This document provides an overview of pharmacotherapy for asthma. It defines asthma as a chronic inflammatory disease of the airways characterized by increased responsiveness to stimuli. Asthma can be triggered by environmental and genetic factors. The main types of asthma and treatments discussed include bronchodilators, leukotriene antagonists, mast cell stabilizers, corticosteroids, anti-IgE antibody therapy, and recent advances in immunotherapy.
The main focus of this presentation is to discuss all the drugs used nowadays in clinical practice to treat/ manage bronchial asthma. Along with the mechanism of action, use and adverse effects of anti-asthma drugs, we have given a highlight of the pathophysiology of asthma and how the drugs individually act at individual set point(s) to bring the clinical outcome.
The main focus of this presentation is to discuss all the drugs used nowadays in clinical practice to treat/ manage bronchial asthma. Along with the mechanism of action, use and adverse effects of anti-asthma drugs, we have given a highlight of the pathophysiology of asthma and how the drugs individually act at individual set point(s) to bring the clinical outcome.
pharmacothrapy of asthma.pptxBronchial asthma is a chronic respiratory diseas...AbhishekKumarGupta86
pharmacotherpy of asthma M pharm 2nd sem.
Bronchial asthma is a chronic respiratory disease characterized by inflammation and narrowing of airways in the lungs, which cause difficulty in breathing.
Symptoms can include coughing, wheezing, shortness of breath and chest tightness. These symptoms can be mild or severe and can come and go over time.
Although asthma can be a serious condition, it can be managed with the right treatment.
Asthma affected an estimated 262 million people in 2019 (1) and caused 455 000 deaths.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
1. DEPARTMENT OF PHARMACOLOGY
ADVANCED PHARMACOLOGY - II
PRESENTATION ON: PHARMACOTHERAPY OF
ASTHMA
By: Kashikant Yadav
M Pharm(Pharmacology)
KARNATAKA COLLEGE OF PHARMACY
2. ASTHMA DEFINITION
Asthma is defined as a chronic inflammation disease of
airway that is characterised by increase responsiveness of
tracheobronchial tree to a multiplicity of stimuli.
Extrinsic: episodic , atopy
Intrinsic: perennial , status asthmaticus.
3. CAUSES
Asthma may be triggered because of :
1)Environmental Factors:
Air pollutants
Smoking
Dust
Pets
Chemicals
2)Genetic Factors:
Family history
Certain genes
6. TYPES
Extrinsic Asthma ( Allergic )
Intrinsic Asthma ( Non- Allergic)
Mixed Asthma ( Extrinsic and Intrinsic)
Occupational Asthma
Drug Induced Asthma
- Aspirin Induced Asthma
- NSAID Induced Asthma
Exercise Induced Asthma
Cough Variant Asthma
- Very Common ( Especially in children )
7.
8.
9. BRONCHODIALATORS
A bronchodilator is a substance that dilates the bronchi and bronchioles,
decreasing resistance in the respiratory airway and increasing airflow to the lungs.
Bronchodilators may be endogenous (originating naturally within the body),
Bronchodilators are either short-acting or long-acting.
e.g : Salbutamol, Theophylline, Ipratropium bromide.
M.O.A :
Increase levels of energy- producing cAMP.
This is done competitively inhibiting phosphodiesterase ( PDE), the enzyme
that breaks down cAMP.
Result: decreased cAMP levels, smooth muscle relaxation bronchodialation,
and increased airflow.
10. Contd…..
Therapeutic uses:
Dilation of airway in asthma, chronic bronchitis, & emphysema
Mild to moderate cases of asthma
Adjunct therapy for the relief of pulmonary edema.
Side effects:
Nausea , vomiting , anorexia
Gastroesophagal reflux during sleep
Sinus tachycardia , extrasystolic , palpitations , ventricular dysrhythmias
Transient increased urination.
11. LEUKOTRIENE ANTAGONISTS
An Leukotriene antagonists is a drug which functions as a leukotriene-
related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor
antagonist and consequently opposes the function of these inflammatory
mediators; leukotrienes are produced by the immune system. Leukotriene
receptor antagonists, such as montelukast, zafirlukast can be used to treat these
diseases. They are less effective than corticosteroids for treating asthma,but
more effective for treating certain mast cell disorders.
M.O.A:
Montelukast , zafirlukast are competitively prevent the bronchoconstrictor
effects of leukotrienes
By blocking their receptor
Prevent leukotrienes from attaching to receptor on cells in the lungs and in
circulation
Blocking the inflammation in the lungs.
12. Contd…..
Kinetics:
The half life of Leukotriene antagonists is less than 5 minutes.
Side effects:
Headache
Stomach pain, heartburn, upset stomach, nausea, diarrhea
Tooth pain
Tired feeling
Fever, stuffy nose, sore throat, cough, hoarseness
Mild rash.
Uses:
Prophylaxis and chronic treatment of asthma.
13. Mast cell stabilizers
Cromolyn - Nedocromil
Act by stabilization of mast cell
membrane
Have poor oral absorption
Given by inhalation
Not bronchodilators
Not effective in acute attack of
asthma
Prophylactic anti-inflammatory
drugs
Children respond better than
adults
14. Uses
Prophylactic therapy in asthma especially in children
Allergic rhinitis
Conjunctivitis
Side effects
Bitter taste
minor upper respiratory tract irritation (burning sensation)
15. Corticosteroids
Are not bronchodilators
Given as prophylactic medications, used alone or combined
with beta-agonists
Mechanism of action
– Inhibition of phospholipase A2 → ↓ prostaglandin and
leukotrienes
– Mast cell stabilization →↓ histamine release
– Upregulation of β2 receptors
16.
17. Routes of administration
Inhalation
Budesonide, Fluticasone, Beclomethasone
Less side effects
Oral
Prednisolone
Parenteral
Hydrocortisone, Methylprednisolone
Status asthmaticus (IV infusion)
18. Side effects of systemic corticosteroids
Adrenal suppression
Growth retardation in children
Osteoporosis
Fluid retention, weight gain, hypertension
Hyperglycemia
Susceptibility to infections
Glaucoma
Cataract
Fat distribution, wasting of the muscles
Psychosis
19. Inhalation therapy has less side effects
Oropharyngeal candidiasis (thrush)
Dysphonia (voice hoarseness)
Withdrawal
Abrupt stop of corticosteroids should be avoide
and dose should be tapered (adrenal insufficiency
syndrome)
20. Anti-IgE antibody
Omalizumab
A monoclonal antibody directed against human IgE
It binds to the IgE on sensitized mast cells and prevents activation
by asthma triggers and subsequent release of inflammatory mediators
Expensive-not first line therapy
21.
22. Differentiating Asthma From COPD
Asthma
Reversible
No parenchymal destruction
Eosinophils , T- cells
Responds well to steroids
COPD
Irreversible
Tissue destruction
Primarily neutrophils
Less responsive to steroids
Smoking
23. Recent Advances in the Treatment of Asthma
Novel class of bronchodilators
Immunomodulatory therapies
Newer anti- inflammatory therapies
Mediator antagonists
Miscellaneous approaches
Cytokine modifiers
Chemokine Receptor antagonist.