Working memory mentally holds and processes incoming information from the sensory organs. Memory is directly related to an infant's mental development index. Premature birth affect hippocampus volume and working memory. However, working memory impairment is mostly associated with diffused white matter damage. The main components of working memory are the central executive, phonological loop, visuo-spatial sketchpad, and episodic buffer. A toddler's working memory and Wernicke's area becomes fully functional around the age of 10 months. The left Wernicke's area is a shared substrate for auditory short-term memory and speech comprehension. They both assist in the development of vocabulary skills. Working memory tasks also activate the supramarginal gyrus bilaterally. Auditory verbal short-term memory and language processing are mediated by the same areas on the left perisylvian cortex. Adolescents exhibit greater activation than young adults in the motor and premotor corticle areas during verbal working memory tasks. They exhibit greater activity than children in the parietal corticle area and the cerebellum during verbal working memory tasks. The lower premotor area is also active during working memory and silent rehearsal. Researchers have found that temporary storage of sentences is linked to activity in the left temporo-parietal region. While the Broca's area was found to be linked to word ordering rather than temporary storage. Spatial working memory tasks activate the right dorso-lateral and medial prefrontal grey matter. Visuo-spatial working memory is dependent upon the integrity of the superior frontal-intraparital network, primary motor cortex, somatosensory, and multiple grey and white matter regions in the frontal and parietal cortices. In conclusion, there are at least three working memory perception-action loops for language processing; one for phonology, another one for sentence processing, and a separate one for semantics.
1. Neural Correlates
of
Working Memory
(Andrews, 2014, August 26)
Working memory mentally holds and process incoming information
from the sensory organs. Houde, et al., 2010
ozella.brundidge@gmail.com 8/20/2017
1
2. Memory is Directly Related to the Mental Development Index
Recognition
Recall
Memory is vital for storage, consolidation, and retrieving representations of objects and events.
Preterms’ are vulnerable to injury from ischemic hypoxia, characterized by a reduction of
blood to the brain. They perform poorer than full-term controls on Pattern Recognition, and
significantly poorer on the Delayed Matched-to-Sample and Spatial Recognition assessments.
2
Aspects of Memory that are
Dependent on the Hippocampus
and Associated Structures
are two
(Rose, Feldman, Jankowski, & Van Rossem, 2011; Volpe, 1995)
&
ozella.brundidge@gmail.com 8/20/2017
3. A previous study revealed a significant
relationship between hippocampal volumes
and Working Memory deficits in 2 year-old
toddlers who were born very premature (30
weeks gestation or weighing <1250 grams).
(Beauchamp, Thompson, Howard, Doyle, Egan, Inder, Anderson, 2008)
Premature Birth Affect Hippocampus Volume and
Working Memory Ability
3
ozella.brundidge@gmail.com 8/20/2017
4. Working Memory Impairment is Associated mostly with
Diffused White Matter Damage
Damage to Diffused White Matter
• Is common in 2nd and 3rd trimester
births
• Affects the connectivity between
distant cortical areas
(Lubsen, Vohr, Myers, Hampson, Lacadie, Schneider, Katz, Constable, & Ment, 2011)
4
Dreamstime, 2015
ozella.brundidge@gmail.com 8/20/2017
5. Central Executive (CE) Master controller which focuses our attention
Phonological Loop (PL) Temporary storage and rehearsal of verbal and
auditory information
Visuo-Spatial Sketchpad Temporary storage of visual and spatial
information
Episodic Buffer Allows the CE, PL, and VSS to interact with each
other and information in long term memory to
facilitate comprehension
Components of Working Memory
(Memorizingmusic.com, February 4, 2013; Baddeley, 2012 in 2013)
(VSS)
ozella.brundidge@gmail.com 8/20/2017 5
6. Working Memory Model
6
Sensory Memory
Working Memory
Attention
Central
Executive
Phonological
Loop
Visuo-spatial
Sketchpad
Episodic
Buffer
Long Term Memory
Encoding Retrieval
(Memorizingmusic.com, Feburary 4, 2013; Baddeley, 2012 in 2013) ozella.brundidge@gmail.com 8/20/2017
7. (Sousa, 2005; Jensen, 2009; Jobard, et al., 2003; Barde, et al., 2012; Leff, Schofield,, Crinion et al. 2009; Wright, et al., 2012)
7
Working Memory and the Wernicke’s area
also become functional around the age of 10
Months. They are able to attach meaning to
toddlers’ newly acquired vocabulary.
