The basal nuclei, also known as basal ganglia, are clusters of gray matter deep within the cerebral hemispheres. They include the caudate nucleus, putamen, and globus pallidus. Together with nearby structures like the substantia nigra and subthalamic nuclei, the basal nuclei help control muscle tone, voluntary and involuntary motor activity, reflexes, associated movements, and arousal through neuronal circuits with motor areas of the cortex. Dysfunctions of the basal nuclei can lead to movement disorders like Parkinson's disease, Huntington's disease, and Tourette syndrome.
Functional Anatomy & physiology of the Basal nucleiRafid Rashid
Provides a good description of the functional anatomy & physiology of the basal nuclei/ basal ganglia for undergraduate medical students. It also describes disorders of the basal ganglia like parkinsonism & chorea.
The body's balance between acidity and alkalinity is referred to as acid-base balance. The blood's acid-base balance is precisely controlled because even a minor deviation from the normal range can severely affect many organs. The body uses different mechanisms to control the blood's acid-base balance.
Muscle spindles are proprioceptors that consist of intrafusal muscle fibers enclosed in a sheath (spindle). They run parallel to the extrafusal muscle fibers and act as receptors that provide information on muscle length and the rate of change in muscle length. The spindles are stretched when the muscle lengthens. This stretch causes the sensory neuron in the spindle to transmit an impulse to the spinal cord, where it synapses with alpha motor neurons. This causes activation of motor neurons that innervate the muscle. The muscle spindles determine the amount of contraction necessary to overcome a given resistance. When the resistance increases, the muscle is stretched further, and this causes spindle fibers to activate a greater muscle contraction.
Have you ever wondered why you sweat when you get too hot from running or shiver on a cold winter's day in this video we are going to explain why your body behaves like this.
Humans are endotherms and this means we are warm blooded we keep our body operating at thirty seven degrees Celsius regardless of the external conditions however this is a real challenge as our environment changes all the time depending on the weather, our clothes, if we are inside by the fire or outside having a snowball fight. So how does this work?
It's quite similar to the heating system in a house. in a house is a thermostat that measures the temperature if the house gets cold the thermostat will tell the radiators to turn on and heat it up if it's too hot they will be told to switch off simple.
Your body works in just the same way here in your brain as a special area called the hypothalamus and it measures the temperature of the blood flowing through it and also it collects information from temperatures senses around the body. it then decides if the temperature is too hot or too cold and we'll try and bring it back to thirty seven degrees Celsius. If you are too hot the hypothalamus can then send signals out to the body by the nervous system that can cause barriers to fact. It can send a signal to your skin and cool sweat glands to secrete the sweat on to the surface of the skin the sweat itself is not cold but it works because it takes the heat away from your body in order to evaporate it.
Another way of losing is vasodilation let kind of these blood vessels narrows this. That said the skin open white and allow blood to flow through them. They heat is radiated from the blood into the air and the blood cools down. If you get too cold you can do the opposite with these blood vessels and place them on keeping the blood away from the surface of the skin this is called vasoconstriction this is when your muscles contract in order to make. Another fact you may have noticed when you are cold against them. If you look more place the at least the Bulls what you realized is that each of the little bugger has a has to hit out at.
These has stood up on and struck a layer of air around the skin air is a fantastic insulate of heat and this will keep you nice and warm.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. Basal Nuclei
• Deep within each cerebral hemisphere are three nuclei
(masses of gray matter) that are collectively termed
the basal nuclei.
• (Historically, these nuclei have been called the basal
ganglia. However, this is a misnomer because a ganglion
is an aggregate of neuronal cell bodies in the peripheral
nervous system. While both terms still appear in the
literature, we use nuclei, as this is the correct term as
determined by the Terminologia Anatomica.
3. • Two of the basal nuclei are side-by-side, just lateral
to the thalamus.
• They are the globus pallidus, which is closer to the
thalamus, and the putamen , which is closer to the
cerebral cortex. Together, the globus pallidus and
putamen are referred to as the lentiform nucleus.
• The third of the basal nuclei is the caudate nucleus.
• Together, the lentiform and caudate nuclei are
known as the corpus striatum .
• Nearby structures that are functionally linked to
the basal nuclei are the substantia nigra of the
midbrain and the subthalamic nuclei of the
diencephalon
4.
5.
6. • Axons from the substantia nigra terminate in the
caudate nucleus and putamen. The subthalamic nuclei
interconnect with the globus pallidus.
7. FUNCTIONS OF BASAL GANGLIA
• Basal ganglia form the part of extrapyramidal
system, which is concerned with integration and
regulation motor activities. Various functions of
basal ganglia are:
8. CONTROL OF MUSCLE TONE
• „Basal ganglia control the muscle tone. In fact,
gamma motor neurons of spinal cord are responsible
for development of tone in the muscles.
