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Anatomy and Physiology I
 Unit 7: The Skeletal System

Physiology of the Skeletal System
Skeletal System
• Bones are made of several
  tissues

• Primarily made of collagen and
  hydroxyapatite -
  Ca10(PO4)6(OH)2

• About 206 bones in the human
  body
Functions of Skeletal System
• SUPPORT: Hard framework that supports and anchors
  the soft organs of the body.

• PROTECTION: Surrounds organs such as the brain and
  spinal cord.

• MOVEMENT: Allows for muscle attachment therefore
  the bones are used as levers.

• STORAGE: Minerals and lipids are stored within bone
  material.

• BLOOD CELL FORMATION: The bone marrow is
  responsible for blood cell production.
Parts of the Skeletal System
• Axial skeleton
  – Skull and bones that support it
  – Includes vertebra and ribs
  – 80 bones


• Appendicular skeleton
  – Limbs
  – 126 bones
Features of a Long Bone:

Epiphysis: Ends of the
bone.

Diaphysis: The shaft of
the bone which surrounds
the medullary cavity.

Articular Cartilage:
Cushions the ends of the
bones and allows for
smooth movement.

Epiphyseal Plate:
Areas made of cartilage
allowing for the growth of
the bone.
Joints
• Where bone meets bone
• Ligament – holds bone to bone
• Types of joints:
  – Immovable - skull
  – Ball-and-socket - shoulder
  – Hinge - knee
  – Pivot – forearm
  – Gliding - vertebrae
Joints
• Cartilage covers ends of movable bones
  – Reduces friction
• Lubricated by fluid from capillaries
Cartilage
Bone Structure
• Periosteum – hard outer covering
  – Cells for growth and repair

• Compact bone – hard strong layer
  – Bone cells, blood vessels, protein with Ca and P

• Spongy bone – at ends of long bones
  – Has small open spaces to lighten weight

• Marrow cavity – hollow in middle of long bones
Bone Marrow
• Red marrow – produces blood cells and
  clotting factors
  – Found in humerus, femur, sternum, ribs,
    vertebrae, pelvis
  – Produces RBC 2 million per second


• Yellow marrow – stores fat
  – Found in many bones
Bone Structure
Haversian System
• Structure of compact bone
• Rings of bone tissue with blood vessels
  and nerves in the center
Haversian System
Bone Development
• Initial skeleton of cartilage in infants

• Replaced with bone by osteoblasts

• More than 300 bones at birth – fuse to 206

• Always growing and breaking down
  – Osteoblasts – form new bone cells
  – Osteoclasts – break bone cells down
  – Osteocytes – mature bone cells
Broken Bones
• Fracture is a break of the bone
• Simple or Complex fracture
• Regrowth of bone:
  – Spongy bone forms in first few days
  – Blood vessels regrow and spongy bone hardens
  – Full healing takes 1-2 months
Homeostatic Imbalances

               Rickets
•Disease of children due to a lack of vitamin D.
•Calcium is not deposited in bones.
•Bones become soft.
•Bowing of the bones, and other deformities occur.
Homeostatic Imbalances

  Osteomalacia
 •“Rickets” of adults.
 •Due to a lack of vitamin D.
 •Calcium is not deposited in the bones.
 •Bones become brittle.
Homeostatic Imbalances
     Osteoporosis
•Bone reabsorption is greater than bone deposition.
•Due to any of the following:
     •Lack of estrogen in women.
     •Lack of exercise to stress the bones.
     •Inadequate intake of calcium and phosphorus.
     •Abnormalities of vitamin D metabolism.
     •Loss of muscle mass.
Age Related Dysfunctions
Arthritis:

Osteoarthritis- 90% of pop. By age 40
     chronic inflammation of articular cartilage
     can be normal age-dependent change
     can also be pathology due to ?
           Age-related changes
           decrease blood supply
           trauma
Osteoarthritis
Osteoporosis

Decline in Bone Density
      Bone Resorption > Bone Deposition

Increase Risk for Fracture
      compression fractures of vertebrae
      hip fractures

