Porphyrins are cyclic tetrapyrroles that are important in producing heme in animals and chlorophyll in plants. They contain four pyrrole rings linked by methylene bridges that fluoresce red when exposed to light. The main types that have clinical significance are uroporphyrin, coproporphyrin, and protoporphyrin, which differ in their side chain substituents. Heme synthesis occurs mostly in the liver and bone marrow and involves multiple steps in the mitochondria and cytoplasm, and is regulated by a negative feedback loop involving free intracellular heme. Porphyrins play important roles in oxygen transport and activation in hemoproteins.