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Dr. S P SRINIVAS NAYAK, profile picture
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Sulfonyl ureas pharmacology Presented by arjumand

The document discusses sulfonylureas, commonly used oral hypoglycemic drugs for treating diabetes mellitus, which enhance insulin release from pancreatic beta cells. It details their mechanism of action, side effects like low blood sugar and weight gain, and interactions with other drugs. The presentation also lists first and second-generation sulfonylureas and cites sources for further reference.

Health & Medicine◦
PRESENTED BY: ARJUMAND NAVEERA PHARMD [PB]. SULTAN –UL-ULOOM COLLEGE OF PHARMACY Guided by: Dr. S P Srinivas Nayak, Assistant Professor, SUCP, Hyd. 3/5/2021 ARJUMAND, SUCP
OBJECTIVES 1. Introduction 2. Types 3. Mechanism of Action 4. Pharmacokinetics 5. Side Effects 6. Drug Interactions 3/5/2021 ARJUMAND, SUCP
Sulfonylureas are most commonly used Oral Hypoglycemic drugs helpful in treating Diabetes Mellitus . They show their effects on beta cells of the pancreas to release insulin which maintains the blood sugar level. They are also called as ATP sensitive Potassium[K] channel blockers. 3/5/2021 ARJUMAND, SUCP
First Generation • Tolbutamide • Chlorpropamide • Tolazamide Second Generation • Glibenclimide • Glimepiride • Glipizide • Gliclazide • Glibornuride 3/5/2021 ARJUMAND, SUCP
Sulfonylureas bind to and close ATP-sensitive K+ (KATP) channels on the cell membrane of pancreatic beta cells, which depolarizes the cell by preventing potassium from exiting. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granules with the cell membrane, and therefore, increased secretion of mature insulin. 3/5/2021 ARJUMAND, SUCP
3/5/2021 ARJUMAND, SUCP
 The most common side effect is low blood sugar. This can make you feel shaky, sweaty, dizzy, and confused. Severe low blood sugar can be life- threatening. To prevent it, eat regularly.  Other side effects can be weight gain, dark urine, and stomach upset. Sulfonylureas can also cause skin rashes and adverse reactions to the sun. 3/5/2021 ARJUMAND, SUCP
Drugs Increasing the activity  NSAIDS, Warfarin, Sulphonamide drugs – By displacing the protein binding  Alcohol , Cimitidine , Chloramphenicol – By decreasing SU metabolism Drugs Decreasing the activity  Diuretics , Corticosteroids – By increasing blood sugar level 3/5/2021 ARJUMAND, SUCP
• Text book of PHARMACOLOGY – KD TRIPATHI • Clinical Pharmacy and Therapeutics [ 3 Edition ] – ROGER WALKER • Wikipedia • Text book of PHARMACOLOGY [ 2 Edition ] – JAGDISH PRASAD 3/5/2021 ARJUMAND, SUCP
3/5/2021 ARJUMAND, SUCP * SULTN UL ULOOM COLLEGE OF PHARMACY *THANK YOU