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ULCERATIVE COLITISREFRACTORY
{LEFT SIDED COLITIS}
DONEY JOSEPH

PHARMD INTERN
Ulcerative colitis is a chronic inflammation of the large intestine
(colon). The colon is the part of the digestive system where water
is removed from undigested material, and the remaining waste
material is stored
Left-sided colitis: As the name
suggests, inflammation extends from
the rectum up through the sigmoid and
descending colon, which are located in
the upper left part of the abdomen.
Signs and symptoms include bloody
diarrhoea, abdominal cramping and pain
on the left side
REASON FOR ADMISSION
History of loose stools since 1 week{8 times daily}, associated
with blood mixed stools
Patient is also a k/c/o of ulcerative colitis since 1.5 years{drug
induced}
No history of fever , anorexia , weight loss, vomiting, etc..
NSAID induced
No pallor/icterus
PREVIOUS REPORTS..
10/01/2013 : histopathology report of colon was Active
ulcerative colitis
On 1/09/2013: colonoscopy report was: ulcerative colitis left
sided
On 17/10/2013: biopsy report was : acute ulcerative colitis
DAY 1..
Bp:110/70 mmhg

pulse: 78bpm

CVS
RS
NAD
CNS
Adv:HB,ESR,PCV,TC,DC,RBS,PBS,SE,TSH,LFT,ECG,AntiHCV,Elisa
Plan for colonoscopy tomorrow
LAB REPORTS
Hematology
Hb- 9.3% ( 13-16g%)

Biochemistry
RBS- 77 mg/dl

WBC- 8200 (4000-11,000) cells/mm3

ElectrolytesSodium- 145 mmol/l
Potassium- 4.2mmol/l
Chloride- 99 mmol/l

DLC- N- 57%
B- 01%
M- 01%

E- 04%
L-37%

ESR- 50 mm/hr (0-10mm/hr)
Anti-HCV,ELISA- negative
PBS: Microcytic hypochromic anemia

Thyroid profile
T3: 1.28 (0.60- 1.81ng/ml)
T4: 7.7 ( 4.5- 10.9 mcg/ml)
TSH:0.69 (0.35- 5.5 IU/ML)
LFT:( mg/dl)
AST: 15 (0-40)

stool microscopy:
No inflammatory cells and parasite

ALT: 12 (0-40)

ova or cyst are not seen.

ALP: 204 (40-376)

ECG: WNL

Albumin: 3.4 ( 3.5-5)
MEDICATIONS..

Inj hydrocortisone iv q6h 100 mg
PROCTOCLYSIS-ENEMA
1-0-1
Capsule VSL3
1-0-0
Tablet mesalamine po 1.2mg 2-0-0
Tablet pantoprazole po 40mg 1-0-0
Tablet eldicet{Pinaverium} po 50 mg 1-0-1
DAY 2..
Bp:110/70 mmhg
CVS
RS
NAD
CNS

pulse: 80bpm

Patient passed stools mixed with blood, patient advised for
PROCTOCLYSIS-ENEMA for colonoscopy
Colonoscopy report: IBD- proctosigmoiditis
Ulcerative proctitis. In this form of ulcerative colitis,
inflammation is confined to the area closest to the anus
(rectum), and for some people, rectal bleeding may be the
only sign of the disease

Proctosigmoiditis. This form involves the rectum and
the lower end of the colon, known as the sigmoid colon..
DAY 3.

BP: 120/80mmhg
pulse:
78bpm
CVS
RS
NAD
CNS
P/A-soft , patient complains of blood mixed stools
ADV: CST
DAY 4.
Bp:120/80bpm

pulse: 80bpm

CVS
RS
NAD
CNS
Freequency of loose stools decreased, decreased amount of blood in the
stool
ADV:to stop Inj hydrocortisone
Started tablet Methylprednisolone 16 mg po 2-0-0
Tablet calcium carbonate
500 mg po 0-1-0
DAY 5..
Bp: 110/70mmhg

pulse: 78bpm

CVS
RS
NAD
CNS
P/A-soft, patient complaints of semi solid stools not associated
with blood{ 3-4} episodes
ADV:CST
DAY 6..

Bp: 120/80 mmhg

pulse: 80bpm

CVS
RS
NAD
CNS
Patient did not have any complaints of loose stools, no history of
blood in the stool
ADV: CST
PHARMACEUTICAL CARE PLAN
Subjective evidence
• Loose stools
associated with
blood
• k/c/o ulcerative
colitis

Objective evidence
• Colonoscopy report
• Histopathology
report
• Biopsy report
FINAL DIAGNOSIS

Based on subjective and objective evidence
ulcerative colitis with refractory – left sided
colitis
GOALS OF TREATMENT
Terminate the acute attack and induce clinical remission.
Maintain remission during quiescent symptom-free periods.
Control symptoms during symptomatic periods.
Prevent or control complications.
Avoid surgery, if possible.
Use the most cost-effective drug treatment.

