The document summarizes the radiological anatomy of the knee joint. It describes the various ligaments, tendons, bones and cartilage that make up the knee, including the medial and lateral menisci, anterior and posterior cruciate ligaments, patellar tendon, and surrounding muscles. It provides imaging protocols for MRI of the knee, covering positioning, slice thickness, pulse sequences and imaging planes used to visualize the different knee structures. Common anatomical variations and pitfalls in interpretation are also discussed.
Anatomy and imaging of wrist joint (MRI AND XRAY)Kajal Jha
Anatomy and imaging of wrist joint (xray and MRI).
this ppt was made as the class presentation by Kajal Jha as the part of the course of BSC MIT at BPKIHS,Dharan . It covers the part of syllabus of third year of BSC MIT of this institution.
Radiological anatomy of Knee joint.pptxAlauddin Md
Radiological anatomy of Knee joint , this is prepared by me for my presentation at department. if someone is benefitted that will be a great pleasure for me.
Anatomy and imaging of wrist joint (MRI AND XRAY)Kajal Jha
Anatomy and imaging of wrist joint (xray and MRI).
this ppt was made as the class presentation by Kajal Jha as the part of the course of BSC MIT at BPKIHS,Dharan . It covers the part of syllabus of third year of BSC MIT of this institution.
Radiological anatomy of Knee joint.pptxAlauddin Md
Radiological anatomy of Knee joint , this is prepared by me for my presentation at department. if someone is benefitted that will be a great pleasure for me.
MRI imaging of knee joint -- from radiological anatomy to pathology. inspired from my dear professor Mamdouh Mahfouz, professor of radio diagnosis - Cairo university.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. BY: DR NIKHIL BANSAL
RESIDENTRADIO-DIAGNOSIS
UNDERGUIDANCEOF:
DR ANANDVERMA
HOD(RADIO-DIAGNOSIS)
MGMC&H
RADIOLOGICAL
ANATOMY OF KNEE JOINT
2. INTRODUCTION
The knee joint is one of the important
weight-bearing joints of the human body
Complex and extensive movements are
performed , involving numerous active and
passive mechanisms.
Knee is more likely to be damaged than most
other joints because it is subject to
tremendous forces during vigorous activity.
Therefore not surprising that the knee is
frequently affected by traumatic and
degenerative conditions
3. PROTOCOL
Field of view (FOV) --small 10 to 14 cm
A matrix of 256 x 256 is usually
standard.
Dedicated knee coil is mandatory as it
improves the signal to noise ratio
4. Patient Positioning
Supine, with the leg in full extension.
The knee is placed in 10 to 15° of external rotation(esp for
sagittal image)
SliceThickness
3-4 mm sections are used for axial, coronal and sagittal
images of the knee.
Adults: 4mm
Children's: 3mm
3DFT(Fourier Transformation) Sub centimeter
5. Imaging Planes and Pulse Sequences
Short echo time (TE) conventional spin echo (CSE) images
generally provide the best contrast for anatomical evaluation
Proton-density images are probably the most sensitive for
detection of meniscal tears.
FSE T2-weighted images have demonstrated high accuracy for
detection of cartilage lesions.
3D Fourier transformation (3DFT) Imaging is becoming
popular
-provides the highest resolution
-with an acceptable S/N ratio
-allowing image reconstruction in any plane.
6. Knee protocol
Fast spin echo PD andT2w in the sagittal plane
(meniscal, cartilage)
STIR sequence in the coronal plane(marrow)
T1W coronal images
T2W axial images
7. Generalanatomy
Knee is the largest and more complex joint of the body
Complexity is the result of fusion of three joint
- lateral tibiofemoral joint
- medial tibiofemoral joint
- femoropatellar joint
It is a compound synovial joint ,incorporating two condylar
joints between condyles of femur and tibia and one saddle
joint between femur and patella.
ARTICULARSURFACE
Formed by – condyles of femur , patella and condyles of
tibia
23. Menisci:
The menisci of the knee are two semilunar,
C-shaped fibrocartilaginous disks that sit
on the peripheral margins of tibial plateau
Upper surfaces of both menisci are concave,
and they articulate with the convex femoral
condyles.
Each meniscus has two ends which are
attached to tibia, and two borders
24. (a) The outer border is thick , convex and
fixed to the fibrous capsule
(b) Inner border is thin concave and free.
Micro-anatomy: Type 1 Collagen
Red Zone: 1/3
White Zone: 2/3
26. MEDIALMENISCUS
Medial meniscus is shaped more like a half -
circle.(open “C”)
The width of the medial meniscus, in contrast to
the lateral meniscus, gradually tapers from
posterior(12mm) to anterior(6mm)
Peripheral margin of the medial meniscus is more
firmly attached to the tibial collateral ligament.
28. Lateralmeniscus
The lateral meniscus has the same width
throughout, approximately 10 mm
Peripheral margin of the lateral meniscus is
attached to the capsule except poster lateral ,
where the popliteal tendon crosses it, and more
posteriorly and centrally near the central
attachment site, where the capsule does not
extend anteriorly into the joint.
29. Anterior hornoflateralmeniscus
The anterior and posterior horns of the lateral
meniscus are about equal in size
Anterosuperiorly transverse ligament is
attached to it.
