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SWOT Analysis of cefuroxime axetil
Cefuroxime axetil is a broad-spectrum cephalosporin antibiotic used orally to treat bacterial infections like pneumonia, bronchitis, ear infections, and skin infections. It is absorbed and broken down into the active form cefuroxime. Common side effects include diarrhea, abdominal pain, rash, and headache. Pseudomembranous colitis has been associated with cefuroxime axetil use and other broad-spectrum antibiotics, so its diagnosis should be considered in patients who develop diarrhea after use. Multiple pharmaceutical companies in Bangladesh produce and market various cefuroxime axetil formulations, with prices varying between different manufacturers.
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SWOT Analysis of cefuroxime axetil
- 1. SWOT Analysis of cefuroximeaxetil Md: Jabiur Rahaman Daffodil International University,Bangladesh Dept. of Pharmacy
- 2. Introduction CEFTIN (cefuroxime axetil)Tablets and CEFTIN (cefuroxime axetil) for Oral Suspension contain cefuroxime as cefuroxime axetil. CEFTIN (cefuroxime axetil) is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration. Its molecular formula is C20H22N4O10S, and it has a molecular weight of 510.48.
- 3. Cefuroxime axetil isin the amorphous form and has the following structural formula:
- 4. CEFTIN (cefuroxime axetil)Tablets are film- coated and contain the equivalent of 250 or 500 mg of cefuroxime as cefuroxime axetil. CEFTIN (cefuroxime axetil) Tablets contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, hydrogenated vegetable oil, hypromellose, methylparaben, microcrystalline cellulose, propylene glycol, propylparaben, sodium benzoate, sodium lauryl sulfate, and titanium dioxide.
- 5. Strength Cefuroxime Axetil -Clinical Pharmacology: • Absorption and Metabolism: After oral administration, Cefuroxime Axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to cefuroxime. Cefuroxime is subsequently distributed throughout the extracellular fluids. The axetil moiety is metabolized to acetaldehyde and acetic acid. • Indications and Usage for Cefuroxime Axetil: • Pharyngitis/Tonsillitis: caused byStreptococcus pyogenes. • Acute Bacterial Otitis Media: caused byStreptococcus pneumoniae,Haemophilus influenzae(including beta- lactamase–producing strains),Moraxella catarrhalis(including beta-lactamase–producing strains), orStreptococcus pyogenes.
- 6. • Acute BacterialMaxillary Sinusitis: caused byStreptococcus pneumoniaeorHaemophilus • Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary BacterialInfections of Acute Bronchitis: caused byStreptococcus pneumoniae,Haemophilus influenza. • Uncomplicated Skin and Skin-Structure Infections: caused byStaphylococcus aureus(including beta- lactamase–producing strains) orStreptococcus pyogenes.
- 7. Pregnancy: Category B.The safety of cefuroxime axetil in pregnancy has not been established. The use of cefuroxime axetil in pregnant women requires that the likely benefit from the drug be weighed against the possible risk to the mother and fetus.
- 8. In present lotsof pharmaceutical industry commercially Manufacturing cefuroxime axetil categories drug shown in table 1…
- 9. • Orion PharmaLtd. • 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 12s pack: 540.00 MRP • AXET • Cefuroxime axetil 125mg/5ml suspension • Suspension • Orion Pharma Ltd. • 70ml bot: 215.00 MRP • AXET • Cefuroxime (as sodium salt) 250mg & 750mg/vial • Injection (IV/IM) • Orion Pharma Ltd. • 250mg vial x 1s pack: 60.00 MRP; 750mg vial x 1s pack: 125.00 MRP • AXETIL • Cefuroxime axetil 125mg, 250mg & 500mg/tablet • Tablet (Film Coated) • Alco Pharma Ltd. • 125mg x 12s pack: 144.00 MRP; 250mg x 8s pack: 176.00 MRP; 500mg x 8s pack: 320.00 MRP
