1) Actinomyces are gram-positive bacteria that normally inhabit the mouth and intestines.
2) Actinomycosis occurs when these bacteria invade tissues, usually through breaks in the mucosa.
3) It most commonly affects the cervicofacial region due to dental infections or procedures. Symptoms include abscesses and draining sinuses.
• Actinomyces species are classified as anaerobic, gram positive and filamentous bacteria.
• It is a chronic granulomatous suppurative and fibrosing disease caused by anaerobic or microaerophilic gram-positive nonacid fast, branched filamentous bacteria.
• Most of the species isolated from actinomycotic lesions have been identified as A. israelii, A. viscosus, A. odontolyticus, A.naeslundii or A. meyeri.
• These microorganisms have been identified in dental plaque, dental calculus, necrotic pulp, and tonsils.
• The usual pattern of this disease is one characterized chiefly by the formation of abscesses that tend to drain by the formation of sinus tracts.
• pus from the abscesses is examined on a clean glass slide, it shows the typical ‘sulfur granules’ or colonies of organisms, which appear in the suppurative material as tiny, yellow grains.
• Another infection that produces this type of sulfur granules is botryomycosis.
Medically Important Histoplasma species .pptxNawangSherpa6
The Presentation here is about Medically important Histoplasma species. How does it infect the Human host? What are it's clinical manifestations and How can we diagnose for their infection and potential application for other studies.
Actinomycetes and Nocardia, Bacteria but similar to fungi usually because of its morphological feature of forming a branching filament network, causing Actinomycosis, Actinomycetoma, Farmer's Lung, etc. Demonstrated under microscope by Gram's stain and ZN staining. Cultured on BHI and Thioglycolate broth. Characteristically produce Supher granules. Penicillin is the drug of choice in allergic to penicillin can be replaced by Erythromycin or Tetracycline. In worst cases surgical removal of affected tissue required.
• Actinomyces species are classified as anaerobic, gram positive and filamentous bacteria.
• It is a chronic granulomatous suppurative and fibrosing disease caused by anaerobic or microaerophilic gram-positive nonacid fast, branched filamentous bacteria.
• Most of the species isolated from actinomycotic lesions have been identified as A. israelii, A. viscosus, A. odontolyticus, A.naeslundii or A. meyeri.
• These microorganisms have been identified in dental plaque, dental calculus, necrotic pulp, and tonsils.
• The usual pattern of this disease is one characterized chiefly by the formation of abscesses that tend to drain by the formation of sinus tracts.
• pus from the abscesses is examined on a clean glass slide, it shows the typical ‘sulfur granules’ or colonies of organisms, which appear in the suppurative material as tiny, yellow grains.
• Another infection that produces this type of sulfur granules is botryomycosis.
Medically Important Histoplasma species .pptxNawangSherpa6
The Presentation here is about Medically important Histoplasma species. How does it infect the Human host? What are it's clinical manifestations and How can we diagnose for their infection and potential application for other studies.
Actinomycetes and Nocardia, Bacteria but similar to fungi usually because of its morphological feature of forming a branching filament network, causing Actinomycosis, Actinomycetoma, Farmer's Lung, etc. Demonstrated under microscope by Gram's stain and ZN staining. Cultured on BHI and Thioglycolate broth. Characteristically produce Supher granules. Penicillin is the drug of choice in allergic to penicillin can be replaced by Erythromycin or Tetracycline. In worst cases surgical removal of affected tissue required.
Chronic suppurative otitis media (CSOM) is one of the most common childhood infectious diseases worldwide and is a leading cause of hearing impairment in resource-limited settings. It is less frequently seen in resource-rich settings. CSOM usually begins as a complication of persistent acute otitis media (AOM) with perforation in childhood. Typical findings may also include thickened granular middle-ear mucosa and mucosal polyps. Occasionally, CSOM will be associated with a cholesteatoma within the middle ear.
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Chronic suppurative otitis media (CSOM) is one of the most common childhood infectious diseases worldwide and is a leading cause of hearing impairment in resource-limited settings. It is less frequently seen in resource-rich settings. CSOM usually begins as a complication of persistent acute otitis media (AOM) with perforation in childhood. Typical findings may also include thickened granular middle-ear mucosa and mucosal polyps. Occasionally, CSOM will be associated with a cholesteatoma within the middle ear.
