The document discusses the anatomy and embryology of the prostate gland. It describes the prostate's shape, size, surfaces, lobes, capsule, fascia, venous and arterial supply, pelvic plexus, lymphatic drainage and embryological development. The prostate develops from the urogenital sinus in males through androgen-dependent budding and condensation of epithelial cells. Its anatomy includes zones, glandular and fibromuscular composition, and relationship to surrounding structures like the bladder neck.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Prostate anatomy, embryology
1. ANATOMY AND EMBRYOLOGY
OF PROSTATE
Dept of Urology
Govt Royapettah Hospital and Kilpauk Medical College
Chennai
1
2. Moderators:
Professors:
Prof. Dr. G. Sivasankar, M.S., M.Ch.,
Prof. Dr. A. Senthilvel, M.S., M.Ch.,
Asst Professors:
Dr. J. Sivabalan, M.S., M.Ch.,
Dr. R. Bhargavi, M.S., M.Ch.,
Dr. S. Raju, M.S., M.Ch.,
Dr. K. Muthurathinam, M.S., M.Ch.,
Dr. D. Tamilselvan, M.S., M.Ch.,
Dr. K. Senthilkumar, M.S., M.Ch.
Dept of Urology, GRH and KMC,
Chennai. 2
3. PROSTATE
Inverted pyramidal shape
18 gms
3*4*2 cms
Anterior,posterior and two lateral surfaces
3
Dept of Urology, GRH and KMC,
Chennai.
4. Inverted pyramidal shape with base (sup),
apex (inf), four surfaces
1. Surfaces: posterior, anterior, right &
left inferolateral
2. Base (aka: vesicular surface): superior
a. Attached to neck of urinary bladder
b. Prostatic urethra enters middle of
base close to anterior surface
4
Dept of Urology, GRH and KMC,
Chennai.
5. Broad base superiorly-outer longitudinal
fibres of detrussor fuse with the fibrous
tissue of the capsule
Narrow apex inferiorly- continuous with
striated sphincter
5
Dept of Urology, GRH and KMC,
Chennai.
6. 3. Apex: inferior
a. Rests on superior fascia of urogenital
diaphragm muscle
b. Associated with sphincter urethrae
c. Contacts medial margins of levator ani
muscles
4. Posterior surface: triangular, flat
5. Anterior surface: narrow, convex
6. Inferiorolateral surfaces
a. Meet with anterior surface
b. Rest on levator ani fascia above
urogenital diaphragm 6
Dept of Urology, GRH and KMC,
Chennai.
8. CAPSULE
TRUE FALSE
- Anatomical capsule - Surgical capsule
- Formed of endopelvic
fascia
- Formed due to
compression of peripheral
zone by enlarging adenoma
False capsule provides plane of clavage for surgical
enucleation of hyper plastic tissue leaving behind
prostatic plexus of veins
8
Dept of Urology, GRH and KMC,
Chennai.
9. True capsule absent in apex and base of
bladder
Posterolaterally fuses with denonvillers fascia
Anteriorly and anterolaterally fuses with
endopelvic fascia
False capsule-compressed AFMS because of
BPH
9
Dept of Urology, GRH and KMC,
Chennai.
10. FASCIA
Levator ani fascia
Endopelvic fascia/pelvic fascia
Lateral prostatic fascia
Between pelvic fascia and prostatic
fascia-space filled by areolar fat which
has NV bundle
10
Dept of Urology, GRH and KMC,
Chennai.
12. LOBES
Anatomically 5 in number
Distinguished in fetal gland < 20 weeks of gestation
Anterior
– Devoid of glandular tissue
Posterior
Middle or median
– Wedge between urethra and ejaculated ducts
– related superiorly to trigone
– Rich in glandular element
– Affected in BPH
Lateral
– Two in number
– Separated by a shallow vertical groove
– Rich in glandular tissue
– Affected in BPH
12
Dept of Urology, GRH and KMC,
Chennai.
13. PROSTATE
70% GLANDS AND 30%
FIBROMUSCULAR STROMA
Tubuloalveolar glands lined by cuboidal or
columnar epithelium
Flattened basal cells beneath secretory
epithelial cells
13
Dept of Urology, GRH and KMC,
Chennai.
