This document summarizes minimal invasive interventional procedures for breast lesions. It discusses ultrasound-guided breast biopsy procedures and whether they can provide minimal invasive diagnosis and treatment of benign and malignant lesions. Various biopsy methods and devices are reviewed, including vacuum-assisted biopsy. Indications, risks, sample size, and follow up after biopsy are addressed. Underestimation rates of ductal carcinoma in situ and atypical lesions with biopsy are discussed. Radiological-pathological concordance and determining appropriate management of biopsy results is also covered. Radiofrequency ablation is presented as a potential minimal invasive treatment option.
Purpose of this presentation is to educate non radiologist about basic CT anatomy of abdominal viscera and basic interpretation of very common diseases
This presentation consist MR procedure of pelvis and hip joint , anatomy and MR planning is shown by picture with positioning block and parameters are included ,it includes basic sequence of both procedures
Purpose of this presentation is to educate non radiologist about basic CT anatomy of abdominal viscera and basic interpretation of very common diseases
This presentation consist MR procedure of pelvis and hip joint , anatomy and MR planning is shown by picture with positioning block and parameters are included ,it includes basic sequence of both procedures
This presentation include biliary anatomy ,indication, contraindication post op care of percutaneus transhepatic biliary drainage with important technique. and advantage and disadvantage of different technique. This is important for radiologist, radiographers, intervention radiologist radiology resident. Thanks
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
computed tomography intravenous urography protocol and advancements ,,, slides coves urinary system anatomy glance ,, contrast media used in procedure , radiation doses and some pathological findings
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
This presentation include biliary anatomy ,indication, contraindication post op care of percutaneus transhepatic biliary drainage with important technique. and advantage and disadvantage of different technique. This is important for radiologist, radiographers, intervention radiologist radiology resident. Thanks
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
computed tomography intravenous urography protocol and advancements ,,, slides coves urinary system anatomy glance ,, contrast media used in procedure , radiation doses and some pathological findings
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
Dr Ian Katz, Dermatopathologist, from Southern Sun Skin Cancer Clinic and Southern Sun Pathology, discusses the pro and cons of using shave biopsies in clinical skin cancer practice.
Indications to CTC are increasing
CTC is recommended in all cases of unfeasibility of colonoscopy
CTC is not ready for mass screening but is ideal for screening on an individual basis.
Sentinel lymph node biopsy before neoadjuvant chemotherapy for clinical axill...Dr./ Ihab Samy
Ihab S. Fayeka MD; Fouad A. Saleepa MD; Hany F. Habashyb MD; Alfred E. Namourc MD ; Iman G. Farahatd MD ;Magdy Kotbe MD
a: department of surgical oncology - national cancer institute - Cairo university - Egypt.
b: department of surgery - Fayoum university hospital - El Fayoum - Egypt.
c: department of medical oncology - national cancer institute - Cairo university - Egypt.
d: department of surgical pathology - national cancer institute - Cairo university - Egypt.
e: department of nuclear medicine - national cancer institute - Cairo university - Egypt.
For correspondance contact: drihab74@hotmail.com
Kasr el-aini journal of surgery Volume 14, No.1, January 2013
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Luc Rotenberg : US guided vacuum breast biopsy and minimal Invasive Interventional procedures
1. !
Minimal Invasive Interventional
procedures in breast lesion
Luc Rotenberg, Grégory Lenczner, Jean Guigui,
Catherine Bèges, Henri Ouazan
RPO – ISHH
Clinique Hartmann-CMC Ambroise Paré
26-27 bdVictor Hugo
92200 Neuilly Sur Seine - France
dr.rotenberg@radiologieparisouest.com
2. !
US guided Breast interventional
procedures:
What possible, what feasible ?
5. !
Breast Intervention: How I Do It
Mary C. Mahoney, Mary S. Newell, Cincinnati, Altlanta
Radiology, 2013, Vol.268: 12-24, 10.1148/radiol.13120985
S Written informed consent is required before all breast interventions
S The risks explained to the patient include bleeding and infection
S Anticoagulation is a relative contraindication to all biopsies
S patients are usually asked to discontinue therapy for a short time prior to the
biopsy
S The patient should be informed of the potential benefits of the biopsy
S including avoidance of surgery with benign results
S preoperative confirmation of malignancy, which allows definitive surgical treatment in one
surgical setting
S Tailored prebiopsy counseling may better prepare women for percutaneous breast
biopsy and improve their overall experience.
6. !
Minimal Invasive Interventions
Methods - Overview
Methods - Comparison
Risk and complications
Tumor cells after
Intervention
Reimbursement
pricing
Preconditions for
Minimal Invasive Interventions
7. !