Maintain or improve quality of life.
TREATMENT OPTIONS
Aminosalicylates:sulfasalazine {3-4g/day}
Mesalamine
Corticosteriods: hydrocortisone{300mg/day}, methyl
prednisolone{20-60mg/day}
Immunomodulators: Azathioprine{2-3mg/kg/day} ,6mercaptopurine{1-1.5mg/kg} , Methotrexate{25mg/week},
Antibiotics:Metronidazole
WHEN SURGERY INDICATED????
1. Fails to respond to medical management acutely or
chronically,
2. Develops uncontrollable drug-related complications,
3. Experiences impaired quality of life from the disease or its
drug therapy,
4. Develops carcinoma of the rectum or colon.
SURGICAL METHODS..
Total proctocolectomy with ileostomy :Total proctocolectomy
with ileostomy is surgery to remove all of the colon (large
intestine) and rectum. Then a hole in abdomen, called a stoma,
is made. Waste will move from the small intestine, out the
stoma, and into a plastic ostomy bag.
ILEAL POUCH ANAL ANASTOMOSIS
The most common procedure for ulcerative colitis is pelvic
pouch or ileal pouch anal anastomosis (IPAA). colon and
rectum will be removed. A new rectum, called a J-pouch, will
be fashioned out of small intestine. This type of surgery
allows to have bowel movements .
CONTINENT ILEOSTOMY:
The least common surgery for UC is continent ileostomy. Also
called the Kock pouch, it's a very technical surgery.. During
the procedure colon and rectum are removed. Small
intestine is used to create a holding place (reservoir) for
waste that will be drained from a valve in abdomen
GOALS ACHIEVED

No more episodes of loose stools and bloody
stools by day 6
PROBLEMS IDENTIFIED

Untreated anemia
MONITORING PARAMETERS
Weight
CBC
Colonoscopy
Glucose levels
Electrolytes level
PATIENT COUNSELLING
About disease:
signs and symptoms
risk factors
complications

About medications:

medication adherence
Possible side effects
LIFE STYLE MODIFICATIONS:
A well-balanced, nutritious diet can help maintain health and a
normal body weight.
Pain medications that contain nonsteroidal antiinflammatory drugs
(NSAIDS), such as ibuprofen and naproxen ,are not usually
recommended
Ulcerative Colitis