14. STRUCTURE OF PROSTRATE
Composition
70% glandular element 30% fibromuscular
stroma made up of
collagen and smooth muscle cells
Traversed by urethra at junction of anterior and middle 1/3rd
14
Dept of Urology, GRH and KMC,
Chennai.
16. McNEAL ZONES
Discrete zones- based on location of ducts
in prostatic urethra,embryological origin and
differing pathological lesion
Transition zone- 5 to 10 %
At an angle btn preprostatic sphincter and
prostatic urethra ,the ducts of TZ arise .
Discrete FMS seperates TZ from other
areas (TRUS) ,commonly gives rise to BHP.
20% Adenocarcinoma
16
Dept of Urology, GRH and KMC,
Chennai.
17. McNEAL ZONES
Central zone-25%
Ducts arise circumferentially around
opening of ejaculatory duct .
Cone shape
Wolffian duct origin
1 to 5 % carcinoma
Peripheral zone-70%
Ducts opening into prostatic sinus along
entite length of prostatic urethra .
70% carcinoma
MC zone of chronic prostatitis 17
Dept of Urology, GRH and KMC,
Chennai.
18. McNEAL ‘S ZONES
Transitional zone surrounds the urethra
proximal to the ejaculatory ducts.
The central zone surrounds the ejaculatory
ducts and projects under the bladder base.
The peripheral zone constitutes the bulk of
the apical, posterior, and lateral aspects of
the prostate.
The anterior fibromuscularstroma extends
from the bladder neck to the striated urethral
sphincter. 18
Dept of Urology, GRH and KMC,
Chennai.
19. McNEAL ZONES
AFMS-upto 1/3rd of prostatic mass
Bladder neck to striated sphincter.
False capsule in BPH.
Clinically P/R- 2 lateral lobes and central
sulcus
middle lobe projects into bladder
relates to pathological enlargement of TZ
laterally and periurethral glands centrally
19
Dept of Urology, GRH and KMC,
Chennai.
23. VENOUS ANATOMY
Veins of the prostate drain into Santorini’s
plexus.(doral vein complex of the
penis/pudental plexus)
DEEP DORSAL VEIN-leaves penis under
Buck’s fascia between corpora cavernosa and
penetrates urogenital diapragm dividing into
three major branches Superficial branch, right
and left lateral venous plexuses.
23
Dept of Urology, GRH and KMC,
Chennai.
24. VENOUS ANATOMY
The superficial branch travels between
puboprostatic ligaments is the centrally
located vein overlying the bladder neck and
prostate.
The superficial branch lies outside the
anterior prostatic fascia
24
Dept of Urology, GRH and KMC,
Chennai.
25. VENOUS ANATOMY
The common trunk and lateral venous
plexuses are covered and concealed by
prostatic and endopelvic fascia
The lateral venous plexus traverse
posterolaterally and communicate freely with
the pudendal obturator and vesical plexuses
25
Dept of Urology, GRH and KMC,
Chennai.
26. VENOUS ANATOMY
The lateral plexus interconnects with the
other venous systems to form inferior
vesical vein,which empties into internal iliac
vein
26
Dept of Urology, GRH and KMC,
Chennai.
29. ARTERIAL SUPPLY
Prostate recieves arterial blood supply from
the inferior vesical artery
Acording to Flocks(1937) after the inferior
vesical artery provides branches to seminal
vesicle and base of the bladder and prostate
the artery terminates in two large groups of
prostatic vessels-the urethral and capsular
groups
29
Dept of Urology, GRH and KMC,
Chennai.
30. 1. Arteries derived
from:
a. Internal pudendal
artery
b. Inferior vesical
artery
c. Middle rectal
artery
30
Dept of Urology, GRH and KMC,
Chennai.
31. ARTERIAL SUPPLY
• Inferior vesical artery
• Divides into two branch
• Urethral artery Capsular artery
• Approaches at bladder Runs posterolaterally
neck at 1 to 5 O’clock along with
and 7 to 11 O’clock neurovascular
• On resection of gland bundle
• These vessels bleed
significantly specially
those at 4 and 8 O’clock
position
31
Dept of Urology, GRH and KMC,
Chennai.
32. ARTERIAL SUPPLY
The urethral vessels enter the prostate at
posterolateral vesicoprostatic junction and supply
the vesical neck and periurethral portion of the
gland.
