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Reticular formation
Learning objectives
 Reticular formation nuclei
 Reticular pathways
 Physiology of Reticular activating system
 Functions of Reticular formation.
Reticular formation
 Dense network of neurons and nerve fibers found in
Core of brainstem
 Indinstinct , not well defined anatomically.
50-80 nuclear masses
It can be: Midbrain, Pontine and Medullary RF.
Consists of :
Aggregates of Neurons
Afferent and Efferent connections.
Reticular formation
 The neurons have long dendrites and axons.
Reticular formation
NUCLEAR COLUMNS:
Median column:
 Raphe nuclei in midbrain
Median Column:
 MAGNOCELLULAR
 Nucleus gigantocellularis in medulla and pontine
tegmental nuclei.
Reticular formation
 Lateral columns:
PARVOCELLULAR
Central nucleus of medulla and pons
Reticular formation
 Cardiac centers
 Respiratory centers
 Vasomotor centers
 Salivatory centers
 Chemoreceptor neurons.
Reticular formation
 They receive afferents from spino-reticular tracts.
 Fibers from this part project upwards as Reticular
activating system.
 Fibers from this part project downwards as medial
and lateral reticulospinal tracts.
Reticular pathways
Connections of RF:
 Afferent connections
 Efferent connections:
Ascending and Descending projections.
Reticular formation
 Afferents:
Receives afferents from almost all ascending sensory
pathways
 Optic pathway
 Olfactory pathway
 Auditory pathway
 Taste pathway
 Spinal and Trigeminal pathway
 Pain, temperature, vibration and kinesthetic sensation.
 Cerebral cortex
 Cerebellum
 Corpus striatum
 Thalmic nuclei
Reticular pathways
 Cortico-reticulo-spinal pathways:
Cortico-reticulo-cerebellar
 Cortico-reticulo-basal ganglia
 Visceral control pathways: control of respiration ,
heart rate and BP
 RAS-Reticular activating system.
Reticular pathways
 RAS:
Also called ARAS from brain stem RF.
Polysynaptic pathway
Also receives collaterals from:
 Spinothalamic tracts
 Trigeminal, auditory , visual and olfactory pathway
systems.
Reticular pathways
 From RAS fibers go to non-specific thalamic
nuclei(intralaminar and midline nuclei)
 From the thalamus the fibers are projected diffusely and
non specifically to whole cortex.
 Some fibers bypass the thalamus to project to whole
cortex.
 RAS is non specific system since it can be stimulated by
any sensation from collaterals.
 It also receives facilitatory feedback impules from motor
cortex and inhibitory feedback impulses from limbic
system.
Reticular pathways
 Functions of ARAS:
Facilitatory to central neurons –increases excitability.
Wakefulness and alertness
Beta rhythm in ECG.
Applied aspects:
 Lesions in RAS-Sleep and coma
 Benzodiazepines and babituraes prevent synaptic
transmission in RAS.
Neurotransmitters of Reticular formation.
 Cholinergic neurons : mid brain and pons to cortex
 Adrenergic neurons: whole of RF to thalamus to cortex
 Nor adrenergic neurons: locus coerulus to cerebellum
 Dopaminergic neurons : midbrain RF to basal ganglia
 Serotonergic neurons: Raphe nuclei to thalamus,
cerebral cortex , thalamus and limbic system
From raphe nuclei to spinal cord (control the transmission
of pain)
Reticular formation
Functions:
 Sleep wakefulness: serotonin-secreting neurons in
raphe nuclei mediate non-REM sleep
 Conditioning and learning: Neural substrate
 Selective attention and sensory inattention:
FILTER
 Control of muscle tone and regulation of postural
reflex changes: RF modulates the tone of extensor
muscles.
Pontine RF has excitatory and Medullary reticulospinal
tract has inhibitory influence on extensor muscle tone.
Reticular formation
 Autonomic functions:
Cortical neurons Through Visceral regulating centers
influences the autonomic functions
 Modulation of Pain: Raphe nuclei fibers going to
spinal cord (substantial gelatinosa) modulate the
perception of pain.
 Control of neuroendocrine system: control the
neuroendocrine system in hypothalamus.

