The document provides an introduction to the phylum Chordata, including three key unifying themes: 1) Chordates evolved from invertebrates but display innovations, 2) Chordates exhibit physical and behavioral specializations through evolution, and 3) Evolutionary innovations led to adaptive radiations. It describes five key characteristics of chordates - notochord, dorsal nerve cord, pharyngeal slits, muscle blocks, and postanal tail. It then discusses the three subphyla of chordates - invertebrate Urochordata and Cephalochordata, and vertebrate Vertebrata. Vertebrates exhibit all five chordate characteristics and have additional defining features like an endos
Chordata is the last phylum of kingdom Animalia.
Which is further subdivided into subphylums, divisions and classes.
The Slides shows the classification of the phylum along with the basis on which it is classified.
(includes examples along with pictures for easy understanding and memorizing)
The chordates are named for the notochord: a flexible, rod-shaped structure that is found in the embryonic stage of all chordates and also in the adult stage of some chordate species.
It is located between the digestive tube and the nerve cord, providing skeletal support through the length of the body.
In some chordates, the notochord acts as the primary axial support of the body throughout the animal's lifetime.
A vertebrate is an animal with a spinal cord surrounded by cartilage or bone. The word comes from vertebrae, the bones that make up the spine. Animals that are not vertebrates are called invertebrates. Vertebrates include birds, fish, amphibians, reptiles, and mammals
Phylum Mollusca-my report..
sorry for some overlapping of texts... i was not able to edit it..it is actually because of the animations that i put it..... i just uploaded it directly :)
Chordata is the last phylum of kingdom Animalia.
Which is further subdivided into subphylums, divisions and classes.
The Slides shows the classification of the phylum along with the basis on which it is classified.
(includes examples along with pictures for easy understanding and memorizing)
The chordates are named for the notochord: a flexible, rod-shaped structure that is found in the embryonic stage of all chordates and also in the adult stage of some chordate species.
It is located between the digestive tube and the nerve cord, providing skeletal support through the length of the body.
In some chordates, the notochord acts as the primary axial support of the body throughout the animal's lifetime.
A vertebrate is an animal with a spinal cord surrounded by cartilage or bone. The word comes from vertebrae, the bones that make up the spine. Animals that are not vertebrates are called invertebrates. Vertebrates include birds, fish, amphibians, reptiles, and mammals
Phylum Mollusca-my report..
sorry for some overlapping of texts... i was not able to edit it..it is actually because of the animations that i put it..... i just uploaded it directly :)
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
2. Unifying Themes
1. Chordate evolution is a history of innovations that is built upon
major invertebrate traits
• They display many of the basic traits that first evolved in the
invertebrates: bilateral symmetry, cephalization, segmentation,
coelom, "gut" tube, etc.
2. Chordate evolution is marked by physical and behavioral
specializations
• For example the forelimb of mammals has a wide range of structural
variation, specialized by natural selection
3. Evolutionary innovations and specializations led to adaptive
radiations - the development of a variety of forms from a single
ancestral group
3. Characteristics of the Chordates
• Notochord, dorsal hollow nerve cord, pharyngeal gill slits,
blocks of muscle, postanal tail
4. Characteristics of the Chordates
The notochord
• All chordate embryos have a notochord, a stiff but flexible rod that
provides internal support
• Remains throughout the life history of most invertebrate chordates;
among, present only in the embryos of vertebrate chordates
5. Characteristics of the Chordates cont.
Dorsal Hollow Nerve Cord (=Spinal Cord)
• A fluid-filled tube of nerve tissue that runs the length of the
animal, dorsal to the notochord
• Present in chordates throughout embryonic and adult life
6. Characteristics of the Chordates cont.
Pharyngeal gill slits
• Pairs of opening through the pharynx
• Invertebrate chordates use them to filter food
• Juvenile fishes use them to them for breathing
• In adult fishes the gill sits develop into true gills
• In reptiles, birds, and mammals the gill slits are vestiges, occurring
only in the embryo
7. Characteristics of the Chordates cont.
Blocks of Muscle - Myotomes
• Surrounding the notochord and nerve cord are blocks of muscle -
myotomes
Postanal Tail
• The notochord, nerve cord, and the myotomes extend to the tail
• Found at some time during a chordate's development
9. SubPhylum Urochordata
• Marine animals; some species are solitary, others are colonial.
