Recent advances have expanded cochlear implant candidacy criteria in several ways:
(1) Younger pediatric patients down to 12 months can now receive implants, as early implantation leads to better language outcomes. (2) Adults who gain limited benefit from hearing aids and have speech recognition scores below 50% are candidates. (3) Patients with residual low-frequency hearing may be candidates for hybrid cochlear implants and hearing aids. New technologies continue to broaden candidacy and improve outcomes for patients.
Auditory brainstem response (ABR)
Approximately 1 of every 1000 children is born deaf. Many more are born with less severe degrees of hearing impairment, while others may acquire hearing loss during early childhood.
combination of technological advances in ABR and otoacoustic emissions (OAE) testing methods are used for evaluation of hearing in newborns.
Auditory brainstem response (ABR)
Approximately 1 of every 1000 children is born deaf. Many more are born with less severe degrees of hearing impairment, while others may acquire hearing loss during early childhood.
combination of technological advances in ABR and otoacoustic emissions (OAE) testing methods are used for evaluation of hearing in newborns.
• Hearing loss is widely recognized as one of the most common human disorders. (Nipalko J.K., 2002). Hearing loss affects up to 10% of the population. The prevalence increases with age and over one third of people older than 65 years have a significant hearing loss. Only approximately 20% of people with hearing loss seek assistance from hearing aids, of these, as many as 16.2% do not wear their devices.
• It has been reported that 5 of 10,000 infants less than 2 years of age are profoundly hearing impaired. They are unable to hear any sound from the outside world.
• The problem is critical for adults and dramatic for children. Early onset profound hearing loss has been shown to have devastating consequences for the development of language that is essential for learning almost anything. It allows us to participate, to understand, to interact with the world around us, and to avoid social isolation. (Moeller, 1998)
• Sensorineural hearing loss is caused by defect of the inner ear or central auditory pathways. Treatment is dependent on the degree of hearing impairment. Hearing aids are indicated for mild to severe sensorineural hearing loss. In patients with severe to profound hearing loss due to cochlear defects or any abnormalities will result in severe handicap. To overcome this severe handicap, application of implantable hearing aids is indicated.
Thia presentation is about how to assess hearing loss, how to categorise it, how to investigate it, and finally how to rehabilitate the deaf people of different ages
The Changing Role of the Coronary Care Cardiologist & The Emerging Role of Ca...Dr.Mahmoud Abbas
The Changing Role of the Coronary Care Cardiologist
&
The Emerging Role of Cardiac Intensive Care Specialists lecture presented by Dr Sherif Mokhtar, President ECCCP at the Egyptian Spanish Critical care Symposium held at Cairo, Egypt on 11 May 2023
Drug induced Kidney Injury in the ICU. Presentation by Dr Sandra Kane Gill , President Society of Critical Care Medicine (SCCM) , USA at the Egyptian Critical care Summit 2022 conference , organized by the Egyptian College of Critical care Physicians (ECCCP) , Egypt
Using Novel Kidney Biomarkers to Guide Drug Therapy.pdfDr.Mahmoud Abbas
Using Novel Kidney Biomarkers to Guide Drug Therapy: Presentation by Dr Sandra Gill , President SCCM at the Egyptian Critical Care Summit 2022 held at Cairo, Egypt and organized by the Egyptian College of Critical care Physicians (ECCCP)
Presentation by Dr Marwa Atef , National Research Center, Cairo, Egypt . Presented at Cairo Textile Week 2021 , the leading textiles conference in Egypt
Cairo Textile Week 2021 Conference -Egypt Textiles & Home Textiles Export Cou...Dr.Mahmoud Abbas
Egyptian Textiles Export
Opportunities & Requirements
Presentation by Engineer Hany Salam, CEO Salam Textiles, Board member Egypt Textiles & Home Textiles
Export Council (THTEC)
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
1. Recent Advances in Cochlear
Implant Candidacy
BY: DR AMIRA EL
SHENNAWY
ASSISTANT PROFESSOR
OF
AUDIOLOGY
CAIRO UNIVERSITY
2. History Of Cochlear Implantation
1800 Alessandro Volta
1957 Djourno & Eyries
1961 Dr Wiliam F House
1970s
1984 FDA approved single channel device in adults
7. Current Implant Technology
Three companies currently have FDA approved implants
Advanced Bionics (California) —HR90 K
Cochlear (Australia) —Nucleus 5
Med-El (Austria) —Sonata ti100
8. Candidacy for CI has changed gradually but
significantly since the first multichannel devices
were implanted in the late 1970s .
