This document discusses non-malignant lymphocyte disorders, including both acquired and congenital types. Acquired disorders are quantitative in nature and include infectious mononucleosis caused by the Epstein-Barr virus and toxoplasmosis. Infectious mononucleosis commonly affects young adults and is characterized by lymphocytosis, reactive lymphocytes, and elevated liver enzymes. Toxoplasmosis is transmitted through undercooked meat or contact with cat feces and poses risks to unborn children.

1. NCS
University System
A Project of NCS Education System
Tanveer Tara
Senior Lecturer
Bachelor of Science in MLT
Masters of Science in Hematology

2. Non Malignant Lymphocyte
disorders.
Acquired and Conjenital
Acquired:Quntative in nature and self limited
reactive process to infection or inflamatory conditions.
Stimulated lymphocytes in infections and inflammatory
conditions are in various stages of activation.
Changes:
Morphological changes,
Lymphadenopathy
Splenomegaly…….

3. Acquired Quantitative disorders
• Lymphocytosis:
• Increased lymphocytes ALC 4x109/L
• Children 9x109/L
• Peripheral Cells 60% to 80%.
• Causes :
• Infectious mononucleosis
• EBV
• Toxoplasmosis
• Cmv
• Infectious LymphocytosisB
• Bordetella
• Lymphocytic Leukomoid Reactions.
• Plasmacytosis

4. INFECTIOUS MONONUCLEOSIS
• Lymphoproliferative cause by EBV.
• Effect young adults 14-24 yeear,
• Children before 4 years of age.
• Transmitted via Saliva ………
• EBV receptors on lympo Cd21.
• Lethargy ,headache ,fever ,chills ,sorethroat,
• :

5. Lab diagnosis
• Counts …high 12-25
• Lymphocytes >50/%
• Reactive lymphocytes
• Plasmacytoids cells also present.
• Paul Bunnel test.
• Increased ALT, AST, and lactic acid
dehydrogenase levels in blood
• Jaundice (occurs in about 5% of cases)

6. Infectiousmononucleosis

7. TOXOPLASMOSIS
• A disease caused by toxoplasmas, transmitted
chiefly through undercooked meat, or in soil
or cat feces. Symptoms generally pass
unremarked in adults, but infection can be
dangerous to unborn children.