This document discusses the neurobiology of emotions. It defines emotions, moods, and affects. The core brain regions involved in emotions are the cerebral cortex, limbic system (particularly the amygdala), and brain stem. The limbic system, including structures like the hippocampus, anterior thalamus, and cingulate gyrus, form circuits important for emotional processing and expression. The amygdala plays a key role in fear and aggression. Other structures like the hypothalamus, prefrontal cortex, and autonomic nervous system are also involved in emotions and physiological arousal. Various neurotransmitters, including monoamines, peptides, GABA, and glutamate mediate emotional processes in the brain.
Emotions enable us to react to situations – for example, anger or fear will set your heart racing, and feeling happy will make you smile. One of the key areas of your brain that deals with showing, recognising and controlling the body's reactions to emotions is known as the limbic system. Learn more about it in this presentation.
Understanding the encoding of memory and its retrieval is a complex task. The neurobiological correlates of memory have been summarised in this presentation for easy understanding of students.
This slideshow is for a presentation I made in my music theory class at the University of Michigan. I hoped to show the links between Indian music and the human brain. More research deserves to be done on this subject.
Emotions enable us to react to situations – for example, anger or fear will set your heart racing, and feeling happy will make you smile. One of the key areas of your brain that deals with showing, recognising and controlling the body's reactions to emotions is known as the limbic system. Learn more about it in this presentation.
Understanding the encoding of memory and its retrieval is a complex task. The neurobiological correlates of memory have been summarised in this presentation for easy understanding of students.
This slideshow is for a presentation I made in my music theory class at the University of Michigan. I hoped to show the links between Indian music and the human brain. More research deserves to be done on this subject.
Had created this slidedeck about 3 years ago for presenting at TED Bangalore (but presented without slides at the event:-)) . Posting the slides here about how the ancient Indian dance form expressions may inform about the basic emotions.
ReadySetPresent (Decision Making PowerPoint Presentation Content): 100+ PowerPoint presentation content slides. Successful and effective strategic decision making is a guarantee to increase productivity in every workplace. Decision Making PowerPoint Presentation Content slides include topics such as: the 6 C’s of decision making, inherent personal and system traps, 10+ slides on decision trees, 10+ slides on decision making methods and tips, 4 slides on the GOR approach to decision making, 8 slides on common pitfalls in decision making, 4 slides on effective strategies in making decisions, 35+ slides on the 8 major decision making traps and how to effectively minimize each, 7 slides on different decision making perspectives, 25 slides on the 3 different types of analysis (grid analysis – paired comparison analysis, and cost/benefit analysis), 4 slides on utilizing planning and overarching questions, 4 modes of decision making and 6 factors in decision making and more!
Love you guys with my whole Limbic system...
Limbic System from where the main feelings comes... Here we go..
It got the main structures seen here along with some other related areas...
CONNECTIONS (Papez circuit simplified)
Different functions of Limbic system... Fear vs. Rage, sham rage, reward and punisment, hippocampus and memory related functions...
Some applied aspects are also covered...
THANK YOU
An overview of Disability certification for Autism, Specific learning disorder (SLD), Mental illness, Intellectual disability (Mental Retardation) and multiple disability in India for medical students
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Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
2. DEFINITION OF EMOTION
• Emotion is a stirred-up state caused by
physiological changes occurring as a response to
some event and which tends to maintain or
abolish the causative event.
• Mood is a pervasive and sustained emotion that
colours the person’s perception of the world.
• Affect meaning short-lived emotion, is defined as
the patient’s present emotional responsiveness.
3. Brain and emotion
• Brain is involved in perceptions and evaluation of
situations that give rise to emotions. The core
parts involved are
CEREBRAL CORTEX
LIMBIC SYSTEM-mainly amygdala
Brain Stem
4.
5. The Limbic System Concept
Paul MacLean popularized term “limbic system”
• Evolution of limbic system allows animals to experience and
express emotions beyond stereotyped brain stem behaviors
Forming a ring around corpus callosum: Cingulate gyrus, medial surface
temporal lobe, hippocampus
6. The Limbic System Concept
• The Papez Circuit(1937)
– Papez circuit of the brain is one of the major pathways of the limbic
system and is chiefly involved in the cortical control of emotion
7. The Limbic System Concept
• The Papez Circuit
-Hippocampus: Hypothesized to mediate behavioral expression
of emotion
Rabies infection: Hyperemotional responses -cytological
changes in hippocampal neurons
- Anterior thalamus Lesions lead to spontaneous laughing,
crying.
- Subcallosal cingulate gyrus has been implicated as playing
an important role in major depression and has been the
target of deep brain Stimulation to treat that depression.
8. The Limbic System Concept
• Difficulties with the Single Emotion System Concept
– Diverse emotions
– Many structures involved in emotion
• No one-to-one relationship between structure and
function
– Limbic system: Utility of single, discrete emotion system
questionable
9. The Amygdala and Associated
Brain Circuits
• Anatomy of the Amygdala
12. The Amygdala and Associated
Brain Circuits
• The Amygdala - Fear and Agression (evidence)
Bilateral amygdalectomy reduces fear and aggression in all animals
tested.
