Blood typing involves determining the presence of antigens on red blood cells. The ABO and Rh blood group systems are most important for blood transfusions. Karl Landsteiner discovered the ABO blood groups in 1901 and was awarded the Nobel Prize for this work. The ABO blood groups are determined by the presence of A and B antigens, and antibodies against antigens not present. Type O blood lacks both antigens and can be donated to all groups, while Type AB has both antigens and is a universal recipient. Compatible blood typing and cross-matching between donor and recipient prevents transfusion reactions.