How do we describe the bonding between transition metal (ions) and their ligands (like water, ammonia, CO etc) ?
The Crystal Field Model gives a simple theory to explain electronic spectra.
How do we describe the bonding between transition metal (ions) and their ligands (like water, ammonia, CO etc) ?
The Crystal Field Model gives a simple theory to explain electronic spectra.
Properties of coordination compounds part 1Chris Sonntag
Present a short review about Crystal field theory and how we can use the results of it to explain various physico-chemical properties of transition metal complexes.
Rasashaastra literally means the “Science of Mercury”. It is a specialized branch of Ayurveda dealing mainly with materials which are known as ‘Rasa dravyaas.
overview of chelating agents with detailed information on their pharmacological action, mechanism, uses and adverse effect for both medical and dental students.
Chelators otherwise called chelants, chelating agents or sequestering agents, are substances or compounds that bind to metal ions to form stable and water-soluble complexes that can easily be excreted from the body system.
If you may recall metabolism of drugs in Pharmacology or Toxicology, you will realize that the whole purpose of metabolism of drugs is to change them from the hydrophobic (water-hating) state which can easy be absorbed by body cells into the more hydrophilic (water-loving) ones that can easily be excreted by the body. This is based on the fact that cells are surrounded by very hydrophobic structures. These structures only allow hydrophobic molecules or at least very tiny hydrophilic molecules to penetrate.
As such chelators are used for heavy metal poisoning such as Iron, Lead, Mercury, Cadmium, Arsenic, et cetera. They are also known to work for common medical problems such as cardiovascular diseases.
This presentation will define chelators, give their classifications, examples and what they are used for.
Biocidal Evaluation of Mixed Ligand Metal Complexes of Mercaptans/ThiolsTope A
Abstract: Coordination complexes are compounds which consists of a (usually metallic) central atom or ion and a surrounding array of bound molecules or ions known as ligands. A mixed ligand complex are chemical entities which consists of a central metal atom and at least two donor groups capable of chelation to metal atom. Sulphur containing 5-membered heterocyclic are known to exhibit useful biological activity. This work discusses the biocidal activities of some mixed ligand complex of Mercaptans/Thiols.
Download the full study for free here: http://topeakintayo.com/res/mixedligand.pdf
Heavy metals and its effects on plants and environmentHaider Ali Malik
Heavy metals are natural constituents of the earth’s crust , but indiscriminate human activities have drastically altered their geochemical cycles and biochemicals balance.
Any toxic metals may be called heavy metals.
Since heavy metals have a propensity to accumulate in selective body organs.
The average safety levels in food or water are often misleading high.
Heavy is any metal or metalloid of environmental concern.
Heavy metals are metallic element that have relatively high density usually greater than 5 g/cm3, or their density is greater than the density of water.
,inhibition and poisoning of enzymes ,inhibition of enzymes ,deactivation of enzymes ,poisoning of enzymes ,inhibition of carbonic anhydrase ,deactivation of carbonic anhydrase ,poisoning of carbonic anhydrase ,epoenzyme ,soft acids ,soft bases
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
2. What is Chelation???
Chelation (KEE-LAY-SHUN)
comes from the Greek word –
“chele”- which means CLAW
“the use of a chelating agent to
bind with a metal in the body to
form a chelate so that the metal
loses its toxic effect or
physiological activity”
4. Common Uses of Chelation
Therapy
Chelation therapy has primarily been used as
agent to detoxify heavy metals such as calcium,
iron, magnesium, lead and zinc.
Binds to these metal ions because of its strong
affinity for cations.
The bound metal ions are then excreted in the
urine.
5. LIGANDS
Ligand is an ion or molecule (functional group)
that binds to a central metal atom to form a
coordination complex.
The bonding between metal and ligand generally
involves formal donation of one or more of the
ligand's electron pairs.
6. MOA
• Heavy metals exert their toxic effects by combining with
and inactivating functional groups (ligands) of enzymes
and important biomolecules - sulfhydril, hydroxyl,
carboxyl etc. leading to inactivation
METAL
ENZYME
COMPLEXING
AGENT
NO TOXIC
EFFECT
7. Chelating agents compete with body ligands for the
heavy metal – also differ in affinity for different
metals
• Chelating agents have high affinity for such metals
and combine with them to form non toxic and water
soluble complexes for elimination
• Possesses: –ve charged groups to attract +ve
charged toxic metals
8.
9. Ideal chelating agent
1. Ideal chelating agents have higher affinity for
toxic metals than for body Ca++ (readily
available in plasma and ECF)
2. Should also have higher affinity for toxic metals
than body ligands
3. Ideally should be water soluble
4. Interval of administration between exposure to
metals and chelating agents should be less
10. Chelating Agent
Classification
1. Penicillamine – Cu, Pb, Hg, Zn
2. Disodium edetate (EDTA) – lead poisoning
3. Dimercaprol (British antilewisite) or BAL –
As, Au, Bi, Ni, Sb and Hg poisoning
11. Penicillamine -------- Degraded product of Penicillin (beta
dimethylcysteine)
Prepared by alkaline hydrolysis of benzyl penicillin – d-
penicillamine
Strong Cu chelating property - useful in Cu poisoning
MOA is same as others – selective chelating of Cu, Hg, Pb and Zn
Absorbed orally - available as 250 mg capsules, metabolized in liver
and excreted in urine
Penicillamine
12. PenicillamineUses
Wilson`s disease: Hepatolenticular degeneration due
to genetic deficiency of ceruplasmin (Cu deposition in
body) – life long therapy (0.5-1 gm daily)
13. Cu and Hg (alternative) Poisoning
Chronic Pb poisoning (adjuvant to edetate)
Cystinuria and cystine stones
Scleroderma: benefits by increasing soluble
collagen
14. BAL or Dimercaprol
World War-II as British anti-Lewisite ---- Arsenical Gas
Oily , pungent smelling, viscous liquid, water soluble