Quality assurance in blood banking involves implementing quality control checks at various stages of the blood collection and processing process. This includes donor screening, blood collection following aseptic techniques, proper storage and labeling of blood components, sterility testing, equipment calibration, and testing blood components for key attributes like volume and factors. Regular internal and external quality audits help ensure standards are maintained.
A brief presentation for second-year students in Iraqi Technical Institutes (studying Medical Laboratory Technology). This introduction covers also the teaching laboratories.
I have listed out the LE cells structure and Microscopical examinaton of LE CELLS, Difference between tart cells and le cells, clinical symptoms and diagnostic procedure.
blood and blood component have an important role in transfusion medicine. when blood contain all its part and no separation is done thats known as whole blood but when you centrifuge and separate it that is know as component. transfusion of whole blood is now adays absolute from transfusion service and blood components are transfuses now a days which is a good practice and beneficial for the patient
A brief presentation for second-year students in Iraqi Technical Institutes (studying Medical Laboratory Technology). This introduction covers also the teaching laboratories.
I have listed out the LE cells structure and Microscopical examinaton of LE CELLS, Difference between tart cells and le cells, clinical symptoms and diagnostic procedure.
blood and blood component have an important role in transfusion medicine. when blood contain all its part and no separation is done thats known as whole blood but when you centrifuge and separate it that is know as component. transfusion of whole blood is now adays absolute from transfusion service and blood components are transfuses now a days which is a good practice and beneficial for the patient
Contents :
Sensitive and specific antibodies
Specific calcification
Cast / brace/ splint
Enzymes of mitochondria and cytosol
Human leucocyte antigen
Inhibitors in biochemistry
Types of joints
Longest and shortest acting drugs
Male and female analogue
Male and female preponderance
Mode of inheritance
Named fractures
Important tables in nutrition chapter
Specific names in orthopedics
Rate limiting enzymes
Physiology of receptors
Right and left laterality
Sensitive and resistive to radiation
Sensitive and specific investigation
Condition and specific terms
Names of staging/grading/prognostic system
Surgery names
Tumor marker
Vectors
X ray views
Important lists
Important tables in anesthesiology
Important tables in dermatology
Important tables in embryology
Clarke’s grouping of heart diseases in pregnancy
Forrest classification
Classification of leprosy
For more details, visit www.medpgnotes.com
You can send your queries to medpgnotes@gmail.com
Contents :
Most commons
Most common type
Most common cause
Most common form
Most common lesion
Most common complication
Most common Joint
Most common indication
Most common manifestation
Most common mode
Most common nerve
Most common side effect
Most common presentation
Most common site
Most common tumor
Contents :
Amyloid
Apoprotein
Arthritis
Avascular necrosis
Bone graft
Brain
Bronchogenic carcinoma
Census
Clotting factors
Contraception
Inflammatory bowel disease
Cerebrospinal fluid
Culture media
Dementia
Electroencephalogram
Engaging diameter
Estrogen
Familial hyperlipoproteinemia
Features of fibroid
Firearm
Gastric motility
Absorption in gut and nephron
Hormones
Hypersensitivity
Immunoglobulin
Inborn errors of metabolism and deficient enzymes
Kidney stones
Lithium
Lung volumes and capacities
Metabolic acidosis
Mosquito
Nerve fibers
Muscles and nerve supply
Changes in pregnancy
Methods for proteins
Protooncogenes and tumor suppressor genes
Radioisotopes
Rickettsial zoonoses
Root values for reflexes
Rapidly progressing glomerulonephritis
Small intestinal biopsy
Specimen preservation in poisoning
Sexually transmitted diseases
Sterilization and disinfection
Tetanus
Toxins in food
Management of poisoning
Vaccination
Vaginal cytology
Vitamins
For more details, visit www.medpgnotes.com
You can send your queries to medpgnotes@gmail.com
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
Assessment & Development Of Palestinian Blood Bank SystemAlaa Sarhan
An- Najah National University Faculty Of Engineering Industrial Engineering Department. “Assessment & Development Of Palestinian Blood ” Bank System. Prepared by: Alaa Sarhan Haneen Tanni. Raya Khwayre Razan Assaf. Supervisor: Dr. Ayham Jaaron. 23/5/2012. Project Outline.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
3. Quality is a process
• Quality is an ongoing
activity,
4. Quality control
• Checks puts in places
to ensure that
process, procedures
and products meets
the quality
requirements.
• (consistency)
5. How to start QC
• Start from today and make a plan for QC.
6. The quality requirements involve:-
• Quality control and proficiency testing
• Internal and external audits
• Personnel and organization
• Premises, equipment and materials
• Documentation
• Blood processing
• Complaints and component recall
• Investigation of errors and accidents
7. RBB must be located , designed, constructed and
adapted to suit the operation to be carried out.It
should include separate areas for :-
a) Donor selection
b) Blood collection
c) Blood processing
d) Storage
e) Laboratory facilities
f) (Supportive facilities)
.
8. QA IN COLLECTION OF BLOOD
• The quality, safety and efficacy of the product
transfused is the result of many steps:-
– Donor selection
– Blood collection
– Component preparation
– Storage , issue and transportation
9. • Donor Selection
• Information collection & evaluation
– Consent form
– Donor is registered for permanent record
– Donor must be checked for possible self harm or
potential harm to recipient( list of questionnaires).
