Benign and malignant neoplasms can be differentiated based on their gross and microscopic features. Benign neoplasms are generally well-circumscribed masses that are spherical or ovoid in shape and are often encapsulated. They are freely movable and uniform in appearance unless changes like hemorrhage or infarction have occurred. Microscopically, benign tumors show characteristic growth patterns and differentiated tumor cells, as well as tumor angiogenesis and stroma formation. In contrast, malignant neoplasms exhibit features of invasion and metastasis.