The document summarizes the structure and components of DNA. It discusses that DNA is composed of four nucleotides - adenine, guanine, cytosine, and thymine - connected by phosphodiester bonds to form two polynucleotide chains in a double helix structure. The three main chemical components of DNA are phosphoric acid, deoxyribose sugar, and nitrogenous bases. Recent advances discussed include identifying passenger mutations in cancer genomes and developing a mouse model called Cancer Rainbow to visualize the functional genomics of oncogenic clonal expansion in tissues.
Causes of Heritability by Structural and Numerical chromosome changes fenta assefa
Chromosomes are thread-like molecules that carry hereditary information for everything.
They are made of protein and one molecule of DNA, which contains an organism’s genetic instructions, passed down from parents In humans, animals, and plants, most chromosomes are arranged in pairs within the nucleus of a cell
Cyclic conformation and nucleic acid sugar puckeringDaniel Morton
Cyclic systems are ubiquitous, in nature and synthetic chemistry. Establishing an understanding of the shape preferences (e.g., strain and energetics) regarding representative cyclic models is a powerful tool in conformational analysis. The expanded review of fundamental cycloalkanes can further assist in preferential conformational analysis of associated derivatives.
Contributed by: Roland Jones, Dane Brankle, and Peter Stevenson, University of Utah, 2015
Causes of Heritability by Structural and Numerical chromosome changes fenta assefa
Chromosomes are thread-like molecules that carry hereditary information for everything.
They are made of protein and one molecule of DNA, which contains an organism’s genetic instructions, passed down from parents In humans, animals, and plants, most chromosomes are arranged in pairs within the nucleus of a cell
Cyclic conformation and nucleic acid sugar puckeringDaniel Morton
Cyclic systems are ubiquitous, in nature and synthetic chemistry. Establishing an understanding of the shape preferences (e.g., strain and energetics) regarding representative cyclic models is a powerful tool in conformational analysis. The expanded review of fundamental cycloalkanes can further assist in preferential conformational analysis of associated derivatives.
Contributed by: Roland Jones, Dane Brankle, and Peter Stevenson, University of Utah, 2015
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Levels of organisation of DNA explains how 2 meters long DNA is compacted into chromatin. Useful self-assessment questions are given in the slides. If you want to know the answer, you can ask in comments.
Genetics and malocclusion /certified fixed orthodontic courses by Indian de...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
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Chromosome structure and packaging of dnaDIPTI NARWAL
Chromosome structure : classification based upon centromere position, autosomes and allosomes
Morphology of chromosome: chromatids, chromomeres, telomeres, sister chromatids
packaging of DNA: nucleosome model
functions of Chromosomes
DNA - The building blocks of all life - lecture notes from a presentation by Jill Pullan to Mansfield U3A Science and Technical group.
http://www.mansfield-u3a.org.uk/.
Chromosomes are known as hereditary vehicles
They are formed of strands of DNA molecules which contain information for the development of different characteristics and performance of various metabolic activities of the cells
The coordination of various function is brought about through the formation of enzymes which are complex protein molecules
Dna replication and importance of its inhibition pdfssuserf4e856
A research topic submitted by some students of the first year in Al-Azhar Pharmacy in Assiut in 2020 in the subject of cell biology under the supervision of Dr. Omar Mohafez holds a PhD in biochemistry and is a professor at the same college.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Levels of organisation of DNA explains how 2 meters long DNA is compacted into chromatin. Useful self-assessment questions are given in the slides. If you want to know the answer, you can ask in comments.
Genetics and malocclusion /certified fixed orthodontic courses by Indian de...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Chromosome structure and packaging of dnaDIPTI NARWAL
Chromosome structure : classification based upon centromere position, autosomes and allosomes
Morphology of chromosome: chromatids, chromomeres, telomeres, sister chromatids
packaging of DNA: nucleosome model
functions of Chromosomes
DNA - The building blocks of all life - lecture notes from a presentation by Jill Pullan to Mansfield U3A Science and Technical group.
http://www.mansfield-u3a.org.uk/.
Chromosomes are known as hereditary vehicles
They are formed of strands of DNA molecules which contain information for the development of different characteristics and performance of various metabolic activities of the cells
The coordination of various function is brought about through the formation of enzymes which are complex protein molecules
Dna replication and importance of its inhibition pdfssuserf4e856
A research topic submitted by some students of the first year in Al-Azhar Pharmacy in Assiut in 2020 in the subject of cell biology under the supervision of Dr. Omar Mohafez holds a PhD in biochemistry and is a professor at the same college.
A brief introduction to human genetics. Relevant to medical students i.e biochem, anatomy and physiology students.
It might be very short but it is also helpful.