• Sessile as adults, but motile during the larval stages
• Possess all 5 chordate characteristics as larvae
• Settle head first on
hard substrates and
undergo a dramatic
metamorphosis
(e.g., tail,
notochord, muscle
segments, and nerve
cord disappear)
10. SubPhylum Urochordata cont.
• Adult body is covered by
an outer envelope or tunic;
composed of fibers of
tunicin embedded in a
mucopolysaccharide matrix
• Tunic encloses a basket-
like pharynx, that is
perforated by gill slits
• Tunicates are filter feeders; plankton is trapped in a sheet of mucus
and cilia later direct the food-laden mucus to the stomach
• Water leaves the animal via an excurrent siphon
11. Chordate Metamerism
• Body segmentation (i.e. metamerism) appears to have evolved in
two lineages of the chordates: the Cephalochordates and the
Vertebrates; probably occurred after divergence from the
Urochordates
• However, segmentation in the chordates does not involve the
coelom
• The cephalochordates and the chordates movement is
accomplished by contraction of muscle fibers that are arranged in
segmented blocks - myotomes
• Presumably, segmentation of muscles developed as an adaptation
for undulatory swimming and rapid burrowing
12. SubPhylum Cephalochordata
• Exclusively marine animals
• Although they are capable of swimming, they usually are buried in
the sand with only their anterior end being exposed
13. SubPhylum Cephalochordata cont.
•All chordate characteristics are present throughout their life history
• They are filter feeders: inside of the oral hood is lined with cilia
-wheel organ
• These cilia, plus cilia in the pharynx help generate a water current
• Water and suspended food particles pass through the oral hood,
equipped with projections called cirri that strain larger particles
• Feed by secreting a mucous net across the gill slits to filter out
food particles that are present in the water.
15. General Characteristics
• Exhibit all 5 chordate characteristics at sometime in their life history
• Usually well cephalized, including a well developed brain and a
number of anterior sensory structures
• Brain is usually encased in a skull, made of hard bone or a cartilage.
• In most vertebrates, the embryonic notochord is replaced by a
vertebral column.
• Possess a distinctive endoskeleton consisting of vertebral column,
limb girdles, two pairs of jointed appendages, and a head skeleton
• Muscles are attached to the skeleton to provide movement
• Often have a muscular perforated pharynx
• Closed circulatory system with a well developed muscular heart;
blood is oxygenated as it flows through vascularized skin, gills or
lungs.
16. Evolutionary Relationships of the Vertebrates
• Earliest vertebrate fossils (jawless ostracoderm fishes; 500 mya)
share many of the novel structures observed in the living vertebrates
• Q. When and from where did these vertebrate characteristics evolve?
• May have evolved from an invertebrate chordate lineage
• This idea is supported by the discovery of a fossilized mid-Cambrain
invertebrate chordate from the Burgess Shale formation - Pikaia
• A ribbon shaped, somewhat fish-like creature about 5 cm in length
• It possessed a notochord and the V-
shaped myomeres
• Resembles Amphioxus, and may
very well be an early cephalochordate
17. Evolutionary Relationships of the Vertebrates cont.
• Speculations regarding vertebrate ancestry have focused on living cephalochordates
and tunicates
• One hypothesis on the evolution of the vertebrates is Garstang's Hypothesis
• It suggests that sessile tunicates were an ancestral stock that evolved a motile larval
stage
• Garstang speculated that at some point larvae failed to metamorphose into an adult,
but developed gonads and reproduced in the larval stage
• And with continued larval evolution a new group of free swimming animals evolved
• Garstang called this process paedomorphosis, a term that describes the presence (or
evolutionary retention) of juvenile or larval traits in the adult body