This document discusses screening in the late 1st trimester (11-13 weeks) of pregnancy. It presents several rare fetal abnormalities detected during nuchal translucency scans over a two year period, including cystic hygroma, acrania, neural tube defects, encephalocele, holoprosencephaly, omphalocele, kyphoscoliosis, sirenomelia, and megacystis. The take home message is that a detailed transvaginal examination and 3D/4D scan along with the nuchal scan can detect additional abnormalities in the late 1st trimester, such as cleft lip/palate, hypoplastic left heart, and atriovent

2. SCREENING IN THE LATE 1ST TRIMESTER (11-
13 WEEKS)
Advantages:
•Earlier diagnosis.
•Pregnancy less obvious, more private.
•May be less bonding.
•Pregnancy termination easier and safer.
We are presenting some of the cases seen at
our center during nuchal translucency scan(11
to 13 weeks) over last two years.

3. CYSTIC HYGROMA WITH ABNORMAL FLOW IN
DUCTUS VENOSUS

4. ACRANIA WITH ABSENT NASAL BONE SEEN AT
13 WEEKS
TRANSVAGINAL EXAMINATION SHOWING
ABSENT CRANIAL VAULT AND NASAL BONE

5. NEURAL TUBE DEFECTS IN A 45 YEAR OLD
PRIMIGRAVIDA

6. DICHORIONIC-DIAMNIOTIC TWIN PREGNANCY AT 11 WKS
– ONE OF THE TWINS SHOWING ENCEPHALOCELE

7. ALOBAR HOLOPROSENCEPHALY
AT 13 WEEKS

8. OMPHALOCOELE AT 14 WKS

9. KYPHOSCOLIOSIS AT 14 WEEKS

10. A RARE CASE OF SIRENOMELIA ALSO KNOWN AS MERMAID’S
SYNDROME AT 12 WEEKS

11. POST TERMINATION IMAGES OF FETUS HAVING
SIRENOMELIA

12. MEGACYSTIS : OVERDISTENDED URINARY BLADDER WITH
FULLNESS IN BOTH THE KIDNEYS SEEN AT 12 WEEKS

13. MEGACYSTIS RESOLVED SPONTANEOUSLY AT 15 WEEKS.
PERSISTENT FULLNESS WAS SEEN IN BOTH THE KIDNEYS TILL
TERM. POSTNATALLY THE BABY WAS DIAGNOSED WITH
POSTERIOR URETHRAL VALVES

14. TAKE HOME MESSAGE
We recommend that a detailed transvaginal
examination including 3D/4D scan should be
done along with nuchal scan to detect other
abnormalities as well.
Some of the other abnormalities which can be
detected this period are cleft lip/palate,
hypoplastic left heart, AVSD.