BACTERIAL INFECTCTIONS OF ORAL CAVITY i /certified fixed orthodontic courses ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
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ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. ACTINOMYCTES
1
• Gram-positive, pleomorphic non–
spore- forming, non–acid-fast
anaerobic or Microaerophilic bacilli.
•
• Actinomyces are very closely related
to Nocardia species; both were once
considered to be fungal organisms.
2. • A. israelii – the
commonest
• A .meyeri
• A.naeslundii
• A.odontolyticus
• A. viscosus
ACTINOMYCOSIS
3. • Normal flora of the oropharynx, GI tract, and female
genital tract.
• This is not an exogenous infection; therefore, no
person-to- person spread of the pathogen occurs
ACTINOMYCES IS A
NORMAL FLORA
DR.T.V.RAO
MD
8
4. RISK Factors
4
• Having a dental disease or recent dental
surgery (for jaw abscess)
• Aspiration (liquids or solids are sucked into
lungs) (for lung abscess)
• Having bowel surgery (for abdominal abscess)
• Swallowing fragments of chicken or other bones (for
abdominal abscess)
• For women: having an intrauterine
contraceptive device (IUD) in place for many
years (for abscess affecting the reproductive
organs)
5. MORPHOLOGIC FEATURES
. Depending upon the anatomic location of lesions,
actinomycosis is of 4 types:
cervicofacial,
thoracic,
abdominal,
and pelvic
Cervicofacial actinomycosis. This is the commonest
form (60%) and has the best prognosis.
6.
7. • This is the most common and
recognized presentation of the
disease.
• Actinomyces species are
commonly present in high
concentrations in tonsillar crypts
and gingivodental crevices.
Many patients have a history of
poor dentition, oral surgery or
dental procedures, or trauma to
the oral cavity.
• Chronic tonsillitis, mastoiditis,
and otitis are also important risk
factors for actinomycosis.
CERVICOFACIAL ACTINOMYCOSIS
7
8. • Periostitis or osteomyelitis
can develop if the infection
extends to facial and
maxillary bones.
• The mandible appears to be
one of the most common
osteomyelitis sites.
CERVICOFACIAL REGION
1
9. • The infection usually
develops after GI
mucosal integrity is
broken from surgical
procedures or trauma.
INTESTINAL ACTINOMYCOSIS
9
10. PELVIC ACTINOMYCOSIS
• Intrauterine contraception devices, usually for longer
than 2 years.
• Pelvic actinomycosis may develop from extension
of intestinal infection, commonly from indolent
Ileocecal disease.
• Patients present with an indolent history of vaginal
discharge, abdominal or pelvic pain, menorrhagia,
fever, weight loss, and prolonged use of an
intrauterine
2
0
11. EXAMINATION OF DISCHARGES
• Examination of
drained fluid under
a microscope
shows "sulphur
granules" in the
fluid.
• They are yellowish
granules made of
clumped organisms
2
2
12. Microscopy
Irrespective of the location of actinomycosis, the following features are:
1. Inflammatory reaction is a granuloma with central
suppuration with formation of abscesses in the centre of
lesions and at the periphery chronic inflammatory cells, giant
cells and fibroblasts are seen.
2) The centre of each abscess contains the bacterial colony,
‘sulphur granule’, characterised by radiating filaments (hence
previously known as ray fungus) with hyaline, eosinophilic,
club-like ends representative of secreted immunoglobulins.
13.
14.
15. • Grow well in enriched
media with brain-
heart infusion and
may be aided in
growth by an
atmosphere of 6-10%
ambient carbon
dioxide.
CULTURING OF
ACTINOMYCES
1
5
16. • Treatment classically
begins with IV
penicillin for 2–6
weeks, followed by oral
therapy with penicillin or
amoxicillin for 6–12
months..
TREATMENT OF ACTINOMYCOSIS
1
6
17. Granulation Tissue:It is granular
and pink appearance of the
tissue in ahealing tissue and in
secondary union of wounds.
23. Gross:
Floor of lesion contain pink eosinophilic granulations
,composed of vascular connective tissue, edge are
sloping & bluish white.
Microscopy:
Surface of ulcer –mixture of blood,fibrin & inflammatory
exudates.
Zone below granulation tissue –composed of
proliferating fibroblast, newly formed small vessels &
varying no. of inflammatory cell.
