Sickle cell anemia is a hereditary blood disorder caused by a genetic mutation that results in abnormal hemoglobin and sickle-shaped red blood cells. It affects approximately 90,000-100,000 people in the United States, primarily those of African descent. Symptoms include episodes of severe pain, organ damage, infections, and stroke due to sickled cells blocking blood flow. While there is no cure, treatment focuses on pain management, blood transfusions, medications, and in some cases stem cell transplants or gene therapy.
An absolute eosinophil count is a blood test that measures the number of one type of white blood cells called eosinophils.
Eosinophils become active when you have certain allergic diseases, infections, and other medical conditions.
I have listed out the LE cells structure and Microscopical examinaton of LE CELLS, Difference between tart cells and le cells, clinical symptoms and diagnostic procedure.
An absolute eosinophil count is a blood test that measures the number of one type of white blood cells called eosinophils.
Eosinophils become active when you have certain allergic diseases, infections, and other medical conditions.
I have listed out the LE cells structure and Microscopical examinaton of LE CELLS, Difference between tart cells and le cells, clinical symptoms and diagnostic procedure.
This presentation is focused on diagnostic utility of Red blood cell indices which will be very useful for undergraduate and postgraduate of medical field.
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
This presentation is focused on diagnostic utility of Red blood cell indices which will be very useful for undergraduate and postgraduate of medical field.
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
This a series of notes on hematology useful for undergraduate and postgraduate medical and paramedical students. Notes are prepared from standard texts and are easy to reproduce in exams.
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1-Differentiate between the different causes of anemia
2. Discuss the investigations that may clarify the diagnosis
3. Recognize the predisposing factors and consequences of iron deficiency anemia and discuss how to manage it
4. Discuss the hereditary basis and clinical features of sickle cell anemia and thalassemia .
prepared by med_students0
Sickle cell anemia is a genetic diseases where red blood cells can take shape of a crescent or a sickle . And this allows them to be more easily destroyed – causing anemia and other complexities
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
3. ANEMIA
Anemia means deficiency of hemoglobin in the
blood, which can be caused by either too few
red cells or too little hemoglobin in the cells.
TYPES
Hemorrhagic anemia: anemia due to
hemorrhage is known as hemorrhagic anemia.
Hemolytic anemia: Hemolysis means
destruction of RBCs.(sickle cell anemia)
4. Types ,,,,,
Nutritional deficiency anemia : nutritive substances
such as iron, protiens and vitamins like C,B12,and
folic acid are necessary for erythropoisis .the
deficiency of these substances leads to
nutritional deficiency anemia.
Aplastic anemia: Aplastic anemia is due to the
disorder of red bone marrow.
Anemia of chronic disease: It is characterized by
short life span of red cells caused by disturbance
in iron metabolism.
5. Sickle cell anemia
Hemolytic anemia
Causes: 1) liver failure
2)Renal disorder
3)Burns
4) congenital or acquired default in the shape of
RBCs.
Sickle Cell Anemia
6. Sickle Cell Disease
What is sickle cell disease?
• Sickle cell disease (SCD) is a group of inherited red
blood cell disorder.
• Healthy red blood cells are round and they move
through small blood vessels carrying oxygen to all
parts of the body.
• In sickle cell disease ,the red blood cells become hard
and sticky and look like a C-shaped farm tool called a
sickle.
7. Continue,,,,,,,
• Sickle cells die early , which causes a constant
shortage of red blood cells.
• Sickle cells can get stuck in small blood vessels
and block the flow of blood and oxygen to
organs in the body . these blokages cause
repeated episodes of severe pain , organ
damage, serious infections , even stroke.
8. Who is affected by SCD….
• It is estimated that sickle
cell disease affects 90,000
-100,000 people in the
United states , mainly
Blacks or African –
Americans.
• These disease occurs
among about 1 of every
500 Black or African –
Americans and among
about 1 out of every
36,000 Hispanic American
births.
9. Pathology ..
• Caused by mutation in
beta globin gene –at
sixth position , glutamic
acid is replaced by
valine.
• Red blood cells typically
live 90-120 days , but
sickle cells only survive
10-20 days.
10. Types of sickle cell disease
1. Sickle cell anemia:
Homozygous state for HbS (βS- βS)
2. Sickle cell trait :
Heterozygous carrier state for HbS (βS -β)
If one parent has sickle cell anemia and other is
normal , all children will have sickle cell trait.
If one parent has sickle cell anemia and other has
sickle cell trait there is 50% chance of either with
each pregnancy.
11. If both parents have sickle cell trait?
AA-normal
AS-sickle cell
trait
SS-sickle cell
Anemia
12. 3. Sickle cell – β thalassemia :
Double heterozygote in which sickle cell gene
is inherited from one parent and beta
thalssemia gene from other parent .
gene type (βsβo-βsβ+)
4. Combination of Hbs with other abnormal
hemoglobin (HbSD, HbSC, HbSO(arab
disease),HbSE).
13. Loss of oxygen
Polymer or rigid rods leading to sickled RBCs
RBCs stick to blood vessels
Stasis
Hypoxia
Pain(vaso-occlusive crisis)
14. Symptoms
• No symptoms infants????
It is able to block the sickling action of the
RBCs so infants who have inherited the
disease do not develop symptoms.
people with sickle cell gene who continue to
carry some HbF are better protected from
severe from of the disease.
15. Symptoms…
• Pain
• Visual blurring
• jaundice
• Syncope
• Dactylitis
• Neck stiffness and head ache
• Neurological symptoms
• Infection
• Leg ulcer
• Weakness and pallor
Dactylit
is
Leg
ulcer
Small remnant
of
spleen
Dying tissue of
leg
17. SICKLING TEST
Principle :
Sodium meta bisulphite reduces the oxygen tension
inducing the typical sickle – shape of red blood
cells.
Sample:
Fresh blood in any anticoagulant.
Method:
mix 1 drop of blood with 1 drop of 2% sodium
meta bisulphate solution on a microscope slide.
19. TREATMENT
• There is no single best treatment for all people
with Sickle cell disease.
• Treatment options are different for each
person depending on the symptoms.
• Treatments can include receiving blood
transfusions, maintaining a high fluid intake
(drinking 8 to 10 glasses of water each day),
receiving IV (intravenous) therapy (fluids given
into a vein) and medications to help with pain.
20. Main treatment methods
There is no known cure for sickle cell anemia.
The four main treatment options are:
• Blood Transfusions
• Drug Treatment
• Blood and Marrow Stem Cell Transplantation
• Gene Therapy
21. Prevention
Genetic screening
Testing for sickle cells in babies.
Chronic vill sampling
Amniotic fluid sampling
Fetal blood samplin
Daily penicillin for newborn babies with the
disease.