This study evaluated the use of Shear Wave Elastography (SWE) on 724 breast tumors compared to conventional ultrasound and BIRADS classification. SWE measures tissue stiffness in kilopascals and provides an elastogram and elastic ratio. The results showed that malignant tumors tended to have higher stiffness (22-300 kPa) and elastic ratios (3.3-26.4) compared to benign tumors (4-45 kPa, elastic ratio of 0.7-4.6). SWE can help reclassify some lesions and guide biopsy, improving diagnosis of breast tumors over conventional ultrasound alone.
Ultrasound elastography is a relatively advanced technique used to know the stiffness of the tissue. It is a non-invasive technique. Broadly classified into Quasistatic and Dynamic elastography.
presentation on ultrasound elastography-introduction ,techniques,physics,application, interpretation and future prospects.sourced from multiple articles.
Physicians have used palpation to detect differences in tissue stiffness as an aid to diagnosis based on the fact that the mechanical properties of tissues are often dramatically affected by the presence of disease processes such as cancer, inflammation, and fibrosis. Elastography depends on the same differences in mechanical properties between healthy and abnormal tissues using imaging to detect these differences at depths not reachable by manual palpation and presents data in color-coded display, can be performed with ultrasound, using manual pressure or low frequency sonic waves, or by MR Elastography imaging.
Ultrasound elastography is a relatively advanced technique used to know the stiffness of the tissue. It is a non-invasive technique. Broadly classified into Quasistatic and Dynamic elastography.
presentation on ultrasound elastography-introduction ,techniques,physics,application, interpretation and future prospects.sourced from multiple articles.
Physicians have used palpation to detect differences in tissue stiffness as an aid to diagnosis based on the fact that the mechanical properties of tissues are often dramatically affected by the presence of disease processes such as cancer, inflammation, and fibrosis. Elastography depends on the same differences in mechanical properties between healthy and abnormal tissues using imaging to detect these differences at depths not reachable by manual palpation and presents data in color-coded display, can be performed with ultrasound, using manual pressure or low frequency sonic waves, or by MR Elastography imaging.
This presentation was held by dr. Antonio Pio Masciotra - italian radiologist - on Novembre 2012 at Prato.
It concerns about neoplastic tissue's elasticity and breast elastography.
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
A Radiological Approach to CraniosynostosisFelice D'Arco
Presentation Summary: Normal Cranial Development (Anatomy and Genetic), Imaging Technique (how to do 3D CT, when to do MRI, why to do not do Plain Film), Imaging Patterns of Craniosynostosis, Associated Complications, Pitfalls.
This presentation was held by dr. Antonio Pio Masciotra - italian radiologist - on Novembre 2012 at Prato.
It concerns about neoplastic tissue's elasticity and breast elastography.
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
A Radiological Approach to CraniosynostosisFelice D'Arco
Presentation Summary: Normal Cranial Development (Anatomy and Genetic), Imaging Technique (how to do 3D CT, when to do MRI, why to do not do Plain Film), Imaging Patterns of Craniosynostosis, Associated Complications, Pitfalls.
Ultrasound Elastography is a new imaging technique that allows a noninvasive estimation and imaging of tissue elasticity distribution within biological tissues using conventional, Real Time Ultrasound equipment with modified software. It can be viewed as an electronic palpation of tissues. Introduced by Ophir et al in 1991, it subsequently evolved into a Real Time Imaging tool.
Detecting Early Liver Fibrosis - A Nutshell for Primary CareJarrod Lee
This presentation summarizes the latest technologies for detecting early liver fibrosis and their role in healthcare today. It is aimed at primary care doctors, to help them better utilize these new developments for their patients.
PRIMARY SQUAMOUS CELL CANCER OF BREAST: A CASE REPORTKETAN VAGHOLKAR
Primary squamous cell cancer (SqCC) of the breast is a rather rare disease. These tumors are known to be
quite aggressive in nature and are usually found to be treatment-resistant. Currently, there is no standard treatment
guideline for the management of primary SqCC of the breast. In this case report, we present a case of primary SqCC of
the breast in 60-year old postmenopausal women presenting as pigmented lesion over the right breast (no lump). Initial
skin biopsy (core) done by dermatologist revealed squamous cell cancer in situ (Bowen’s disease); however surgical
resection of the lesion and subsequent histopathological examination revealed primary SqCC (no secondary sites were
found elsewhere in the body).
