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The Neural
Correlates of
Executive
Function
1
(Berride & Arnsten, 2015)
Prefrontal Cortex
Prefrontal Cortex is Responsible for Executive Function
(Kuo, et al., 2008; Miller & Cohen, 2001)
Executive Function
• Plays an important role in cognitive control
• Is involved in supervisory attention
• Orchestrates thought and action according
to internal goals
• Provides top-down bias signals to other
brain structures to guide the flow of activity
along neural pathways
2
(Berride & Arnsten, 2015)
Create Plans Engages
Prefrontal Cortex
(Jensen, 2009; Brundidge, 2014) 3
ozella.brundidge@gmail.com 4/13/2017
Capacity to Hold
Thoughts in
Mind
Make Decisions
Observe
Behaviors
Follow Rules
Post-Pone
Gratification
Hold Thoughts
in Mind
Working Memory
Capacity to Defer
Gratification
Reset the Brain’s Rules
for Behavior under
Different Circumstances
Executive System
Prefrontal Cortex
Executive Control System
• Divided attention
• Working memory
• Conceptual transfer
• Feedback utilization
• Selective attention
• Self-regulation
• Self-monitoring
• Inhibition
• Initiative
• Conceptual reasoning
• Planning
• Strategic organization
• Efficiency
• Fluency
• Speed of processing
Cognitive Flexibility
Attentional Control
Goal Setting
Information Processing
(Anderson, 2002, 2008 in Anderson & Reid, 2012, Figure 1, p.3) 4
(Coppin, n.d.)
Prefrontal Cortex
Executive Function Construct is Composed of Multiple
Inter-Related High Functioning Cognitive Skills
Formulating
Goals
Carrying Out Planned
Goals Effectively
(Anderson, 2002, 2008; Lezak, 1982; Welsh & Pennington, 1988 in Anderson & Reidy, 2012; Building Furniture for
American Girl Dolls, nd; Family Wealth and Legacy, LLC , 2017; Edusol, 2017 ) 5
Planning Out How
to Achieve Goals
Executive Function (EF)Key Elements of the Executive Function System
(Anderson, 2002, 2008; Lezak, 1982; Welsh & Pennington, 1988 in Anderson & Reidy, 2012)
Attention
&
Initiation of
Activity
Working
Memory
& &
Monitoring
Performance
Selection of Sufficient
Problem-Solving
Strategies
6
Anticipation
and
Deployment of
Elementary Abilities Play a Pivotal Role in Executive Function (EF)
Cognitive planning encompasses the neurological processes involved in the
formulation, evaluation and selection of a sequence of thoughts and actions to
achieve a desired goal.
Problem solving refers to how a child perceives, thinks, gains understanding of
his or her world, and includes remembering and decision-making.
(Rose, et al., 2011; Sprouts Development, 2014; Wikipedia, 28 January 2017; Mental Health Daily, 2016; Stonsny, 28 October 2011)
Cognitive Planning
Problem Solving
Elementary Abilities Play a Pivotal Role in Executive Function (EF)
• Cognitive flexibility refers to the brain's ability to transition from thinking about
one concept to another.
• The quicker a child is able to switch or “shift” her thinking from one dimension to
another the greater her level of cognitive flexibility.
• Behaviorally, self-regulation is the ability to act in your long-term best interest,
consistent with your deepest values.
• Emotionally, self-regulation is the ability to calm yourself down when you're upset
and cheer yourself up when you're down.
(Rose, et al., 2011; Sprouts Development, 2014; Wikipedia, 28 January 2017; Mental Health Daily, 2016; Stonsny, 28 October 2011)
Cognitive
Flexibility
Self-Regulation
Nonverbal Disabilities that are Associated with Executive Function
9
Nonverbal Learning Disabilities such as Visuospatial and
Visuomotor deficits, are Reportedly on a Continuum with
Attention and Executive Functioning Disorders. These deficits
and disorders may negatively affect Academic Performance
and Social Interactions.
