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ADENOVIRUS Maria Ellery M. Mendez, MD,  DPASMAP, FPAMS, FPAAAMI  Department of Microbiology  Our Lady of Fatima University
PROPERTIES ,[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],Virus attachment (adsorption) Interaction of penton base with cellular integrins Virus internalization into endosomes CYTOSOL Uncoating NUCLEUS
PROPERTIES ,[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS ,[object Object],[object Object],[object Object],[object Object]
EPIDEMIOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL FINDINGS ,[object Object],[object Object],[object Object],[object Object]
CLINICAL FINDINGS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL FINDINGS EYE INFECTIONS
CLINICAL FINDINGS ,[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL FINDINGS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LABORATORY DIAGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LABORATORY DIAGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT No specific treatment for adenovirus infections
PAPOVAVIRUSES
PROPERTIES ,[object Object],[object Object],PAPILLOMA VIRUS
PROPERTIES ,[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS ,[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS Squamous epithelium of skin (warts) & mucous membrane (genital, oral & conjunctival) (+) epithelial proliferation Hand, foot, throat, eyes, cervix Local multiplication Resolution (latency) Cell transformation
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL Association of HPV with Clinical Lesions HPV TYPE CLINICAL LESION SUSPECTED ONCOGENIC POTENTIAL 1, 4 Plantar warts Benign 2,4,26,27,29 Common warts Benign 3,10,28,41 Flat warts Rarely malignant 5,8 Epidermodysplasia verruciformis in patients w/ CMI deficiency 30% progress to malignancy 6,11 Anogenital condylomas; laryngeal papillomas; dysplasias and intraepithelial neoplasias Low
CLINICAL HPV TYPE CLINICAL LESION ONCOGENIC POTENTIAL 7 Hand warts of meat and animal handlers Benign 9,12,14,15,17,19-25, 36,46,47 Epidermodysplasia verruciformis Some progress to CA (eg, HPV-17, HPV-20) 13, 32 Oral focal epithelial hyperplasia Possible progression to CA 16,18,30,31,33  35,39,45,51,52 56 High-grade dysplasias & CA of genital mucosa; laryngeal & esophageal CA High correlation with genital & oral CA 34,40,42-44, 53-55, 58, 59, 61,62,64 66-69  Intraepithelial neoplasias (genital, other mucosal sites) Some progress to CA 75,77 Common warts in organ transplant patients 37 Keratoacanthoma Benign
CLINICAL COMMON WART
CLINICAL FLAT WARTS
CLINICAL PLANTAR WARTS
CLINICAL MULTIPLE WARTS SUBUNGUAL WART
CLINICAL LABIAL CONDYLOMA
CLINICAL INTERGLUTEAL CONDYLOMA
LABORATORY DIAGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES POLYOMA VIRUS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS INHALATION Multiplication in RT Primary viremia KIDNEYS Transient secondary viremia IMMUNOCOMPETENT IMMUNODEFICIENT Latent indefinitely in kidney BK virus – urinary tract Hemorrhagic cystitis JC virus – CNS  PML
CLINICAL ,[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object]
PARVOVIRUS
PROPERTIES ,[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PROPERTIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PATHOGENESIS Virus in  URT Local replication Viral replication in erythroid precursor cells in BM Viremia   Rash & arthralgia (erythema infectiosum)   Normal host (slight drop in hemoglobin)  Host with chronic hemolytic anemia Aplastic crisis
PATHOGENESIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL ,[object Object],[object Object],[object Object],[object Object],[object Object]
LABORATORY ,[object Object],[object Object],[object Object],[object Object]
TREATMENT ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]

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Adenovirus.micro

  • 1. ADENOVIRUS Maria Ellery M. Mendez, MD, DPASMAP, FPAMS, FPAAAMI Department of Microbiology Our Lady of Fatima University
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  • 15. CLINICAL FINDINGS EYE INFECTIONS
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  • 20. TREATMENT No specific treatment for adenovirus infections
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  • 28. PATHOGENESIS Squamous epithelium of skin (warts) & mucous membrane (genital, oral & conjunctival) (+) epithelial proliferation Hand, foot, throat, eyes, cervix Local multiplication Resolution (latency) Cell transformation
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  • 32. CLINICAL Association of HPV with Clinical Lesions HPV TYPE CLINICAL LESION SUSPECTED ONCOGENIC POTENTIAL 1, 4 Plantar warts Benign 2,4,26,27,29 Common warts Benign 3,10,28,41 Flat warts Rarely malignant 5,8 Epidermodysplasia verruciformis in patients w/ CMI deficiency 30% progress to malignancy 6,11 Anogenital condylomas; laryngeal papillomas; dysplasias and intraepithelial neoplasias Low
  • 33. CLINICAL HPV TYPE CLINICAL LESION ONCOGENIC POTENTIAL 7 Hand warts of meat and animal handlers Benign 9,12,14,15,17,19-25, 36,46,47 Epidermodysplasia verruciformis Some progress to CA (eg, HPV-17, HPV-20) 13, 32 Oral focal epithelial hyperplasia Possible progression to CA 16,18,30,31,33 35,39,45,51,52 56 High-grade dysplasias & CA of genital mucosa; laryngeal & esophageal CA High correlation with genital & oral CA 34,40,42-44, 53-55, 58, 59, 61,62,64 66-69 Intraepithelial neoplasias (genital, other mucosal sites) Some progress to CA 75,77 Common warts in organ transplant patients 37 Keratoacanthoma Benign
  • 37. CLINICAL MULTIPLE WARTS SUBUNGUAL WART
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  • 45. PATHOGENESIS INHALATION Multiplication in RT Primary viremia KIDNEYS Transient secondary viremia IMMUNOCOMPETENT IMMUNODEFICIENT Latent indefinitely in kidney BK virus – urinary tract Hemorrhagic cystitis JC virus – CNS PML
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  • 54. PATHOGENESIS Virus in URT Local replication Viral replication in erythroid precursor cells in BM Viremia Rash & arthralgia (erythema infectiosum) Normal host (slight drop in hemoglobin) Host with chronic hemolytic anemia Aplastic crisis
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