Anger, sadness, and disgust may also be affected.
S.M. case study(dec1994): Inability to recognize fear in facial
expressions(Urbach Wieth Disease).
Electrical stimulation of amygdala -> Increased vigilance or
attention.
Fearful faces produce greater amygdala activity than happy/neutral
faces.
13. The Amygdala and Aggression
– Predatory Aggression—Attacks
Against different species for food
Few vocalizations; Attack head or neck
No activity in sympathetic division of ANS
– Affective aggression-For show
Used for show, not kill for food
High levels of sympathetic activity
Makes vocalizations; Threatening posture
The Amygdala and Associated
Brain Circuits
14. KLUVER-BUCY SYNDROME(1939)
-Due to b/l destruction of amygdaloid body and inf
temporal cortex
- Decreased agression(tameness)
-Increase in sexual activity
-Compulsive tendency to place objects in mouth.
-Decreased emotionality
-Changes in eating behavior
-Visual agnosia
In Humans caused by
Herpes and other Encephalitis
Cerebral trauma
Alzheimers and other Dementias
Niemann-Pick disease and CVA
The Amygdala and Associated
Brain Circuits
15. – Surgery to Reduce Human Aggression
Amygdalectomy results in -
• Reduced aggressive asocial behavior
• Increased ability to concentrate
• Decreased hyperactivity
Psychosurgery – last resort
The Amygdala and Associated
Brain Circuits
16. The Amygdala and Associated
Brain Circuits
In Schizophrenic patient –
Exposure to scary face – amygdala not activated.
Exposure to neutral face – inappropriate hyperactivation of
amygdala.
Schizophrenic patient often have impairements in ability to identify and
interpret emotional stimuli. The neurobiological explanation for this may be
inefficient information processing with in Ventral system.
Consistently in fMRI and PET studies, with emotionally valenced pictures,
faces, and odors, patients showed diminished activation in limbic and paralimbic
regions, especially the amygdala.
• Aggressive symptoms- orbitofrontal cortex and amygdala
17. HYPOTHALAMUS
• The Hypothalamus and Aggression (evidence)-
Removal of cerebral hemispheres but not
hypothalamus -> sham rage
This Behavior reversed with small lesions in
hypothalamus.
18. HYPOTHALAMUS
• The Hypothalamus and Aggression (Cont’d)
– Flynn, 1960s
Elicited affective aggression by
stimulation medial hypothalamus
Predatory aggression elicited by
stimulating lateral hypothalamus
19. PREFRONTAL CORTEX
Emotional symptoms such as happiness and sadness are regulated by prefrontal
cortex and amygdala.
Left prefrontal cortex appears to lift the mood.
Activation of the right prefrontal cortex causes depression.
Lesion to the right prefrontal area may produce laughter, euphoria, and moria or
witzelsucht, a tendency to joke and make puns.
In treating depression, rTMS therapy targets the area left dorsolateral prefrontal
cortex (DLPFC). The DLPFC is readily accessible to the magnetic field and is highly
interconnected with limbic structures, which plays a dominant role in mood
modulation and major depression.
23. • Vagus nerve stimulation (VNS) for treatment-resistant depressions-
Little is understood about exactly how vagal nerve stimulation modulates
mood but proposed mechanisms include alteration of norepinephrine release by
projections of solitary tract to the locus coeruleus, elevated levels of
inhibitory GABA related to vagal stimulation and inhibition of aberrant cortical
activity by reticular system activation.
Autonomic nervous system controls physiological arousal
24. AUTONOMIC&ENDOCRINE RESPONSES TO EMOTION
Limbic stimulation causes changes in respiration & blood pressure
Hypothalamic autonomic responses are triggered by a complex phenomenon mediated
by the cortical and limbic structures.
The fear and rage responses mediated by the limbic system cause stimulation of
various parts of the hypothalamus, especially the lateral areas and produce diffuse
sympathethic Discharge.
The physical symptoms of panic attacks can be reproduced by Carbon dioxide,
Yohimbine, and Caffeine and Epinephrine administration.
The massive sympathetic discharge during stress is called the flight or fight response“.
Stress via cortical and limbic connections causes release of corticotropin-releasing
hormone (CRH) from the paraventricular nuclei of the hypothalamus. CRH release
mediates endocrine and immune response
25. EMOTIONAL MEMORY
Emotion has powerful influence on learning and memory
Amygdala, in conjunction with prefrontal cortex &medial temporal lobe, is involved
in consolidation and retrieval of emotional memories.
Amygdala, prefrontal cortex and hippocampus are also involved in the acquisition,
extinction and recovery of fears to cues and contexts.