Role of Tomosynthesis in Assessing the Size of the Breast LesionApollo Hospitals
To assess the role of 3D tomosynthesis in the evaluation of the size of malignant breast lesions and to compare it with the size in 2D, Ultrasound and final Histopatholgy.
Original StudyType of Breast Cancer Diagnosis, Screening,a.docxvannagoforth
Original Study
Type of Breast Cancer Diagnosis, Screening,
and Survival
Carla Cedolini,1 Serena Bertozzi,1 Ambrogio P. Londero,2 Sergio Bernardi,3,4
Luca Seriau,1 Serena Concina,1 Federico Cattin,1 Andrea Risaliti1
Abstract
Organized, invitational breast cancer screening in our population succeeded in detecting early-stage tumors,
which have been consequently treated more frequently with breast and axillary conservative surgery, com-
plementary breast irradiation, and eventual hormonal therapy. The diagnosis of invasive cancer with screening
in our population resulted in a survival gain at 5 years from the diagnosis.
Introduction: Breast cancer screening is known to reduce mortality. In the present study, we analyzed the prevalence
of breast cancers detected through screening, before and after introduction of an organized screening, and we
evaluated the overall survival of these patients in comparison with women with an extrascreening imaging-detected
breast cancer or those with palpable breast cancers. Materials and Methods: We collected data about all women
who underwent a breast operation for cancer in our department between 2001 and 2008, focusing on type of tumor
diagnosis, tumor characteristics, therapies administered, and patient outcome in terms of overall survival, and re-
currences. Data was analyzed by R (version 2.15.2), and P < .05 was considered significant. Results: Among the 2070
cases of invasive breast cancer we considered, 157 were detected by regional mammographic screening (group A),
843 by extrascreening breast imaging (group B: 507 by mammography and 336 by ultrasound), and 1070 by extra-
screening breast objective examination (group C). The 5-year overall survival in groups A, B, and C were, respectively,
99% (95% CI, 98%-100%), 98% (95% CI, 97%-99%), and 91% (95% CI, 90%-93%), with a significant difference
between the first 2 groups and the third (P < .05) and a trend between groups A and B (P ¼ .081). Conclusion: The
diagnosis of invasive breast cancer with screening in our population resulted in a survival gain at 5 years from the
diagnosis, but a longer follow-up is necessary to confirm this data.
Clinical Breast Cancer, Vol. 14, No. 4, 235-40 ª 2014 Elsevier Inc. All rights reserved.
Keywords: Breast cancer, Breast cancer screening, Invasive breast cancer, Mammographic screening, Overall survival
Introduction
Because of the detection of early-stage tumors, breast cancer
screening reduced breast cancer mortality in Europe by 25%-31%
in patients who were invited for screening and by 38%-48% in
those who were actually screened during the last decade of the
twentieth century and the first decade of the twenty-first.1 In our
region of Italy, an organized breast cancer screening was firstly intro-
duced in 2005, but despite the high compliance of invited women
1Clinic of Surgery
2Clinic of Obstetrics and Gynecology
University of Udine, Udine, Italy
3Department of Surgery, Ospedale Civile di Latisana, Udine, Italy
4 ...
Comprehensive review of Isolated Axillary lymph nodal metastasis of unknown origin- Clinically unknown primary axilla which includes detailed approach and management of inguinal lymph nodal metastasis also
Report on LUS for post COVID19 Infection Patients, NGUYEN THIEN HUNG et al, M...hungnguyenthien
Report of LUS on 11 patients (5 man and 6 female) underwent COVID-19 infection for average 30 days showed that lung lesions were still existed with small evident and LUS score total <10.
Lung Ultrasound Post-COVID-19 Infection, Hung Nguyen Thien and Ultrasound Dep...hungnguyenthien
11 cases (5 male and 6 female) were post COVID-19 infection, enrolled in LUS with remained lesions in left posterior basal lung than right one. LUS score total < 10 according to protocol of ROUBY.
Evaluation of Hyperferritinemia in Diabetic Patientshungnguyenthien
Hyperferritinemia with normal transferrin saturation, with or without iron overload is often found in patients with hepatic steatosis and/or hepatitis. The metabolic hyperferritinaemia (disorder of iron and glucose and/or lipid metabolism) may occur with the incidence up to 49% in type 2 diabetes mellitus.
A review on of AAA at Medic Center for 10 years (1990-2000), 246/987 cases of AAA dissecting were detected and documented by ultrasound and CT scanning confirmed, # 24.9%, that had been prothesis grafting later in Binh dan hospital.