– Blood Collection:
• Aseptic technique
• Seal closed method
10. Blood processing
• After blood Collection immediate storage
at 1-6ºC
• Components preparation has to be done
within 6 hours after collection
• Labels/Records : ABO and Rh grouping
• Screening, expiry date and volume of the
blood
11. • Equipment requirements :-
• All the equipment in blood transfusion laboratory
should meet mandatory specifications.
• A written record of periodic function checks and
maintenance on each piece of equipment should be
mandatory.
• A preventive maintenance should be planned for
trouble free operation.
• Uninterrupted power supply should be maintained
for all the equipment with efficient back-up system.
• Annual maintenance contract with manufacturers
and suppliers should be obtained.
12. Equipments Method of control Frequency of
control
Control executed by
Laboratory
refrigerator,
freezers, water
bath
Thermometer, precision
thermometer
Daily Technologist
blood bag
refrigerators,
Freezer containing
transfusates
Graphic recorder plus
independent audible
and visual alarm for
appropriate high and
low temperature
parameter
Daily Technologist
Laboratory
refrigerator,
Freezer, water bath
Precision thermometer
# For Calibration #
Every 6 month Technologist
Equipments QC
13. Equipment Method of control Frequency of control Control executed
Cryofuge
Precision RPM meter plus
stopwatch to control speed,
acceleration and retardation
Twice / month Technologist
Cryofuge Temperature Daily Technologist
Table centrifuge RPM meter plus stopwatch
to control speed,
acceleration and retardation
Daily Technologist
Haemoglobin
spectrophotometer
Calibrate with standard Daily Technologist
Haemoglobin
spectrophotometer
Hb- QC Sample Monthly Technologist
Equipments QC
14. Equipment Method of control Frequency of control Control executed by
Cell counter Calibration; reference
samples,
Daily Technologist
pH meter Control solution
pH 4-7, 7-10
Each time of use
Technologist
Platelet agitator Frequency of agitation Monthly Technologist
Laminar flow hood Air pressure Daily Microbiologist
Laminar flow hood and
sterile area filter
Particle counter 3 times / Month Microbiologist
Equipments QC
15. Equipment Method of control Frequency of
control
Control executed by
Blood mixer Control weighing and mixing Twice /month BM Engineer
Blood bag tube
sealer
Pressure on bag and tube Every bag and
weld
Technologist
Blood transport
container
Temperature control device Every time on
use (on receipt)
Technologist
Equipments QC
16. -Control for equipment
–Control for reagents
–Control for techniques
Based upon internal QC and external QC.
Internal quality control are subdivided into
Color codes for Anti sera by the FDA:
17. Quality control for reagents
• Select the reagent with high specifications- reference
preparation has been established for ABO, Rh and anti-
human globulin (AHG)
• Use according to manufacturer's instruction
The new reagent has to be assessed & confirmed
satisfactory
The appearance each reagent has to be checked each
day
The reactivity and specificity has to checked each new lot
18. Grouping laboratory
Parameters to be
checked
Minimal
requirement for
testing
Control samples Frequency of
control
Control executed
by
ABO Typing Use of Anti A and
Anti B duplicate
reagent
One blood sample
each of the
following: O,A and
B
Each test series
or at least once a
day provided
the same
reagent are used
throughout
Grouping
laboratory
19. Parameters to be
checked
Minimal
requirement for
testing
Control
samples
Frequency of
control
Control
executed by
Rh- D typing
Using 2 anti D sera
from different
batches, and should
be different clones.
1 Rh – D Positive
1 Rh – D
Negative
Sample
Each test series
/ at least once a
day provided
the same
reagent are
used
throughout
Grouping lab.
Anti globulin
testing, tube method
Washing the cells 3
times before adding
anti globulin
Addition of
sensitized
blood cells to
negative test
Each negative
test
Grouping lab
Grouping laboratory
20. Blood Processing and Quality Control
No leakage or puncture.
• Whole blood
• Pack Red cell
• Platelets
• FFP
• Cryoprecipitate
21. QC of Blood Components
Products Storage Volume
W/B 2ºC to 6 ºC 500ml ±50 ml
P/C 2ºC to 6 ºC 280ml ± 50ml
Platelets 20ºC to 24ºC Volume > 40ml
22. QC of Blood Components
Blood Components Sterility
W/B No Growth
P/C No Growth
Platelets No Growth
23. FFP CP
Every 10 unit/week estimate the
volume
Volume: 220-250ml
Storage:
24 months at below –30ºC
12 months at –25 to –30ºC
3 months at –18 to –25ºC
Factor VIII : > 70 IU/unit
every 2 months
Every 10 unit/week estimate the
volume
Volume : 10-20 ml
Storage:
24 months at below –30ºC
12 months at –25 to –30ºC
3 months at –18 to –25ºC
Factor VIII : > 70 IU/unit
Fibrinogen : > 140 mg per
unit
24. FFP CP
Macroscopic : no
abnormal color or visible
clots
Residual cell:
Leukocyte: < 0.1 x 10⁹/l
Red cell: < 6.0 x 10 ⁹/l
Platelets : < 50 x 10 ⁹/l
Macroscopic : homogenous
Sterility: no growth
26. QC OF INFECTIOUS DISEASE TEST
• To reduce the blood borne infectious disease
• Does not use assay beyond its expiry date.
• Storage conditions for samples.
• Preparation of samples.
• Test kit manufacturer's controls for every assay
• Positive and negative control
• Positive and negative control as test sample.
27. –Following manufacturer instructions for
performing an assay
–Adequate training
–Using sensitive assays to screen samples
–IQAS (Internal Quality Assurance System)
–EQAS (External Quality Assurance System)