- 10. • AXETIL • Cefuroximeaxetil 125mg/5ml suspension • Suspension • Alco Pharma Ltd. • 70ml bot: 190.00 MRP • AXIM • Cefuroxime axetil 125mg, 250mg & 500mg/tablet • Tablet (Film Coated) • Aristopharma Ltd. • 125mg x 10s pack: 150.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 10s pack: 450.00 MRP • AXIM • Cefuroxime axetil 125mg/5ml suspension • Suspension • Aristopharma Ltd. • 70ml bot: 198.00 MRP • AXIM • Cefuroxime (as sodium salt) 750mg/vial • Injection (IV/IM) • Aristopharma Ltd. • 1 vial pack: 125.00 MRP • CEBAC-A • Cefuroxime axetil 125mg/tablet • Tablet (Film Coated) • Seema Pharmaceuticals Ltd. • 125mg x 8s pack: 120.00 MRP
- 11. • CEFOTIL • Cefuroximeaxetil 125mg, 250mg & 500mg/tablet • Tablet (Film Coated) • Square Pharmaceuticals Ltd. • 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 6s pack: 270.00 MRP • CEFOTIL • Cefuroxime axetil 125mg, 250mg & 500mg/tablet • Tablet (Film Coated) • Square Pharmaceuticals Ltd. • 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 6s pack: 270.00 MRP • CEFOTIL • Cefuroxime axetil 125mg/5ml suspension • Suspension • Square Pharmaceuticals Ltd. • 70ml bot: 198.00 MRP • CEFOTIL 1.5 IV • Cefuroxime (as sodium salt) 1.5gm/vial • Injection (IV) • Square Pharmaceuticals Ltd. • 1.5gm vial x 1s pack: 200.00 MRP • CEFOTIL 750 • Cefuroxime (as sodium salt) 750mg/vial • Injection (IV/IM) • Square Pharmaceuticals Ltd. • 750mg vial x 1s pack: 125.00 MRP
- 12. Weakness • side effectsof cefuroxime (Ceftin): Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: • diarrhea that is watery or bloody; • fever, chills, body aches, flu symptoms; • chest pain, fast or pounding heartbeats; • unusual bleeding; • blood in your urine; • seizure (convulsions); • pale or yellowed skin, dark colored urine, fever, confusion or weakness; • jaundice yellowing of the skin.
- 13. • Adverse Reactions: CefuroximeAxetil Tablets in Clinical Trials: Multiple-Dose Dosing Regimens: 7 to 10 Days Dosing Using multiple doses of Cefuroxime Axetil tablets, 912 patients were treated with Cefuroxime Axetil (125 to 500 mg twice daily). There were no deaths or permanent disabilities thought related to drug toxicity.
- 14. • Abdominal pain •Abdominal cramps • Flatulence • Indigestion • Headache • Vaginitis • Rash • Hives • Itch • Dysuria • Chills • Chest pain • Shortness of breath • Mouth ulcers • Swollen tongue • Sleepiness
- 15. • precautions whentaking cefuroxime axetil (Ceftin): Before taking cefuroxime, tell your doctor or pharmacist if you are allergic to it; or to penicillins or other cephalosporin antibiotics (e.g., cephalexin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
- 16. Opportunity • Pseudomembranous colitishas been reported to be associated with the use of cefuroxime axetil and other broad-spectrum antibiotics. Therefore, it is important to consider its diagnosis in patients administered cefuroxime axetil who develop diarrhea. Treatment with broad-spectrum antibiotics, including cefuroxime axetil, alters the normal flora of the colon and may permit overgrowth of Clostridia. Studies indicate that a toxin produced by C. difficile is one primary cause of antibiotic- associated colitis. Mild cases of colitis may respond to drug discontinuance alone.
- 17. Moderate to severecases should be managed with fluid, electrolyte, and protein supplementation as indicated. When the colitis is severe or not relieved by discontinuance of cefuroxime axetil administration, consideration should be given to the administration of oral vancomycin or other suitable therapy. Other possible causes of colitis should also be considered.
- 18. Threat • In presenttime cefruoxime axetil in Bangladesh lots of pharmaceutical produce this types of drug and doctors should be prescribed this drug too much for the treatment. cefroxime axetil is a second generation drug for this condition it should be prevented many microbial agent.Many pharmaceutical industry produce this categoris drug so that they uses lots of API that’s vary the price of this drug for example:
- 19. CEFOBAC 1.5 IV Cefuroxime(as sodium salt) 1.5gm/vial Injection (IV) Popular Pharmaceuticals Ltd. 1 vial pack: 200.00 MRP On the other hand AXIM Cefuroxime (as sodium salt) 750mg/vial Injection (IV/IM) Aristopharma Ltd. 1 vial pack: 125.00 MRP In this list we make little difference between two companies product.price make a fact to compare with two pharmaceutical industries product.