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Authors –
Dr. Tanmayi Kulkarni
Co-authors –
Dr. Dhaval K. Thakkar
Dr. V. M. Kulkarni
Institution –
Dr. D. Y. Patil
Medical College,
Pimpri, Pune
Clinical profile:
26 years old female patient, primigravida had come with 7 months amenorrhea.
Also, complaints of decreased fetal movements since that morning.
Ultrasound image shows well defined, anechoic,
asymmetric, multiseptate, thin-walled cystic masses
Ultrasound of coronal and sagittal image of fetal head and neck reveals well
defined, anechoic, asymmetric, multiseptate, thin-walled cystic masses
Diagnosis
Cystic Hygroma
Differential Diagnosis
1. Cystic Hygroma
2. Encephalocele
3. Meningomyelocele
4. Teratomas
Cystic Hygroma
• Hygroma- Moist Tumour
• Anomalies of the lymphatic system
• Characterized by single or multiple cysts within the soft tissue.
• Usually bilateral.
• Involves the posterior aspect of neck.
• Contain clear or cloudy fluid.
Prognosis
• Prognosis is poor.
• It depends on the associated Chromosomal anomalies.
• Usually leads to oligohydramnios or fetal demise.
Pathogenesis
• Fetal Lymphatic system develops at around
5th week of gestation
• Failure to establish lymphatic connection
lead to accumulation of the lymphatic fluid.
• Dilatation of the lymphatic sac leads to the
formation of cystic structure
• Usually partitioned by the fibrous bands
corresponding to nuchal ligament.
Associated Anomalies
Chromosomal anomalies
• Turner"s syndrome (45, X0 or mosaic 46, XX/45, X): 45-50% of cases
• Trisomy 21
• Trisomy 18 15 % of cases
• Trisomy 13
• Trisomy 22 mosaicism
• Partial trisomy 11q/22q
• 13q-syndrome
• 18p-syndrome
• balanced translocation t (6q; 12q
References
1. Brown LR, Reiman HM, Rosenow EC et-al. Intrathoracic lymphangioma. Mayo Clin. Proc. 1986;61
(11): 882-92.
2. Faul JL, Berry GJ, Colby TV et-al. Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis,
and lymphatic dysplasia syndrome. Am. J. Respir. Crit. Care Med. 2000;161 (3 Pt 1): 1037-46.
3. Miyake H, Shiga M, Takaki H et-al. Mediastinal lymphangiomas in adults: CT findings. J Thorac
Imaging. 1996;11 (1): 83-5.
4. Shaffer K, Rosado-de-christenson ML, Patz EF et-al. Thoracic lymphangioma in adults: CT and MR
imaging features. AJR Am J Roentgenol. 1994;162 (2): 283-9.
5. Webb WR, Higgins CB. Thoracic imaging, pulmonary and cardiovascular radiology. Lippincott
Williams & Wilkins. (2005) ISBN:078174119X.
6. Mernagh JR, Mohide PT, Lappalainen RE et-al. US assessment of the fetal head and neck: a state-of-
the-art pictorial review. Radiographics. 1999;19 Spec No : S229-41.
7. Merz E, Bahlmann F. Ultrasound in obstetrics and gynecology. Thieme Medical Publishers. (2005)
ISBN:1588901475.
8. Hsieh YY, Lee CC, Chang CC et-al. Prenatal sonographic diagnosis of Cantrell's pentalogy with cystic
hygroma in the first trimester. J Clin Ultrasound. 1998;26 (8): 409-12.
9. Rosati P, Guariglia L. Prognostic value of ultrasound findings of fetal cystic hygroma detected in early
pregnancy by transvaginal sonography. Ultrasound Obstet Gynecol. 2000;16 (3): 245-50.
10. Rosati P, Guariglia L. Transvaginal ultrasound detection of septated and non-septated cystic hygroma
in early pregnancy. Fetal. Diagn. Ther. 12 (3): 132-5. -
11. Entezami M, Albig M, Knoll U et-al. Ultrasound Diagnosis of Fetal Anomalies. Thieme. (2003)
ISBN:1588902129. 12. Eisenberg RL. Clinical Imaging. Lippincott Williams & Wilkins. (2010)
ISBN:0781788609.