(Amy Lynn, n.d.)
By 10 to 12 Months old the Toddler’s Brain is able to
Distinguish and Remember Phonemes
ozella.brundidge@gmail.com 8/20/2017
8. Left Wernicke’s Area (pSTG) is a Shared Substrate for
Auditory Short-Term Memory and Speech Comprehension
(Barde, Yeatman, Lee, Glover, & Feldman, 2012; Leff, Schofield, Crinion, Seghier, Grogan, Green, &
Price, 2009; Wright, Stamatakis, & Tyler, 2012)
Immediate
Memory
Working
Memory
8
Navigate Your Life, n.d.
pSTG – Posterior Superior Temporal Gyrus
Two Types of
Auditory Short-Term Memory
ozella.brundidge@gmail.com 8/20/2017
9. (Sousa, 2005; Jensen, 2009; Jobard, et al., 2003; Hickock, Bushsbaum, & Humphries, 2003; Buschsaum & D’Eposito, 2008;
Bavelier, Newport, & Supalla, 2003)
Working Memory and Wernicke’s Area Assist in the
Development of Vocabulary Skills
9
(Bavelier, 2003)
ozella.brundidge@gmail.com 8/20/2017
11. Auditory Verbal Short-Term Memory and Language Processing are
Mediated by the same Areas on the Left Perisylvian Cortex
(Koenigs, Acheson, Barbey, Solomon, Postle, Grafman, 2011; Bavelier, Newport, & Supalla, 2003; Vigneau, et al., 2006)
11
Posterior Superior Temple
Region of the Perisylvian
Cortex
Inferior Frontal Region of
the Left Perisylvian Cortex
(2003)
ozella.brundidge@gmail.com 8/20/2017
12. Areas of the Left Perisylvian Cortex
Mediate Auditory-Verbal Short-Term Memory
The yellow color indicates voxels where damage is associated with Significantly Lower
Digit Span. Significant voxels were found only in left perisylvian cortex.
12
(Koenigs, Acheson, Barbey, Solomon, Postle, & Grafman, 2011, Figure 1)
Voxel-based Lesion Symptom Mapping (VLSM) Analysis revealed Areas where Damage is
Associated with Significantly Lower Digit Span Scores.
ozella.brundidge@gmail.com 8/20/2017
13. Adolescents Exhibit Greater Activity than Young Adults in the
Motor and Premotor Cortical Areas during Verbal Working Memory Tasks
13
Adolescents (11-15 yo) performed a parametric of Sternberg’s working memory task while undergoing a functional
magnetic resonance imaging (MRI) procedure. Imaging data revealed activation in the frontal lobe’s Motor (BA4)
and Premotor (BA 6) areas.
(O’Hare, Lu, Houston, Bookheimer, & Sowell, 2008)
Figure 3 panel C, p. 14
ozella.brundidge@gmail.com 8/20/2017
14. Adolescents Exhibit Greater Activity than Children in the
Parietal Cortical Area and the Cerebellum during Verbal Working Memory Tasks
14
(O’Hare, Lu, Houston, Bookheimer, & Sowell, 2008)
Figure 3 panel C, p. 14
Adolescents (11-15 yo) performed a parametric of Sternberg’s working memory task while undergoing a functional
magnetic resonance imaging (MRI) procedure. Imaging data revealed activation in the parietal lobe and the
cerebellum.