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Ulcerative Colitis

  • 1. ULCERATIVE COLITISREFRACTORY {LEFT SIDED COLITIS} DONEY JOSEPH PHARMD INTERN
  • 2. Ulcerative colitis is a chronic inflammation of the large intestine (colon). The colon is the part of the digestive system where water is removed from undigested material, and the remaining waste material is stored
  • 3. Left-sided colitis: As the name suggests, inflammation extends from the rectum up through the sigmoid and descending colon, which are located in the upper left part of the abdomen. Signs and symptoms include bloody diarrhoea, abdominal cramping and pain on the left side
  • 4. REASON FOR ADMISSION History of loose stools since 1 week{8 times daily}, associated with blood mixed stools Patient is also a k/c/o of ulcerative colitis since 1.5 years{drug induced} No history of fever , anorexia , weight loss, vomiting, etc.. NSAID induced No pallor/icterus
  • 5. PREVIOUS REPORTS.. 10/01/2013 : histopathology report of colon was Active ulcerative colitis On 1/09/2013: colonoscopy report was: ulcerative colitis left sided On 17/10/2013: biopsy report was : acute ulcerative colitis
  • 6. DAY 1.. Bp:110/70 mmhg pulse: 78bpm CVS RS NAD CNS Adv:HB,ESR,PCV,TC,DC,RBS,PBS,SE,TSH,LFT,ECG,AntiHCV,Elisa Plan for colonoscopy tomorrow
  • 7. LAB REPORTS Hematology Hb- 9.3% ( 13-16g%) Biochemistry RBS- 77 mg/dl WBC- 8200 (4000-11,000) cells/mm3 ElectrolytesSodium- 145 mmol/l Potassium- 4.2mmol/l Chloride- 99 mmol/l DLC- N- 57% B- 01% M- 01% E- 04% L-37% ESR- 50 mm/hr (0-10mm/hr) Anti-HCV,ELISA- negative PBS: Microcytic hypochromic anemia Thyroid profile T3: 1.28 (0.60- 1.81ng/ml) T4: 7.7 ( 4.5- 10.9 mcg/ml) TSH:0.69 (0.35- 5.5 IU/ML)
  • 8. LFT:( mg/dl) AST: 15 (0-40) stool microscopy: No inflammatory cells and parasite ALT: 12 (0-40) ova or cyst are not seen. ALP: 204 (40-376) ECG: WNL Albumin: 3.4 ( 3.5-5)
  • 9. MEDICATIONS.. Inj hydrocortisone iv q6h 100 mg PROCTOCLYSIS-ENEMA 1-0-1 Capsule VSL3 1-0-0 Tablet mesalamine po 1.2mg 2-0-0 Tablet pantoprazole po 40mg 1-0-0 Tablet eldicet{Pinaverium} po 50 mg 1-0-1
  • 10. DAY 2.. Bp:110/70 mmhg CVS RS NAD CNS pulse: 80bpm Patient passed stools mixed with blood, patient advised for PROCTOCLYSIS-ENEMA for colonoscopy Colonoscopy report: IBD- proctosigmoiditis
  • 11. Ulcerative proctitis. In this form of ulcerative colitis, inflammation is confined to the area closest to the anus (rectum), and for some people, rectal bleeding may be the only sign of the disease Proctosigmoiditis. This form involves the rectum and the lower end of the colon, known as the sigmoid colon..
  • 12. DAY 3. BP: 120/80mmhg pulse: 78bpm CVS RS NAD CNS P/A-soft , patient complains of blood mixed stools ADV: CST
  • 13. DAY 4. Bp:120/80bpm pulse: 80bpm CVS RS NAD CNS Freequency of loose stools decreased, decreased amount of blood in the stool ADV:to stop Inj hydrocortisone Started tablet Methylprednisolone 16 mg po 2-0-0 Tablet calcium carbonate 500 mg po 0-1-0
  • 14. DAY 5.. Bp: 110/70mmhg pulse: 78bpm CVS RS NAD CNS P/A-soft, patient complaints of semi solid stools not associated with blood{ 3-4} episodes ADV:CST
  • 15. DAY 6.. Bp: 120/80 mmhg pulse: 80bpm CVS RS NAD CNS Patient did not have any complaints of loose stools, no history of blood in the stool ADV: CST
  • 17. Subjective evidence • Loose stools associated with blood • k/c/o ulcerative colitis Objective evidence • Colonoscopy report • Histopathology report • Biopsy report
  • 18. FINAL DIAGNOSIS Based on subjective and objective evidence ulcerative colitis with refractory – left sided colitis
  • 19. GOALS OF TREATMENT Terminate the acute attack and induce clinical remission. Maintain remission during quiescent symptom-free periods. Control symptoms during symptomatic periods. Prevent or control complications. Avoid surgery, if possible. Use the most cost-effective drug treatment. Maintain or improve quality of life.
  • 20. TREATMENT OPTIONS Aminosalicylates:sulfasalazine {3-4g/day} Mesalamine Corticosteriods: hydrocortisone{300mg/day}, methyl prednisolone{20-60mg/day} Immunomodulators: Azathioprine{2-3mg/kg/day} ,6mercaptopurine{1-1.5mg/kg} , Methotrexate{25mg/week}, Antibiotics:Metronidazole
  • 21. WHEN SURGERY INDICATED???? 1. Fails to respond to medical management acutely or chronically, 2. Develops uncontrollable drug-related complications, 3. Experiences impaired quality of life from the disease or its drug therapy, 4. Develops carcinoma of the rectum or colon.
  • 22. SURGICAL METHODS.. Total proctocolectomy with ileostomy :Total proctocolectomy with ileostomy is surgery to remove all of the colon (large intestine) and rectum. Then a hole in abdomen, called a stoma, is made. Waste will move from the small intestine, out the stoma, and into a plastic ostomy bag.
  • 23. ILEAL POUCH ANAL ANASTOMOSIS The most common procedure for ulcerative colitis is pelvic pouch or ileal pouch anal anastomosis (IPAA). colon and rectum will be removed. A new rectum, called a J-pouch, will be fashioned out of small intestine. This type of surgery allows to have bowel movements .
  • 24. CONTINENT ILEOSTOMY: The least common surgery for UC is continent ileostomy. Also called the Kock pouch, it's a very technical surgery.. During the procedure colon and rectum are removed. Small intestine is used to create a holding place (reservoir) for waste that will be drained from a valve in abdomen
  • 25. GOALS ACHIEVED No more episodes of loose stools and bloody stools by day 6
  • 28. PATIENT COUNSELLING About disease: signs and symptoms risk factors complications About medications: medication adherence Possible side effects
  • 29. LIFE STYLE MODIFICATIONS: A well-balanced, nutritious diet can help maintain health and a normal body weight. Pain medications that contain nonsteroidal antiinflammatory drugs (NSAIDS), such as ibuprofen and naproxen ,are not usually recommended