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Cystic hygroma dt-2

  • 1. Authors – Dr. Tanmayi Kulkarni Co-authors – Dr. Dhaval K. Thakkar Dr. V. M. Kulkarni Institution – Dr. D. Y. Patil Medical College, Pimpri, Pune
  • 2. Clinical profile: 26 years old female patient, primigravida had come with 7 months amenorrhea. Also, complaints of decreased fetal movements since that morning. Ultrasound image shows well defined, anechoic, asymmetric, multiseptate, thin-walled cystic masses
  • 3. Ultrasound of coronal and sagittal image of fetal head and neck reveals well defined, anechoic, asymmetric, multiseptate, thin-walled cystic masses
  • 5. Differential Diagnosis 1. Cystic Hygroma 2. Encephalocele 3. Meningomyelocele 4. Teratomas
  • 6. Cystic Hygroma • Hygroma- Moist Tumour • Anomalies of the lymphatic system • Characterized by single or multiple cysts within the soft tissue. • Usually bilateral. • Involves the posterior aspect of neck. • Contain clear or cloudy fluid. Prognosis • Prognosis is poor. • It depends on the associated Chromosomal anomalies. • Usually leads to oligohydramnios or fetal demise.
  • 7. Pathogenesis • Fetal Lymphatic system develops at around 5th week of gestation • Failure to establish lymphatic connection lead to accumulation of the lymphatic fluid. • Dilatation of the lymphatic sac leads to the formation of cystic structure • Usually partitioned by the fibrous bands corresponding to nuchal ligament.
  • 8. Associated Anomalies Chromosomal anomalies • Turner"s syndrome (45, X0 or mosaic 46, XX/45, X): 45-50% of cases • Trisomy 21 • Trisomy 18 15 % of cases • Trisomy 13 • Trisomy 22 mosaicism • Partial trisomy 11q/22q • 13q-syndrome • 18p-syndrome • balanced translocation t (6q; 12q
  • 9. References 1. Brown LR, Reiman HM, Rosenow EC et-al. Intrathoracic lymphangioma. Mayo Clin. Proc. 1986;61 (11): 882-92. 2. Faul JL, Berry GJ, Colby TV et-al. Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. Am. J. Respir. Crit. Care Med. 2000;161 (3 Pt 1): 1037-46. 3. Miyake H, Shiga M, Takaki H et-al. Mediastinal lymphangiomas in adults: CT findings. J Thorac Imaging. 1996;11 (1): 83-5. 4. Shaffer K, Rosado-de-christenson ML, Patz EF et-al. Thoracic lymphangioma in adults: CT and MR imaging features. AJR Am J Roentgenol. 1994;162 (2): 283-9. 5. Webb WR, Higgins CB. Thoracic imaging, pulmonary and cardiovascular radiology. Lippincott Williams & Wilkins. (2005) ISBN:078174119X. 6. Mernagh JR, Mohide PT, Lappalainen RE et-al. US assessment of the fetal head and neck: a state-of- the-art pictorial review. Radiographics. 1999;19 Spec No : S229-41. 7. Merz E, Bahlmann F. Ultrasound in obstetrics and gynecology. Thieme Medical Publishers. (2005) ISBN:1588901475. 8. Hsieh YY, Lee CC, Chang CC et-al. Prenatal sonographic diagnosis of Cantrell's pentalogy with cystic hygroma in the first trimester. J Clin Ultrasound. 1998;26 (8): 409-12. 9. Rosati P, Guariglia L. Prognostic value of ultrasound findings of fetal cystic hygroma detected in early pregnancy by transvaginal sonography. Ultrasound Obstet Gynecol. 2000;16 (3): 245-50. 10. Rosati P, Guariglia L. Transvaginal ultrasound detection of septated and non-septated cystic hygroma in early pregnancy. Fetal. Diagn. Ther. 12 (3): 132-5. - 11. Entezami M, Albig M, Knoll U et-al. Ultrasound Diagnosis of Fetal Anomalies. Thieme. (2003) ISBN:1588902129. 12. Eisenberg RL. Clinical Imaging. Lippincott Williams & Wilkins. (2010) ISBN:0781788609.