ozella.brundidge@gmail.com 8/20/2017
15. Premotor Cortex is Brodmann Area (BA 6)
The lower premotor area is activated during
• Working memory
• Silent rehearsal
(Vigneau, Beaucousin, Herve, Duffau, Crivello, Houde, Mazoyer, & Tzourio-Mazoyer 2006)
15
Lower
Premotor Area
(www.imgarcade.com, 2017)
Frontal
Lobe
ozella.brundidge@gmail.com 8/20/2017
16. Linking Word Ordering to the Broca's area (BA 44) and Temporary Storage to the
Left Temporo-Parietal Region during Sentence Processing Tasks
Left Temporo-Parietal activation
correlates with test takers’ Digit
Span outcome. The Broca’s area is
not activated during verbal
working memory tasks.
(Meyers, Obleser, Anwander, & Friederici, 2012)
16ozella.brundidge@gmail.com 8/20/2017
17. Spatial Working Memory Tasks Activate the
Right Dorsolateral and Medial Prefrontal Grey Matter
• This region is also called the Guenon (BA 9).
• It is part of the Superior Frontal-Intraparietal
Network.
• DTI revealed relational activities in this
region while participants performed spatial
working memory tasks.
(Klingberg, 2006)
17
(2006) Wikipedia, November 22, 2014
Guenon (BA 9)
ozella.brundidge@gmail.com 8/20/2017
18. Visuo-Spatial Working Memory Cytoarchitecture
Visuo-Spatial Working Memory is
dependent upon the integrity of the:
• Superior frontal-intraparietal network
• Primary motor cortex (PMC)
• Somatosensory cortex (SSC)
• Multiple grey and white matter regions
in the frontal and parietal cortices.
(Klingberg, 2006; Desikan, Segonne, Fischl, Quinn, Dickerson, Blacker, Buckner, et al., 2006)
18ozella.brundidge@gmail.com 8/20/2017
19. (Vigneau, Beaucousin, Herve, Duffau, Crivello, Houde, Mazoyer, & Tzourio-Mazoyer, 2006)
Phonology
Semantics
Sentence
Processing
The Efficiency of the Working Memory Perception-Action Loops
can be Measured using the WISC-IV and WAIS Tests
19
WISC-IV – Wechsler Intelligence Scale for Children; WAIS - Wechsler Adult Intelligence Scale
There are Working Memory
Perception-Action Loops
Identifiable for each
Language Component.
ozella.brundidge@gmail.com 8/20/2017
20. Letter-Number Sequencing Subtest Assess
Auditory Sequential Working Memory
The tasks on this subtest involve Mental Manipulation,
Visual-Spatial Imaging, and Processing Speed. The tester is read a
sequence of numbers and letters, and then asked to recall the
numbers in ascending order and the letters in alphabetical order.
20Case Study Student’s Grade 6 IEPozella.brundidge@gmail.com 8/20/2017
22. End of
Neural Correlates
of
Working Memory
(Andrews, 2014, August 26)
Working memory mentally holds and process incoming information.
Houde, et al., 2010
ozella.brundidge@gmail.com 8/20/2017 22
Editor's Notes
Federal Officials Order Medicaid To Cover Autism Services.
http://www.tilrc.org/assests/news/0814news/0814bene26.html
Consolidation is a neurological process that involves gradually converting information from short-term memory into long-term memory. Remember, short-term memories are only stored for about 20 to 30 seconds.
Cerebral hypoxia can also be classified by the cause of the reduced brain oxygen: ... Ischemic hypoxia ( or "stagnanthypoxia") – Reduced brain oxygen is caused by inadequate blood flow to the brain.