Preconditions for Minimal Invasive Interventions:
Complementary Breast Diagnostic
Clinical Examination Mammography Sonography
Radiological
Special X-Rays
Color Doppler
Sonography MRI
8. !
Breast Biopsy : Ultrasound
Why Ultrasound Guidance?
• Real-time imaging of the breast
• Patient is lying on their back
• Ultrasound has excellent contrast resolution
• Cost effective
• Non-ionizing
• Portable
9. !
S Side
S Size
S h x L x l
S Location
S Quadrant
S Radius zone
S Distance to the nipple
Balistic target tracking
• US
• RX
• MRI
10. !
• Side
• Size
• h x L x l
• Location
• Quadrant
• Radius zone
• Distance to the
nipple
S Deep / cutaneous plane
US balistic target tracking
11. !
S Vacuum assisted devices
S Mammotome
S 1995, 11 et 8 g
S Vacora (Bard)
S 2003, 10 g
S 2007, 14 g
S Atec (Suros - Hologic)
S 2007, 12 g 9 g
S Seno RX (Bard)
S 2009, 10 g, 7 g
S Intact 2009
S Large core devices
S 16 g
S 14 g
S Single use devices +++
S Other biopsy devices
S Spirotome & Coramate
(Medinvents)
S 2007, 14 et 9 g
S Celero (Hologic)
S 2008 12 g
S Finesse (Bard)
S 2010 14 g
Choice of the Needle
15. !
Indications for diagnostic representative or
ablative Vacuum - Biopsy (VABB) /US
1. After Large Core Needle Biopsy (LCNB) and suspicion of breast cancer (BI-RADS®
4c / 5, missmatch / discordance of the results of diagnostic imaging and histology)
2. Suspicious lesions (BI-RADS® 4 / 5) diameter ~ 5 mm
3. Resection of definitely benign, but symptomatic findings or High risk patients
1. symptomatic Fibroadenoma
2. recurrent symptomatic cysts
4. Intraductal / intracystical proliferations : singulary Papilloma, complex cyst
5. Neoadjuvant Chemotherapy
6. Suspiscious of local recurrence
7. Hazardous or dangerous location : deep, superficial, implants…
16. !
Indications for diagnostic representative or
ablative Vacuum - Biopsy (VABB) /US
1. After Large Core Needle Biopsy (LCNB) and suspicion of breast cancer (BI-RADS®
4c / 5, missmatch / discordance of the results of diagnostic imaging and histology)
2. Suspicious lesions (BI-RADS® 4 / 5) diameter ~ 5 mm
3. Resection of definitely benign, but symptomatic findings or High risk patients
1. symptomatic Fibroadenoma
2. recurrent symptomatic cysts
4. Intraductal / intracystical proliferations : singulary Papilloma, complex cyst
5. Neoadjuvant Chemotherapy
6. Suspiscious of local recurrence
7. Hazardous or dangerous location : deep, superficial, implants…
24. !
Interactive Case Review of Radiologic and Pathologic Findings from
Breast Biopsy: Are They Concordant? How Do I Manage the Results?
Christopher P. Ho, MD, Jennifer E. Gillis, MD, Kristen A. Atkins, MD, Jennifer A. Harvey, MD, and , Brandi T. Nicholson, MD
University of Virginia Heath System, Chalottesville, Va. Radiographics, Volume 33-4 , 2013
S To successfully perform a minimally invasive breast biopsy
S it is important to not only be familiar with the technique
S but also with how to determine radiologic-pathologic concordance
S and the appropriate treatments for patients after the procedure
S When reviewing pathologic results for concordance
S it is important to ensure that microcalcifications are identified in the
histologic specimen
S and the specific pathologic diagnosis is consistent
S with the morphologic characteristics seen at mammography
S and the pretest probability of malignancy.
25. !
Interactive Case Review of Radiologic and Pathologic Findings from
Breast Biopsy: Are They Concordant? How Do I Manage the Results?
Christopher P. Ho, MD, Jennifer E. Gillis, MD, Kristen A. Atkins, MD, Jennifer A. Harvey, MD, and , Brandi T. Nicholson, MD
University of Virginia Heath System, Chalottesville, Va. Radiographics, Volume 33-4 , 2013
S At the follow-up examination
S both the histologic and imaging findings should be revisited
S and the mass should be assessed at mammography or US to ensure that it is stable
S If it has grown in size or its morphologic characteristics have changed
S If calcifications increase in number or extent or the mass changes
S Increases in size or its features become more suspicious
S appropriate action should be taken
S Excision is typically recommended
S If the lesion is stable at follow-up examination
S the patient may return to the general screening population
27. !
