Poisoning can occur through inhalation, ingestion, injection or skin contact with harmful substances. Common causes of poisoning include accidental ingestion of cleaning agents, plants or chemicals by children, and chemical exposure for workers. Diagnostic tests may include toxicology studies of vomit, urine or blood to identify the poison, and imaging tests like chest xrays. Treatment involves emergency resuscitation, preventing further absorption using activated charcoal or gastric lavage, administration of antidotes, intravenous fluids and monitoring vital signs. Outcomes depend on the poison absorbed and speed of treatment.
Poisoning
Poison
Medicinal Poisoning
Environmental Poisoning
Factors Affecting Environmental poisoning
Drug Poisoning
Role of Pharmacist to Prevent Poisoning
Diagnosis
Treatment
Poisoning is a lethal disruption of body’s physilogical machanism by the induction of an exogenic biological or chemical agent.
A poison is any substance that is harmful to your body.
Poisons may include-
Prescription or over-the-counter medicines taken in doses that are too high
Overdoses of illegal drugs
Carbon monoxide from gas appliances
Household products, such as laundry powder or furniture polish
Pesticides
Indoor or outdoor plants
Metals such as lead and mercury
poisoning, its types and emergent management.bhartisharma175
it explain about definition, causes, types of poison, severity , diagnostic evaluation, complication of poisoning, emergent management, supportive management and nursing management.
Poisoning
Poison
Medicinal Poisoning
Environmental Poisoning
Factors Affecting Environmental poisoning
Drug Poisoning
Role of Pharmacist to Prevent Poisoning
Diagnosis
Treatment
Poisoning is a lethal disruption of body’s physilogical machanism by the induction of an exogenic biological or chemical agent.
A poison is any substance that is harmful to your body.
Poisons may include-
Prescription or over-the-counter medicines taken in doses that are too high
Overdoses of illegal drugs
Carbon monoxide from gas appliances
Household products, such as laundry powder or furniture polish
Pesticides
Indoor or outdoor plants
Metals such as lead and mercury
poisoning, its types and emergent management.bhartisharma175
it explain about definition, causes, types of poison, severity , diagnostic evaluation, complication of poisoning, emergent management, supportive management and nursing management.
Poisoning is one of the very alarming topic now a days. This presentation will give you a basic idea on poisoning, drug poisoning, animal poisoning, plant poisoning, household poisoning, industrial poisoning, treatment of poisoning e.t.c
This presentation includes the first aid measures one can provide in case of accidental as well as intentional poisoning in order to minimize the morbidity and mortality in victims with poisoning.
ALL ABOUT DROWNING AND NEAR DROWNING,
THEIR SYMPTOMS AND SIGNS
HOW TO MANAGE THEM AT SITE OF INCIDENT,EMERGENCY DEPARTMENT,ICU
PEDIATRIC DROWNING ALSO COVERED
Poisoning is one of the very alarming topic now a days. This presentation will give you a basic idea on poisoning, drug poisoning, animal poisoning, plant poisoning, household poisoning, industrial poisoning, treatment of poisoning e.t.c
This presentation includes the first aid measures one can provide in case of accidental as well as intentional poisoning in order to minimize the morbidity and mortality in victims with poisoning.
ALL ABOUT DROWNING AND NEAR DROWNING,
THEIR SYMPTOMS AND SIGNS
HOW TO MANAGE THEM AT SITE OF INCIDENT,EMERGENCY DEPARTMENT,ICU
PEDIATRIC DROWNING ALSO COVERED
Clinical toxicology /certified fixed orthodontic courses by Indian dental aca...Indian dental academy
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In biology, poisons are substances that can cause death, injury or harm to organs, tissues, cells, and DNA usually by chemical reactions or other activity on the molecular scales, when an organism is exposed to a sufficient quantity.
Poisoning and Overdose have increased in recent times at exponential ratio, and most cases are with the initial attempt to harm oneself. this is very unfortunate. This presentation will help doctors and other health workers to be able to determine how to assist a patients who had overdosed on dangerous substances.
a emergency treatment of poisoning.describe of ingested poisons,inhaled poisons,absorbed poison,food poisoning,injected poisoning,snake bite. management of treatment
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Objectives Define poisoning correctly. Enumerate the causes of poisoning in children and adults. Describe the assessment findings and possible toxins that can cause signs & symptoms of poisoning. Discuss the diagnostic tests & treatments for poisoning.
3. Definition Inhalation, ingestion, and injection of, or skin contamination from, any harmful substance. Common environmental emergency. Prognosis depends on the amount of poison absorbed, its toxicity, and the time interval between poisoning and treatment.
6. Adults Chemical company employee chlorine carbon dioxide hydrogen sulfide nitrogen dioxide ammonia Companies that ignore safety standards.
7. Adults Improper cooking Canning Storage of food Ingestion of or skin contamination from plants and accidental Intentional drug overdose or chemical ingestion
31. Toxicology studies Poison levels in the mouth Vomitus Urine Stool or blood, or on the victim’s hands or clothing, confirm the diagnosis. If possible, have the family or patient bring the container holding the poison to the ED for comparable study.
32. Chest X-ray Inhalation poisoning may show aspiration pneumonia. Petroleum distillate inhalation, they may show pulmonary infiltrates or edema. Abdominal x-rays may reveal iron pills or other radiopaque substances.
