This document presents information on blue light protection in sun care products and introduces MicahTM, a new active ingredient from Hallstar. MicahTM is unique in that it stops the formation of free radicals from nearly all light sources, including blue light, before they can cause skin damage. Clinical research shows that MicahTM prevents markers of skin aging and inflammation caused by UVA and visible light. It offers a new category of protection compared to UV filters and antioxidants. MicahTM is easy to formulate at a low use level and supports claims around anti-aging, anti-dark spots, and protection from environmental elements like pollution and blue light from devices.

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September2017
Presented by Dennis Zlotnik
Senior Market DevelopmentManager, Beauty & Personal Care
Hallstar
Change Your Suncare Story:
Micah Blazes the
Trail in Blue Light
Protection
TM

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SUNCARE:
Highly regulated but
ripe for innovation

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Suncare: Highly regulated but ripe
for innovation
Suncare products
$24.91
Global growth
potential
BILLION
Source: “Scorching Grow th forSuncare”? happi. May 9, 2017. www.happi.com.

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An industry focused on UVA and UVB – with
minimal differentiation
Source: Mintel
Brand (SPF) Avobenzone Homosalate Octisalate Octocrylene Octocrylene TiO2 ZNO
Aveeno Baby (55) 3 10 5 2.8 6
Walgreens (55) 3 10 5 2.75 6
La Roche (60) 3 15 5 5 6
Coppertone (50) 3 10 5 7 5
CVS (70) 3 15 5 10 6
Clarins (50+) 3 10 5 2.7 6
50+YEARS OF UVB FOCUS 5-10YEARS OF UVA FOCUS
Source: Mintel

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A threat – and an opportunity
BLUE LIGHT

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Blue light: A challenge waiting for a solution
No product
protects against
nearly every light
form except
Micah™
UVB
UVA I
UVA II
VISIBLE
BLUE LIGHT

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What exactly is blue light?
BLUE LIGHT

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Where does blue light come from?
30%of sunlight
is blue light

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Exposure to blue light is increasing
10 HOURS
39 MINUTES/DAY
SPENT LOOKING AT SCREENS
SINCE 2015
HOUR INCREASE
+1
88%
OF MILLENNIALS USE
TWO SCREENS AT ONCESources: “Millennials master the second screen.” Business Wire. January 28, 2016.
www.businesswire.com
The Total Audience Report: Q1 2016. Nielsen. June 27, 2016. nielsen.com.

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How does blue light compare with UVA light?
Blue light penetrates deeper
UVB
(280 – 320 nm)
UVA-II
(320 – 360 nm)
UVA-I
(360 – 400 nm)
VISIBLE
BLUE LIGHT
(400 – 700 nm)

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Blue light’s effect on skin is comparable to UVA
DNA mutations – leads to
skin aging and cancer
Damage to skin cells
Loss of skin elasticity
Fine lines and wrinkles
Pigment production/
discoloration
BLUE LIGHTUV
DNA mutations – leads to skin
aging and cancer
Damage to skin cells
Loss of skin elasticity
Fine lines and wrinkles
Pigment production/
discoloration
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Connecting oxidative stress, free radicals
and aging
Oxidative Stress
Imbalance between the
production of reactive oxygen
species (ROS) free radicals
(FR), and the ability of the body
to neutralize these species
Solar Light-Induced
Oxidative Stress
A major cause of ROS/FR
generation in human skin
Visible Signs
of Aging
• Damage to extracellular matrix
• Loss in skin elasticity
• Fine lines and wrinkles

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Visible light produces significant
oxidative stress
About 50% of
solar-induced
oxidative stress is
from visible light -
not UVA.
50%
Source: Zastrow, et al. National Center for Biotechnology Information.
https://www.ncbi.nlm.nih.gov/pubmed/19319493

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Consumer media is catching on to blue light
Blue light is harmful, because it’s the highest energy
wavelength of visible light.
– Huffington Post, July 2014
‘Blue Light’ or high-energy visible (HEV) light emitted
from your phones, computers, and tablets penetrates
more deeply into layers of skin than the sun's UV rays,
thus accelerating aging.
– Elle, October 2016
It appears that HEV light could be the ninja of skin aging.
– Get the Gloss, August 2016
Though scientists and derms don’t know as much about
it as UV light, preliminary research suggests the effects
may be similarly damaging.
– Women’s Health, March 2016

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Clinical research is proving the dangers of
blue light
Visible light can cause cell dysfunction through the
action of reactive oxygen species on DNA and that this
may contribute to cellular aging.
– Bernard Godley, et al. Journal of Biological Chemistry, 2005
We determined for the first time the free radical action
spectrum covering UV and visible light (280–700 nm).
– Leonhard Zastrow, et al. Skin Pharmacology and Physiology, 2009
Visible rays of 400-500 nm length of wave cause an
increase of the concentration of oxygen's active form.
– A. Tsibadze, et al. Georgian Med News, 2015

