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Body fluid compartments slide share

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body fluid compartments

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Body fluid compartments slide share

  1. 1. BODY FLUID COMPARTMENTS Dr Anu Priya J
  2. 2. Introduction • Body is formed of solids & fluids • The fluid part is more than 2/3 of the whole body. • Water forms most of the fluid part
  3. 3. 40% 15% 20% 5% Total Body water Blood volume 7% of body weight 5L in a 70 kg adult male
  4. 4. ECF constitutes of: A. Interstitial fluid including lymph B. Plasma C. Transcellular fluids Transcellular fluids:  CSF  Intraocular fluid  Gastrointestinal secretions  Pleural fluid  Pericardial fluid  Peritoneal fluid  Synovial fluid  Fluid in urinary tract More the amount of fat, lesser the ECF volume Elderly – lesser ECF volume Infants & children – greater ECF volume
  5. 5. Body electrolytes • 7% of total body weight • Functions of electrolytes in the human body − Maintenance of acid-base balance − Maintenance of normal osmolality and volume of body fluids − Ions like Na+,Ca2+,K+,Cl- , etc affects excitability of cells
  6. 6. Distribution of ions across the cell membrane at rest Ion ICF (mmol/L of H20) ECF(mmol/L of H20) Na+ 1.5 150 K+ 150 5.5 Cl- 9 125 Ca2+ 0.0001 1.2 Protein anion 65 <5 Mg2+ 58 3 HCO3- 10 2.8 PO4 3- 75 4
  7. 7. Deuterium oxide/heavy water, Tritium oxide, Aminopyrine Inulin, Mannitol, Sucrose 131I
  8. 8. Applied aspect Infants are prone to dehydration i.e., infants are more vulnerable for water loss due to: • Absolute ECF volume is lesser • Increased body surface area compared to mass • Higher metabolic rate • Physiologic inability of the infant’s kidneys to concentrate urine see http://www.ihrdni.org/068b-022.pdf
  9. 9. Thank you
  10. 10. Measurement of body fluid volumes • Total body water is measured using dilution principle. • A marker is injected that will be evenly distributed in all the compartments of body fluids. • Marker that diffuses freely not only in the water outside the cells, but also crosses the cell membrane to reach the intracellular fluid.
  11. 11. • ECF volume is measured using substances that cannot enter the cells, but can freely cross the capillary membrane and thus distribute evenly in the ECF compartments. • Plasma volume is measured using substances that binds specifically to plasma proteins, and will not diffuse into the interstitium. Measurement of body fluid volumes
  12. 12. http://www.ihrdni.org/068b-022.pdf

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