Roger J. Jackman & al, Radiology February 2001 218:497-502
Stereotactic Breast Biopsy of Nonpalpable Lesions: Determinants of Ductal
Carcinoma in Situ Underestimation Rates
S DCIS underestimation rates by biopsy device were
S 20.4% (76 of 373) at large-core biopsy
S 11.2% (107 of 953) at vacuum-assisted biopsy (P < .001)
S 24.3% (35 of 144) of masses
S 12.5% (148 of 1,182) of microcalcifications (P < .001)
S and by number of specimens per lesion
S 17.5% (88 of 502) with 10 or fewer specimens
S 11.5% (92 of 799) with greater than 10 (P < .02).
S DCIS underestimations increased with lesion size
1.9 times more frequent with masses
than with calcifications
1.8 times more frequent with LCB than
with VAB
1.5 times more frequent with 10 or fewer
specimens per lesion than with more
than 10 specimens per lesion.
28. !
Projektpartner
1. Fraunhofer-Institut für Integrierte Schaltungen IIS, Erlangen,
Kohr et al. Radiology 255: 723 - 730 (2010)
N = 991; N = 147 cases of atypia
The upgrade rate is significantly higher when ADH involves at
least three foci.
Surgical excision is recommended even when ADH involves
fewer than three foci and all mammographic calcifications
have been removed, because the upgrade rate is 12%.
Minimal Invasive Interventions
Wagoner et al. Am J Clin Pathol 131: 112 - 121 (2009)
N = 123;
Patients with ADH restricted to fewer than 3 foci may not need
surgical excision, especially when the mammographic
abnormality is completely removed by VAB.
29. !
Atypical Lobular Hyperplasia and Lobular Carcinoma in Situ at Core Breast Biopsy:
Use of Careful Radiologic-Pathologic Correlation to Recommend Excision or
Observation
Kristen A. Atkins, Michael A. Cohen, Brandi Nicholson, Sandra Rao.
Northwestern Memorial Hospital, Prentice Women’s Hospital, Chicago.
Radiology, 2013, Vol.269: 340-347, 10.1148/radiol.13121730
S By consensus of the physicians involved in the diagnosis and treatment of breast
disease at the University of Virginia, all cases of ALH or LCIS diagnosed at core
needle biopsy receive a recommendation for surgical excision of the biopsy site.
S with careful pathologic-radiologic correlation, noninvasive ALH and LCIS were not
independent risk factors for worse pathology on excision
S None of the 43 (95% CI: 0%, 8%) benign concordant cases determined with careful
radiologic-pathologic correlation were upgraded at subsequent surgical excision or
extended imaging follow-up
S which suggests that arbitrary excision in all cases of ALH or LCIS may not be necessary.
S In essence, we have reaffirmed the work of Liberman et al , AJR Am J Roentgenol
1999;173(2):291–299
S LCIS (and we have added ALH) with concordant imaging-histologic analysis need not
undergo surgical biopsy
S comprehensive communication between the radiologist and pathologist, triaging
of the biopsy results works well and may save many patients from undergoing
surgical excision
30. !
Atypical Lobular Hyperplasia and Lobular Carcinoma in Situ at Core Breast Biopsy:
Use of Careful Radiologic-Pathologic Correlation to Recommend Excision or
Observation
Kristen A. Atkins, Michael A. Cohen, Brandi Nicholson, Sandra Rao.
Northwestern Memorial Hospital, Prentice Women’s Hospital, Chicago.
Radiology, 2013, Vol.269: 340-347, 10.1148/radiol.13121730
S Advance in Knowledge
S When careful radiologic-pathologic correlation is conducted in the setting of a
breast core biopsy with atypical lobular hyperplasia or lobular carcinoma in situ
S some women can be safely triaged to observation
S of the 43 benign concordant cases, none were upgraded at surgery or extended
follow-up (95% confidence interval: 0%, 8%)
S Implication for Patient Care
S Focused and complete radiologic-pathologic correlation may obviate
excisional biopsy in patients with benign concordant biopsy findings.
S Additional validation of this is required before this approach can be universally
applied
31. !
Discussion
to excise or to sample ?
— Excision for probably benign lesion + clip
S Birads 3
S Birads 4a
— Sample for suspicious or malignant lesion
S Birads 4 b & c
S Birads 5 & 6
37. !
Radiofrequency ablation
Alterning electrical current (420-500 kHz)
= Minimally invasive procedure
using a thin electrode needle
Ø Ionic agitation
Ø heating of the surrounding tissue
Ø T> 60°C, Necrosis
38. !
Breast is RF friendly
Volume of ablation for a given quantity of RF energy
S Lung (13 ± 3.5 mm)
Breast (11.8 ± 3.5 mm)
S Soft tissue (9.8 ± 1.0 mm)
S Kidney (7.3 ± 0.6 mm)
Specificity of the breast tissue
- Electric conductivity
- Thermal diffusion
- Low vascularity
Manenti G et al. Radiology 2009
Ahmed M, Radiology 2004
39. !