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Micah™
the only product that stops blue light
damage before it starts
Micah
TM
Compound: “C4”
n-Butyl Ester

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Micah™
: A new category in suncare and
anti-aging
Not an antioxidant
Bypasses the limitations of UV
filters and antioxidants by
stopping free radical formation
without stability limitations
Not a UV filter
A “pre-oxidant” or quenching
mechanism

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1 4
How UVA and visible blue light generate free
radicals
UVA/Vis
PS*
Photoexcited
Chromophore
PS
e.g. Porphyrins,
Flavins, Melanin,
Bilirubin
1O2
Singlet
Oxygen
3O2
Molecular
Oxygen
3
2

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3
2
4
How UVA and visible blue light generate free
radicals
PS*
Photoexcited
Chromophore
PS
e.g. Porphyrins,
Flavins, Melanin,
Bilirubin
1O2
Singlet
Oxygen
3O2
Molecular
Oxygen
O2
.-
H2O2 •OH
VISIBLE SIGNS OF PHOTOAGING
MAPK
Pathway
Oxidation
▲ AP-1
▼ TGF-b
▲ DNA Damage
▲ Lipid Damage
▲ Protein Damage
▲ Collagen I, III Breakdown & Inflammation
▼Procollagen Production
▲ IL1-a, IL-6, MMP-1
1 UVA/Vis

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How Micah™
works: Stopping the formation of
free radicals
PS*
Photoexcited
Chromophore
PS
e.g. Porphyrins,
Flavins, Melanin,
Bilirubin
MicahTM
Compound
UVA/Vis

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x
1O2
Singlet
Oxygen
3O2
Molecular
Oxygen
How Micah™
works: Stopping the formation of
free radicals
O2
.-
H2O2 •OH
VISIBLE SIGNS OF PHOTOAGING
MAPK
Pathway
Oxidation
▲ AP-1
▼ TGF-b
▲ DNA Damage
▲ Lipid Damage
▲ Protein Damage
▲ Collagen I, III Breakdown & Inflammation
▼Procollagen Production
▲ IL1-a, IL-6, MMP-1
UVA/Vis
PS*
Photoexcited
Chromophore
PS
e.g. Porphyrins,
Flavins, Melanin,
Bilirubin
MicahTM
Compound

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Micah™
is not a UV Filter
Chemical UV filters
• Only absorb up to UVA II or 360 nm
• Limited efficacy in longer wavelength UVA (UVA I)
• No blue light protection

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Micah™
is not a UV Filter
UVB
UVA I
UVA II
VISIBLE
BLUE LIGHT
MicahTM
does not
rely on absorbency
Stops formation of
free radicals from
nearly every kind
of light

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Micah™
is not an antioxidant
Antioxidants like Vitamins A and C “mop up” or quench
free radicals after the fact
• Limited to a one-time occurrence
• Photo, thermal and oxidatively unstable
• Formulation challenges – color, texture

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Micah™
is not an antioxidant
Micah™
• Proactively stops formation of free radicals – doesn’t work after the fact
• Works until metabolized – isomerizes back and forth between its two states
• Highly stable structures

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Proof of concept:
Micah™
prevents visible light damage
MicahTM
prevented 93% of
UVA-induced ROS/FR from forming
UVA (320 – 400 nm)
MicahTM
compound effectively prevented visible light-
induced ROS/FR in ALA-treated ex vivo porcine skin
Visible Light (630 nm)

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Micah™
stopped free radicals formed by visible
red light
No fluorescence appears in HaCaT cells exposed to
visible light that were treated with MicahTM
Visible Light (-) MicahTM
(-) Visible Light (+) MicahTM
(-) Visible Light (+) MicahTM
(+)
Cells pre-treated w ith ALA Cells pre-treated w ith ALA Cells pre-treated w ith ALA

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Proof of concept: Micah™
stopped UVA-induced
ROS/free radicals
Stops UVA damage at use level of .20%
* Significantly differentfrom non-irradiated controls
# Significantly differentfrom irradiated vehicle
Positive Controls

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Proof of concept: Micah™
prevented skin
inflammation, redness, irritation from IL-1a
* Significantly differentfrom non-irradiated controls
# Significantly differentfrom irradiated vehicle
Positive Controls

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Proof of concept: Micah™
prevented skin
inflammation, redness, irritation from IL-6
* Significantly differentfrom non-irradiated controls
# Significantly differentfrom irradiated vehicle
Positive Controls

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Proof of concept: Micah™
reduced photoaging
caused by other markers from 8-OHdG
* Significantly differentfrom non-irradiated controls
# Significantly differentfrom irradiated vehicle
Positive Controls