VSS-e.g. objects and their locations
Baddeley, A.D., Working memory: theories, models, and controversies, Annu. Rev. Psychol. 63 (2012):1-29
1. a central executive is the master controller which focuses our attention;
2. phonological loop for temporary storage and rehearsal of verbal and auditory information;
3. a visuo-spatial sketchpad for temporary storage of visual and spatial information, e.g. objects and their locations; and
4. An episodic buffer allows these different elements to interact with each other and information in long term memory to facilitate comprehension.
left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension
Slide 20 Wernicke's area: Receptive language processing
(Jackson, 1999; Weems & Reggia, 2006; Cerruti, 2010; Frey & Fischer, 2010; Robson, et al., 2010; Trollinger, et al., 2010; Bach, et al., 20131; Barde, et al., 2012;
Syntactic comprehension –left posterior temporal lobe (Wright, Stamatakis, & Tyler et al., 2012)
)
Bavelier, D., Newport, E. L., & Supalla, T. (2003, January 1). Children Need Natural Languages, Signed or Spoken. The Dana Foundation. http://www.dana.org/Cerebrum/Default.aspx?id=39306
Buchsbaum, B. R. & D'Esposito (2008). Repetition suppression and reactivation in auditory-verbal short-term recognition memory. Cerebral Cortex, 19, 1474-1485. doi:10.1093/cercor/bhn186
Slide 35 Supramarginal overview
By: Daphne Bavelier, Ph.D., Elissa L. Newport, Ph.D., and Ted Supalla, Ph.D.
Bavelier, Newport, & Supalla, 2003
Xiang, et al., (2010) wrote that
“…the inferior parietal lobule is connected by large bundles of nerve fibers to both Broca's area and Wernicke's area (Catani et al. 2005; Parker et al. 2005; Powell et al. 2006).
a functional connectivity topology can be observed in the perisylvian language networks connecting the 3 sub regions of Broca's complex (pars opercularis, pars triangularis, and pars orbitalis) to the the left middle frontal, parietal, and temporal areas.
Xiang and colleagues’ (2010) results support the assumption of the functional division for phonology, syntax, and semantics of Broca's complex as proposed by the memory, unification, and control (MUC) model and indicated a topographical functional organization in the perisylvian language networks, which suggests a possible division of labor for phonological, syntactic, and semantic function in the left frontal, parietal, and temporal areas.
Subjects performed a parametric verbal Sternberg working memory task to examine cerebro-cerebellar (Desmond et al., 2003, Chen and Desmond, 2005).
Stimuli were generated using MacStim 3.0 psychological experimentation software (CogState, West Melbourne, Victoria, Australia) and were visually presented to subjects in the scanner using magnet-compatible 3-D goggles (Resonance Technology, Northridge, CA).
Stimuli consisted of a horizontal array of uppercase consonant letters and pound (#) symbols. There were three types of arrays: high WM load (6 letters), medium WM load (3 letters and three “#” symbols), and low WM load (one letter and five “#” symbols).
Stimuli and Task Parameters
Subjects performed a parametric verbal Sternberg working memory task, similar to that used
by Desmond and colleagues to examine cerebro-cerebellar networks in adults (Desmond et al.,
2003, Chen and Desmond, 2005). Stimuli consisted of a horizontal array of uppercase
consonant letters and pound (#) symbols. There were three types of arrays: high WM load (6
letters), medium WM load (3 letters and three “#” symbols), and low WM load (one letter and
five “#” symbols). For the medium and low load stimuli, letter array position was
counterbalanced across all possible array positions. Within the task, the overall appearance of
a given letter was counterbalanced, as was the order of presentation of load conditions. Stimuli
were generated using MacStim 3.0 psychological experimentation software (CogState, West
Melbourne, Victoria, Australia) and were visually presented to subjects in the scanner using
magnet-compatible 3-D goggles (Resonance Technology, Northridge, CA).
Subjects were instructed to remember the letters in each array. Letter arrays were presented
for 1.5 seconds, followed by a three second delay (see Figure 1). Following this delay, a
lowercase letter probe stimulus was presented for 1.5s. For all load conditions, the probe
stimulus matched the previously presented letter(s) on half of the trials. Position of the probe
stimulus within the array was counterbalanced. Subjects were instructed to respond by pushing
a button with their index finger if the probe stimulus matched an array letter and to push a
button with their middle finger when the probe stimulus did not match an array letter. The task
consisted of four blocks of each load condition (12 WM blocks total), with four trials in each
24-second block. Thirteen 12-second rest blocks, in which subjects fixated on a cross hair,
alternated with the WM blocks, for a total task time of 7 minutes, 24 seconds.