(Taylor, Klein, Minich, Hack, 2000 in Cserjesi, et al., 2012)
Adult Cortical Areas Activated while Performing Tasks Requiring
Attention for Cognition
Brodmann Area
Cortical Area
Left-
Hemisphere
Right-
Hemisphere
BA 6
Premotor & Supplementary
Motor Area
 yes  yes
BA 7
Precuneus/Somatosensory
Cortex
 yes  yes
BA 9
Guenon/Dorsolateral
Prefrontal Cortex
 yes  yes
BA 19
Tertiary Visual Association
Area (V3)
 yes No
BA 40
Supramarginal Gyrus
 yes  yes
(Lloyd, 2007; Wright, 1976; Wikimedia Commons, 2012; Wikipedia, 26, July 2017; DynamicBrain, 2017) 10
BA 9
BA 19
BA 40
Frontal
cortex
The Left Thalamus is Activate while Performing Verbal Working Memory
Tasks and both Thalamus are Active during Executive Function Tasks
(Fulton, 2013; Jensen, 2005; Awh, et al., 1996; Smith, et al., 1996; Mandal, Sep 17, 2014) 11
The Thalamus:
• Is located just above the brain stem between the
cerebral cortex and the midbrain
• Relays sensory and motor signals to the cerebral
cortex
• Is responsible for regulating consciousness,
sleep, and alertness
Left
Thalamus
Bailey, R. (2017, August 07)
Right
Thalamus
Executive System’s Verbal Working Memory Model
12
Dorsolateral Prefrontal
• A context-independent and highly
transferable skill
• Ability to rapidly adjust strategies and thought processes from one
context to another
• Ability to draw inferences and understand relationships between
concepts outside of the formal, specific instruction, and practice related
to those concepts
(Jensen, 2009)
13
Relationship Between Fluid Intelligence and
Executive Functions
14(Goitia, Manes, Torralva, Sigman, Duncan, Cetkovich, & Roca, 2017; Lindner, et al., 2016)
• Frontal deficits are entirely explained by Fluid Intelligence (g) for
some classical executive tasks – Verbal Fluency, Trail Making Test B,
and the Wisconsin Card Sorting Test.
• However, other executive tasks, including tests of multitasking,
decision making, and social cognition deficits go beyond those
predicted by fluid intelligence loss.
The Frontal Lobe is Functional during both
Fluid Intelligence and Executive Function Activities
• Multitasking and Social Cognition
tasks can be used to reveal Anterior
Prefrontal (BA 10) Deficits
• While Dorsolateral (BA 9) deficits
are associated with Fluid Intelligence
(g) and classical executive deficits
15
Goitia, Manes, Torralva, Sigman, Duncan, Cetkovich, & Roca, 2017; Roca et al., 2010 in 2017
BA 10
Wikipedia August 6, 2017)
BA 9
Executive Function Tasks Engage the Cerebellum
A Major Component of Cerebellar Output Targets Nonmotor Areas of the Cerebral Cortex
16
Attention
Executive
Control
Working
Memory
(Strick, Dum, & Fiez, 2009; Glickstein 2007, Timmann & Daum 2007)
Regulate
Emotions
Nonmotor Effects of Cerebellar Damage are
Associated with Executive Function Activities
17
Attention
Executive
Control
Working
Memory
(Timmann & Daum 2007 in Strick, et al., 2009)
Researchers found a Relationship
between Damaged Cerebellar and
Impairments on Standardized
Measures of:
LBW, PT birth, and SGA infants were more likely to have significantly lower performance on cognitive
skills underlying school readiness
18
(Caravale, Mirante, Vagnoni, & Vicari, 2012; Michel, Roethlisberger, Neuenschwander, & Robers, 2011; Rose,
Feldman, Jankowski, & Van Rossem, 2008)
AttentionMemory
Thinking
Processing
Sensory
Information
ozella.brundidge@gmail.com 5/18/2017
Executive
Functions
Inhibition
Updating
Shifting
Nonlinguistic
Abilities
Visual-Motor
Integration
Visual Perceptual
(Worldasrtsme.com, nd)
Recall
Recognition
Representational
Competence
Early Cognitive
Skills to Look for in
Young Children
Visuospatial
End of
Executive
Function
Improved survival rate in preterm
infants has broadened research in
executive function, cognitive skills,
and neuropsychological outcomes.
