Pterygium is a wing-shaped growth of conjunctiva that encroaches on the cornea. It is more common in people living in hot, dusty climates who are exposed to sun and ultraviolet rays. Pterygium is a degenerative condition where subconjunctival tissue proliferates as vascularised granulation tissue under the epithelium, destroying the corneal epithelium, Bowman's layer and superficial stroma. It presents as a triangular fold of conjunctiva on the cornea, usually on the nasal side. Surgical excision is required if it encroaches the pupil or causes diplopia. Recurrence after excision is common, ranging from 30-50%, but use of
This presentation describes the background of the cornea and the corneal diseases in general, also it describes in detailed manner how to manage the corneal ulcer with its different causes
This presentation describes the background of the cornea and the corneal diseases in general, also it describes in detailed manner how to manage the corneal ulcer with its different causes
Ectropion
It is an outward turning of the eyelid margin . This more frequently affects the lower eyelid.Upper eyelid ectropion is uncommon.Classified in 5 types
1)Congenital 2) Involutional 3) Paralytic 4) Cicatricial 5) Mechanical
Involutional ectropion is more common.Congenital ectropion is very rare.
Symptoms Epiphora :- excessive tearing.Excessive dryness.
Foreign body sensation Irritation.Burning.Redness.Chronic conjunctivitis KeratinizationCorneal exposure
Grading
Lid margin is out rolled and depending on out rolling ectropion can be classified as under:
Grade I –only punctum is everted
Grade II –lid margin is everted and palpebral conjunctiva is visible
Grade III –fornix is also visible
Etiological factors
Horizontal lid laxity:-can be demonstrated by pulling the central part of the lid 8 mm or more from the globe, with a failure to snap back to its normal position on release without the patient first blinking.
Medial canthal tendon laxity
demonstrated by pulling the lower lid laterally and observing the position of the inferior punctum If the lid is normal the punctum should not be displaced more than 1–2 mm
Lateral canthal tendon laxity
characterized by a rounded appearance of the lateral canthus and the ability to pull the lower lid medially more than 2 mm.
>Normally, the displacement should only be 0-2 mm.
Treatment
1 medical therapy
2 surgical therapy
Ectropion
It is an outward turning of the eyelid margin . This more frequently affects the lower eyelid.Upper eyelid ectropion is uncommon.Classified in 5 types
1)Congenital 2) Involutional 3) Paralytic 4) Cicatricial 5) Mechanical
Involutional ectropion is more common.Congenital ectropion is very rare.
Symptoms Epiphora :- excessive tearing.Excessive dryness.
Foreign body sensation Irritation.Burning.Redness.Chronic conjunctivitis KeratinizationCorneal exposure
Grading
Lid margin is out rolled and depending on out rolling ectropion can be classified as under:
Grade I –only punctum is everted
Grade II –lid margin is everted and palpebral conjunctiva is visible
Grade III –fornix is also visible
Etiological factors
Horizontal lid laxity:-can be demonstrated by pulling the central part of the lid 8 mm or more from the globe, with a failure to snap back to its normal position on release without the patient first blinking.
Medial canthal tendon laxity
demonstrated by pulling the lower lid laterally and observing the position of the inferior punctum If the lid is normal the punctum should not be displaced more than 1–2 mm
Lateral canthal tendon laxity
characterized by a rounded appearance of the lateral canthus and the ability to pull the lower lid medially more than 2 mm.
>Normally, the displacement should only be 0-2 mm.
Treatment
1 medical therapy
2 surgical therapy
ACCORDING TO AYURVEDA THE DISEASES OF SCLERA ARE CALLED AS SHUKLAGATA ROGAS. THE PROBABLE MODERN CORRELATION OF SHUKLAGATA ROGAS LIKE ARMA(PTERYGIUM) ETC. ARE EXPLAINED IN THIS PPT.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
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3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
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Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
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2. Pterygium (L. Pterygion = a wing) is a wing-shaped fold of
conjunctiva encroaching upon the cornea from either side
within the inter-palpebral fissure.
Etiology. The disease is more common in people living in hot
climates such as exposure to sun (ultraviolet rays), dry heat,
high wind and abundance of dust.
3. Pathology
Pterygium is a degenerative and hyperplastic condition of
conjunctiva.
The subconjunctival tissue undergoes elastotic degeneration and
proliferates as vascularised granulation tissue under the
epithelium, which ultimately encroaches the cornea.
The corneal epithelium, Bowman's layer and superficial stroma
are destroyed.
5. It presents as a triangular fold of conjunctiva encroaching the
cornea in the area of palpebral aperture, usually on the nasal
side, but may also occur on the temporal side.
6. Deposition of iron seen sometimes in corneal epithelium
anterior to advancing head of pterygium is called stocker's line.
7.
8. Types.
Depending upon the progression
1. Progressive pterygium is thick, fleshy and vascular with a
few infiltrates in the cornea, in front of the head of the
pterygium (called cap of pterygium).
2. Regressive pterygium is thin, atrophic, attenuated with very
little vascularity. There is no cap. Ultimately it becomes
membranous but never disappears.
9. Symptoms.
Pterygium is an asymptomatic
Visual disturbances occur when it encroaches the pupillary area
or due to corneal astigmatism
Occasionally diplopia
Complications .
Cystic degeneration and infection
Rarely, neoplastic change
10. Differential diagnosis.
Pterygium must be differentiated from pseudopterygium.
Pseudopterygium is a fold of bulbar conjunctiva attached to
the cornea. It is formed due to adhesions of chemosed bulbar
conjunctiva to the marginal corneal ulcer. It usually occurs
following chemical burns of the eye.
11.
12. Treatment.
Surgical excision for:
(1) Cosmetic reasons,
(2) Once the pterygium has encroached pupillary area,
(3) diplopia due to interference in ocular movements.
Complication.
Recurrence (30-50%).
13. Reduction of recurrence.
1. Use of mitomycin-C
2. Surgical excision with bare sclera.
3. Surgical excision with free conjunctival auto-graft
4. In recurrent recalcitrant pterygium, surgical excision coupled
with lamellar keratectomy and lamellar keratoplasty.
14. Surgical techniqueof pterygiumexcision
1. After topical anaesthesia, eye is cleansed, draped and
exposed using universal eye speculum.
2. Head of the pterygium is lifted and dissected off the cornea
very meticulously
15. 3. The main mass of pterygium is
then separated from the sclera
underneath and the conjunctiva
superficially.
4. Pterygium tissue is then
excised taking care not to
damage the underlying medial
rectus muscle
5. Haemostasis is achieved and
the episcleral tissue exposed is
cauterised thoroughly.
16. 6.
i. In simple excision the conjunctiva is
Sutured back to cover the sclera
ii. In bare sclera technique, some part of
conjunctiva is excised and its edges are
sutured to the underlying episcleral tissue
leaving some bare part of sclera near the
limbus
iii. Limbal conjunctival autograft transplantation
(LLAT) to cover the defet after pterygium
excision is the latest and most effective
technique in the management of pterygium.