BIRADS- 5 NON CANCER, Dr Đỗ Bình Minh Dr Hương Gianghungnguyenthien
Một số bệnh lý vú lành tính có hình ảnh học giống ung thư được trình bày gồm sẹo nan hoa (radial scar), bệnh tuyến xơ hóa (sclerosing adenosis), bệnh vú xơ hóa do đái tháo đường (diabetic fibrous breast disease), viêm vú mạn tính gồm hoại tử mỡ (fat necrosis) và lao vú.
CAP va ARFI trong Gan Mỡ , Nguyễn Thiện Hùng, Nguyễn thị Hồng Anh , Phạm thị ...hungnguyenthien
Đối chiếu CAP, Fibroscan,ARFI, và Siêu âm B-Mode trên 84 bệnh nhân gan mỡ không do rượu. B-Mode và CAP tương hợp trong khi Fibroscan và ARFI không tăng theo độ mỡ CAP.
Case 430: FACIAL EDEMA, Dr PHAN THANH HẢI, Dr LÊ NGỌC VINHhungnguyenthien
Woman 33yo, with history onset one year ago, fever and some red macula appeared at abdominal skin that biopsy result of macula was lipoma. But it is not in stop of progress, a lot of red macula were getting more over 2 legs and upper arms to her right face.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. OBJECTIVES: To evaluate shear wave elastography of breast tumors in comparison to conventional ultrasound and BIRADS classification.
3. MATERIAL and METHODS A descriptive, cross-sectional, prospective study. In comparison the SWE to conventional ultrasonography, mammography and biopsy (FNA and core biopsy) from November 2009 to November 2010 at Medic Medical Center. Conventional ultrasound MEDISON with linear probe 10MHz, and Supersonic Imagine system, linear probe 15MHz . 724 breast tumors with 568 benign tumors and 156 malignant tumors .
4. Fig.1: A breast tumor with regular contour ( BIRADS III) on conventional US. On SWE system this tumor becomes BIRADS IV on B-Mode and the stiffness (hard).
8. With 724 cases: 568 benign tumors (fibrocystic changes, fibroadenona, phyllodes tumors) # 78 % (4 to 45 kPa), with elastic ratio ER from 0.7 to 4.6. 156 malignant tumors # 22 % (from 22 to 300 kPa), with ER from 3.3 to 26.4. Nota: *kPa :stiffness with kiloPascal units *ER (elastic ratio): proportion of stiffness of tumor and surrounding tissue. Results: Table 1: Distribution of elastic values of benign and malignant breast tumors. kPa Benign tumors Malignant tumors < 20 527 20 <30 27 4 30 <40 9 10 40 <50 5 32 50 <60 19 60 <70 12 > 70 79
9. Discussions: Diagnostic criteria= elastogram, dimension, homogeneity, elastic value, and elastic ratio. 1/156 cases of malignant tumor: most of cases with elastic value from 40kPa to 70kPa or more. 14 cases with elastic value less than 40kPa, but ER higher than 4 times. 2/ Benign tumors with elastic value of 20kPa. 41 cases (#7%) more than 20kPa but lower than 45kPa: fibroadenoma with great dimension, huge phyllodes tumors (inhomogenous elastogram with blue color dominant).
10. 3. Proposal management : Breast tumors with BIRADS II-III, low stiffness, low ER : follow up. Breast tumors with BIRADS III and high stiffness: reclassified to BIRADS IV and biopsy. Breast tumors with BIRADS IV and low stiffness:reclassified to BIRADS III and follow up. With a benign of biopsy result their results are not false negative. Elastogram analysis: very high kPa value, no need to check In case of low kPa, must refer elastic ratio (ER). The higher ER the higher possibility of malignancy.
11. 4. Elastogram analysis : Benign tumor = between blue and yellow code (from soft to hard) and homogenous. Malignant tumor: elastogram changes from yellow to red (hard) and homogenous. Because of central necrosis the center of tumor is always softer than (blue). So need to evaluate altogether elastic value (stiffness), elastic ratio and elastogram to gain an exact diagnosis. Elastogram may help choosing the area of biopsy.
15. CONCLUSIONS: Malignant tumor has elastic value of 40-70kPa and more. Benign tumor, under 20kPa. SWE improves sensibility and speficity of ultrasound in diagnosing breast tumor and decreases the rate of breast biopsy.