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Proof of concept: Ex vivo human skin – MMP-1
* Significantly differentfrom non-irradiated controls
# Significantly differentfrom irradiated vehicle

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Micah™
boasts an impressive safety dossier
Micah
™
Safety Tests
Safety Test RX-14477 (C3) RX-14478 (C4) RX-14450 (C20)
Genotoxicity/Amestest ✓ ✓ ✓
Ocular irritation (HET-CAM) ✓ ✓ ✓
Phototoxicity — in vivo (22 volunteers) ✓ ✓ ✓
Phototoxicity RHE — in vitro NA ✓ NA
Phototoxicity MTT — ex vivo NA ✓ NA
Sensitization/HRIPT (50 volunteers) ✓ ✓ ✓

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Early industry recognition for Micah™
[The fused-ring cyanoacrylates
chemistry] is important and unique
because there is nothing else that
kills the aging phenomenon at the
beginning … this is a long-awaited
breakthrough.
Paolo Giacomoni, Ph.D.,
Biochemist, atomic physicist and
former director of research at both
Estée Lauder and L’Oréal

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Early industry recognition for Micah™

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Formulating with Micah™
: Easy and flexible
• Efficacy-to-cost usage: Just .20%
• Odorless and colorless
• No effect on aesthetics
• Useable in any product type
• Solubility easily managed

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A wide array of applications and new concepts
Micah
™
opens the door to unique new products
A few ideas:
• More effective sunscreens with extended
visible light protection
• Standalone blue light protection
• Antioxidant enhancers
• Pollution-specific antioxidant packages
• Unique anti-aging moisturizers or serums
• On-the-go or multi-functional products

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Micah™
supports powerful, clinically-backed
claims
High performance supports several
product claims:
• Prevent skin darkening and dark spots
• Blue and red light protection
• Anti-aging, anti-wrinkle
• Pollution and environmental protection
• Cell and DNA protection
• Free radical eliminator/quencher

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Micah™
consumer personas: Broader
Asian market
TARGET DEMOGRAPHIC
BroaderAsian Market
Women,15-50
MICAH’S ROLE
Halts UVA-1 and visible light skin
damage by eliminating ROS/FR
Reduces presenceof IL-1a(skin barrier
function), IL-6 (inflammation), lipid
peroxidation, 8-OHdG (oxidative stress)
PRODUCT CLAIMS
• Anti-dark spot
• Anti-wrinkle
• Skin protectionfrom
solar elements
• Cell/DNA protection

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Micah™
consumer personas: Skin types IV – VI
TARGET DEMOGRAPHIC
Skin Types IV-VI
EXPOSURE TO UVA-1 & VISIBLE LIGHT
Both UVA-1 and visible light can induce
pigmentation in skin types IV-VI,
pigmentation induced by visible light was
darker and more sustained
MICAH’S ROLE
Micah’s™ mechanism of action could
prevent excess pigmentationfrom
occurring in skin type IV-VI populations
PRODUCT CLAIMS
Prevention from PPD in UVA-1/VisibleLight

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Micah™
consumer personas: Urban consumer
TARGET DEMOGRAPHIC
Urban Consumer
BLUE LIGHT INDOOR AND OUTDOOR
Blue light from electronic devices and indoor
elements can induce oxidative stress,
leading to visible signs of aging.
MICAH’S ROLE
Micah’s™
mechanism of action prevents
the formation of oxidative stress induced
by blue light
PRODUCT CLAIMS
• Anti-aging/Anti-wrinkle
• Blue light protection

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Consumer personas: Metropolitan
TARGET DEMOGRAPHIC
Metropolitan
EXPOSURE TO UVA-1 & VISIBLE LIGHT
Living in stressfulenvironments overwhelms the body’s natural
defenses againstFR damage.Ongoing oxidative stress directly
relates to an increased rate of aging and eventual illness.
PRODUCT CLAIMS
• Environmental protection
• Smog protection
• Smoke protection
• Defending against nature’s elements
MICAH’S ROLE
Eliminates majority of light-induced ROS/FR to free up AOX package
to focus on neutralizing non-solar generated FR (ozone, pollutants,
sunscreens,alcohol, severe physical and emotional stress,poor
nutrition, obesity and toxins.

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Blue light: Quick takeaways
• The suncare market is ripe
for innovation
• Blue light is gaining traction
with consumers
• Blue light causes skin
photoaging similar to UVA

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Micah™
: Quick takeaways
• Micah’s mechanism
presents a new category
of suncare
• Offers the only protection
against blue light
• Proven through
clinical testing
• Easy to formulate
with and supports
multiple claims
• Effects match the needs
of key demographics

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Start a new chapter
in suncare
Learn what Micah™
can do for your products.
Contact Dennis Zlotnik at dzlotnik@hallstar.com today.