A common disease of cattle and may also in dog, cat, sheep, goat, mare, Buffalo. The slides contain an introduction, causes of torsion, clinical signs and symptoms, torsion causes, treatment.
A common disease of cattle and may also in dog, cat, sheep, goat, mare, Buffalo. The slides contain an introduction, causes of torsion, clinical signs and symptoms, torsion causes, treatment.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. OPD No :3457 Date of admission:1/2/18
Date of discharge :2218
Doctor on duty :Dr. SHARAD KUMAR
Name & RO :rajinder kumar, meran sahib.
Species :bovine SEX :Female
3. History:
H/o dystocia observed since yesterday .
animal has completed the gestation period ,
animal has parturated three times earlier
healthy calves
Per vaginal examination :
Oedema observed in birth canal and probably
emphysema observed in fetus.foul smell was
observed.
4. Diagnosis :
Vaginal delivery not possible [refer to surgery for c-
section]
Treatment :
Inj. DNS -5L i/v
inj,. NSS -5L i/v
Inj. Enrocin-12ml i/m-3 days i/m
5. Commonly termed as C-Section in which uterus is exteriorized
to take out the young one from the pregnant dam.
CS is delivery of fetus , usually at parturation by
laparohysterotomy.
This operation is performed when mutation, forced extraction
and fetotomy are deemed inadequate or too difficult to be
employed to relieve the impending or present dystocia.
7. Maternal reasons:
• A relatively oversized fetus
• Inadequate cervical dilation
• Abnormal pelvic conformation
• Prepubic tendon rupture
• Uterine rupture
• Uterine torsion
• Uterine inertia
• Hydrops of the amnion or allantois
• Congential or traumatically induced vaginal
Constriction.
8. Fetal indications:
• Fetal malposition that is not correctable per Vagina
• Absolute fetal oversize
• Fetal monsters
• Emphysematous fetuses.
9. Ancillary indications:
• Elective cesarean section for the delivery of embryo
transfer calves
• The production of gnotobiotic Calves
• Terminal cesarean sections.
10.
11.
12. --Standing left paralumbar celiotomy:
Incision : caudal 3rd of paralumbar fossa
13. • Left flank incision is the most common technique
and is most appropriate for the standing animal.
• A right flank incision is uncommon; however, it is
indicated if the left flank approach is obstructed by
adhesion as a result of previous surgery
14. Left flank
laparotomy:
• The risk of small intestine
coming out from the site of
wound is negligible (merit).
• The rumen may cause
hindrance to access of the
uterus (demerit).
Right flank
laparotomy:
• Allow good access to a calf
in the right uterine horn
(merit).
• The risk of the small
intestine to come out from
the laparotomy wound is
higher (demerit).
15. ventro-lateral celiotomy :
Restrain : lateral recumbancy
Incision : parallels the superficial mammary vein , before
cutting an angle by the udder
16.
17. • A ventro lateral incision is particularly indicated for
the removal of an emphysematous foetus.
• The cow should be in right lateral recumbency for
ventro-Iateral laparotomy.
ADVANTAGES:
It gives good exposure of the uterus.
• Another advantage is, it minimizes the risk of
contamination from uterine contents to the
abdominal cavity or peritoneum.
DISADVANTAGES :
• Repair of the abdominal muscle layers are more
difficult because the muscles remain under tension
and sutures may tear the muscles.
• Risk of post-operative soiling of wound is more.
18. Left oblique celiotomy :
Discovered by parish-et –al
Standing celiotomy
Incision : extends cranoiventrally at an 45 angle to end 3 cm
caudal to the last rib
19. Ventral midline celiotomy:
Restrain : dorsal recumbancy
Incision : starting at the udder and extended towards the
xiphoid cartilage
Paramedian celiotomy;
Restrain : dorsal recumbancy
Midline or paramedian incision :
• It is not commonly used in the field condition because general
anaesthesia or heavy sedation is required and respiratory
function of the dam is compromised in this condition.
• Risk of post operative soiling of wound or herniation is higher.