Nucleic acids are macromolecules that store genetic information and enable protein production. Nucleic acids include DNA and RNA. These molecules are composed of long strands of nucleotides. Nucleotides are composed of a nitrogenous base, a five-carbon sugar, and a phosphate group.
DNA Methylation and Epigenetic Events Underlying Renal Cell Carcinomaskomalicarol
Renal cell carcinoma (RCC) refers to a group of tumors that develop from the epithelium of the kidney tubes, including clear cell
RCC, papillary RCC, and chromophobe RCC. Most clear cell renal
carcinomas have a large histologic subtype, genetic or epigenetic
genetic von Hippel-Lindau (VHL). A comprehensive analysis of
the genetic modification genome suggested that chromosome 3p
loss and chromosome gains 5q and 7 may be a significant copy
defect in the development of clear kidney cell cancer. A more potent renal cell carcinoma may develop if chromosome 1p, 4, 9,
13q, or 14q is also lost. Renal carcinogenesis is not associated with
chronic inflammation or histological changes. However, regional hypermethylation of DNA in CpG C-type islands has already
accumulated in cancer-free kidney tissue, implying that the presence of malignant kidney lesions may also be detected by modified
DNA methylation. Modification of DNA methylation in cancerous
kidney tissue may advance kidney tissue to epigenetic mutations
and genes, leading to more serious cancers and even determining
a patient’s outcome
Genes code for gene products. What does this statement mean Briefly.pdfjibinsh
Genes code for gene products. What does this statement mean? Briefly describe the structure of
DNA by using the following terms: nucleotide, strand, complementary, deoxyribose, phosphate,
anti-parallel, base pairing, adenine, cytosine. How many DNA molecules are in a chromosome?
How many genes are in an average bacterial chromosome? What is the purpose of DNA
replication? (\"To make more DNA\" would not be a complete answer.) Summarize the process
of DNA replication by using the following terms: replication fork, template, nucleotide, primer,
DNA polymerase, DNA ligase. (Know what each term means.) Summarize the process of RNA
synthesis (transcription) by using the following terms: template, promo RNA polymerase,
rRNA, mRNA, tRNA, terminator. (Know what each term means.) Where are operons found and
what is the advantage of organization of genes within operons? What are some fundamental
differences in organization of genes between prokaryotes and eukaryotes? How do eukaryotes
produce mRNA that they can use for translation? Summarize the process of protein synthesis
(translation) by using the following terms: genetic code, ribosome, mRNA, protein, amino acid,
tRNA, codon, anticodon, start codon, stop codons, polypeptide. (Know what each term means.)
Be able to predict the sequence of a complementary strand in both DNA and RNA synthesis, w
hen the template sequence is given. Be able to use genetic code table to predict amino-acid
sequence of a encoded by a nucleic acid, when the nucleic acid sequence is given. Classify
mutations by type and briefly describe how mutations arise, are prevented or repaired. Explain
why mutations are important by giving at least three different examples. Why do bacteria and
viruses mutate so much faster than eukaryotes? What are some consequences of Briefly explain
(and be able to compare and contrast) three different mechanisms of horizontal gene in bacteria:
transformation, conjugation and transduction. What are some practical implications of these
phenomena?
Solution
3. Genes code for gene products
Gene is a portion of DNA. It is made up of nucleotide sequences. It expresses itself and transfer
from one generation to next generation.
Gene expression means the nucleotide sequence is used for synthesizing a biomolecules-
generally it is protein but it may be RNA molecules. Here gene products are those proteins and
RNAs.
4. Structure of DNA
DNA or deoxyribonucleic acid is the molecule that contains all genetic information of an
organism.
DNA has a double helix shape, which is like a ladder twisted into a spiral. Each spiral is
composed of polynucleotides. Each nucleotide is made up of - deoxyribose, a kind of sugar with
5 carbon atoms; a phosphate group made of phosphorus and oxygen, and nitrogenous base. There
are four types of nucleotide: Adenine (A), Thymine (T), Cytosine (C), Guanine (G). Nucleotides
are joined to one another by covalent bonds between the sugar of one nucleotide and the
phosphate of the next, kn.
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The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
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The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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Structure Of DNA & Recent advances in genomes
1. Structure Of DNA & Recentadvances in genomes
By Muhammad HabibUllah 2015-ag-7783
Farooq Zahid 2016-ag-9907
Husnain Ali 2016-ag-5273
UAF Sub Campus Depalpur Okara
Bsc Hons. Agri sciences 4th semester Section B
Deoxyribonucleic acid (DNA) is composed of four deoxyribonucleotides,
i. deoxyadenylate (A),
ii. deoxyguany late (G),
iii. deoxycytidylate (C)
iv. thymidylate (T)
To construct a lengthy polypeptide chain, these units are connected by 3′ to 5′
phosphodiesterlinkages. DNA is the genetic substancefound in all creatures, and it
binds with histone protein in chromosomes. The helical helix of DNA is formed by
two polynucleotide chains. Phosphoric acid, deoxyribose sugar, and four different
2. forms ofnitrogenous bases are the major chemical components ofDNA. Phosphoric
acid forms an ester link with sugar, a glycosidic connection between sugar and base,
and a hydrogen bond between bases. These are the fundamental elements that make
up the entire DNA structure. The importance of the nucleotide sequence of DNA
cannot be overstated. The genetic information is encoded in a certain base sequence;
if the base is changed, the information is changed as well.
