Contents :
Amyloid
Apoprotein
Arthritis
Avascular necrosis
Bone graft
Brain
Bronchogenic carcinoma
Census
Clotting factors
Contraception
Inflammatory bowel disease
Cerebrospinal fluid
Culture media
Dementia
Electroencephalogram
Engaging diameter
Estrogen
Familial hyperlipoproteinemia
Features of fibroid
Firearm
Gastric motility
Absorption in gut and nephron
Hormones
Hypersensitivity
Immunoglobulin
Inborn errors of metabolism and deficient enzymes
Kidney stones
Lithium
Lung volumes and capacities
Metabolic acidosis
Mosquito
Nerve fibers
Muscles and nerve supply
Changes in pregnancy
Methods for proteins
Protooncogenes and tumor suppressor genes
Radioisotopes
Rickettsial zoonoses
Root values for reflexes
Rapidly progressing glomerulonephritis
Small intestinal biopsy
Specimen preservation in poisoning
Sexually transmitted diseases
Sterilization and disinfection
Tetanus
Toxins in food
Management of poisoning
Vaccination
Vaginal cytology
Vitamins
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Contents
AMYLOID...............................................................................................................................................................................................................................................................3
APOPROTEIN.......................................................................................................................................................................................................................................................3
ARTHRITIS ...........................................................................................................................................................................................................................................................4
AVASCULAR NECROSIS...................................................................................................................................................................................................................................4
BONE GRAFT .......................................................................................................................................................................................................................................................5
BRAIN.....................................................................................................................................................................................................................................................................5
BRONCHOGENIC CARCINOMA.....................................................................................................................................................................................................................7
CENSUS..................................................................................................................................................................................................................................................................7
CLOTTING FACTORS ........................................................................................................................................................................................................................................8
CONTRACEPTION..............................................................................................................................................................................................................................................9
INFLAMMATORY BOWEL DISEASE......................................................................................................................................................................................................... 11
CEREBROSPINAL FLUID.............................................................................................................................................................................................................................. 12
CULTURE MEDIA ............................................................................................................................................................................................................................................ 13
DEMENTIA......................................................................................................................................................................................................................................................... 15
ELECTROENCEPHALOGRAM ..................................................................................................................................................................................................................... 16
ENGAGING DIAMETER ................................................................................................................................................................................................................................. 16
ESTROGEN......................................................................................................................................................................................................................................................... 17
FAMILIAL HYPERLIPOPROTEINEMIA.................................................................................................................................................................................................... 17
FEATURES OF FIBROID................................................................................................................................................................................................................................ 18
FIREARM............................................................................................................................................................................................................................................................ 19
GASTRIC MOTILITY ....................................................................................................................................................................................................................................... 20
ABSORPTION IN GUT AND NEPHRON.................................................................................................................................................................................................... 21
HORMONES....................................................................................................................................................................................................................................................... 23