24.
25. chronic granulomatous disease
characterised by production of polyps
and other manifestations of hyperplasia
of nasal mucosa(predominantly).
The etiological agent is
Rhinosporidium seeberi.
26. Rhinosporidium seeberi:
Initially believed to be a sporozoan, but
later considered to be a fungus and has
been provisionally placed under the
Family -Olipidiaceae,
Order -chytridiales of phycomyetes by
ASHWORTH.
27. Spore is the ultimate infecting
unit.
It measures about 7 microns,
about the size of a red cell.
It is also known as a spherule.
It has a clear cytoplasm with 15
- 20 vacuoles.
It is enclosed in a chitinous
membrane which protects the
spore from hostile
environment.
It is found only in connective
tissue spaces and is rarely
intracellular.
30. Common sites affected:
Nose - 78%
Nasopharynx
Tonsil
Eye - 1%
Skin - very rare
Also affects the lips, palate, uvula,
maxillary antrum, epiglottis, larynx,
trachea, bronchus, ear, scalp, vulva,
vagina, penis, rectum, and the skin.
31. Lesions in the nose can be
polypoidal, reddish and
granular masses.
They could be multiple
pedunculated and friable.
They are highly vascular
and bleed easily.
Their surface is studded
with whitish dots
(sporangia)
They can be clearly seen
with a hand lens.
The whole mass is covered
by mucoid secretion.
32. The largest sporangia are usually in a
subepithelial location.
The size of the globular sporangia
depend on the stage of maturation.
Young trophic forms (immature
sporangia) are spherical ,10-100
micrometer in diameter and have a
central basophilic nucleus.
These develop into mature sporangia by
a process of progressive enlargement
and endosporulation.
33. Increased vascularity is due to the
release of angiognenesis factor from the
rhinosporidial mass.
Rhinosporidial spores stain with
sudan black, Bromphenol blue etc.
34. These spores are also
passed in the nasal
discharge.
Special stains:
R. Seeberi is visualized
by fungal stains such as
PAS, Gomori's
methenimine silver and
mucicarmine.
37. Microscopy:
Polypoidal structure lined by respiratory epi, with
underlying edematous stroma, showing numerous
sporangia with endospores.
Large thick walled sporangia with endospores
surrounded bymixed inflammatory infiltrates.
38. Diagnosis is based on the fine-needle aspiration cytology (Giemsa
stained) or histopathological demonstration of the characteristic
thickwalled sporangia in various stages of development and containing
numerous sporangiospores.
R. seeberi can be easily identified in sections stained with hematoxylin
and eosin with many sporangia.
39. Treatment::
anti-rhinosporidial effect is
dapsone (4,4-
diaminodiphenyl sulphone)
which appears to arrest the
maturation of the sporangia
and to promote fibrosis in the
stroma, when used as an
adjunct to surgery.
40. Tuberculosis
Tissue response in tuberculosis represents classical
example of chronic granulomatous inflammation in
humans.
CAUSATIVE ORGANISM. Tubercle bacillus or Koch’s
bacillus (named after discovery of the organism by
Robert Koch
45. Gross:
Greyish white area of lung-focus of lesion.
Presence of hilar LN ,blackish mark &enlarged.
C/S-stuuded with grey white tubercles
46. Microscopy:
Central necrosis
Epitheloid cells in centre with langhans type giant cell
surrounded by lymphocytes &fibroblast.
Langhans type giant cell seen with nuclear arranged in
ring pattern.
Editor's Notes
Microscopic appearance of sulphur granule lying inside an abscess. The margin of the colony shows hyaline filaments highlighted by Masson’s trichrome stain
Active granulation tissue has inflammatory cell infiltrate, newly formed blood vessels and young fibrous tissue in loose matrix
Nasal rhinosporidiosis associated with a giant cell granuloma inflammation
. A, Cut section of matted mass of lymph nodes shows merging capsules and large areas of caseation necrosis
(arrow). B, Caseating epithelioid cell granulomas with some Langhans’ giant cells in the cortex of lymph nod
There is central caseation necrosis, surrounded by elongated epithelioid cells having characteristic slipper-shaped nuclei, with interspersed Langhans’ giant cells. Periphery shows lymphocytes
. The sectioned surface of the lung parenchyma shows presence of minute millet-seed sized tubercles.