The capsular branches run along the pelvic
sidewall in the lateral pelvic fascia posterolateral
to the prostate providing branches that course
ventrally and dorsally to supply the outer portion
of the prostate. 32
Dept of Urology, GRH and KMC,
Chennai.
33. ARTERIAL SUPPLY
On histologic examination the capsular
arteries and veins are surrounded by an
extensive network of nerves (Walsh and
Donker 1982)
These capsular vessels provide
macroscopic landmark to aid in the
identification of microscopic branches of the
pelvic plexus that innervate the corpora
cavernosa
33
Dept of Urology, GRH and KMC,
Chennai.
34. ARTERIAL SUPPLY
The major arterial supply to carpora cavernosa
is derived from the internal pudendal artery
However pudendal arteries can arise from
obturator inferior vesical and superior vesical
arteries.
Because these aberrant branches travel along
lower part of bladder and anterolateral part of
prostate, they are divided during radical
prostatectomy(Erectile dysfn)
34
Dept of Urology, GRH and KMC,
Chennai.
37. PELVIC PLEXUS
The autonomic innervatin of the pelvic organs and external
genitalia arises from pelvic plexus which is formed by
parasympathetic, visceral, efferent,preganglionic fibres
that arise from sacral center(S2 To S4)and Sympathetic
fibres via hypogastric nerve from thoracolumbar center
Para sympathetic sacral + superior hypogastric plexus=
inferior hypogastric plexus(PELVIC PLEXUS)
37
Dept of Urology, GRH and KMC,
Chennai.
39. PELVIC PLEXUS
The pelvic plexus in men is located retroperitoneally
on either side of rectum 5to11cm from the anal verge
and forms a fenestrated rectangular plate that is in the
sagittal plane within its mid point at the level of tip of
seminal vesicle
Length 4 to 5 cm
The pelvic plexus provides visceral branches that
innervate the bladder ureter,seminal vesicles,prostate,
rectum,membranous urethra,and carpora cavernosa.
39
Dept of Urology, GRH and KMC,
Chennai.
40. PELVIC PLEXUS
The branches of inferior vesical artery and vein
that supply the bladder and prostate perforate
the pelvic plexus.
For this reason ligation of the so called pelvic
pedicle in its mid portion not only interrupts
the vessel but also transects the nerve supply
to the prostate ,urethra and carpora cavernosa.
40
Dept of Urology, GRH and KMC,
Chennai.
41. PELVIC PLEXUS
The branches to the membranous urethra
and carpora cavernosa travel outside the
prostatic capsule in the lateral pelvic fascia
dorsolaterally between the prostate and
rectum.
Although these nerves are microscopic their
anatomic location can be estimated
intraoperatively by use of capsular vessels
as landmark
This is refered as neuro vascular bundle
of Walsh
41
Dept of Urology, GRH and KMC,
Chennai.
42. NV BUNDLE OF WALSH
ACCORDING TO Takenaka and Costello (2004) the
cavernous branches join the capsular arteries and
veins in the spray like distribution to form the
neurovascular bundle 20 to 30mm distal to the junction
of bladder and prostate
The neurovascular bundle is located in the lateral
pelvic fascia between the prostatic and levator fascia-
a crescentric deposition with respect to posterolateral
capsule of the prostate
42
Dept of Urology, GRH and KMC,
Chennai.
47. EMBRYOLOGY OF PROSTATE
Primitive gut tube endoderm gives rise to
foregut,midgut ,hindgut and cloaca.
Cloaca is divided by urorectal septum during
embryogenesis to create separate urinary and
digestive outlets.
The ventral urinary compartment is called the
primitive urogenital sinus ,which further
segments into urinary bladder at its cranial
end and the urethra at its caudal terminus.
47
Dept of Urology, GRH and KMC,
Chennai.
48. Prostate develops from urogenital sinus through
dihydrotestosterone stimulation.
Prostate budding :
prostate develops caudal to bladder
neck via proliferation of epithelial buds
extending out from urogenital sinus epithelium
and this process is androgen dependant.
Prostate buds invade at stereotyped locations
that pattern the future development of zones of
prostate. 48
Dept of Urology, GRH and KMC,
Chennai.