Subjects were trained on the task prior to the start of the scanning session. Training included
a verbal description of the task and then two practice runs, each containing 5 trials. All subjects
were able to perform the task prior to the start of the scanning session. Once the subject was
in the scanner, task instructions were reviewed again before the start of the task.
Data acquisition
Functional imaging data were collected on the UCLA Division of Brain Mapping’s researchdedicated
3 Tesla Siemens Allegra head-only magnet. Multi-slice echo-planar imaging (EPI)
was used with a gradient echo EPI sequence. We used a TR of 3 sec, with a TE of 25. Slice
thickness was 3 mm with a 1 mm skip, 36 total slices, with 64x64 pixels yielding a resolution
in-plane of 3mm with whole-brain acquisition. A high-resolution T2-weighted EPI volume
was collected in the anterior commissure-posterior commissure plane (slice thickness=3mm,
36 total axial slices covering the entire brain with 1mm gaps between slices, TR=5000ms,
TE=33ms, flip angle=90 degrees, matrix size 128 x 128 with 1.5 x 1.5 mm in-plane voxel
dimensions), coplanar with the functional scan, to allow for spatial registration of each subject’s
data into a standard coordinate space.
Image and Statistical Analysis
Functional imaging data were analyzed using FSL (FMRIB’s Software Library,
http://www.fmrib.ox.ac.uk/fsl/index.html, (Smith et al., 2004). Data were corrected for
possible motion artifacts by co-registering each BOLD image in the time series to the middle
volume in the series using a 6-parameter rigid-body transformation. Volumes that had more
than 2mm of head motion were excluded and the remaining time series data were analyzed.
For a given subject, if excessive head motion occurred on more than 17 volumes within each
task condition, that subject was excluded. Slice timing correction was applied to correct each
voxel’s time series given that slices were acquired in an interleaved fashion. Data were spatially
smoothed using a 6 mm (FWHM) Gaussian kernel and a high pass filter cutoff period of 50
seconds was imposed. Finally, all data were registered in a two-step process. First, each
subject’s EPI data were registered to their own T2-weighted structural image with a 6-
parameter transformation for within subject analyses, and then to the MNI-152 standard space
template with a 12-parameter transformation for group averaging (Jenkinson and Smith,
2001, Jenkinson et al., 2002).
Single subject analyses were carried out using FMRIB’s fMRI Expert Analysis Tool (FEAT,
version 5.63). In these analyses, low, medium, and high WM loads were modeled separately.
The hemodynamic response function (HRF) was specified as a gamma variate function (mean
lag of 6 seconds) and convolved with the modeled components. Statistical analysis of the time
series data was carried out using FMRIB’s Improved Linear Model (FILM). A voxel-wise
general linear model was applied so that each voxel’s time course was individually fit to the
model with local autocorrelation correction (Woolrich et al., 2001). Overall WM responses
were determined by comparing WM activity (collapsed across loads) with rest. Orthogonal
contrasts were then used to compute linear and nonlinear response functions across load
conditions. Linear functions were modeled as [−1 0 1] and identified voxels that showed
increasing activity with increasing WM load. Nonlinear functions were modeled as [−1 2 −1]
to investigate the extent to which the change between easy and medium loads differed from
the change between medium and hard loads. Z statistic images were thresholded using clusters
determined by Z > 1.7 and a (corrected) cluster significance threshold of p = 0.05.
Higher-level group analysis was carried out using FLAME (FMRIB’s Local Analysis of Mixed
Effects). FLAME takes each subject’s time series data and models all subjects in each group
(children, adolescents, young adults). Thus, group average responses for the linear and
nonlinear contrasts were derived. Thus, a one-way analysis of variance (ANOVA) with the
factor of age group was used to examine group differences in activation for these contrasts.