• Basal ganglia decrease the muscle tone by inhibiting
gamma motor neurons through descending inhibitory
reticular system in brainstem.
• During the lesion of basal ganglia, muscle tone
increases leading to rigidity.
9. CONTROL OF MOTOR ACTIVITY
• „i. Regulation of Voluntary Movements
• Movements during voluntary motor activity are
initiated by cerebral cortex. However, these
movements are controlled by basal ganglia, which are
in close association with cerebral cortex. During
lesions of basal ganglia, the control mechanism is
lost and so the movements become inaccurate and
awkward.
10. • Basal ganglia control the motor activities because of
the nervous (neuronal) circuits between basal ganglia
and other parts of the brain involved in motor
activity.
• Neuronal circuits arise from three areas of the
cerebral cortex:
a. Premotor area
b. Primary motor area
c. Supplementary motor area
11. • All these nerve fibers from cerebral cortex reach
the caudate nucleus.
• From here, the fibers go to putamen.
• Some of the fibers from cerebral cortex go directly
to putamen also. Putamen sends fibers to globus
pallidus.
• Fibers from here run towards the thalamus,
subthalamic nucleus, and substantia nigra.
• Subthalamic nucleus and substantia nigra are in turn,
projected into thalamus.
• Now, the fibers from thalamus are projected back
into primary motor area and other two motor areas,
• i.e. premotor area and supplementary motor area
12. ii. Regulation of Conscious Movements
• Fibers between cerebral cortex and caudate nucleus
are concerned with regulation of conscious
movements. This function of basal ganglia is also
known as the cognitive control of activity. For
example, when a stray dog barks at a man,
immediately the person, understands the situation,
turns away and starts running.
13. iii. Regulation of Subconscious Movements
• Cortical fibers reaching putamen are directly
concerned with regulation of some subconscious
movements, which take place during trained motor
activities, i.e. skilled activities such as writing the
learnt alphabet, paper cutting, nail hammering, etc.
14. CONTROL OF REFLEX
MUSCULAR ACTIVITY
• Some reflex muscular activities, particularly visual
and labyrinthine reflexes are important in
maintaining the posture. Basal ganglia are
responsible for the coordination and integration of
impulses for these reflex activities.
• During lesion of basal ganglia, the postural
movements, especially the visual and labyrinthine
reflexes become abnormal. These abnormal
movements are associated with rigidity. Rigidity is
because of the loss of inhibitory influence from the
cerebral cortex on spinal cord via basal ganglia.
15. CONTROL OF AUTOMATIC
ASSOCIATED MOVEMENTS
• Automatic associated movements are the movements
in the body, which take place along with some motor
activities. Examples are the swing of the arms while
walking, appropriate facial expressions while talking
or doing any work. Basal ganglia are responsible for
the automatic associated movements.
• Lesion in basal ganglia causes absence of these
automatic associated movements, resulting in
poverty of movements. Face without appropriate
expressions while doing any work is called mask-like
face. Body without associated movements is called
statue-like body.
16. ROLE IN AROUSAL MECHANISM
• Globus pallidus and red nucleus are involved in
arousal mechanism because of their connections with
reticular formation.
• Extensive lesion in globus pallidus causes drowsiness,
leading to sleep.
18. CLINICAL CONNECTION |
Disorders of the Basal
Nuclei
• Parkinson’s disease (PD) is a progressive disorder of
the CNS that typically affects its victims around
age 60. Neurons that extend from the substantia
nigra to the putamen and caudate nucleus, where
they release the neurotransmitter dopamine (DA),
degenerate in PD.
• Uncontrollable shaking (tremor) and muscle rigidity
(stiffness) are hallmark signs of Parkinson’s disease.
19. Huntington disease (HD)
• Huntington disease (HD) is an inherited disorder in
which the caudate nucleus and putamen degenerate,
with loss of neurons that normally release GABA or
acetylcholine.
• A key sign of HD is chorea, in which rapid, jerky
movements occur involuntarily and without purpose.
Progressive mental deterioration also occurs.
Symptoms of HD often do not appear until age 30 or
40.
• Death occurs 10 to 20 years after symptoms first
appear.
20. Tourette syndrome
• Tourette syndrome is a disorder that is
characterized by involuntary body movements
(motor tics) and the use of inappropriate or
unnecessary sounds or words (vocal tics).
• Although the cause is unknown, research suggests
that this disorder involves a dysfunction of the
cognitive neural circuits between the basal nuclei
and the prefrontal cortex.