Role of calcium, vitamin D, estrogen, exercise
      Calcitonin vs. Parathyroid Hormone
Osteoporosis

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Anatomy unit 7 physiology of the skeletal system

  • 1. Anatomy and Physiology I Unit 7: The Skeletal System Physiology of the Skeletal System
  • 2. Skeletal System • Bones are made of several tissues • Primarily made of collagen and hydroxyapatite - Ca10(PO4)6(OH)2 • About 206 bones in the human body
  • 3. Functions of Skeletal System • SUPPORT: Hard framework that supports and anchors the soft organs of the body. • PROTECTION: Surrounds organs such as the brain and spinal cord. • MOVEMENT: Allows for muscle attachment therefore the bones are used as levers. • STORAGE: Minerals and lipids are stored within bone material. • BLOOD CELL FORMATION: The bone marrow is responsible for blood cell production.
  • 4. Parts of the Skeletal System • Axial skeleton – Skull and bones that support it – Includes vertebra and ribs – 80 bones • Appendicular skeleton – Limbs – 126 bones
  • 5. Features of a Long Bone: Epiphysis: Ends of the bone. Diaphysis: The shaft of the bone which surrounds the medullary cavity. Articular Cartilage: Cushions the ends of the bones and allows for smooth movement. Epiphyseal Plate: Areas made of cartilage allowing for the growth of the bone.
  • 6. Joints • Where bone meets bone • Ligament – holds bone to bone • Types of joints: – Immovable - skull – Ball-and-socket - shoulder – Hinge - knee – Pivot – forearm – Gliding - vertebrae
  • 7. Joints • Cartilage covers ends of movable bones – Reduces friction • Lubricated by fluid from capillaries
  • 9. Bone Structure • Periosteum – hard outer covering – Cells for growth and repair • Compact bone – hard strong layer – Bone cells, blood vessels, protein with Ca and P • Spongy bone – at ends of long bones – Has small open spaces to lighten weight • Marrow cavity – hollow in middle of long bones
  • 10. Bone Marrow • Red marrow – produces blood cells and clotting factors – Found in humerus, femur, sternum, ribs, vertebrae, pelvis – Produces RBC 2 million per second • Yellow marrow – stores fat – Found in many bones
  • 12. Haversian System • Structure of compact bone • Rings of bone tissue with blood vessels and nerves in the center
  • 14. Bone Development • Initial skeleton of cartilage in infants • Replaced with bone by osteoblasts • More than 300 bones at birth – fuse to 206 • Always growing and breaking down – Osteoblasts – form new bone cells – Osteoclasts – break bone cells down – Osteocytes – mature bone cells
  • 15. Broken Bones • Fracture is a break of the bone • Simple or Complex fracture • Regrowth of bone: – Spongy bone forms in first few days – Blood vessels regrow and spongy bone hardens – Full healing takes 1-2 months
  • 16. Homeostatic Imbalances Rickets •Disease of children due to a lack of vitamin D. •Calcium is not deposited in bones. •Bones become soft. •Bowing of the bones, and other deformities occur.
  • 17. Homeostatic Imbalances Osteomalacia •“Rickets” of adults. •Due to a lack of vitamin D. •Calcium is not deposited in the bones. •Bones become brittle.
  • 18. Homeostatic Imbalances Osteoporosis •Bone reabsorption is greater than bone deposition. •Due to any of the following: •Lack of estrogen in women. •Lack of exercise to stress the bones. •Inadequate intake of calcium and phosphorus. •Abnormalities of vitamin D metabolism. •Loss of muscle mass.
  • 19. Age Related Dysfunctions Arthritis: Osteoarthritis- 90% of pop. By age 40 chronic inflammation of articular cartilage can be normal age-dependent change can also be pathology due to ? Age-related changes decrease blood supply trauma
  • 21. Osteoporosis Decline in Bone Density Bone Resorption > Bone Deposition Increase Risk for Fracture compression fractures of vertebrae hip fractures Role of calcium, vitamin D, estrogen, exercise Calcitonin vs. Parathyroid Hormone