This document discusses the physical examination of urine, including collection, preservation, and analysis methods. It describes examining the urine's volume, color, odor, appearance, pH, and specific gravity. Specific gravity is measured using a urinometer, refractometer, or dipstick. Abnormal readings may indicate conditions like diabetes, kidney disease, or urinary tract infections. The document provides details on testing urine and interpreting the results of the physical examination.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
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1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
3. Collection of urine
• Done in clean container
• Should be examined freshly
• Best sample early morning
• Culture-sterile containers are used
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4. Types of sample
• Random sample-ordinary qualitative test
• Early morning sample –nephritis
• 2hr post prandial sample-DM
• Mid stream urine collection-culture
• 24hrurine sample-quantitative analysis
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5. Collection method
• 24hr urine –void & discard urine at particular
time. Collect all urine for next 24hr.
• Mid stream urine-initial portion of urine
should be discard. only the mid stream urine
should be collected.
• Catheterized specimen-insertion of tube or
catheter through the ureter into the bladder
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6. Preservation of urinePreservative Concentration limitation
toluene 2ml/100ml Floats on the surface of the
urine. good for constituent
formalin 3drops /100ml
urine
Good for sediment.
Precipitate protein.
thymol 1crystal/100ml Interfere with acid
precipitation test for protein
chloroform 5ml/100ml Forms upper layer. changes
cellular sediment
charactrestics.
Boric acid 0.3gm/120ml of
urine
Yeast can still grow .uric acid
crystal get precipitated.
Conc.HCL 10ml/24hr urine Best preservative for all
chemical examination,
especially for ca,uric acid
,crea,urea.
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11. • Anuria -complete suppression of urine
formation .
-renal collapse
-severe case of acute nephritis
-burns
-transfusion reaction
-traumatic shock
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12. colour
• Normal –straw colour
• Colourless- dilution DM
• Milky-chyluria due to filariasis ,ABD Lymphodenopathy
• Yellow to Brown -jaundice
• Brownish yellow or green-bile pigment
• Orange red or orange brown-urobilinogen
• Bright red-fresh blood
• Brownish black-poisoning
• Black-alkaptnuria
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13. odor
• Fresh urine-aromatic odour
• Urine allow to stand-strong ammonic smell
because of decomposition of urea with
liberation of ammonia.
• Ketone bodies-fruity odor
• Infants with phenylketouria-musty odour
• Putrid odor-UTI
• Fecal odor –E.coli cystitis
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14. Appearance
• Normal-clear
• Cloudy due to
-amorphous phosphate(neutral or alkaline
condition)
-amorphous urates(acidic urine)
• Which disappear on heating.
• In disease – urine cloudy due to
-presents of WBC
-presents of bacteria or fungi
-colloidal suspension of fat or chyle
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15. pH
• Average - 4.6-8.0
• Average pH -6.0-presents of sulphates,
phoshate,chloride.
• Alkaline urine-vegetarian &urine on standing
• Measurements of pH-
1.litmus paper
2.pH paper or nitrazine paper
3.Dip stick method
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16. Dip stick method
• Reagent
0.2% w/w methyl red
2.8%w/w bromo thymol blue
97.0%w/w non reactive ingradiant
• Principle:-
- Based on double indicator principle.
-gives broad range of colors covering entire urinary PH.
-color change from
orange-yellow-green-blue
(Acidic) (alkaline)
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17. Acidic urine
High protein intake and ingestion of acidic
fruits.
Respiratory acidosis
Metabolic acidosis-uremia, diabetes mellitus,
starvation .
E.coli infection
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18. Alkaline urine
• Respiratory alkalosis
• Metabolic alkalosis(excessive vomiting)
• UTI due to proteus and pseudomonas
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19. SPECIFIC GRAVITY
• Normal specific gravity-1.015-1.025
• Urines of low specific gravity are called
hyposthenuric (<1.007) while urines of fixed
sp.gravity of about 1.010 are known as
isothenuric.
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21. urinometer
• This is a bulb shaped instrument that has a
cylindrical stem ,which contains a scale
calibrated in sp.gravity reading. This instrument
is floated in a cylinder containing urine.
• The depth to which it sinks in the urine indicates
the sp.gravi
of urine
• Stem reading-1.000 to
1.060.
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22. Urinometer method
• Principle:-The method of measuring
sp.gravity of urine is based on the principle of
buoyancy. An increased solute concentration or
increased sp.gravity increases the upthrust of
the solution correspondingly.
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23. procedure
• Mix the urine & pour into the cylinder of 25ml capacity.
• Carefully float the urinometer by grasping the stem of
urinometer at the top and inserting slowly into the urine.
• Swirl the urinometer slightly as it is inserted.make sure the
instrument floats freely away from the sides of container.
• Take the reading from the graduation gives on the stem at
lower meniscus formed at eye level.
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25. Correction for temperature
• To correct the sp.gravity reading for
temp, place the thermometer in the urine &
note the exact temp.
• Then add 0.001 to the reading for each 3ºC
above the temperature for which the
urinometer is caliberated.
• Subtract 0.001 from the reading for each 3ºC
which the urine is below the temp of
caliberation.
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26. • Eg:-
Temp of urine is 32ºC
caliberation temp is20ºC
sp.gravity of the urine is measure at 1 .011
corrected sp.gravity =
[(32-20)×0.001] +1.011=1.015
3
10/13/2018 26SUNIL KUMAR.P
27. Correction for abnormal solute
concentration
• Albumin :- for each gram of albumin/100ml,
sp.gravity rises by 0.003 and this is subtracted
.
• Glucose :- for each gram of glucose /100ml,
sp.gravity raises by 0.004 and this must be
subtracted.
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28. Correction for dilution
• If the volume of urine is insufficient for
measuring sp.gravity, urine can be diluted
with distilled water.
• Multiply the last two numbers of the
recorded sp.gravity by the dilution factor.
• Eg:- urine dilution is1:5 , record
sp.gravity is 1.003
corrected sp.gravity is 1.003×5=1.015
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29. Disadvantages of urinometer
• Large amount of urine is required.
• Turbid urine may make reading of the scale
difficult.
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30. refractometer
• To determine the sp.gravity of urine by this
method require only few drops of urine.
• PRINCIPLE:-
The refractive index of a solution is related to
the content of dissolved solids present in
solution.
µ=Va/Vs
This ratio varies directly with
the number of dissolved parti-
cles in the solution .
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31. Conti……….
Although the instrument measures the
refractive index of a solution , scale reading is
generally calibrated in terms of sp.gravity.
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32. Dipstick method
• Reagent
2.8% w/w bromothymol blue
28.4% w/w NaOH
• Principle
PH change of pretreated polyelectrolyte in
relation to ionic strength, the released hydrogen
ion is indicated by PH indicator.
• Colour changes from a dark blue at a low
sp.gravity to yellow green at high sp.gravity
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33. • High sp.gravity
excessive sweating
glycosuria
acute nephritis
albuminuria
all causes of oliguria
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34. • Low specific gravity(less than 1.010)
-excessive water intake
-chronic nephritis
-dibetic incipidus
-all causes of polyuria except DM
• Low or fixed sp.gravity(1.010-1.012)
-chronic nephritis
-ADH deficiency
-arteroscerotic kidney
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