Tiberius ruled Rome from 14-37 CE with a bitter and suspicious personality, instituting a reign of terror. His adopted grandson Caligula became insane after a few months in power, sacrificing slaves and claiming to be a god before being assassinated. Claudius expanded the Roman Empire but was poisoned by his wife Agrippina to make way for Nero, who became a tyrant, murdering family members and being blamed for the Great Fire of Rome before committing suicide.