19
(Berride & Arnsten, 2015)
(Aylward. 2002)

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The neural correlates of executive function

  • 1. The Neural Correlates of Executive Function 1 (Berride & Arnsten, 2015) Prefrontal Cortex
  • 2. Prefrontal Cortex is Responsible for Executive Function (Kuo, et al., 2008; Miller & Cohen, 2001) Executive Function • Plays an important role in cognitive control • Is involved in supervisory attention • Orchestrates thought and action according to internal goals • Provides top-down bias signals to other brain structures to guide the flow of activity along neural pathways 2 (Berride & Arnsten, 2015)
  • 3. Create Plans Engages Prefrontal Cortex (Jensen, 2009; Brundidge, 2014) 3 ozella.brundidge@gmail.com 4/13/2017 Capacity to Hold Thoughts in Mind Make Decisions Observe Behaviors Follow Rules Post-Pone Gratification Hold Thoughts in Mind Working Memory Capacity to Defer Gratification Reset the Brain’s Rules for Behavior under Different Circumstances Executive System Prefrontal Cortex
  • 4. Executive Control System • Divided attention • Working memory • Conceptual transfer • Feedback utilization • Selective attention • Self-regulation • Self-monitoring • Inhibition • Initiative • Conceptual reasoning • Planning • Strategic organization • Efficiency • Fluency • Speed of processing Cognitive Flexibility Attentional Control Goal Setting Information Processing (Anderson, 2002, 2008 in Anderson & Reid, 2012, Figure 1, p.3) 4 (Coppin, n.d.) Prefrontal Cortex
  • 5. Executive Function Construct is Composed of Multiple Inter-Related High Functioning Cognitive Skills Formulating Goals Carrying Out Planned Goals Effectively (Anderson, 2002, 2008; Lezak, 1982; Welsh & Pennington, 1988 in Anderson & Reidy, 2012; Building Furniture for American Girl Dolls, nd; Family Wealth and Legacy, LLC , 2017; Edusol, 2017 ) 5 Planning Out How to Achieve Goals
  • 6. Executive Function (EF)Key Elements of the Executive Function System (Anderson, 2002, 2008; Lezak, 1982; Welsh & Pennington, 1988 in Anderson & Reidy, 2012) Attention & Initiation of Activity Working Memory & & Monitoring Performance Selection of Sufficient Problem-Solving Strategies 6 Anticipation and Deployment of
  • 7. Elementary Abilities Play a Pivotal Role in Executive Function (EF) Cognitive planning encompasses the neurological processes involved in the formulation, evaluation and selection of a sequence of thoughts and actions to achieve a desired goal. Problem solving refers to how a child perceives, thinks, gains understanding of his or her world, and includes remembering and decision-making. (Rose, et al., 2011; Sprouts Development, 2014; Wikipedia, 28 January 2017; Mental Health Daily, 2016; Stonsny, 28 October 2011) Cognitive Planning Problem Solving
  • 8. Elementary Abilities Play a Pivotal Role in Executive Function (EF) • Cognitive flexibility refers to the brain's ability to transition from thinking about one concept to another. • The quicker a child is able to switch or “shift” her thinking from one dimension to another the greater her level of cognitive flexibility. • Behaviorally, self-regulation is the ability to act in your long-term best interest, consistent with your deepest values. • Emotionally, self-regulation is the ability to calm yourself down when you're upset and cheer yourself up when you're down. (Rose, et al., 2011; Sprouts Development, 2014; Wikipedia, 28 January 2017; Mental Health Daily, 2016; Stonsny, 28 October 2011) Cognitive Flexibility Self-Regulation
  • 9. Nonverbal Disabilities that are Associated with Executive Function 9 Nonverbal Learning Disabilities such as Visuospatial and Visuomotor deficits, are Reportedly on a Continuum with Attention and Executive Functioning Disorders. These deficits and disorders may negatively affect Academic Performance and Social Interactions. (Taylor, Klein, Minich, Hack, 2000 in Cserjesi, et al., 2012)