F. Misher separated DNA from nucleous in 1869, and Altman coined the term
nucleic acid in 1889. The suitable DNA double helix model provided by Watson
and Crick can explain the gene's specificity.
3. DNA's chemical Composition is as follows: There are three primary components in
deoxyribonucleic acid.
1. Phosphoric acid (H3PO4)
2. Pentosesugar
3. Nitrogenous Base
1. Phosphoric acid, like phosphate, is found in nature and forms the backboneof
DNA molecules, with sugar molecules. It connects the nucleotides byforming
an ester phosphatebond between the deoxyribosesugars of two neighbouring
nucleotides. This bond connects the 3prime carbon in one nucleotide to the
5prime carbon in the following nucleotide.
4. 2. Deoxyribose sugar is a pentose sugar with the molecular formula C5H10O4.
Pentosesugar has a pentagonal ring structure with 3 and 5 prime carbonatoms
attached to phosphoric acid and 1 prime carbon atom attached to the base.
3. There are two types of nitrogenous base.
1. Purine
2. pyrimidine
it is completely fabricated of adenine and guanine with two heterocyclic
rings C,H,O, and N atoms.
5. The 1prime C of the ribose sugar joins the base through a glycosidic bond in DNA,
and this molecule is known as nucleoside. The complete compound is called a
nucleotide when 5prime C is connected to phosphoric acid by an ester bond. A
strand is formed when two deoxyribonucleotides are linked by a phosphodiester
link. DNA contains two strands becauseit is a double helix. The other strand runs
in the opposite or antiparallel direction, i.e., if one strand runs from 3 prime to 5
prime end forward, the other runs from 5 prime to 3 prime end backward. A
hydrogen connection between two nitrogenous bases connects the two strands.
Adenine always creates two bonds with thymine, while cytosine always creates
three bonds with the guanine base.
NUCLEOSIDE NUCLEOTIDE
6. Double Helix structure of DNA
The ‘backbones' of DNA molecules are made up of sugar and phosphates in an
alternating pattern. The rungs of the ladder are made up of hydrogen-bonded bases.
Recent advances in genomes
7. There are many recent advances are covered in the genomes. Some important
advances are discussed here….
1. PassengerMutations in More Than 2,500 Cancer Genomes:Overall
MolecularFunctionalImpact and Consequences
In comparison to a homogeneous background expectation, the percentage of
genes in different gene categories influenced by driver (grey band) and
probable passenger (faded yellow band) LoFs (dashed black line). Different
tumor kinds are represented by the data points in the boxplot. A Kolmogorov
Smirnov (KS) testwas used to determine statistical significance between these
percentages for each of the cancer cohorts.
In comparison to a uniform genomic backdrop, heat map demonstrating
enrichment (red color) and depletion (blue color) of motif gain (upper panel)
and loss (bottom panel) events induced by putative passenger mutations for
distinct TFs. The red-hued TFs are well-known cancer genes. The statistical
significance values for several TFs have been given.
Gain (positive alteration bias) and loss (negative alteration bias) of motif
events found across ETS TF-regulated target genes (on the x axis). The green
triangle represents pan-cancer alteration bias, while the coloured circles
represent alteration bias for distinct cancer cohorts. The frequency of motif-
altering occurrences is shown by the size of the circles.
Genes that are differently expressed due to gain of motif events in TFs
belonging to the ETS TF family are shown in a Q-Q plot. (E) The presence of
significant deletions in the germline and somatic tissues that can engulf or
partially erase coding areas and TF binding peaks.
8. 2. A cancer rainbow mouse for visualizing the functional genomics of
oncogenic clonal expansion
Field cancretization is a premalignant process characterized by the
distribution of clones of oncogenic mutations throughout the epithelium. The
processes underlying the rapid spread of oncogenic clones are unknown, and
the timelines ofintestinal field cancretization can be diverse. Forfluorescently
barcoding somatic mutations and immediately observing clonal proliferation
and spread of oncogenes, we use a Cancer rainbow (Crainbow) modelling
system. Crainbow found that ß-catenin (Ctnnb1) mutations in intestinal stem
cells causeextensive oncogeneproliferation during perinatal development but
not in adults. Mutations that damage the stem cell microenvironment
extrinsically, on the other hand, can quickly propagate through the adult gut.