This chapter discusses language access services and cross-cultural communication in healthcare. It notes that over 50 million people in the US speak a language other than English, including 8% who have limited English proficiency. When language barriers are present, healthcare encounters can result in misunderstandings and medical errors. The chapter reviews legislative requirements for language services, resources available, and the importance of using trained interpreters rather than ad hoc interpreters to avoid problems. Effective communication involves awareness of linguistic and cultural differences in areas like non-verbal behavior and concepts of illness.