Subjects performed a parametric verbal Sternberg working memory task to examine cerebro-cerebellar (Desmond et al., 2003, Chen and Desmond, 2005).
Stimuli were generated using MacStim 3.0 psychological experimentation software (CogState, West Melbourne, Victoria, Australia) and were visually presented to subjects in the scanner using magnet-compatible 3-D goggles (Resonance Technology, Northridge, CA).
Stimuli consisted of a horizontal array of uppercase consonant letters and pound (#) symbols. There were three types of arrays: high WM load (6 letters), medium WM load (3 letters and three “#” symbols), and low WM load (one letter and five “#” symbols).
Stimuli and Task Parameters
Subjects performed a parametric verbal Sternberg working memory task, similar to that used
by Desmond and colleagues to examine cerebro-cerebellar networks in adults (Desmond et al.,
2003, Chen and Desmond, 2005). Stimuli consisted of a horizontal array of uppercase
consonant letters and pound (#) symbols. There were three types of arrays: high WM load (6
letters), medium WM load (3 letters and three “#” symbols), and low WM load (one letter and
five “#” symbols). For the medium and low load stimuli, letter array position was
counterbalanced across all possible array positions. Within the task, the overall appearance of
a given letter was counterbalanced, as was the order of presentation of load conditions. Stimuli
were generated using MacStim 3.0 psychological experimentation software (CogState, West
Melbourne, Victoria, Australia) and were visually presented to subjects in the scanner using
magnet-compatible 3-D goggles (Resonance Technology, Northridge, CA).
Subjects were instructed to remember the letters in each array. Letter arrays were presented
for 1.5 seconds, followed by a three second delay (see Figure 1). Following this delay, a
lowercase letter probe stimulus was presented for 1.5s. For all load conditions, the probe
stimulus matched the previously presented letter(s) on half of the trials. Position of the probe
stimulus within the array was counterbalanced. Subjects were instructed to respond by pushing
a button with their index finger if the probe stimulus matched an array letter and to push a
button with their middle finger when the probe stimulus did not match an array letter. The task
consisted of four blocks of each load condition (12 WM blocks total), with four trials in each
24-second block. Thirteen 12-second rest blocks, in which subjects fixated on a cross hair,
alternated with the WM blocks, for a total task time of 7 minutes, 24 seconds.
Subjects were trained on the task prior to the start of the scanning session. Training included
a verbal description of the task and then two practice runs, each containing 5 trials. All subjects
were able to perform the task prior to the start of the scanning session. Once the subject was
in the scanner, task instructions were reviewed again before the start of the task.
Data acquisition
Functional imaging data were collected on the UCLA Division of Brain Mapping’s researchdedicated
3 Tesla Siemens Allegra head-only magnet. Multi-slice echo-planar imaging (EPI)
was used with a gradient echo EPI sequence. We used a TR of 3 sec, with a TE of 25. Slice
thickness was 3 mm with a 1 mm skip, 36 total slices, with 64x64 pixels yielding a resolution
in-plane of 3mm with whole-brain acquisition. A high-resolution T2-weighted EPI volume
was collected in the anterior commissure-posterior commissure plane (slice thickness=3mm,
36 total axial slices covering the entire brain with 1mm gaps between slices, TR=5000ms,
TE=33ms, flip angle=90 degrees, matrix size 128 x 128 with 1.5 x 1.5 mm in-plane voxel
dimensions), coplanar with the functional scan, to allow for spatial registration of each subject’s
data into a standard coordinate space.
Image and Statistical Analysis
Functional imaging data were analyzed using FSL (FMRIB’s Software Library,
http://www.fmrib.ox.ac.uk/fsl/index.html, (Smith et al., 2004). Data were corrected for
possible motion artifacts by co-registering each BOLD image in the time series to the middle
volume in the series using a 6-parameter rigid-body transformation. Volumes that had more
than 2mm of head motion were excluded and the remaining time series data were analyzed.