  • 10. Adult Cortical Areas Activated while Performing Tasks Requiring Attention for Cognition Brodmann Area Cortical Area Left- Hemisphere Right- Hemisphere BA 6 Premotor & Supplementary Motor Area  yes  yes BA 7 Precuneus/Somatosensory Cortex  yes  yes BA 9 Guenon/Dorsolateral Prefrontal Cortex  yes  yes BA 19 Tertiary Visual Association Area (V3)  yes No BA 40 Supramarginal Gyrus  yes  yes (Lloyd, 2007; Wright, 1976; Wikimedia Commons, 2012; Wikipedia, 26, July 2017; DynamicBrain, 2017) 10 BA 9 BA 19 BA 40 Frontal cortex
  • 11. The Left Thalamus is Activate while Performing Verbal Working Memory Tasks and both Thalamus are Active during Executive Function Tasks (Fulton, 2013; Jensen, 2005; Awh, et al., 1996; Smith, et al., 1996; Mandal, Sep 17, 2014) 11 The Thalamus: • Is located just above the brain stem between the cerebral cortex and the midbrain • Relays sensory and motor signals to the cerebral cortex • Is responsible for regulating consciousness, sleep, and alertness Left Thalamus Bailey, R. (2017, August 07) Right Thalamus
  • 12. Executive System’s Verbal Working Memory Model 12 Dorsolateral Prefrontal
  • 13. • A context-independent and highly transferable skill • Ability to rapidly adjust strategies and thought processes from one context to another • Ability to draw inferences and understand relationships between concepts outside of the formal, specific instruction, and practice related to those concepts (Jensen, 2009) 13
  • 14. Relationship Between Fluid Intelligence and Executive Functions 14(Goitia, Manes, Torralva, Sigman, Duncan, Cetkovich, & Roca, 2017; Lindner, et al., 2016) • Frontal deficits are entirely explained by Fluid Intelligence (g) for some classical executive tasks – Verbal Fluency, Trail Making Test B, and the Wisconsin Card Sorting Test. • However, other executive tasks, including tests of multitasking, decision making, and social cognition deficits go beyond those predicted by fluid intelligence loss.
  • 15. The Frontal Lobe is Functional during both Fluid Intelligence and Executive Function Activities • Multitasking and Social Cognition tasks can be used to reveal Anterior Prefrontal (BA 10) Deficits • While Dorsolateral (BA 9) deficits are associated with Fluid Intelligence (g) and classical executive deficits 15 Goitia, Manes, Torralva, Sigman, Duncan, Cetkovich, & Roca, 2017; Roca et al., 2010 in 2017 BA 10 Wikipedia August 6, 2017) BA 9
  • 16. Executive Function Tasks Engage the Cerebellum A Major Component of Cerebellar Output Targets Nonmotor Areas of the Cerebral Cortex 16 Attention Executive Control Working Memory (Strick, Dum, & Fiez, 2009; Glickstein 2007, Timmann & Daum 2007) Regulate Emotions
  • 17. Nonmotor Effects of Cerebellar Damage are Associated with Executive Function Activities 17 Attention Executive Control Working Memory (Timmann & Daum 2007 in Strick, et al., 2009) Researchers found a Relationship between Damaged Cerebellar and Impairments on Standardized Measures of:
  • 18. LBW, PT birth, and SGA infants were more likely to have significantly lower performance on cognitive skills underlying school readiness 18 (Caravale, Mirante, Vagnoni, & Vicari, 2012; Michel, Roethlisberger, Neuenschwander, & Robers, 2011; Rose, Feldman, Jankowski, & Van Rossem, 2008) AttentionMemory Thinking Processing Sensory Information ozella.brundidge@gmail.com 5/18/2017 Executive Functions Inhibition Updating Shifting Nonlinguistic Abilities Visual-Motor Integration Visual Perceptual (Worldasrtsme.com, nd) Recall Recognition Representational Competence Early Cognitive Skills to Look for in Young Children Visuospatial
  • 19. End of Executive Function Improved survival rate in preterm infants has broadened research in executive function, cognitive skills, and neuropsychological outcomes. 19 (Berride & Arnsten, 2015) (Aylward. 2002)

Editor's Notes

  1. Executive function is controlled by the prefrontal cortex which exerts a top-down guidance of attention, thought, action, and emotion.