HYPERSENSITIVITY....................................................................................................................................................................................................................................... 24
IMMUNOGLOBULIN....................................................................................................................................................................................................................................... 24
INBORN ERRORS OF METABOLISM AND DEFICIENT ENZYMES ................................................................................................................................................ 25
KIDNEY STONES.............................................................................................................................................................................................................................................. 28
LITHIUM............................................................................................................................................................................................................................................................. 29
LUNG VOLUMES AND CAPACITIES.......................................................................................................................................................................................................... 30
METABOLIC ACIDOSIS.................................................................................................................................................................................................................................. 31
MOSQUITO......................................................................................................................................................................................................................................................... 31
NERVE FIBERS................................................................................................................................................................................................................................................. 32
MUSCLES AND NERVE SUPPLY................................................................................................................................................................................................................. 33
CHANGES IN PREGNANCY .......................................................................................................................................................................................................................... 41
METHODS FOR PROTEINS.......................................................................................................................................................................................................................... 42
PROTOONCOGENES AND TUMOR SUPPRESSOR GENES................................................................................................................................................................ 43
RADIOISOTOPES............................................................................................................................................................................................................................................. 44
RICKETTSIAL ZOONOSES............................................................................................................................................................................................................................ 45
ROOT VALUES FOR REFLEXES.................................................................................................................................................................................................................. 45
RAPIDLY PROGRESSING GLOMERULONEPHRITIS........................................................................................................................................................................... 45
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SMALL INTESTINAL BIOPSY...................................................................................................................................................................................................................... 46
SPECIMEN PRESERVATION IN POISONING......................................................................................................................................................................................... 46
SEXUALLY TRANSMITTED DISEASES .................................................................................................................................................................................................... 47
STERILIZATION AND DISINFECTION..................................................................................................................................................................................................... 47
TETANUS............................................................................................................................................................................................................................................................ 48
TOXINS IN FOOD............................................................................................................................................................................................................................................. 48
MANAGEMENT OF POISONING................................................................................................................................................................................................................. 49
VACCINATION.................................................................................................................................................................................................................................................. 50
VAGINAL CYTOLOGY..................................................................................................................................................................................................................................... 52
VITAMINS .......................................................................................................................................................................................................................................................... 53
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3AMYLOID
AMYLOID
AL Primary Amyloidosis
(multiple Myeloma/B-Cell Neoplasm)
AA Secondary Amyloidosis (MC – Rheumatoid arthritis)
Aβ2m Hemodialysis Associated Amyloidosis
AA
(Pyrin)
Familial Mediterranean Fever
Aβ Alzemier’s disease
ACal Medullary Carcinoma Thyroid
ATTR Familial Amyloidotic Neuropathy
