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Brain mechanisms involved in learning
Glutamate
• It is the most abundant excitatory
  neurotransmitter in the nervous system

• It plays a key role in learning
  (LTP), highly concentrated in
  Hippocampus, amygdala

• Stored in the vesicles of the presynaptic
  neuron

• Nerve impulses (action potential)
  triggers release into the synapse

• Glutamite then binds with specialised
  receptors on the dendrites of the
  postsynaptic neuron
NMDA (N-methyl D-aspartate)
• A specialised receptor (found on dendrites) that
  receives Glutamate (vital to LTP)
NMDA (N-methyl D-aspartate)
• Evidence: Morris water maze experiment - NDMA
  blocked - rats unable to spatially learn (no LTP)
• Tissen's (2000) study on modified NMDA receptors
  of mice
Hippocampus
• largely responsible for LTP
• Consolidation of declarative
  memories
• involved in spatial learning and
  navigation
• Along with the thalamus &
  amygdala – it is responsible for
  intiating and processing fear
  response
• Evidence: MRI's indicate a
  larger right hippocampus area
  of London cab drivers
  compared to population
• Morris water maze experiment
  with removal of Hippocampus
Amygdala
• Responsible for emotional learning,
• fear conditioning (classical conditioning),
• It is also involved in positive conditioning
• Evidence: fMRI show greater amygdala
  activity when consolidating memories
  more emotional (stressful) in nature in
  comparison to semantic type memories
• People who have had their amygdala
  removed (for example in treatment of
  extreme cases of epilepsy) not only lose
  their ability to fear, they also do not
  recognize anger in others.
• Anxiety disorders/ phobias = greater
  activity in amygdala
• Bipolar patients have reduced volume in
  amygdala
Thalamus
• Thalamus: is one of the brain
  structures for initiating &
  processing fear response (part
  of classical conditioning)
• It is also responsible for spatial
  learning
• Evidence - rats with damaged
  thalamic regions showed no
  improved in formation of
  repetitive maze task.
Cerebellum
• Involve in motor learning (making
  fine adjustments to movements)
• involved some emotional functions
  such as regulating fear and pleasure
  responses,
• it is even involved in triggering some
  reflexive motor responses
  (conditioned responses) such as an
  eye blink in response to a
  conditioned stimulus such as a tone
• Evidence: Neuroimaging - show
  higher cerebellum activity when
  observing/ imagining a sequence of
  movements

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VCE U4 Psychology - Brain mechanisms involved in learning

  • 2. Glutamate • It is the most abundant excitatory neurotransmitter in the nervous system • It plays a key role in learning (LTP), highly concentrated in Hippocampus, amygdala • Stored in the vesicles of the presynaptic neuron • Nerve impulses (action potential) triggers release into the synapse • Glutamite then binds with specialised receptors on the dendrites of the postsynaptic neuron
  • 3. NMDA (N-methyl D-aspartate) • A specialised receptor (found on dendrites) that receives Glutamate (vital to LTP)
  • 4. NMDA (N-methyl D-aspartate) • Evidence: Morris water maze experiment - NDMA blocked - rats unable to spatially learn (no LTP) • Tissen's (2000) study on modified NMDA receptors of mice
  • 5. Hippocampus • largely responsible for LTP • Consolidation of declarative memories • involved in spatial learning and navigation • Along with the thalamus & amygdala – it is responsible for intiating and processing fear response • Evidence: MRI's indicate a larger right hippocampus area of London cab drivers compared to population • Morris water maze experiment with removal of Hippocampus
  • 6. Amygdala • Responsible for emotional learning, • fear conditioning (classical conditioning), • It is also involved in positive conditioning • Evidence: fMRI show greater amygdala activity when consolidating memories more emotional (stressful) in nature in comparison to semantic type memories • People who have had their amygdala removed (for example in treatment of extreme cases of epilepsy) not only lose their ability to fear, they also do not recognize anger in others. • Anxiety disorders/ phobias = greater activity in amygdala • Bipolar patients have reduced volume in amygdala
  • 7. Thalamus • Thalamus: is one of the brain structures for initiating & processing fear response (part of classical conditioning) • It is also responsible for spatial learning • Evidence - rats with damaged thalamic regions showed no improved in formation of repetitive maze task.
  • 8. Cerebellum • Involve in motor learning (making fine adjustments to movements) • involved some emotional functions such as regulating fear and pleasure responses, • it is even involved in triggering some reflexive motor responses (conditioned responses) such as an eye blink in response to a conditioned stimulus such as a tone • Evidence: Neuroimaging - show higher cerebellum activity when observing/ imagining a sequence of movements