Hippocampus is critical for long-term,declarative memory storage
Propranolol impairs memory for emotionally provocative story but not for
emotionally neutral story.
26. Chemical Neurotransmitters involved
in Emotions
• Monoamine neurotansmitters – Norepinephrine,
Serotonine, Dopamine.
• Aminoacid transmitters – GABA, Glutamate.
• Peptide neurotransmitters – CRH, Neuropeptide Y,
Substance P, Opioid.
27. Serotonergic System
• Neurotransmitter Serotonin
– Serotonergic raphe neurons
project to the hypothalamus
and limbic structures via the
medial forebrain bundle
– Serotonin turn-over
aggression in rodents
– Drug PCPA blocks serotonin
synthesis aggression
28. Serotonergic System
5HT 1A receptor knock out mice show a marked elevation of anxiety and fear
behaviour.
Postsynaptic 5HT 1A receptor gene expression is under tonic inhibition by adrenal
steroids.
Downregulation of 5HT 1A receptor in response to chronic stress.
Upregulation of 5HT 2A receptor during chronic stress
.
Chronic administration 5HT 1A receptor partial agonist and 5HT 2A receptor antagonist
exert anxiolytic effect.
5HT 1A receptor agonist and 5HT 2A receptor antagonist decrease rodent aggression.
Drugs such as Risperidone actually have more antagonist effect at 5HT 2A receptors
than D2 receptors.
Depressed patient have reduced concentration of serotonine metabolite 5-HIAA in CSF.
29. Noradrenergic System
Norepinephrine (NE) released primarily from locus coeruleus(LC) which
located in pons.
Exposure to acute stress/fear results in increase in NE in LC,
hypothalamus, hippocampus, amygadala, and cerebral cortex.
Repeated exposure to stress/chronic stress- decreased release of NE in LC.
(learned helplessness)
Patients with PTSD and panic disorder show evidence of increased NE
activity.
Mice lacking Alpha-2 adrenergic receptors have hightened autonomic
activation and concomitant anxiety behaviour.
30. Corticotropin relasing hormone (CRH) system
Central nucleus of amygdala contains CRH.
Axons of central nucleus cells target locus coeruleus neurons (which have
CRH receptors and contain NE).
In animal administration of CRH in cerebral ventricles effectively induces
anxiety responses, including hypervigilance, enhancement of the freezing
posture, and decreased exploration in unfamiliar situations.
31. γ-Amino Butyric Acid and the Benzodiazepine System- Role of
GABA and benzodiazepine receptors in anxiety is well documented in animal
studies.
Several studies of panic disorder patients have shown reduced GABA-A and
benzodiazepine binding, using PET and SPECT imaging, in areas such as the cortex,
hippocampus, and insula when compared to controls.
Dopaminergic System- Inhibition in nucleus accumbens dopamine activity
results in abnormalities in motivation and reward mechanisms.
Glutamate system- NMDA receptors are prominently involved in the
conditioning of fear learning.
Blockade of the NMDA receptor with antagonists such as APV can block fear
acquisitions, and some studies show that it may even block expression.
.
32. Neuropeptide Y- NPY has anxiolytic effects.
NPY has been shown to be involved in fear consolidation, with
preclinical studies showing that the administration of NPY impairs the
retention of traumatic memories and reduces anxiety during stressful
tasks
Recently it has been observed that the neuropeptide cholecystokinin
(CCK) is involved in panic disorders.(antagonists of CCK-B receptor have
anxiolytic effect).
33. Concluding Remarks
• Neural Pathways
Experience, expression of emotion involves widespread activity in the
nervous system from cortex to ANS as well as: limbic structures,
hypothalamus, amygdala
Structures involved in emotions have other functions, including
learning and memory
34. References
(1) Stephan B. Hamann, Ralph Adolphs : Normal recognition of emotional similarity between facial expressions
following bilateral amygdala damage Neuropsychologia 37 (1999) 1135±1141.
(2) Stahl’s Essential psychopharmacology – third edition.
(3) Kaplan and Sadock’s comprehensive textbook of psychiatry.9th edition.
(4) Fish psychopathology 3rd edition
(5) Gaul C Jordan B, Wustmann T, Preuss UW [Klüver-Bucy syndrome in humans]. Nervenarzt. 2007
Jul;78(7):821-3.
(6) Anne L. etal Klüver-Bucy Syndrome After Bilateral Selective Damage of Amygdala and Its Cortical
Connections, The Journal of Neuropsychiatry and Clinical Neurosciences 1998;10:354-358.
(7) Gothard k etal. Neural Responses to Facial Expression and Face Identity in the Monkey Amygdala. PresS. J
Neurophysiol (November 8, 2006). doi:10.1152/jn.00714.2006 .
(8) Guyton and Hall Textbook of Medical Physiology, 12th Edition
(9) Lin D. Nature, 2011 Feb 10;470(7333):221-6.Functional identification of an aggression locus in the mouse
hypothalamus