49. These regions prepare for epithelial bud
invasion by mesenchymal condensation ,a
process in which urogenital sinus
mesenchymal cells become closely packed
together.This condensation is androgen
independent.
In humans prostate budding occurs during
10th week of gestation.
49
Dept of Urology, GRH and KMC,
Chennai.
50. A. Pronephros is group of tubules
emptying on either side into the
primary nephric ducts, which
extend caudad to discharge
ultimately into the cloaca. Later in
development a second group of
tubules arises, more caudal in
position than the pronephric
tubules. B. Mesonephric tubules in
their growth extend toward the
primary nephric ducts and open
into them. C. represents
approximately the conditions
attained by the human embryo
toward the end of the 4th week. D.
Depicts the conditions after sexual
differentiation has taken place:
female-left, male-right. Müllerian
ducts arise during the 8th week, in
close association with the
mesonephric ducts. The müllerian
ducts are the primordial tubes from
which the oviducts, uterus, and
vagina of the female are formed.
Note that although both
mesonephric and müllerian ducts
appear in all young embryos, the
müllerian ducts become vestigial in
50
Dept of Urology, GRH and KMC,
Chennai.
55. Normal Development of Prostate and
Seminal Vesicle
10th week development of male accessory sexual glands
Mesenchyme induces
endodermal evagination
5
reductase
Testostero
ne
DHT
55
Dept of Urology, GRH and KMC,
Chennai.
56. Prostate and Seminal Vesicle
Development
11th week- 5 independent solid cords of
prostatic tissue develop lumens and acini
13th week- prostatic acini began to develop
secretory activity
Mesenchyme surrounding prostate develops
into muscle and connective tissue
56
Dept of Urology, GRH and KMC,
Chennai.
59. MOLECULAR FEATURES OF
PROSTATE DEVELOPMENT
Induction of prostate budding:
AR signalling throughDHT is the primary
motivating force.Epithelial expression of NK
homeobox transcription family member
Nkx3.1 is earliest marker of induction of
prostate development at molecular level.
Genes required for prostate epithelial budding
TP63
59
Dept of Urology, GRH and KMC,
Chennai.
60. Mutations in TP63: abolish epithelial budding.
Mutations in Noggin: impair ventral lobe
budding.
AR signalling is required in the mesenchyme
for epithelial budding but dispensable in
epithelium.
Thus the action of androgens in this process
appears to be indirect.
60
Dept of Urology, GRH and KMC,
Chennai.
61. This has led to hypothesis that
messenchymal cells secrete inductive
factors in response to androgens called
Andromedins.
Mesenchymal condensation: BMP signalling
pathway.
61
Dept of Urology, GRH and KMC,
Chennai.
62. APPLIED ANATOMY
Placement of fascial incision above and
parallel to the bundle for nerve sparing
radical prostatectomy
For wide resection and bundle sacrifice
parallel incision made below and posterior to
bundle(avoiding rectal injury)
Endopelvic fascia incised much laterally
from bladder and prostate to avoid
venous complex injury
62
Dept of Urology, GRH and KMC,
Chennai.
63. APPLIED ANATOMY
In perineal operation surgical anatomic entry
line is along the lateral edge of
prostatorectal(denonvilliers fascia) and
medial to bundle if preservation aimed
High anterior release of NV bundles at the
apex before division of dorsal vein complex-
speed up recovery of sexual function and
continence
63
Dept of Urology, GRH and KMC,
Chennai.
64. APPLIED ANATOMY
In retropubic surgery distal transection of the
puboprostatic ligaments far beyond the
prostatourethral junction may lead to
sphincteric(membranous) urethral injury-so
proximal transection advised
NO MANS LAND-zone distal to prostato
urethral junction( NV bundle+ sphincter)-for
preservation of erectile function and urinary
control
64
Dept of Urology, GRH and KMC,
Chennai.
65. APPLIED ANATOMY
ACCESSORY PUDENTAL ARTERY-
Cadaver 70% angio 7% men 4% (rogers et
al 2004)-anterolateral surface of prostate-
Preservation needed for erectile function
Incising the apex in enlarged prostatic
gland-not to slope but a perpendicular cut
65
Dept of Urology, GRH and KMC,
Chennai.