Due to increasing experience, improvement of
technology and the proven reliability, the selection
criteria are broadened with shifting borders.
Main extensions are related to age, additional
handicaps, residual hearing & special etiologies of
deafness.
9. The obvious goal for careful selection of CI
patients is to never have a single patient
perform more poorly with their CI than they
did with their hearing aids (Gifford,H 2011).
10. Stages in Patient Selection
I. Questionnaire
Age - Aetiology
Onset of HL ( pre , peri , postlingual )
Duration of sensory deprivation ( plasticity )
Hearing aid use
II. Audiological investigations
III. Language assessment
IV. Radiological examination
11. V. Psychological assessment
IQ testing
VI. Vestibular testing
VII. Medical & Otological examination
VIII. Electrical stimulation of the cochlea
Counseling…………..
14. FDA approval for implanting children:
1990 > 2 years
1998 = 18 months
2000 = 12 months
15. Changes in age of implantation are due to:
1.Better / early identification of HL (universal
hearing screening )
2.Increased public awareness
3. Increased professional awareness
4.Changes in technology :
Electrode array – Programming – Processors
Telemetry
16. The literature has demonstrated that in terms of
speech development and language acquisition , the
best results come from children implanted under the
age of 2 years similar to normal hearing children
(Sharma et al ., 2002 ).
All CI devices can be safely indicated for children 12
months or older .
However, implanting children younger than 12
months remains controversial.
17. Further reductions in age at implantation are currently
limited by the nature of audiologic testing in very young
children.
In cases of HL due to meningitis or hereditary hearing loss ,
implantation should be considered before the age of 12
months.
18. Audiological evaluation
Behavioral audiometry ( age appropriate )
Tympanometry & acoustic reflexes
ABR , ear specific & frequency specific
ASSR
OAE
Aided free field testing
Special tests : EABR , EMLR , ESR, Electrical late
event related potentials.
19. Audiometric Thresholds
For children aged 12-23 months hearing threshold
for both ears should equal or exceed 90 dB.
For individuals older than 24 months hearing
threshold should equal or exceed 70 dB.
Speech detection with best fit hearing aids in a sound
field equal to or worse than 55 dB.
20. Hearing aid trial for 3 months.
During HA trial , child should be making at least
month to month auditory progress as well as speech
and language progress. If this is not the case then, CI
evaluation should be considered ( Gifford, H 2011 ).
Teenagers ???
21. Speech & Language assessment
Psychological assessment , IQ testing
Counseling , family support , motivation & realistic
expectations.
Medical and Otological examination
22. Radiological assessment:
CT scan traditionally is the gold-standard imaging modality
Superior visualization of the bony structure of the otic capsule
and the course of the facial nerve .
Weakness: can miss cochlear fibrosis, retrocochlear pathology, CNS
abnormalities, and cochlear nerve hypoplasia/absence
Magnetic resonance imaging (MRI)
More effective at identifying cochlear fibrosis
Able to identify presence/absence of cochlear nerve and caliber
Weakness: inferior visualization of bony anatomy, inability to detect
the presence of the round window, oval window, or an enlarged
vestibular aqueduct; often requires anesthesia for young patients
23.
24. Vaccination
Children with cochlear implants are at higher risk for
meningitis, though overall rate is low (<0.6%)
Streptococcus pneumoniae has been the most common
organism isolated in the children with cochlear implants who
developed meningitis
Current vaccine recommendations:
Patients <2 years old
Prevnar (7-valent) only
Patients 2-5 years old
Prevnar and Pneumovax (23-valent)
Patients >5 years old
Pneumovax only
Additionally, all patients <5 year old should receive the Hib vaccine
Vaccination should be completed at least 2 weeks prior to
surgery
26. History :
Onset & course of hearing loss
Duration (plasticity)
Aetiology ( fever , trauma )
History of HA use
Means of communication
Education
Motivation , realistic expectations
Prelingual adults ???????
27. When to refer an Adult for a CI?
• Bilateral severe to profound sensorineural hearing
loss
• Limited benefit from appropriate hearing aids i.e.
poor speech recognition
• Telephone use is difficult, limited or impossible
• Patient relies heavily on speech reading or note
writing to understand speech
• Patient is distressed by the inability to communicate
efficiently on a daily basis
• No medical contraindications
28.
29.
30. Speech recognition testing is the cornerstone in adult
CI patient selection,
Where the best-aided scores on open-set sentence
tests of <50% in the ear to be implanted and <60%
in contralateral ear is considered as an indication for
implantation.
