A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
Physicians have used palpation to detect differences in tissue stiffness as an aid to diagnosis based on the fact that the mechanical properties of tissues are often dramatically affected by the presence of disease processes such as cancer, inflammation, and fibrosis. Elastography depends on the same differences in mechanical properties between healthy and abnormal tissues using imaging to detect these differences at depths not reachable by manual palpation and presents data in color-coded display, can be performed with ultrasound, using manual pressure or low frequency sonic waves, or by MR Elastography imaging.
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
A comprehensive study about new and upcoming modalities in imaging and screening of breast lesions with description about every new modalities with their advantages and pitfalls.
Physicians have used palpation to detect differences in tissue stiffness as an aid to diagnosis based on the fact that the mechanical properties of tissues are often dramatically affected by the presence of disease processes such as cancer, inflammation, and fibrosis. Elastography depends on the same differences in mechanical properties between healthy and abnormal tissues using imaging to detect these differences at depths not reachable by manual palpation and presents data in color-coded display, can be performed with ultrasound, using manual pressure or low frequency sonic waves, or by MR Elastography imaging.
Introduction to mammography and its equipment.
Different views on mammography & supplementary views.
Birads mammographic lexicon
Birads ultrasound lexicon
Imaging of suspicious mammary lymph nodes
Categories in BIRADS 2013.
Magnetic Resonance Elastography is an advanced imaging technique in MRI. This method is a method of "virtual palpation" of internal organs with the help of MRI.
Mammography : quality control (quality assurance)Kajal Jha
Mammography quality control. This is the class presentation for the syllabus of BSC MIT at BPKIHS Dharan. It is the concise ppt dealing with the quality control of mammography and hence quality control. Mammography is an x-ray imaging
method used to examine the breast for the early detection of cancer and other breast diseases. It is used as both a diagnostic and screening tool.
- also known as Mastography
Magnetic Resonance Elastography is an advanced imaging technique in MRI. This method is a method of "virtual palpation" of internal organs with the help of MRI.
Mammography : quality control (quality assurance)Kajal Jha
Mammography quality control. This is the class presentation for the syllabus of BSC MIT at BPKIHS Dharan. It is the concise ppt dealing with the quality control of mammography and hence quality control. Mammography is an x-ray imaging
method used to examine the breast for the early detection of cancer and other breast diseases. It is used as both a diagnostic and screening tool.
- also known as Mastography
This presentation was held by dr. Antonio Pio Masciotra - italian radiologist - on Novembre 2012 at Prato.
It concerns about neoplastic tissue's elasticity and breast elastography.
Breast Reconstruction at Perimeter Plastic SurgeryDr. Mark Deutsch
After breast cancer survivors have endured a mastectomy, many choose to pursue breast reconstruction surgery to help enhance their natural beauty. Dr. Deutsch at Perimeter Plastic Surgery is one of the most accomplished breast reconstruction surgeons in the Southeast. In this presentation, Perimeter Plastic Surgery explains what Breast Reconstruction is and the different options patients have for their procedure.
Evolution of Hypofractionated Radiotherapy in Breast Cancerkoustavmajumder1986
Hypofractionated radiotherapy in breast cancer is one of the major evolution. It started few decades back. We have to know its history and radiobiological perspective. In this presentation I have tried to cover as much as possible. It would be helpful for all Radiation Oncologist specially the trainees.
http://cancer-treatment-madurai.com Breast cancer is a type of cancer that starts in the tissues of the breast. Dr.S.G.Balamurugan is one of the best cancer doctor in India, offers low cost breast cancer diagnosis, breast cancer treatments and breast cancer care at Guru Cancer Hospital, Madurai.
Breast conserving surgery followed by adjuvant radiotherapy is adopted in the early detected cases and mastectomy followed by radiotherapy or chemotherapy in the advanced cases are the general practices.
