This document discusses inclusion body hepatitis (IBH) in poultry. It was first observed in Pakistan in 1987-1988 and is caused by an adenovirus. Clinical signs include sudden death, jaundice, and difficulty breathing. Post-mortem findings include fluid-filled pericardium, pale liver, and congested organs. Prevention involves vaccination, sanitation, avoiding stressors, and using adenovirus-free stock.

2. IBH, HPS IN POULTRY
By
Dr. Naeem Tahir
Assistant Manager
Sales
Jadeed Farms (Pvt.)
ltd.
Faisalabad.

3. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum findings
Vaccination &
treatment
Prevention & control
Post mortem lesions

4.  Hydro pericardium means water in
pericardium (the membrane surrounding
the heart filled with water)
 Also called as Angara, Hydro pericardium
pulmonary edema, hepato nephrosis
complex or inclusion body hepatitis etc.
 First observed in Pakistan in 1987-88.
 Caused by Adenovirus strain K31/89
 Broilers, layers as well as breeder birds are
susceptible birds.
 Birds shed virus in feces which is source of
infection

5. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & control
Post mortem lesions

6.  In Pakistan, first epidemic in late 1987
 Sporadic cases recorded as early as 1985
 Recorded in Iraq, Mexico, South and Central
America, Russia and Japan
 In India, first report in 1994

7. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & control
Post mortem lesions

8.  Highly pathogenic to day old chicks caused
80% mortality.
 Most susceptible age is 3 to 5 weeks.
 No sex predisposition.
 Over crowding.
 Unhygienic and poor sanitary conditions.
 Presence of hepatotoxins and mycotoxins in
feed.
 Any type of stress in farm.

9. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & control
Post mortem lesions

10.  Externally it is very much difficult to
diagnose it.
 Chalky gray to bright light yellow mucoid
droppings.
 Sudden death.
 Jaundice signs in some birds
 Sudden mortality in 3rd week peaks in 4/5
week subsides in 5/6 week.
 Sometimes birds show signs of difficult
breathing.

11. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & control
Post mortem lesions

12.  Febrile carcass similar to gumboro and fowl
typhoid.
 Most important organ to be observed is heart
 Pericardium sac is distended with fluid.
 Mostly amount of fluid is 5-8 ml
 Color of fluid is clear of light yellow
 Non clotted fluid but gelatinizes on exposure to
air.
 Misshapen and flabby heart i.e. soft and cracks
on touching.
 Sub cutaneous and body fat of pale yellow color
 Enlarged, congested, pale and necrotic liver.
 Pale bone marrow death of bird occur due to

13. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & control
Post mortem lesions

14.  ½ cc inj. Preferable intramuscular on 15-17
or 21 day of age.
 No treatment but supportive therapy can be
done
 Protein and fat content of diet reduced.
 Provide glucose in water.
 Feed grains only.
 Provide liver tonic medicines like hepamerz
or jetepar @ 2 teaspoon/gal water.

15. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & Control
Post mortem lesions

16.  Adenovirus free chicks
 Proper cleanliness and disinfection of the
shed.
 Isolate sick birds.
 Keep all birds of same age.
 Hepatotoxin and mycotoxin free feed.
 Stress free environment.

17. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & Control
Outbreak Management

18.  No treatment.
 Vaccinate birds , repeat vaccine only if
previous vaccine was done 15-20 days
before.
 Surviving birds are susceptible to E. coli,
respiratory infections, coccidiosis, IBD and
ND so precautionary measures should be
taken.
 To avoid secondary infections specially
respiratory infections use broad spectrum
antibiotics after vaccination.

19. IBH, HPS IN POULTRY
Introduction
Prevalence of disease
Predisposing factors
Symptoms
Postmortum Findings
Vaccination &
Treatment
Prevention & Control
Post mortem lesions