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reticular formation.pptx

  • 2. Learning objectives  Reticular formation nuclei  Reticular pathways  Physiology of Reticular activating system  Functions of Reticular formation.
  • 3. Reticular formation  Dense network of neurons and nerve fibers found in Core of brainstem  Indinstinct , not well defined anatomically. 50-80 nuclear masses It can be: Midbrain, Pontine and Medullary RF. Consists of : Aggregates of Neurons Afferent and Efferent connections.
  • 4.
  • 5.
  • 6.
  • 7. Reticular formation  The neurons have long dendrites and axons.
  • 8. Reticular formation NUCLEAR COLUMNS: Median column:  Raphe nuclei in midbrain Median Column:  MAGNOCELLULAR  Nucleus gigantocellularis in medulla and pontine tegmental nuclei.
  • 9. Reticular formation  Lateral columns: PARVOCELLULAR Central nucleus of medulla and pons
  • 10. Reticular formation  Cardiac centers  Respiratory centers  Vasomotor centers  Salivatory centers  Chemoreceptor neurons.
  • 11. Reticular formation  They receive afferents from spino-reticular tracts.  Fibers from this part project upwards as Reticular activating system.  Fibers from this part project downwards as medial and lateral reticulospinal tracts.
  • 12. Reticular pathways Connections of RF:  Afferent connections  Efferent connections: Ascending and Descending projections.
  • 13. Reticular formation  Afferents: Receives afferents from almost all ascending sensory pathways  Optic pathway  Olfactory pathway  Auditory pathway  Taste pathway  Spinal and Trigeminal pathway  Pain, temperature, vibration and kinesthetic sensation.  Cerebral cortex  Cerebellum  Corpus striatum  Thalmic nuclei
  • 14.
  • 15. Reticular pathways  Cortico-reticulo-spinal pathways: Cortico-reticulo-cerebellar  Cortico-reticulo-basal ganglia  Visceral control pathways: control of respiration , heart rate and BP  RAS-Reticular activating system.
  • 16. Reticular pathways  RAS: Also called ARAS from brain stem RF. Polysynaptic pathway Also receives collaterals from:  Spinothalamic tracts  Trigeminal, auditory , visual and olfactory pathway systems.
  • 17. Reticular pathways  From RAS fibers go to non-specific thalamic nuclei(intralaminar and midline nuclei)  From the thalamus the fibers are projected diffusely and non specifically to whole cortex.  Some fibers bypass the thalamus to project to whole cortex.  RAS is non specific system since it can be stimulated by any sensation from collaterals.  It also receives facilitatory feedback impules from motor cortex and inhibitory feedback impulses from limbic system.
  • 18. Reticular pathways  Functions of ARAS: Facilitatory to central neurons –increases excitability. Wakefulness and alertness Beta rhythm in ECG. Applied aspects:  Lesions in RAS-Sleep and coma  Benzodiazepines and babituraes prevent synaptic transmission in RAS.
  • 19. Neurotransmitters of Reticular formation.  Cholinergic neurons : mid brain and pons to cortex  Adrenergic neurons: whole of RF to thalamus to cortex  Nor adrenergic neurons: locus coerulus to cerebellum  Dopaminergic neurons : midbrain RF to basal ganglia  Serotonergic neurons: Raphe nuclei to thalamus, cerebral cortex , thalamus and limbic system From raphe nuclei to spinal cord (control the transmission of pain)
  • 20. Reticular formation Functions:  Sleep wakefulness: serotonin-secreting neurons in raphe nuclei mediate non-REM sleep  Conditioning and learning: Neural substrate  Selective attention and sensory inattention: FILTER  Control of muscle tone and regulation of postural reflex changes: RF modulates the tone of extensor muscles. Pontine RF has excitatory and Medullary reticulospinal tract has inhibitory influence on extensor muscle tone.
  • 21. Reticular formation  Autonomic functions: Cortical neurons Through Visceral regulating centers influences the autonomic functions  Modulation of Pain: Raphe nuclei fibers going to spinal cord (substantial gelatinosa) modulate the perception of pain.  Control of neuroendocrine system: control the neuroendocrine system in hypothalamus.