Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Body fluid compartments slide share


Published on

body fluid compartments

Published in: Health & Medicine
  • Be the first to comment

Body fluid compartments slide share

  2. 2. Introduction • Body is formed of solids & fluids • The fluid part is more than 2/3 of the whole body. • Water forms most of the fluid part
  3. 3. 40% 15% 20% 5% Total Body water Blood volume 7% of body weight 5L in a 70 kg adult male
  4. 4. ECF constitutes of: A. Interstitial fluid including lymph B. Plasma C. Transcellular fluids Transcellular fluids:  CSF  Intraocular fluid  Gastrointestinal secretions  Pleural fluid  Pericardial fluid  Peritoneal fluid  Synovial fluid  Fluid in urinary tract More the amount of fat, lesser the ECF volume Elderly – lesser ECF volume Infants & children – greater ECF volume
  5. 5. Body electrolytes • 7% of total body weight • Functions of electrolytes in the human body − Maintenance of acid-base balance − Maintenance of normal osmolality and volume of body fluids − Ions like Na+,Ca2+,K+,Cl- , etc affects excitability of cells
  6. 6. Distribution of ions across the cell membrane at rest Ion ICF (mmol/L of H20) ECF(mmol/L of H20) Na+ 1.5 150 K+ 150 5.5 Cl- 9 125 Ca2+ 0.0001 1.2 Protein anion 65 <5 Mg2+ 58 3 HCO3- 10 2.8 PO4 3- 75 4
  7. 7. Deuterium oxide/heavy water, Tritium oxide, Aminopyrine Inulin, Mannitol, Sucrose 131I
  8. 8. Applied aspect Infants are prone to dehydration i.e., infants are more vulnerable for water loss due to: • Absolute ECF volume is lesser • Increased body surface area compared to mass • Higher metabolic rate • Physiologic inability of the infant’s kidneys to concentrate urine see
  9. 9. Thank you
  10. 10. Measurement of body fluid volumes • Total body water is measured using dilution principle. • A marker is injected that will be evenly distributed in all the compartments of body fluids. • Marker that diffuses freely not only in the water outside the cells, but also crosses the cell membrane to reach the intracellular fluid.
  11. 11. • ECF volume is measured using substances that cannot enter the cells, but can freely cross the capillary membrane and thus distribute evenly in the ECF compartments. • Plasma volume is measured using substances that binds specifically to plasma proteins, and will not diffuse into the interstitium. Measurement of body fluid volumes
  12. 12.