For a given subject, if excessive head motion occurred on more than 17 volumes within each
task condition, that subject was excluded. Slice timing correction was applied to correct each
voxel’s time series given that slices were acquired in an interleaved fashion. Data were spatially
smoothed using a 6 mm (FWHM) Gaussian kernel and a high pass filter cutoff period of 50
seconds was imposed. Finally, all data were registered in a two-step process. First, each
subject’s EPI data were registered to their own T2-weighted structural image with a 6-
parameter transformation for within subject analyses, and then to the MNI-152 standard space
template with a 12-parameter transformation for group averaging (Jenkinson and Smith,
2001, Jenkinson et al., 2002).
Single subject analyses were carried out using FMRIB’s fMRI Expert Analysis Tool (FEAT,
version 5.63). In these analyses, low, medium, and high WM loads were modeled separately.
The hemodynamic response function (HRF) was specified as a gamma variate function (mean
lag of 6 seconds) and convolved with the modeled components. Statistical analysis of the time
series data was carried out using FMRIB’s Improved Linear Model (FILM). A voxel-wise
general linear model was applied so that each voxel’s time course was individually fit to the
model with local autocorrelation correction (Woolrich et al., 2001). Overall WM responses
were determined by comparing WM activity (collapsed across loads) with rest. Orthogonal
contrasts were then used to compute linear and nonlinear response functions across load
conditions. Linear functions were modeled as [−1 0 1] and identified voxels that showed
increasing activity with increasing WM load. Nonlinear functions were modeled as [−1 2 −1]
to investigate the extent to which the change between easy and medium loads differed from
the change between medium and hard loads. Z statistic images were thresholded using clusters
determined by Z > 1.7 and a (corrected) cluster significance threshold of p = 0.05.
Higher-level group analysis was carried out using FLAME (FMRIB’s Local Analysis of Mixed
Effects). FLAME takes each subject’s time series data and models all subjects in each group
(children, adolescents, young adults). Thus, group average responses for the linear and
nonlinear contrasts were derived. Thus, a one-way analysis of variance (ANOVA) with the
factor of age group was used to examine group differences in activation for these contrasts.
Neuropsychological Tests
Short-Term Memory—Digit Span is the quintessential neuropsychological test of verbal STM. In Digit Span (Wechsler, 1997), the subject hears a sequence of digits and attempts to repeat the sequence in order. Sequence length is increased until the subject can no longer correctly repeat the sequence. The maximum sequence length for each subject is interpreted as the subject’s digit span (Koenigs, Acheson, Barbey, Solomon, Postle, Grafman, 2011).
Diffusion tensor imaging (DTI) measures the characteristics of white matter.
Lesions Associated with Digit span (scores of 4 or less) - the most severe impairments in auditory-verbal STM capacity were associated with relatively large lesions involving left perisylvian cortex. (Koenigs et al., 2011). employing voxel-based lesion symptom mapping (VLSM) (Bates et al., 2003). largest cluster of significant voxels (z score 3.5 significant) was located in superior and middle temporal gyri in the mid- to posterior region of left temporal lobe, while smaller clusters were located in left inferior frontal gyrus and left inferior parietal lobule.
Hernandez, B. (2017, May 26). Tips for remembering how to spell Wednesday and other tricky words. Retrieved from https://www.thoughtco.com/spelling-tricky-words-wednesday-1833083
Neuropsychological Tests
Short-Term Memory—Digit Span is the quintessential neuropsychological test of verbal STM. In Digit Span (Wechsler, 1997), the subject hears a sequence of digits and attempts to repeat the sequence in order. Sequence length is increased until the subject can no longer correctly repeat the sequence. The maximum sequence length for each subject is interpreted as the subject’s digit span (Koenigs, Acheson, Barbey, Solomon, Postle, Grafman, 2011).
Federal Officials Order Medicaid To Cover Autism Services.
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