31. Choosing the most appropriate ear
Audiological factors :
1. Residual hearing
In the early years of CI , the audiologically worse ear was
chosen so that (un) expected iatrogenic cochlear damage
would have fewer consequences.
In the late 1990s the better ear with the most residual
hearing was preferred as studies had shown that better
preserved peripheral neural pathways would lead to better
results after CI.
32. 2. Duration of HL
It is generally accepted that duration of deafness has
a negative effect on CI performances.
Most clinicians choose the ear with the shortest
duration of deafness.
3. Only functioning labyrinth
33. Surgical Factors
1.Anatomic variations : cochlear ossification,
cochlear malformation and cochlear nerve
malformation.
2.Otological medical history : otitis media ,
cholesteatoma and temporal bone fracture.
Personal factors
Handedness , (right ear advantage)
34. Contraindications for implantation
Completely atretic VIII nerve
Small internal auditory canal syndrome
Agenesis of cochlea: Michel deformity
Active middle ear/mastoid infection
Tympanic membrane perforation
Severe organic brain dysfunction
Severe mental retardation
Psychosis, unrealistic expectations
35. Hybrid CI (Electro Acoustic Stimulation)
The expanded criteria have led to research questions
centering on advanced uses of the technology.
Specifically, could an implant benefit other users
previously not considered to be a candidate?
A group that was felt to be underserved with
conventional amplification were those patients with
the following audiometric profile
36.
37. Audiogram
Below 1.5 kHz – No or moderate HL
Above 1.5 kHz – Severe to profound sensorineural
hearing impairment.
Dead regions of the cochlea (elderly) .
Speech scores
The patient's monosyllable word score should be ≤
60% at 65dB SPL in the best aided condition.
38. Hearing preservation surgery
Two methods are commonly used for inserting the
electrode into the cochlea:
Round-window insertion VS
Cochleostomy insertion.
Round-window insertion has found a wider
acceptance because it is considered to be less
traumatic (controversial).
39. EAS electrodes for cochlear implants :
Long-term research has shown that mechanical flexibility
of the electrode array is one of the key factors for
preserving residual hearing.
Studies with different lengths of electrodes have shown that
an insertion depth of 10 mm has a good chance of
preserving residual.
Electrodes that can be inserted to a depth of 18–
22 mm are a good compromise.
40. EAS audio processors
Combines cochlear implant technology with a digital
hearing aid. This device uses one microphone for the
input, but has two separate digital sound processors
for differentiated processing.
The parallel processing of these signals, however, is
performed separately and optimized for both
acoustic hearing (focusing on low-frequency hearing)
and cochlear implant stimulation (focusing on high-
frequency hearing).
41. The hearing aid is integrated in the ear hook and the
amplified signals are forwarded to the auditory
pathway via an ear mould.
The ear mould used for the acoustic component is
similar to a conventional hearing aid ear mould and
can be exchanged.
42. Bilateral CI
Recent Trend towards BILATERAL use of CI/s
-- 1992: 0-1%
-- 2007: 14-15%
70% of bilateral CI usage is among 18 years and under age
group.
Simultaneous CI
Sequential CI
43. Advantages of bilateral implantation
Improved hearing in quiet (binaural summation)
Improved hearing in noise (binaural squelch, head shadow
effect, and binaural redundancy)
Improved sound lateralization
Improved sound localization
Assurance that the ―better hearing ear‖ is
implanted/‖captured‖
Qualitative listening improvement (more ―balanced‖;
―richer quality‖; more ―confident‖ feeling; and less fatigued)
44. Disadvantages
Increased costs (2 devices, batteries, etc.)
Multiple pieces of equipment to manage
Surgical and medical risks
Future developments
No or limited ―natural‖ hearing remaining
Different processing strategies & speech
processors (with sequential bilateral CIs)
45. Bimodal stimulation
CI in one ear and HA in the other.
Binaural stimulation
Residual hearing in contralateral ear
After established electrical stimulation
Balancing between the two ears
Future technology
Cost effectivness
47. Meningitis:
9% of childhood deafness.
Commonest organism to cause HL is S pneumoniae.
Labyrinthitis ossificans.
Implantation before 12 months of age.
Trauma:
BILATERAL OTIC CAPSULE FRACTURES ARE
UNCOMMON
Intraluminal fibrosis or ossification may occur which
makes electrode insertion difficult.
48. Hyperbilirubinemia
risk of auditory neuropathy.
Auditory neuropathy /dyssynchrony:
Many clinicians have been conservative about the
outcome.
Sydney CIC has the most experience.