  2. The executive function (EF) system located in the prefrontal cortex provides top-down bias signals to other brain structures to guide the flow of activity along neural pathways. Berride, C. W. & Arnsten, A. F. T. (2015). Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function. Current Opinion in Behavioral Sciences, 4, 33-40. https://doi.org/10.1016/j.cobeha.2015.01.002 Miller, E. K. & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167-202. https://doi.org/10.1146/annurev.neuro.24.1.167 Coppin, P. (n.d.) Prefrontal cortex. http://www.edtech.engineering.utoronto.ca/object/prefrontal-cortex
  3. The four categories of the executive control system are cognitive flexibility, attentional control, goal setting, and information processing.
  4. The EF construct is composed of multiple inter-related high functioning cognitive skill such as formulating goals, planning, and carrying out planned goals. Edusol (2017). Plan goal. Employability Enhancement Program. http://www.edusolacademy.in/employability_pgm.php Family Wealth and Legacy, LLC (2017). Step Two: Formulate your Goals and Objectives. http://familywealthandlegacy.com/page/formulate-your-goals-and-objectives Building Furniture for American Girl Dolls (n.d). Girl with doll house. https://www.pinterest.com/pin/308848486924758044/?lp=true Refer to sociodramatic play
  5. The key elements of the EF system including initiation of activity, working memory, attention, mental flexibility, self-regulation, and monitoring of performance.
  6. Cognitive flexibility – from Mental Health Daily Mental Health Blog (2016). What Is Cognitive Flexibility http://mentalhealthdaily.com/2015/07/24/ what-is-cognitive-flexibility/ Self-regulation – Stosny, S. (Oct 28, 2011). Self-Regulation-To feel better, focus on what is most important. Psychology Today blog. Retrieved from https://www.psychology today.com/blog/anger-in-the-age-entitlement/201110/self-regulation Cognitive planning – Wikipedia (28 January 2017). Planning (cognitive). Retrieved from https://en.wikipedia.org/wiki/Planning_(cognitive) Problem solving – Sprouts Development (2014). Problem Solving Skills. Retrieved from http://sproutsdevelopment.com/resources/problem-solving/
  7. Cognitive flexibility – from Mental Health Daily Mental Health Blog (2016). What Is Cognitive Flexibility http://mentalhealthdaily.com/2015/07/24/ what-is-cognitive-flexibility/ Self-regulation – Stosny, S. (Oct 28, 2011). Self-Regulation-To feel better, focus on what is most important. Psychology Today blog. Retrieved from https://www.psychology today.com/blog/anger-in-the-age-entitlement/201110/self-regulation Cognitive planning – Wikipedia (28 January 2017). Planning (cognitive). Retrieved from https://en.wikipedia.org/wiki/Planning_(cognitive) Problem solving – Sprouts Development (2014). Problem Solving Skills. Retrieved from http://sproutsdevelopment.com/resources/problem-solving/
  8. Nonverbal disabilities such as visuospatial and visuomotor deficits are on the same continuum with attention and EF disorders. Nonverbal learning disabilities is considered to be on a continuum with executive functioning and attention disorders, and may hinder academic performance as well as social interactions (Taylor, Klein, Minich, Hack, 2000).
  9. In adults, the most active cortical area while performing tasks requiring attention for cognition are the left premotor and supplementary motor areas (BA 6). Other cortical areas active to a lesser extent are the right BA 6, and the precuneus/somatosensory cortex, guenon/dorsolateral prefrontal cortex, tertiary visual association area, and supramarginal gyrus bilaterally. DynamicBrain (2017). Motor cortex. https://www.dynamicbrain.ca/brain-anatomy-images.html Wikipedia (26, July 2017) Brodmann area 9. Wikipedia. https://en.wikipedia.org/wiki/Brodmann_area_9 Wikimedia Commons (28 September 2012). Broadman area 19. https://commons.wikimedia.org/wiki/Category:Brodmann_area_19#/media/File:BA17,18,19_-_Visual_cortex_(V1,_V2,_V3)_-_lateral_view.png Wright, A. (1976). Brodman are 40. Chapter 8: Higher Cortical Functions: Language. http://nba.uth.tmc.edu/neuroscience/s4/chapter08.html
  10. The left thalamus is activated by verbal working memory tasks which are controlled by the EF system. Mandal, A. (2014). What is the Thalamus? News Medical.Net. https://www.news-medical.net/health/What-is-the-Thalamus.aspx Bailey, R. (August 07, 2017). Get a Description and Diagram of Thalamus Gray Matter. ThoughtCo. https://www.thoughtco.com/thalamus-anatomy-373229
  11. The dorsolateral prefrontal (Guenon BA 9), Broca’s area BA 45 and BA 46, angular cingulate, and the left thalamus are components of the EF system’s verbal working memory model.