33. ABG analysis, Serum electrolyte levels & CBC Evaluate oxygenation, ventilation and the metabolic status of seriously poisoned patients.
34. What test tell you . . . Toxicology studies ( including drug screens) of poison levels in the mouth, vomitus, urine, stool or blood, or on the victim’s hands or clothing, confirm the diagnosis. If possible, have the family or patient bring the container holding the poison to the ED for comparable study. In inhalation poisoning chest X-rays may show aspiration pneumonia. In petroleum distillate inhalation, they may show pulmonary infiltrates or edema. Abdominal x-rays may reveal iron pills or other radiopaque substances. ABG analysis, serum electrolyte levels, and CBC are used to evaluate oxygenation, ventilation and the metabolic status of seriously poisoned patients.
39. Poisoning victim Exhibits altered LOC routinely receives oxygen, glucose, and naloxone. Activated charcoal Effective in eliminating many toxic substances. Specific treatment depends on the poison.
41. Poisoning victim Prevent further absorption by administering activated charcoal, including emesis, or by administering gastric lavage and cathartics for specific treatment, contact the poison center. The treatment’s effectiveness depends on the speed of absorption and the time elapsed between ingestion and removal.
42. Emesis Never induce emesis if you suspect corrosive acid poisoning, if the patient is unconscious or has seizures or if the gag reflex is impaired, even in a conscious patient. Instead, neutralize the poison by instilling appropriate antidote by an NG tube. Common antidotes include milk, magnesium salts, activated charcoal, or other chelating agents, such as deferoxamine and edetate disodium.
43. Intravenous Therapy Use large quantities of I.V. fluids to force the poison through the kidneys to be excreted. Kind of fluid you use depends on the patient’s acid-base balance and cardiovascular status and on the flow rate necessary for effective diuresis of poison. If ingested poisoning severe and requires peritoneal dialysis or hemodialysis, assist as necessary.
44. Inhaled poison Prevent further absorption of inhaled poison, remove the patient to fresh or uncontaminated air. Provide supplemental oxygen and , if needed, intubation. Prevent further absorption from skin contamination, remove the clothing covering the contaminated skin and immediately flush the area with large amounts of water.
45. Inhaled poison If patient is in severe pain, give analgesics as ordered frequently monitor fluid intake and output, vital signs and LOC. Keep the patient warm and provide support in a quiet environment. If the poison was ingested intentionally, refer the patient for counseling to help prevent future attempts at suicide.
Facts : Adolescents tend to overdose on over-the-counter drugs instead of prescription drugs. Elderly patients who overdose do so usually because of polypharmacy, improper use of their prescribed medication, improper storage of the medication, improper storage of the medication ( not in its original container ), or mistaking identity of the medication..
Because of their curiosity and ignorance, children are the most common poison victims. In fact, accident poisoning ( usually from the ingestion of salicylates (aspirin), cleaning agents, insecticides, paints, cosmetics and plants ) is the fourth leading cause of death in children. In adults, poisoning is most common among chemical company employee – particularly those in companies that use chlorine, carbon dioxide, hydrogen sulfide, nitrogen dioxide, and ammonia – and in companies that ignore safety standards. Other causes of poisoning in adults include improper cooking, canning, and storage of food, ingestion of or skin contamination from plants and accidental or intentional drug overdose (usually barbiturates) or chemical ingestion.
The pathophysiology of poison depends on the substance that’s inhaled or ingested. The extent of damage depends on the pH of the substance, the amount ingested, its form ( solid or liquid), and the length of exposure to it. Substance with alkaline pH cause tissue damage by liquefaction necrosis, which softens the tissue. Acids produce coagulation necrosis. Coagulation necrosis denatures (changes the molecular composition of) proteins when the substance contacts tissue. This limits the extent of the injury by preventing penetration of the acid into the tissue.The mechanism of action for inhalants are unknown but they’re believed to act on the CNS similarly to a very potent anesthetic. Hydrocarbons sensitize the myocardial tissue and allow it to be sensitive to catecholamines, resulting in arrhythmias.
Coagulation necrosis denatures (changes the molecular composition of) proteins when the substance contacts tissue. This limits the extent of the injury by preventing penetration of the acid into the tissue.
The patient history should reveal the poison’s source and form of exposure ( ingestion, inhalation, injection, or skin contact). Assessment findings vary with the poison.
Prevent further absorption by administering activated charcoal, including emesis, or by administering gastric lavage and cathartics ( magnesium sulfate) for specific treatment, contact the poison center ( local or national). The treatment’s effectiveness depends on the speed of absorption and the time elapsed between ingestion and removal.
Never induce emesis if you suspect corrosive acid poisoning, if the patient is unconscious or has seizures or if the gag reflex is impaired, even in a conscious patient.Instead, neutralize the poison by instilling appropriate antidote by an NG tube. Common antidotes include milk, magnesium salts ( Milk of manganese, activated charcoal, or other chelating agents, such as deferoxamine and edetate disodium.
If several hours have passed since the patient ingested the poison, use large quantities of I.V. fluids to force the poison through the kidneys to be excreted. The kind of fluid you use depends on the patient’s acid-base balance and cardiovascular status and on the flow rate necessary for effective diuresis of poison. If ingested poisoning severe and requires peritoneal dialysis or hemodialysis, assist as necessary.