist at the
same time (i.e. metritis and LDA, secondary ketosis and LDA). A combination of
percussion and/or ballottement with simultaneous auscultation is normally diagnostic.
Diagnosis is confirmed at surgery.
2. Paracentesis of the displaced abomasum contents (aided by ultrasonography) would
reveal the presence of fluid with no protozoa and a PH of 2, but is rarely undertaken
or is necessary.
TREATMENT:
1. MANAGEMENT
The rolling technique takes time and requires three people and the LDA recurs in up
to 60% of cases. Surgical correction of LDA is the option preferred by most
practitioners. There are many surgical techniques, but right flank omentopexy is the
preferred method andhas largely replaced the bilateral flank approach. In many
practices, toggling (Grymer/Sterner method) is performed because of cost savings, but
this method is not without its problems and published reports describe an 85%
successrate.
A- Rolling technique
The cow is cast onto her right side (166) and may be hobbled to prevent injury to
attendants. The cow is then pulled onto her back and supported (167), while the left
flank is balloted to help the abomasum rise to the midline. Alternatively, the cow can
be gently rocked along her long axis. The cow is then quickly passed onto her left side
(168) so that the abomasum floats to its normal position on the right side. The hobbles
are removed and the cow is allowed to stand.
B- Right flank omentopexy approach
An intravenous NSAID such as ketoprofen or flunixin is administered preoperatively.
A right laparotomy is performed in the standing cow under distal paravertebral
analgesia without sedation (169). The surgeon’s left arm is directed initially towards
4. the cow’s tail head over the dorsal sac of the rumen, then around behind the omentum
into the left sublumbar fossa. The abomasum is football sized and lies high up on the
left side under the costal arch, buoyed by its gas content. The abomasum is punctured
and deflated using a 14 gauge needle connected to a flutter valve or suction pump.
The needle is guarded by the surgeon’s hand when passed through the abdominal
cavity.
Release of gas causes the abomasum to sink towards the ventral midline, pulled by its
liquid contents. The surgeon’s hand is now directed forward from the incision site
alongside the lower right flank wall towards the ventral midline just caudal to the
xiphisternum. Near the midline the greater omentum is grasped with the left hand and
slowly pulled up to the ventral margin of the incision. The ‘sow’s ear’ (170),
abomasum (171) and pylorus can be readily identified. An
omentopexy is performed whereby a continuous suture taking four 3 cm bites of
omentum is used to close the peritoneum and transversus muscle layer, picking up a
deep bite of omentum with each needle pass such that the omentum is fixed along the
whole length of the closure. Some surgeons elect to perform a pyloropexy, but this
may necessitate considerable pressure to hold the pylorus at the level of the flank
incision. Rolling the cow immediately prior to right flank omentopexy can make the
surgery simpler because the abomasum will be found repositioned in the lower right
abdomen when the surgeon enters the abdominal cavity. The laparotomy wound is
then closed routinely.
Administration of large volumes of oral fluids is recommended by some practitioners
to distend the rumen and prevent potential re-displacement, but cows often begin
eating immediately after surgery. Animals, especially those where the LDA was not
detected early (172) and those with secondary ketosis, take several weeks to fully
recover their appetite and milk yield.
C- Grymer/Sterner method
Recently, toggling of the abomasum (Grymer/Sterner method) through the ventral
abdominal wall overlying the tympanitic abomasum has been described as a more
cost effective procedure than right flank omentopexy. The cow is cast into dorsal
recumbency with the abomasum restored to its normal midline position. The
5. abomasum is locatedas quickly as possible by percussion and two toggles with nylon
sutures are introduced into the abomasum through wide-bore trocars approximately
5–10 cm apart. The trocars are removed and the nylon sutures tied together. Failure
accurately to locate the abomasum may result in toggling the omentum or other
viscera, although this method is reported to be about 85% effective.
D- Right ventral paramedian abomasopexy
In this technique the cow is sedated and cast in dorsal recumbency. A right
paramedian incision is made after local analgesia, the abomasum, which will have
floated back into the midline, is identified and an abomasopexy anchors it to the
ventral body wall. While this method is preferred by some surgeons, it carries risks
associated with sedation and casting in dorsal recumbency, and a greater risk of
wound breakdown.
2- Supportive therapy
A- Concurrent puerperal metritis is treated for three consecutive days with
oxytetracycline
B- NSAID (e.g. ketoprofen @0.3mg/kg or flunixin
@1.1-2.2 mg/kg administered for 2 days ).
C- Fifty per cent dextrose (400 ml i/v) is used to treat secondary acetonaemia and
propylene glycol can also be administered (p/o q12h).
E- Oral potassium chloride administered as a drench may be indicated in some cases
and will hasten recovery when weakness due to hypokalaemia is present.
Prevention/control measures
High concentrate levels must be avoided immediately following calving. Sufficient
long fibre (e.g. hay orchopped straw) should be provided during the early
post partum period. There must be prompt treatment of retained placenta and early
cases of puerperal metritis.
Control measures for hypocalcaemia, including use of acidifying diets during the dry
period, should be instituted. Overconditioning of dry cows must be prevented. The
increasing prevalence of LDA in heifers is a concern and a review of their late
gestation nutrition, calving management and introduction into the milking herd is
indicated.
DILATION/RIGHT-SIDED DISPLACEMENT
OF THE ABOMASUM
6. Dilation and right-sided displacement of the abomasum (RDA) occurs occasionally in
dairy cows during early lactation, but it is much less common than LDA.two-thirds of
the way up the right flank just cranial to the right sublumbar fossa.
DIFFERENTIAL DIAGNOSIS
Gas may accumulate in the caecum and spiral colon, causing high pitched metallic
sounds on percussion in the right caudal abdomen. Abomasal volvulus leads to pings
over a much larger (>60 cm diameter) area, and more severe systemic signs.
DIAGNOSIS
Diagnosis is based on clinical findings and elimination of
other potential causes of poor appetite and milk yield.
TREATMENT:
Reported treatment for abomasal dilation includes 40% calcium borogluconate (400
ml i/v).
substituting some concentrates with hay for 3–5 days
oral and intravenous fluids as necessary.
Hyoscine or metaclopromide have been reported to be useful for abomasal dilatation,
but there is little supporting evidence. Most cases of uncomplicated RDA resolve
spontaneously within several days.
Right flank laparotomy accompanied by decompression and drainage of the
abomasum (often as a last resort) may relieve the problem, but why such surgery
should be successful remains uncertain.
A similar aetiology as for LDA is suspected for RDA, therefore similar husbandry and
dietary control measures apply. RDA is not a major disease concern in dairy cattle.