This document provides an overview of systemic lupus erythematosus (SLE), an autoimmune disorder characterized by inflammation of multiple organ systems. It discusses the epidemiology, etiology, clinical manifestations, diagnostic criteria, treatment approaches, and new developments for SLE. Key points include that SLE affects multiple organ systems, is associated with various autoantibodies, and treatment involves managing symptoms, preventing flares and organ damage through immunosuppression and addressing traditional cardiovascular risk factors.