Systemic Senile Amyloidosis
AIAPP Type II diabetes
AANF Isolated Atrial Amyloidosis
Aα Familial Renal amyloidosis
Electron microscopic finding of amyloid Non branching fibrils
X ray Crystallographic finding of amyloid Cross β–pleated sheet conformation
Characteristic feature of long standing type II DM Islet amyloid protein (amylin)
Protein affected in Alzheimer’s disease β-amyloid
Most Specific feature of AL type of amyloidosis Macroglossia
APOPROTEIN
LDL Apo B-100
Apo E
VLDL Apo B-100
Chylomicron Apo B-48
HDL Apo A I
Apo A II
Cofactor for Lipoprotein Lipase Apo C II (Main)
Apo C I
Inhibitor for Lipoprotein Lipase Apo A II (Main)
Apo C III
Lipoprotein increases risk of CHD & Atherosclerosis
Lipoprotein not showing Electrophoretic mobility Chylomicron
Lipoprotein having maximum triacylglycerol Chylomicron
Maximum exogenous triacylglycerol Chylomicron
Lipoprotein having maximum Cholesterol LDL
Lipoprotein having maximum protein & Phospholipid HDL
Exogenous trigylcerides maximum in Chylomicrons
Endogenous triglycerides maximum in VLDL
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4ARTHRITIS
ARTHRITIS
RHEUMATOID ARTHRITIS & VARIANTS SERONEGATIVE ARTHRITIS
Symmetrical
Small Joint
More Osteoporosis
Erosions
Asymmetrical
Large Joints
Less Osteoporosis
Periostitis,Syndesmophytes
RA
SLE
Scleroderma
Dermatomyositis
Ankylosing Spondylitis
Psoriatric arthropathy
Reiter Syndrome
Enteropathic Arthritis
ARTHRITIS
OSTEOARTHRITIS RHEUMATOID ARTHRITIS PSORIATIC ARTHRITIS
PIP,DIP,1
st
CMC Any Small joint PIP,DIP,MCP,Wrist
Sparing of MCP joint Sparing of DIP NO SPARING
MC connective tissue disorder associated with Scleritis Rheumatoid arthritis
MC Tarsal Tunnel Syndrome occurs in
(Compression of Tibial Nerve)
1
st
Rheumatoid arthritis
2
nd
Ankylosing Spondylitis
3
rd
Osteoarthritis
MC weakened muscle in Osteoarthritis Quadriceps
MC Late Complication of Acetabular Fracture Secondary Osteoarthritis
(Post traumatic Osteoarthritis)
MC type of Anaemia in Rheumatoid arthritis Normochromic Normocytic Anaemia
AVASCULAR NECROSIS
BONE DISEASE
Lower pole of Patella Synding Larsen Joharresen Disease
Tibial Tuberosity Osgood Shlatter Disease
Calcaneum Sever’s Disease
Navicular Kohler’s Disease
2
nd
Metatarsal Freiberg’s Disease
5
th
Metatarsal Islene Disease
Capitulum Panner’s Disease
Ring epiphysis of Vertebra Scheurmann’s Disease
Central Nucleus of Vertebral Body Calve’s Disease
Lunate Keinboch’s Disease
Proximal Pole of Scaphoid Preiser’s Disease
Femoral Head Legg-Calve-Perthe’s Disease
Those written in ITALICS are TRACTION/PULLING APOPHSITIS
All the others are crushing type
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5BONE GRAFT
BONE GRAFT
Ideal Source of bone Graft Ilium
Commonest Source of Cortical Bone Graft Fibula
Best source for Cortical/Corticocancellous bone Graft Anterior Iliac Crest
Best Source for Cancellous bone Graft Posterior Iliac Crest
BRAIN
ANTERIOR HYPOTHALAMUS
Paraventricular Nucleus Oxytocin release
Supraoptic Nucleus Vasopressin release
Medial Preoptic Nucleus Sexual drive in Males
POSTERIOR HYPOTHALAMUS
Lateral area Thirst & Hunger
Ventromedial Nucleus Satiety centre
Mamillary body Feeding Reflexes
Dorsomedial Nucleus GI Stimulation
Arcurate Nucleus &
Periventricular Zone
Neuroendocrinal Control
Structure of brain involved in emotion Hypothalamus, Limbic system
Sensory action of emotion Limbic system
Expressive action of emotion Hypothalamus
Osmoreceptors are located in Anterior Hypothalamus
Consolidation of long term memory Hippocampus
Window of Limbic system Amygdala
Reward centre Medial forebrain bundle
Functions of Limbic system Emotion, Memory, Higher function
Addiction associated with Reward Centre
Conation means Desire to take action
Longetrm memory stored in Various part of Neocortex
Memory doesnot involve processing in Hippocampus Implicit/Non destructive skill
Nucleus controlling Circadian Rhythm Suprachiasmatic nucleus
Blobs of visual cortex a/w Colour Processing
Parvocellular pathway carry signal for detection of Colour vision, shape, Fine details
Two main afferent to cerebellar cortex Climbing fibres & Mossy fibres
Only output from cerebellar cortex Purkinje cells
Neocerebellum to Ventral lateral nucleus of thalamus
through
Dentate nucleus
Largest & most lateral cerebellar peduncle Middle cerebellar peduncle
Afferent tract to middle cerebellar peduncle Pontocerebellar
Posterior perforated substance located in Floor of interpeduncular fossa
Pain sensitive cranial nerve 2,3,5,7,9,10
Vertical & Upside down cortical representation of body Homunculus
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6BRAIN
inCerebrum
Anterior perforated area bounded laterally by Limen Insulae (Gyrus ambiens)
White fibres connecting cortical areas in Same
hemisphere
Association fibres
White fibres connecting corresponding cortical fibres
crossing midline
Commisural fibres
Cerebral cortex connected to lower levels of brain by Projection fibres
Fibres of genu of corpus callosum curve forward into
frontal lobes to form
Forceps minor
Intracellular inclusion bodies found in choroid plexus Biond’s ring tangles
Main afferent to basal ganglia Corticostriate projection
Tightness of blood brain barrier Close apposition of astrocyte
Vestibular nucleus location Beneath floor of 4
th
ventricle
Largest sensory root of trigeminal nerve composed of Pseudounipolar neurons
LMN includes Anterior horn cells,Anterior spinal root,Peripheral nerve
Anterior & Lateral spinothalamic tract ends in Ventral Posterolateral nucleus of thalamus
Uncrossed ascending tracts Nucleus gracilis,cuneatus,Spinoolivary
Filum terminale mainly composed of Piamater
Ventral roots of spinal nerve contains Somatic efferent
Anterior & Posterior gray columns united by Grey commissure
Cranial nerves entrapped in apex of Petrous bone 5,6
Parasympathetic Cranial Nerves 3,7,9,10
Initiation of Voluntary movements by Corticospinal & corticobulbar
Maintenance of posture in normal adult depends on Integrity of Reflex arc
Cell bodies of Orexinergic neurons present in Lateral hypothalamic area
Function of Microglia Phagocytosis
Function of Oligodendrocytes Myelin formation
Function of Astrocyte Blood Brain barrier
Neuroglial cells of ectodermal origin Astrocyte,Oligodendrocytes
Neuroglial cells of mesodermal origin Microglia
Fibrous astrocyte found in White matter
Protoplasmic astrocytes found in Grey matter
Repetetive stimulus increase pain means Hypersensitisation
Pain receptors Nociceptors (Free nerve endings)
Ascending pain pathway in dorsal midbrain inhibited by Enkephalin,Seratonin
Afferent fibres from Lateral geniculate body end in Layer 4 of Visual Cortex
DOMINANT HEMISPHERE
CATEGORIAL HEMISPHERE
NON DOMINANT HEMISPHERE
REPRESENTATIONAL HEMISPHERE
Language Function
Mathematical & scientific Skills
LEFT SIDED OLFACTION
Music & Art awareness
Visuospatial Orientation
Form,Shape,Faces,Body images
RIGHT SIDED OLFACTION