This document provides an overview of valvular heart disease, conduction disorders, and bradydysrhythmias. Key points include descriptions of infective endocarditis risk factors and presentations, characteristics of murmurs from mitral regurgitation, mitral stenosis, aortic stenosis, and aortic insufficiency. Bundle branch blocks, hemiblocks, heart blocks, and types of bradydysrhythmias are also summarized. Treatment approaches are outlined depending on whether a bradydysrhythmia is stable or unstable, has a wide or narrow QRS complex, and is slow or very slow.
Heart block is an abnormal heart rhythm where the heart beats too slowly, which results in the electrical signals being partially or totally blocked between the upper chambers (atria) and lower chambers (ventricles). Heart block is also called atrioventricular (AV) block.
Its a medical presentation describing how to approach to various cardiac arrhythmias in systematic way. Illustrated with more ECG photographs from standard sources.
Heart block is an abnormal heart rhythm where the heart beats too slowly, which results in the electrical signals being partially or totally blocked between the upper chambers (atria) and lower chambers (ventricles). Heart block is also called atrioventricular (AV) block.
Its a medical presentation describing how to approach to various cardiac arrhythmias in systematic way. Illustrated with more ECG photographs from standard sources.
Note of management acute heart failure
Initially I just read the ESC 2016 guideline and was interested in choosing inotropic agents. I started to reads books and looked for more information.
An overview of the most commonly encountered emergencies in endurance athletes. The Baker to Vegas Law Enforcement Relay Race is the Largest of its kind in the world. This Year over 7000 runners will be competing in the 120 mile race.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
3. Valvular Disorder
Things to know
Endocarditiis presentation
Murmurs, Rheumatic HD
Specific high risk diseases
4. Infective Endocarditis
Risk Factors: Abnormal or artificial valve
Mitral valve most common, IVDA -> Tricuspid (staph)
Most common bug -> Staph
Tooth extraction -> Strep
Acute -> high fever, murmur, flu like symp., younger
Subacute -> Strep viridans, Anemia, older
Prophylaxis? Depends on bug and procedure
5. Infective Endocarditis
Vasculitis and Embolic manifestations
Janeway lesions: Non-tender, hemorrhagic, flat, on
palms and soles.
Osler nodes -> tender, tips of fingers and toes
Roth spots and splinter hemorrhages
6. Infective Endocarditis
Dx by echo, blood cultures, high ESR/CRP
Rx: Vancomycin for Staph, PCN for Strep
Prophylaxis if abnormal valve and procedure
Procedure site determines bug and Abx
Classic broad question -> dental and Amoxicilin,
GI/GU more gram negative coverage
Controversial in mitral valve prolapse (no on boards)
7. End Point of Valve
Disease
Heart Fails and dilates
Valves become regurgitant
ECG shows LVH as ventricles expand
LBBB develops as heart and conduction system
stretches which is poor prognostic sgin
8. Murmurs: MR. ASS, MS.AID
Mitral
Regurgitation
Mitral
Stenosis
Aortic
Stenosis
Aortic
Insufficiency
SYSYTOLIC
DIASTOLIC
9. Aortic Stenosis
Symptoms progress from : SOB, CHF, Syncope (bad!)
Murmur: Systolic, up into the neck, slow carotid
upstroke
ECG : LVH, LBBB
Exercise-induced syncope
Vasodilators can make it worse
Rx: Surgical (moderate to severe)
11. Mitral Stenosis
Cardiovascular collapse in pregnant patient during
delivery
Murmur: Diastolic, Opening SNAP
Atrial fib common, blood backs up into left atrium ->
lungs = CHF, Chronic -> Hemoptysis
AF can cause decompensation, crash quick due to
loss of KICK, CARDIOVERT if Acute.
12. Mitral Regurgitaion
Ischemia + SHOCK + new MURMUR = ruptured
chordae tendineae/papillary muscle
Murmur: Radiates widely, esp. into axilla
Atrium stretches and produces A. Fib
Mitral valve prolapse can get worse and overtime lead
to regurgitation
14. Bundle Branch and
Fascicular Blocks
RBBB:
ECD: Wide QRS, Abnormal QRS complexes in right
precordical leads (V1- V2) (rSR’). We know this.
Incomplete RBBB
RBBB block morphology with a normal QRS width
Common finding in children and young adult
15. LBBB
ECG: Wide QRS.
Abnormal morphology: RR’ or large wide R (I, V5, V6)
Anormal repol., QS or RS pattern in right precordial leads
(V1,V2)
16. Hemi Blocks
Left anterior vs posterior block
Anterior more common (left coronary blood supply)
Ant: left axis deviation, QR (I, aVL), RS (II,III, aVF)
Post: Right axis, RS (I, aVL), QR (II,III, aVF)
Bifascicular block
Most common combination: LAF with RBBB
Marker for advance cardiac disease
17. Heart Blocks
SA node: Blood supply Rt corornary (65%), circumflex
(25%), both (10%)
AV node: Post. Descending artery (rt coronary 90%)
SA blocks (sick sinus, sinus pause, sinus arrest, etc.)
Absence of P and ORS, and T cycles
Ventricular activity -> dependent on escape rhythm
Rx: pacemaker + medication to suppress
tachydysrhythmias
18. AV node Blocks
First –Degree AV Block – conduction delay in AV node, PR
prolong
Second –Degree Block – intermittent loss of conduction
between artia and ventricle
Mobitz I (Wenckebach) : PR increases until dropped beat,
generally goes not need emergency Tx
Mobitz II: PR normal from beat to beat with an occ. Abrupt
dropped beat.
Rx: Can progress to complete block, pacer.
Third-degree AV Block – No conduction through AV
No assos. of P and QRS
Pace and pacemaker
19. Bradydysrhythmia
Sinus Bradycardia
<60bpm, high vagal tone, medications, hyothyroidism
Signs and symptoms – generally asymptomatic, or
signs of hypoperfusion
Rx: Direct towards degree of patient
symptoms, atropine, pacing, vasopressors.