Drawing illustrates the RF ablation device correctly placed so as to produce a thermal
lesion volume (black outline) that is concentric to the tumor and that encompasses the
tumor and a sufficient margin of noncancerous tissue.
Fornage B D et al. Radiology 2004;231:215-224
40. !
US monitoring to ensure accurate placement of the RF device in the
Geometric center of the tumor to be ablated.
Fornage B D et al. Radiology 2004;231:215-224
41. !
MR images show visualization and segmentation of the RF ablation–induced lesion in three
perpendicular planes (left to right: axial, sagittal, coronal).
Manenti G et al. Radiology 2009;251:339-346
42. !
Fornage B D et al. Radiology 2004;231:215-224
Close-up view of the specimen in a shows the
well-defined tumor in the center of the ablation zone
43. !
Fornage B D et al. Radiology 2004;231:215-224
a negative reaction to NADH-
diaphorase stain, which confirmed
the absence of viable tumor cells
after RF ablation
44. !
Axial MR images show successful RF ablation
in 55-year-old woman with breasts with a
dense glandular pattern.
Manenti G et al. Radiology 2009;251:339-346
Images show residual enhancement in 66-
year-old patient with breasts with a fatty
glandular pattern.
45. !
Cryotherapie
S nonoperable liver metastases from colorectal cancers
S Cryotherapy uses coldness to achieve tumor destruction
S Local anesthesia
S Energy is produced by an external generator composed of an argon or
nitrogen freezing system and a helium heating system
S Several probes can be used simultaneously for larger tumors
S The probe is inserted in the center of the tumor under imaging guidance
(US or MRI) through a tiny incision
S Iceball is created at the needle tip destroying the tumor as well as 5–10
mm of additional breast tissue surrounding the lesion
46. !
Littrup P J et al. Radiology 2005;234:63-72
Iceball
47. !
Cryotherapie
S During each freeze cycle, temperatures from –185°C to -70°C
S Tumor destruction in real time under US or MRI.
S Tumor destruction is the result of cell damage from membrane
rupture during the successive freeze-thaw cycles
S In the center of the tumor, cells are completely destroyed
S in the periphery, a necrotic zone of some millimeters with viable
cells is observed
S cryotherapy ablation zone needs to be larger than the tumor size
to be effective.
S T < 2 cm
48. !
Implications for breast cancer management
S The aim of breast conservation surgery
S to remove the entire tumor
S achieve negative surgical margins
S preserve the breast and patient’s body self-image
S Minimally invasive approaches
S must offer at least the same advantages as surgery
S should be at least equivalent to tumor excision with proven
negative surgical margins
S Minimally invasive ablation techniques may replace
surgical resection in the future
S If they do, having imaging modalities that can detect
tumor destruction would be essential.
49. !
Patient categories may benefit more from these techniques
S Elderly breast cancer patients
S often undertreated
S worse outcome compared with younger patient
S minimally invasive approaches may allow these patients with
multiple comorbid conditions to be suitable for local treatments
and be cured
S neoadjuvant chemotherapy
S challenge to be overcome in the future by novel and less
invasive approaches
S Residual disease can potentially be ablated without the need for
surgery in an outpatient setting and can increase quality of life
Implications for breast cancer management
50. !
S USBP are essential tools in the diagnosis of nonpalpable
lesions
S devices used for biopsy have limitations, which lead to
increased failure and underestimation rates for
diagnosing of various breast lesions
S USBB must be handled cautiously
S careful interpretation of some histopathologic results is
ensured
S Complications are rare (<2%) and include hematomas,
persistent bleeding, vasovagal episodes, and wound
infection
USBB can be a useful tool for both the diagnosis and
optimal patient management
Implications for breast cancer management
51. !
S Percutaneous image-guided biopsy techniques have replaced
open surgical biopsies
S considered to be the standard procedure for the diagnosis of
breast cancer
S None of the ablative techniques described are used alone in
current clinical practice for the treatment of breast cancer and
are used only in study settings.
S Surgery remains the standard local treatment of breast cancer,
with radiation therapy if needed clinically
S The value of these treatments compared with traditional open
surgery needs to be confirmed by large prospective studies.
S In addition, cost-effectiveness and long-term effect on
cosmetic outcomes still need to be investigated.
Implications for breast cancer management
52. !
S Balistic consultation
S Faisability
S Explanation
S Concordance +++
S Device and guidance
S Success rate : 95 à 98 %
S Under-estimation :
S ≈ 10 % VABB , less with Intact
S ≈ 20 % LCNB
S = Surgery if boarder line lesion
S Present & Next Futur :
S Minimal invasive therapy
S Benign
S Malignant ?
Take home