They reported variable outcome due to wide
variability of impairments.
49. Many of the children had successful implantation
with a smaller number failing to gain significant
benefit.
75 % of the patients benefited from the CI due to
surviving OHCs when IHCs are compromised.
Patients who did not benefit ,may have dysfunction
in afferent neural synapses, CN or higher auditory
systems.
During patient selection, electrically evoked CAP
should be tested .
50. Usher Syndrome
Most common cause of blindness in humans.
Autosomal recessive
Type I (USH1) most severe 30- 40 % :
Severe to profound congenital HL , motor
developmental delay & progressive retinopathy.
Early implantation is critical to developing
effective oral – auditory skills prior to visual loss.
52. Keratitis Icthiosis Deafness Syndrome (KID)
Rare congenital disorder of the ectoderm.
Heterogeneous mutation in the Connexin 26 gene
Autosomal dominant.
Congenital icthyosis , vascular keratits , SNHL ,
alopecia and squamous cell carcinoma may occur.
CI produces good audiological results BUT Wound
complications are very common , failure to heal,
partial extrusion of the implant.
53. Multi handicapped
Patients with additional disabilities such as mild
motor disability, cerebral palsy , cognitive
disabilities, specific learning disabilities, behavioral
disorders and sight impairment have been
implanted.
Multi-handicapped children receive benefit from
cochlear implantation. The rate of this improvement
is slow but offers better quality of life due to better
auditory-communication skills, better self-
independence and social integration.
55. C I in Unilateral Deafness
Up to now treatment modalities for single sided
deafness are; NO treatment , Conventional
contralateral routing of signal or BAHA.
CI makes a new treatment modality for those
patients.
Study done by Arndt et al., 2011 revealed that CI
improved hearing abilities in single sided HL &
superior to alternative options. CI didn’t interfere
with speech understanding in the normal ear.
56. CI in Unilateral deafness and tinnitus
Tinnitus is a frequent often disabling condition.
In patients who are deaf with tinnitus in the affected
ear, treatment based on acoustic input are
impossible.
Tinnitus suppression using electric stimulation has
been reported to be successful (Buechner et
al.,2010).
Several studies (Kleinjung 2009: Van de Heyning et
al., 2008 and Moller 2003 ) concluded that CI may
represent a chance for complete suppression of
tinnitus in selected cases.
58. Audiological
Mapping very young children:
difficulty in obtaining behavioral results’
evolution of recent technology helps assist in
mapping through the use of ECAP measurements.
Mapping the multi handicapped.
59. Surgical Challenges
Implanting very young children
Children below 12 months usually have poorly pneumatized
mastoid bones leading to greater intraoperative blood loss
and risk of facial nerve injury.
Greater anesthesia risk ,size of airway & difficulty
maintaining cardiovascular fluid & temp homeostasis.
Thin scalp : care in drilling well for body of device.
Increased incidence of otitis media
Fortunately, cochlea is adult size at birth.
60. Hearing preservation surgery
A special surgical technique to preserve the residual
hearing of the patient (in most routine cochlear
implant surgeries, any residual hearing will likely be
destroyed).
This is a very realistic goal for many patients with
sloping hearing loss (EAS ).
Achieved by performing ―Soft surgery‖
61. Dysplastic Cochlea
Due to increased knowledge of temporal bone
anatomy and improved imaging techniques more
patients with Mondinin dysplasia , Common
cavity, hypoplastic cochlea and large vestibular
aqueducts are implanted.
Modifications in surgical techniques.
Likelihood of CSF gusher .
62. Labyrinthitis Ossificans
Consequence of meningitis
Ossification partially or completely block the lumen
of scala tympani & or scala vestibuli.
Several techniques:
Drilling a basal tunnel , circum-modiolar drill-out,
use of double or split electode array.
64. New Devices
If and when the totally implantable cochlear
implant (TICI) becomes a reality, it will
require a modification of current surgical
techniques to implant a microphone and
possibly adding hardware to the ossicles.
65. Overall the selection criteria have
been broadened with increasing
experience and technological
improvement.
This development may continue
and the borderline between HA &
CI will shift further.
However, the basis for success
still remains good rehabilitation,
a team approach and the
willingness of the patient to
undergo the whole process of CI.
Editor's Notes
Sound is received by a microphone located on the BTE sound processor (1); it is processed and coded, then sent via the transcutaneous radiofrequency link to the implanted receiver-stimulator (2); data are decoded and sent to the multi-electrode array (3), stimulating spiral ganglion neurons, which then transmit the signal via the auditory nerve (4) toward higher processing centers