• However this technique gives excellent access to the uterus.
20.
21. Generally caesarean section in cattle is performed under the
local infiltration anaesthesia using 2% lignocain
hydrochloride
Sedation should be avoided (if possible) because it can cause
recumbency during surgery and may be detrimental to foetal
survival.
If sedation is necessary, xylazine is commonly used (0.05-0.1
mg/kg b.w. I/M).
Unfortunately, xylazine is an ecbolic (increase
contraction of uterus),making surgery more difficult
and cause ruminal bloat which can obstruct the access
to the uterus.
22. Epidural anaesthesia:
Epidural anaesthesia is not essential but is useful to
prevent straining and tail movement during
surgery. Sometime it causes recumbency during
surgery (demerit).
23. The surgical technique is performed in following steps:
1. Opening of the flank
2. Locating the uterus
3. Opening of the uterus
4. Removal of the foetus
5. Management of the placenta
6. Closing of the uterine incision
7. Closing of the laparotomy incision
24. Preparation of the Surgical site and washing of hand .
Apply betadine iodine on the site.
A large bold incision is made into the abdomen.
Control the bleeding, ligation.
Follow a blunt dissection.
Cut a facial layer, and two muscle layers.
Reach to the peritoneum.
Hold the peritoneum and make a stab incision.
Let the peritoneal fluid to drain, and open it.
25. Try to reflect the omentum.
Reach to the gravid uterus and exteriorate.
Palpate the fetal parts.
Apply a sterilized drap on it.
Make an incision on uterus avoiding injury to a fetus.
Hold fetal legs and gently remove it.
Avoid intra-peritoneal contamination.
If the foetus in anterior presentation, then removed rear
end of foetus first at caesarean section and if the foetus is
in posterior presentation, then remove front end.
26. Hold the incised uterine edges.
Remove the fetal membranes gently if possible.
Remove the uterine fluid.
Wash it with the normal saline-3 times, Start suturing the uterus with
Lambert followed by Cushing suturing technique in a double layer
using #1 catgut.
27. Suture two muscle layers separately using #2 catgut by lock
stitch or simple continuous method.
Suture the peritoneum using #1 catgut, by lock stitch or simple
continuous method.
Apply some antibiotic powder in-between 2 muscle layers.
Suture skin layer with a cotton thread using horizontal
mattress method
Management of placenta:
• If the placenta is easily and quickly detachable, it should be
carefully removed from the uterus.
• If not, it should be left in the site even when the cervix is
closed.
• Furea bolus is kept in the uterus.
28. Skin,
Subcutaneous fascia
Combined aponeurosis of the two oblique muscles
which forms the external sheath of the rectus
abdominis
Transverse abdominis
Peritoneum.
29. Peritonitis
Wound breakdown
Seroma formation - A pocket of sterile serous
fluid accumulates between muscle layers or
under the skin. This can be confirmed when a
sterile needle is inserted - serum flow-out.
Retention of the foetal membranes
Metritis
Infertility
Mastitis (E. coli infection)
Sudden death.
30. Utmost care should be taken to avoid the spillage of
uterine contents into the peritoneal / abdominal
cavity.
It should be lavaged with sterile normal saline
containing non- irritant antibiotics to counteract
the infection, reduce the chances of postoperative
adhesions and infection.
The uterine torsion in case of cattle and buffaloes
should be then corrected. 50-60 units of oxytocin
hasten the uterine involution. A 5% solution of
dextrose and normal saline solution should be
invariably included in the schedule as most deaths
have hypoglycemia and hypochloraemia.
31. Give a broad-spectrum antibiotic.
Analgesic, Anti-inflammatory drug.
Anti histaminic - For 3 to7 days.
Oxytocin - 100 IU.
Glucose 5%.
Haemostatics if necessary.
Give laxative feeds.
Daily dressing of a wound.
Editor's Notes
This operation is performed when mutation, forced extraction and fetotomy are deemed inadequate or too difficult to be emplyoued to relieve the impending or present dystocia.