Accelerated partial breast irradiation is an alternative to whole breast irradiation in carcinoma breast patients Post breast conserving surgery with equivalent outcome, less duration & less burden on the patient.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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How to Give Better Lectures: Some Tips for Doctors
Mr Mammography New
1. Current & Potential Utility of MRI in Diagnosis & Management of Breast Cancer By: Dr. Norran Hussein, MS Cairo University
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4. A basic MRM 1) Dynamic 2) Subtraction 3) Curve pre 1 min 2 min 3 min 4 min 5 min
5. A basic MRM 1) Dynamic 2) Subtraction 3) Curve 1 minute subtraction pre 1 min
6. MRI BIRADS Lexicon Is it a : Mass Focus Non mass like Enhancement Other findings? Kinetic Curve analysis Shape Margin Distribution Symmetrical/ Assymetrical BIRADS Category Enhancement Pattern
8. Post Operative& Radiated 58 year old woman who underwent left lumpectomy for Ca Breast 2 years before, followed by sessions of Radio & chemotherapy which were completed 3 months later. Bilateral MLO Mammography Ultrasonography of the scar L R
9. Case 6 Axial Subtraction Saggital T2 Axial T1 Axial T2 IR MIP
10. Axial Dynamic post contrast Fat suppressed FLASH, with signal-time analysis curve Pathology: Recurrent Invasive Duct Carcinoma
22. MRI of Implant Failure Suspicious Findings: Loss of Round or Oval form Contour Bulge
23. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture Capsular contracture occurs when the AP diameter of the implant is nearly equal to the TS diameter. (normally AP:TS ratio is 1:2)
24. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture Axial T2 Fat Sat shows collapsed shell with residual saline The saline is usually absorbed, and linguine sign is not visible in saline implants
29. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture In double lumen implants, if the inner shell ruptures, a mixture between the saline and silicone occurs: The salad oil phenomenon.
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31. MR Diffusion ADC maps in a patient with a malignant breast Tumour. Images are shown in 8 spatial locations with the tumour seen as a hypointense area on the last 2 images.
33. ADC maps in a patient with a malignant breast lesion. Images of 8 spatial locations show the decreased ADC values of the tumour. Other hypointense areas were attributed to fat.
34. Normal MRS of the Breast 7 6 5 4 3 2 1 0 -1 Frequency (ppm) Fat Choline Water Un Sat FA Un Sat FA
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39. However….. Lesion size Magnet strength Lactating breast < 2.5 2.5 – 4.9 > 5.0 (cm 3 ) Probability (%) The Probability to Detect Choline in Breast Cancer is Higher in the Larger Lesions
46. Response to chemotherapy A promising application is the use of breast MRS for predicting response to cancer treatment. Current clinically available methods such as palpation and imaging rely on changes in tumor size, which take several weeks before any changes are detectable. Breast MRS, in contrast, reflects changes in intracellular metabolism that would occur before any gross morphological change.
47. Response to chemotherapy In the results of a study presented in RSNA 2003 meeting: 12 women with biopsy proven Ca, were examined with MRS before and within 24hrs of chemotherapy. Patients which showed decreased choline within 24hrs showed a tumour reduction size, after 12 wks of ttt. Patients with cte or elevated choline within 24hrs, failed to have anatomic response to therapy.
66. Follow up chemotherapy A 55 year old woman who underwent left conservative surgery 1year & 4 months ago followed by radio& chemotherapy. Ultrasonography of the right breast Mammography L R
67. Case 8 Axial T1 Axial T2 IR Saggital T2 Axial Subtraction
68. Case 8 MIP Axial Dynamic post contrast Fat suppressed FLASH, with signal-time analysis curve
69. Pre operative: a 43 year old lady presenting with a right breast lump & axillary swelling. The examination was performed during the 2nd week of the menstrual cycle.
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73. MRI Appearance of Various Implants Single lumen Silicone Saline Water suppressed T2 WIs of single lumen silicon implant Axial T2 Fat Sat
74. MRI Appearance of Various Implants Single lumen Double lumen silicone saline
75. MRI Appearance of Various Implants Single lumen Double lumen Fat suppressed T2 W water suppressed T2 W
76. MRI Appearance of Various Implants Single lumen Double lumen Multicompartmental Outer saline & 2 inner silicone comaprtments
77. MRI Appearance of Various Implants Single lumen Double lumen Multicompartmental Single lumen silicone with saline Injection
80. MRI of Implant Failure Suspicious Findings: Loss of Round or Oval form Contour Bulge
81. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture Capsular contracture occurs when the AP diameter of the implant is nearly equal to the TS diameter. (normally AP:TS ratio is 1:2)
82. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture Axial T2 Fat Sat shows collapsed shell with residual saline The saline is usually absorbed, and linguine sign is not visible in saline implants
87. MRI of Implant Failure Diagnostic Findings: Deflation Capsular Contracture Extracapsular Rupture Intracapsular Rupture In double lumen implants, if the inner shell ruptures, a mixture between the saline and silicone occurs: The salad oil phenomenon.
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