30. Posteriorhornoflateralmeniscus
It differs from medial
meniscus
its attachment to the
capsule is interrupted by
the popliteal tendon,
Superiorly it gives origin
to ligament of wrisberg (
meniscofemoral ligament)
which appear as round dot
adjacent to superior aspect
of the posterior horn
31. DiscoidMeniscus
A discoid meniscus refers to a meniscus, almost always
the lateral one, that is not C-shaped but disklike.
it covers most of the tibial plateau to varying degrees
rather than just its periphery.
is usually seen in children and adolescents, in whom it
may be asymptomatic and noted incidentally.
It is prone to tearing
The prevalence of discoid lateral meniscus (1.5%-15.5%)
is greater than that of discoid medial meniscus
32. High-resolution coronal images allow better depiction of
this enlarged meniscus.
A discoid meniscus is said to be present if three or more
5mm-thick contiguous sagittal images demonstrated
continuity of the meniscus between the anterior and
posterior horns.
Another criteria was height difference of 2mm on
coronal image.
34. Pitfalls…
The posterior horns are seen
on coronal views as flat
bands that should not be
confused with discoid
menisci
35. NORMALVARIATIONSANDPITFALLS
1. Wrisberg and Humphry Ligaments: The
meniscofemoral ligaments of Wrisberg and Humphry
originate from the superior aspect of the posterior horn of
the lateral meniscus.
The Wrisberg ligament is located posterior to the posterior
cruciate ligament and seen in 33% sagittal image.
The Humphry ligament is anterior to the posterior cruciate
ligament
1 of these 2------ 70 %
Both---------------6%
37. PopliteusTendon
Popliteus tendon and its hiatus separate the
lateral meniscus from the joint capsule.
Signal intensity from the popliteus tendon
sheath or fluid within its hiatus could be
mistaken for a meniscal tear on both
sagittal and coronal images
38. T 1w show the popliteus
tendon. as it courses medially
and inferiorly in the more
medial section.
(a) Image shows the tendon
above the lateral meniscus.
(b) Image shows the tendon
(arrow) has moved behind the
meniscus.
(c) Image shows the tendon
(arrow) is inferior to the
meniscus.
39. TransverseLigament
Connects the anterior horns of both menisci
The signal intensity produced from the loose
connective tissue between the transverse
ligament and the most medial part of the
anterior horn of the lateral meniscus can be
mistaken for a meniscal tear.
This error can be avoided by tracing the cross -
section of the ligament through the
infrapatellar fat pad on more central MR
imaging sections
42. AnteriorCruciateLigament
Anatomy
extends from its semicircular attachment at
the lateral femoral condyle to the anterior
intercondylar region of the tibia.
It is just posterior to the transverse ligament and just
anterior to the central attachment of the anterior horn of
the lateral meniscus where some fibers mix.
The tibial attachment is larger than the femoral and
fanlike in shape.
43.
44. ligament measures
approximately 4 X 1 cm
may consist of two or more
distinct bundles separated
by loose connective tissue
and fat, more prominent at
the mid- and distal
portions.
45. MRIAppearance
ACL is best seen on sagittal
oblique images with slices
parallel to the cortex of the
lateral femoral condyle.
ACL may appear as a solid
low-signal-intensity band
46. Coronalimage
ACL as a c fanlike
structure adjacent to the
horizontal segment of the
PCL near the medial
surface of the lateral
femoral condyle
Proximally, the signal
intensity is uniformly low,
whereas distally it may be
slightly increased.
48. PosteriorCruciateLigament
Anatomy
The PCL arises at the lateral surface of the medial femoral
condyle and extends to the posterior surface of the intercondylar
region below the level of articular surface of tibia.
It is wider and thicker than the ACL.
Sagittal images best show the PCL; it appears as a uniformly
low-signal-intensity structure and arcuate in shape in routine
MR imaging
It has a nearly horizontal takeoff at the femoral origin and then
an abrupt descent at about 45 degrees to the tibia.
103. Biceps femoris tendon
Biceps femoris
Popliteal artery
Lateral head of
gastrocnemius muscle
Head of fibula
Semimembranosus
muscle
Gracilis
tendon
Semimembranosus
tendon
Medial head of
gastrocnemius
muscle
Semitendinosus
tendon
ideal MR technique should yield images
with good contrast and spatial resolution of
the osseous and soft tissue structures of the
knee in a reasonable time to maximise patient
acceptability
to realign the anterior cruciate ligament parallel with the sagittal imaging plane.
double echo sequence, the Tj-weighted pulse sequence
can also generate proton density Images. In one investigation,
discrete meniscal tears that were undetectable
on Ti-weighted and T1-weighted images could be
depicted only on the proton density weighted images.. When interpreting the proton density images it
must be kept in mind that they are susceptible to the
magic angle effect a that not every increase in signal
intensity corresponds to a pathologic lesion.
Three dimensional Fourier transformation (3D FT) Imaging
The examination strategy should
follow both a standard protocol that addresses most
clinical questions and specific protocols used selectively
for any specific question.
Although enlarged menisci have been recognized at magnetic resonance (MR) imaging, there are no criteria for the MR imaging diagnosis.
The normal lateral meniscus tapers rapidly
from the periphery to the free edge (arrows in d-f), but the discoid meniscus demonstrates continuity between the anterior and posterior
horns on all three images
(a) ligament of Wrisberg posterior to posterior cruciate ligament (arrow). This may simulate an
intraarticular loose body.
(b) arrow).
C, Ligament of Humphry (arrow) anterior to and separate from posterior cruciate lIgament. could be mistaken for an osteochondral or meniscal fragment.
as it courses medially and inferiorly in the
more medial section.
If the knee is flexed more
than 5 degrees, it may appear lax.