  12. Fluid intelligence encompasses problem solving, pattern recognition, abstract thinking, reasoning skills, and ability to draw inferences and understand relationships. Bipolar disorder …lesions in lateral and dorsomedial frontal regions impair the performance in fluid intelligence tests (Duncan et al., 1995; Woolgar et al., 2010) and similar regions are active in functional imaging studies of fluid intelligence test performance (Bishop et al., 2008; Duncan et al., 2000; Esposito et al., 1999; Prabhakaran et al.,1997). In Goitia, Manes, Torralva, Sigman, Duncan, Cetkovich, & Roca, 2017
  13. There is a relationship between fluid intelligence and executive functions. Frontal lobe deficits are entirely explained by fluid intelligence (g) when using some classical executive tasks such as verbal fluency, Trail Making Test B, and the Wisconsin Card Sorting Test. However, multitasking, decision making, and social deficits are EF tasks that exceed those predicted by fluid intelligence loss. Lindner, P., Carlbring, P., Flodman, E., Hebert, A., Poysti, S., Hagkvist, F., Johansson, R., Does cognitive flexibility predict treatment gains in Internet-delivered psychological treatment of social anxiety disorder, depression, or tinnitus? PeerJ Computer Science. https://peerj.com/articles/1934/ tests of multitasking and of social cognition, are not explained by differences in g. Roca M1, Manes F2, Cetkovich M2, Bruno D3, Ibáñez A4, Torralva T2, Duncan J5. The relationship between executive functions and fluid intelligence in schizophrenia. Front Behav Neurosci. 2014 Feb 24;8:46. doi: 10.3389/fnbeh.2014.00046 Goitia, B., Manes, F., Torralva, T., Sigman, M., Duncan, J., Cetkovich, M., & Roca, M. (2017). The relationship between executive functions and fluid intelligence in euthymic Bipolar Disorder patients. Psychiatric Research, 257(2017), 346-351. http://dx.doi.org/10.1016/j.psychres.2017.07.066
  14. The frontal lobe is functional during both fluid intelligence and executive function activities. Brodmann area 10. https://en.wikipedia.org/wiki/Brodmann_area_10
  15. At the same time, a close examination of this neuropsychological literature reveals a high degree of inconsistency (Burk 2007, Frank et al. 2007, Glickstein 2007 in 2009) Lesions that damage cerebellar tissue, which is interconnected with area 46, are unlikely to cause motor deficits, just as lesions that damage cerebellar tissue, which is interconnected with M1, are unlikely to result in cognitive deficits (2009)
  16. Michel, E., Roethlisberger, M., Neuenschwander, R., & Roebers, C. M. (2011). Development of Cognitive Skills in Children with Motor Coordination Impairments at 12-Month Follow-up. Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 17(2). doi: 10.1080/09297049.2010.525501 Worldartsme.com (nd). Hands on manipulatives. Retrieved from http://worldartsme.com/images/hands-on-manipulatives-clipart-1.jpg Wooden activity cube toy bead shape sorter xylophone clock educational toddler. Retrieved from https://i.ebayimg.com/00/s/ODAwWDYwMA==/z/3xwAAOSw4CFYx-Kb/$_58.JPG Dreamstimes (2017). Colorful train with happy smiling kid on and colorful pencils, playing blocks, ABC book, numbers for preschool active learning. Retrieved from https://teachingsexed.files.wordpress.com/2014/03/meaningful-engagement.jpg Ebay (2017). Children born preterm, small for gestational age, or with low birth weight have significantly lower cognitive school readiness after controlling for social factors and prenatal risks. Retrieved from https://www.ebay.co.uk/p/8189-active-cube-sun-preschool-learning-toys-by-legler/1934697559
  17. The prefrontal cortex functions as a top-down guidance of attention, thought, action, and emotion.